Roles of anti-inflammatory system after drug-induced kidney injury

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860101
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Kyoto University
• Principal Investigator: Nakagawa Shunsaku 京都大学, 医学(系)研究科(研究院), その他 (50721916)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 薬剤性腎障害 / 尿細管間質性腎炎

Outline of Final Research Achievements

Drug-induced kidney injury (DKI) can cause progressive renal dysfunction and sever systemic outcomes. However, there are few approaches to repair or resolve the inflammation and fibrosis after DKI. In this study, we tried to identify the intrinsic anti-inflammatory system in the kidney.
After the administration with cisplatin, the expression levels of pro-inflammatory cytokines, IL-6 and CCL2 were significantly increased in the mouse kidneys at day2 after the treatment. On the other hands, the expression levels of anti-inflammatory cytokines, IL-10 and IL-27 were increased in the kidney at 7 days after the administration. Taken together, there results suggested the active roles of anti-inflammatory system in the kidney during cisplatin-induced kidney injury.

Free Research Field

臨床薬学