1988 Fiscal Year Final Research Report Summary
ELUCIDATION OF PATHOPHYSIOLOGICAL SIGNIFICANCE OF ATRIAL NATRIURETIC PEPTIDE
| Project/Area Number |
62570525
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
内分泌・代謝学
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| Research Institution | TOKYO WOMEN'S MEDICAL COLLEGE |
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Principal Investigator |
NARUSE Mitsuhide SECOND DEPARTMENT OF MEDICINE, TOKYO WOMEN'S MEDICAL COLLEGE, 第2内科, 講師 (40120018)
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| Co-Investigator(Kenkyū-buntansha) |
HIROSE Shigehisa DEPARTMENT OF CHEMISTRY, TOKYO INSTITUTE OF TECHNOLOGY (10134199)
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| Project Period (FY) |
1987 – 1988
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| Keywords | ATRIAL NATRIURETIC PEPTIDE / MITRAL DISEASE / ATRIAL PRESSURE / ATRIAL FIBRILLATION / 存在様式 |
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| Research Abstract |
The pathophysiologic significance of the different molecular form of human atrial natriuretic polypeptide (ANP). especially beta-hanp, was investigated. Immunoreactive (ir-) hANP levels and its molecular form were determined by radioimmunoassay and high-performance gel permeation chromatograpy. Atrial ir-hANP levels were significantly higher in mitral disease than in non-cardiac or other cardiac diseases. The increase was mainly due to an increase in ir-beta-hANP, which correlated with atrial pressure. Although plasma ir- hANP consisted mainly of ir-alpha-hANP, ir-beta-hANP was significantly elevated in mitral disease and in sick sinus syndrome after atrial pacing. Atrial ir-beta-hANP and ir-gamma-hANP could be converted to ir-alpha-hANP when incubated with plasma. These results suggest that human atrium responds to a hemodynamic overload by increasing ANP production with a shift to the beta-hANP form, which could be reflected in the increased plasma ir-beta-hANP levels.
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