2015 Fiscal Year Final Research Report
Study on the antitumor mechanism of Rb-dependent mitochondrial metabolic remodeling
| Project/Area Number |
26870443
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
Tumor biology
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| Research Institution | Mie University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 細胞老化 / エネルギー代謝 / Retinoblastoma |
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| Outline of Final Research Achievements |
Cellular senescence is widely recognized as an important tumor suppressor function and accompanies metabolic remodeling. In this study, we demonstrate a novel role of Retinoblastoma (Rb) in oncogene-induced senescence. Our combined metabolic and gene expression analyses show that Rb mediates senescence-associated metabolic remodeling through transcriptional activation of a set of metabolic genes including glycolytic genes.
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| Free Research Field |
エピジェネティクス
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