2015 Fiscal Year Final Research Report
Relationship between portal venous congestion and functions of splanchnic organs
| Project/Area Number |
26861064
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 小腸 / 門脈 / 肝臓 / うっ血 / アポトーシス |
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| Outline of Final Research Achievements |
In clinical settings of hepato-pancreato-biliary and liver transplant surgery, portal venous congestion (PVC) is common pathophysiology. Therefore, effect and therapeutic approach for PVC was investigated by rat model. Intestinal mucosa was injured by PVC via apoptosis. By the induction of congestive preconditioning (CPC), intestinal mucosal injury and survival rate were significantly improved. The anti-apoptotic pathways was suspected to be involved in this availability, based on the result from immunohistochemical analysis.
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| Free Research Field |
肝胆膵・移植外科学
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