Search for lung cancer stem cells in pulmonary venous blood in primary lung cancer.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861131
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: YONEDA Kazue 産業医科大学, 医学部, 助教 (80724806)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 原発性肺癌 / 肺静脈血 / 腫瘍細胞

Outline of Final Research Achievements

Control of the recurrence of distant metastases after surgery is a major problem for improvement of prognosis after resection of primary lung cancer. There are not many cases where relapse or distant metastasis still occurs even if tumor can be completely resected. The involvement of circulating tumor cells in the blood is suggested for tumor hematogenous metastasis. We have quantitated the CTC of peripheral blood and pulmonary venous blood of lung cancer patients and found association with distant metastasis.
In this study, we aimed to find a new target for lung cancer treatment by trying to isolate lung cancer cells having proliferation and engraftment ability from the blood of the pulmonary vein leading from the lung to the general circulation, but this time in the lung cancer patients who were performed surgery, it is rarely seen that cancer cells in the pulmonary vein blood with self-proliferating ability outside the body.

Free Research Field

translational research（胸部腫瘍）