Functional analysis of protein disulfide isomerase P5 as anti-cancer target

2015 Fiscal Year Final Research Report

• Project/Area Number: 26870287
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Drug development chemistry; Biological pharmacy
• Research Institution: Kyoto University
• Principal Investigator: HORIBE TOMOHISA 京都大学, 医学(系)研究科(研究院), 講師 (20467468)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: ケミカルバイオロジー / タンパク質 / 分子シャペロン

Outline of Final Research Achievements

We performed the functional analysis of protein disulfide isomerase (PDI) P5 in cancer cells using inhibitors to reductase activity of P5, which we previously screened and identified using a chemical compound library. It was found that one of these inhibitors could decrease the secretion levels of soluble MICA from cancer cells. We also examined the effect of the inhibitors on the cancer cells viability, and found that the inhibitors had cytotoxic activity to cancer cells.

Free Research Field

分子生物学