2015 Fiscal Year Final Research Report
A basic study on radiation-induced epithelial-to-mesenchymal transition and control of cancer stem cell differentiation in esophageal cancer
Project/Area Number |
26860985
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Radiation science
|
Research Institution | Kanazawa University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Keywords | EMT / radiation / esophageal cancer / metformin / treatment-resistance / cancer stem cell |
Outline of Final Research Achievements |
There is a possibility to be brought great gospel by understanding the characteristics of epithelial-to mesenchymal transition (EMT) and cancer stem cell as pivotal factors which determine the malignant potential and treatment-resistance of cancer. In the present study, we examined the synergistic effect of anti-diabetic drug, metformin, in esophageal cancer treatment through the control of radiation-induced EMT and cancer stemness. In our study with esophageal cancer cell line and ectopic rectal transplant model mouse of esophageal cancer cell, the inhibitory effects of metformin on tumor growth and radiation-induced EMT as an effective therapeutic adjunct on cancer treatment were proven in vitro and in vivo.
|
Free Research Field |
oncology
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