2017 Fiscal Year Final Research Report
Developmental programmed cell death of central auditory system
| Project/Area Number |
26893098
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-08-29 – 2018-03-31
|
| Keywords | 先天性難聴 / 聴覚中枢 / 蝸牛 / 人工内耳 |
|---|
| Outline of Final Research Achievements |
Congenital profound hearing loss model by antimicrobial drug amikacin which have ototoxicity have been used. Histologic examination about the hair cells and spiral ganglion neuron in cochlea was carried out in normal and the amikacin-treated animals. In amikacin-treated animals degeneration was significant both hair cells and spiral ganglion neurons in the basal turn of cochlea. The amikacin-treated congenital hearing loss model is suspected to be affected especially high frequency sound with frequency characteristics of cochlea.
|
| Free Research Field |
耳科学
|
