2016 Fiscal Year Final Research Report
Modulation of neural circuits by volatile anesthetic in the mouse brain during postnatal development and senium
| Project/Area Number |
26861249
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 吸入麻酔薬 / 脳内神経伝達 |
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| Outline of Final Research Achievements |
Volatile anesthetics have been reported to inhibit the hyperpolarization-activated cation current (Ih) that contributes to generation of synchronized oscillatory neural rhythms. Meanwhile, the developmental change of Ih has been speculated to play a pivotal role during maturation. We examined the effect of volatile anesthetic sevoflurane on Ih in developing striatum. Our analyses showed that the changes in Ih of cholinergic interneurons occurred in conjunction with maturation. In addition, sevoflurane caused significant inhibition of Ih in a dose-dependent manner. Moreover, sevoflurane significantly decreased spike firing during the rebound activation, which is essential for responses to the sensory inputs from the cortex and thalamus. The sevoflurane-induced inhibition of Ih in striatal cholinergic interneurons may lead to alterations of the acetylcholine-dopamine balance in the neural circuits during the early postnatal period.
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| Free Research Field |
麻酔科学
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