1988 Fiscal Year Final Research Report Summary
Relationship between the concentration of serum lipids and dietary factors in Zen monks.
| Project/Area Number |
62304053
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| Research Category |
Grant-in-Aid for Co-operative Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
医学一般
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| Research Institution | Kyoto University |
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Principal Investigator |
TORU KITA Kyoto University, 医学部 (60161460)
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| Co-Investigator(Kenkyū-buntansha) |
中谷 矩章 東海大学, 医学部, 助教授
YUJI MATSUZAWA Osaka University, 医学部, 講師 (70116101)
KOREAKI NAKAYA Tokai University
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| Project Period (FY) |
1987 – 1988
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| Keywords | cholesterol / dietary factors / LDL / fatty acids / Zen monks / 血小板 |
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| Research Abstract |
In Japan the incidences of heart attacks and cerabral srtokes are rapidly increasing, which correlates with a greater consumption of Western style food. Epidemiologic surveys conducted in many countries over the past 30years have all shown that atherosclerosis becomes more severe as the mean LDL level rises in a population. In Japan, it is well known that Zen monks have long life span, possibly because of their diet. In this study, we focused on their serum lipid levels and dietary habits.
The mean levels of total cholesterol and LDL-cholesterol were 28.5, and 32.8% lower in Zen monks than in control Japanese males. There were no significant difference in the level of triglyceride in both groups. The mean levels of total and LDL-cholesterol were almost same in both caucasian and Japanese Zen monks and were apparently lower than that in control Japanese males. This suggested that there are no race difference in the level of serum cholesterol when people eat animal product-free diet. In addition, the serum lipid levels in Zen monks before they started thraining were compared with those 6 months after they underwent training. The mean levels of total and LDL-cholesterol decreased by 18.1 and 16.3%, respectively. The results of the nutritional intake revealed differences between Zen monks and control males. No significant differences were observed between the groups in mean intake of total calories. Zen monks consumed virtually no cholesterol or animal products (fat protein) and ate only vegetable fats with an extremely high ration of polyunsaturated to saturated fat (P/S ratio). These data suggest that the dietary habits of Zen monks give rise to relatively low levels of LDL-cholesterol. We are now planning to investigate what factors in fatty acids influence serum cholesterol level.
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Research Products
(16 results)
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[Publications] Kita,T.;Yokode,M.;Kume,N.;Ishii,K.;Nagano,Y.;Mikami,A.;Kita,M.;Fuhii,K.;Kawai,C.;Domae,N.;Ishihara,H.;Kimura,M.;Itokawa,Y.: Jap.Circl.J.52. 99-104 (1988)
Description
「研究成果報告書概要(和文)」より
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[Publications] Wu,D-J.;Fujiwara,H.;Tanaka,M.;Onodera,T.;Matsuda,M.;Ishida,M.;KAwamura,A.;Takemura,G.;Fujiwara,T.;Nagano,Y.;Ishii,K.;Kita,T.;Kawai,C;Hamashima,Y.: Jap.Circl.J.52. 327-340 (1988)
Description
「研究成果報告書概要(和文)」より
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[Publications] Kita, T.,;Yokode, M.,;Kume, N.,;Ishii, K.,;Nagano, Y.,;Mikami, A.,;Kita, M.,;Fujii, K.,;Kawai, C.,;Domae, N.,;Ishihara, H.,;Kimura, M.; Itokawa, Y.: "The concentration of serum lipids in Zen monks and control males in Japan." Jap. Circl. J.52. 99-104 (1988)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Kita, T.,;Nagano, Y.,;Yokode, M.,;Ishii, K.,;Kume, N.,;Narumiya, S.,;Kawai, C.: "Prevention of atherosclerotic progerssion in Watanabe rabbits by probucol." Am. J. Cardiol.62. 13-19 (1988)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Wu, D-J.,;Fujiwara, H.,;Tanaka, M.,;Onodera, T.,;Matsuda, M.,;Ishida, M.,;Kawamura, A.,;Takemura, G.,;Fujiwara, T.,;Nagano, Y.,;Ishii, K.,;Kita, T.,;Kawai, C.; Hamashima, Y.: "Distribution and progression of coronary arterial and aortic lesions in the conventional WHHl rabbit -quantitative analysis-." Jap. Circl. J.52. 327-340 (1988)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Yokode, M.,;Kita, T.,;Arai, H.,;Kawai, C.,;Narumiya, S.,;Fujiwara, M.: "Cholesteryl ester accumulation in macrophages incubated with low density lipoprotein pretreated with cigarette smoke extract." Proc. Natl. Acad. Sci. U.S.A.85. 2344-2348 (1988)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Ishii, K.,;Kita, T.,;Kume, N.,;Nagano, Y.,;Kawai, C.: "Uptake of acetylated LDL by peritoneal macrophages obtained from normal and Watanabe heritable hyperlipidemic rabbits, an animal model for familial hypercholesterolemia." Biochim. Biophys. Acta. 962. 387-389 (1988)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Kita, T.,;Kumi, N.,;Tsujita, Y.,;Ito, T.,;Watanabe, Y.;Kawai, C.: "Induction of hepatic LDL receptors in heterozygous WHHL rabbits treated with CS-524 alone or CS-514 in combination with cholestyramine." Drugs Affecting Lipid Metabolism. 251-254 (1987)
Description
「研究成果報告書概要(欧文)」より
