Tissue-specificity in the reprogramming process.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860365
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Nagoya University
• Principal Investigator: ARIOKA YUKO 名古屋大学, 医学部附属病院, 特任助教 (10709497)
• Research Collaborator: YAMADA Yasuhiro 京都大学, iPS細胞研究所, 教授 ; ITO Hiroyasu 岐阜大学, 医学系研究科, 准教授
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: iPS細胞 / 体細胞初期化過程 / 組織幹細胞 / 組織特異性

Outline of Final Research Achievements

It remains unclear whether the reprogramming process shows the opposite direction of the development (differentiated cells → tissue stem cells/progenitor cells → iPS cells). To address this, we investigated the reprogramming process using hair follicles. Some cells transiently exhibited the hair follicle stem cell marker (Lgr5); however, the Lgr5-positive cells were unlike native ones. On the other hand, we found that the Lgr5-positive cells were efficiently converted into iPS cells.

Free Research Field

幹細胞学