2015 Fiscal Year Final Research Report
Development of c-kit targeted adenovirus for GIST
| Project/Area Number |
26893090
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
|
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
|
| Keywords | 遺伝子治療 / 消化管間質腫瘍 / 腫瘍溶解ウイルス療法 |
|---|
| Outline of Final Research Achievements |
The gastrointestinal stromal tumor (GIST) is related with activity of c-kit which is cell surface protein on GIST cells. The c-kit has been already used as a molecular target for the first line GIST therapy, and is also promising target molecule for targeted-adenovirus which is expected as an oncolytic virus therapy for next generation cancer therapy. In this study, two candidate motifs was identified for c-kit targeted-adenovirus by adenovirus-library screening system. In the future, c-kit targeted-adenovirus with these candidate motifs are expected as a for new oncolytic adenovirus therapy against GIST.
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| Free Research Field |
消化器内科
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