2016 Fiscal Year Final Research Report
The therapeutic effect of Astaxanthin for Systemic Inflammatory Response Syndrome
| Project/Area Number |
26861226
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Research Collaborator |
HATTORI Mizuki 富山大学, 附属病院, 助教
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | アスタキサンチン / 敗血症 / 全身炎症反応症候群 / 抗酸化作用 / 酸化ストレス / 5-FU誘発腸炎 |
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| Outline of Final Research Achievements |
Systemic inflammatory response syndrome (SIRS) is the leading cause of death intensive care units. Oxidative stress plays as important role in SIRS. The aim of this study was to evaluate the effects of Astaxanthin, that is one of antioxidants, in SIRS. In 5-FU induced enteritis mice, the number of intestinal crypt cells was deceased and apoptotic cells was increased. Both in enteritis mice and TNF-alfa stimulated HCT 116 cells, expression of inflammatory cytokines and ROS (reactive oxygen species) increased. In contrast, in Astaxanthin + 5-FU group , the number of intestinal crypt cells was inceased and apoptotic cells was less than 5-FU group, and expression of inflammatory cytokine reduced. In Astaxanthin + TNF-alfa group, expression of ROS was less than TNF-alfa stimulated HCT 116 cells group. The protective effects of Astaxanthin are likely attributable to the decrease in oxidative stress.
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| Free Research Field |
敗血症
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