Are APOBEC deaminases oncogenic in HPV infection?

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861318
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Kanazawa University
• Principal Investigator: Wakae Kousho 金沢大学, 医学系, 助教 (70638303)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: APOBEC / 子宮頸癌 / hypermutation / HPV

Outline of Final Research Achievements

This study aimed to clarify the pathophysiological role of APOBEC deaminases in HPV infection. We obtained the following conclusion. 1. APOBECs are induced by interferons and HPV 2. APOBECs hypermutate HPV or host genomes, and their expression correlates with integration of HPV genome into the host 3. On the contrary, APOBECs decrease infectivity of HPV virion when expressed in virion-producing cells. These finding revealed the bilateral role of APOBECs as antiviral and oncogenic molecules, in HPV infection.

Free Research Field

virology