2016 Fiscal Year Final Research Report
Exploration for Telomere related biomarker of adult gliomas
| Project/Area Number |
26861171
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
Arita Hideyuki 大阪大学, 医学系研究科, 特任助教(常勤) (60570570)
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| Research Collaborator |
ICHIMURA Koichi
YAMASAKI Kai
MATSUSHITA Yuko
NARITA Yoshitaka
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | Glioma / telomere / TERT / IDH |
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| Outline of Final Research Achievements |
Gliomas are the most common primary brain tumors in adults. They are divided into several histological subtypes base on histology, but each subtype contains clinically diverse phenotypes. We hypothesized that telomere-related genes, mainly TERT promoter, may be a prognostic marker for this tumor. We conducted genetic analysis for a Japanese cohort, and investigated the relationships between genetic alteration and clinical courses. Our results indicated that TERT promoter mutations are useful to define glioma subclasses with different clinical courses in combination with IDH1/2 or MGMT methylation status.
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| Free Research Field |
脳神経外科学
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