2016 Fiscal Year Final Research Report
Functional and genetic diversity of the activating receptor to recognize microbially cleaved antibody
| Project/Area Number |
26870334
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Immunology
Human genetics
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
Hirayasu Kohyuki 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (30585170)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 細菌感染 / Bacteria / Immunoglobulin / 活性化レセプター / プロテアーゼ |
|---|
| Outline of Final Research Achievements |
In this study, a comprehensive search for interaction between pathogens and host immune receptors was performed. In this process, it was found that microbial pathogens have evolved to acquire antibody-cleaving proteases in order to escape from the host immune system of antibody recognition. Moreover, it was also found that an orphan activating immune receptor, LILRA2, recognizes these microbially disrupted antibody in order to counteract the microbial immune evasion strategy.
|
| Free Research Field |
免疫遺伝学
|
