Pathogenetic and therapeutic studies of myeloid leukemia with Down syndrome using xenograft model

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860795
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Kyoto University
• Principal Investigator: SAIDA SATOSHI 京都大学, 医学(系)研究科(研究院), 助教 (70638254)
• Co-Investigator(Renkei-kenkyūsha): ITO Etsuro 弘前大学, 小児科, 教授 (20168339) ; NAKAHATA Tatsutoshi 京都大学, iPS細胞研究所, 教授 (20110744) ; OGAWA Seishi 京都大学, 大学医医学研究科, 教授 (60292900) ; WATANABE Ken-ichiro 京都大学, 大学院医学研究科, 臨床教授 (20324634)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 白血病 / ダウン症候群 / 一過性異常骨髄増殖症 / 急性巨核芽球性白血病

Outline of Final Research Achievements

Transient abnormal myelopoiesis (TAM) is a clonal pre-leukemic disorder in neonates of Down syndrome. In this study, we established a xenograft model of the leukemia, which mimicked the progression of TAM to myeloid leukemia (ML-DS). Using comprehensive genetic and epigenetic analyses in this xenograft model, we found an important factor in a progression from TAM to ML-DS.

Free Research Field

血液腫瘍