2016 Fiscal Year Final Research Report
Effect of Japanese cedar-specific subcutaneous immunotherapy on allergen-specific T cells
Project/Area Number |
26860817
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pediatrics
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Research Institution | Nagoya City University |
Principal Investigator |
NOMURA Takayasu 名古屋市立大学, 大学院医学研究科, 研究員 (50587334)
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Research Collaborator |
SAITOH Shinji
ITO Yasuhiko
OZEKI Kazuyoshi
SUZUKI Motohiko
NAKAMURA Yoshihisa
YOKOTA Makoto
TSUGE Ikuya
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | 舌下免疫療法 / スギ花粉症 / 抗原特異的T細胞 |
Outline of Final Research Achievements |
The contribution of antigen-specific TH cells in peripheral blood to immunologic mechanisms underlying sublingual immunotherapy (SLIT) remains unclear. To clarify the role of antigen-specific TH cells, we used a sensitive method analyzing activation marker CD154-positive TH cells with multicolor flow cytometry. We assessed antigen-specific TH cells in patients with Japanese cedar pollinosis receiving SLIT at baseline and during the first pollen season after the initiation of SLIT. A total of 18 patients were enrolled in the present study. Of these, 8 patients received SLIT (SLIT group) and 10 patients received symptomatic treatment only (control group). Although seasonal pollen exposure significantly increased the number of Japanese cedar-specific interleukin 5- and interleukin 4-producing TH cells in the control group, SLIT ameliorated this increase in the SLIT group. The present study indicates that peripheral allergen-specific TH2 cells are involved in mechanisms underlying SLIT.
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Free Research Field |
小児アレルギー
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