Drug discovery of next generation-erythropoiesis stimulating agent

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860179
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: Tohoku University
• Principal Investigator: Kaneko Hiroshi 東北大学, 医学(系)研究科(研究院), 助教 (80635558)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: GATA転写因子 / エリスロポエチン / 創薬

Outline of Final Research Achievements

Erythropoietin (EPO) is a humoral factor potentiating erythropoiesis. EPO expression was strictly regulated by oxygen level in vivo. Recent studies revealed that Epo expression is repressed by GATA transcription factors in a part of epithelial tissues in vivo. In this study, I utilized genetic and pharmacological approach to inhibit the function of GATA factors and elucidated that disturbance of GATA factors resulted in the release of Epo expression from non-canonical EPO producing cells. These evidences clearly demonstrated the validity of GATA factors as novel therapeutic target of renal anemia.

Free Research Field

分子生物学、分子血液学