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1989 Fiscal Year Final Research Report Summary

Expulsion mechanism of adult-taeniid cestodes induced by mucosal responses of definitive hosts.

Research Project

Project/Area Number 63480086
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 基礎獣医学
Research InstitutionHokkaido University

Principal Investigator

KAMIYA Masao  Faculty of Vet. Med., Hokkaido Univ. professor, 獣医学部, 教授 (30081665)

Co-Investigator(Kenkyū-buntansha) OKAMOTO Munehiro  Faculty of Vet. Med., Hokkaido Univ. research associate, 獣医学部, 助手 (70177096)
OKU Yuzaburo  Faculty of Vet. Med., Hokkaido Univ. associate professor, 獣医学部, 助教授 (60133716)
OHBAYASHI Masashi  Dep. of Vet. Med., Rakunogakuen Univ. professor, 獣医学部, 教授 (60001517)
Project Period (FY) 1988 – 1989
KeywordsTaenia / Echinococcus / Golden hamster / Worm-expulsion / Prednisolone / Alternative / Cricetidae / Heteromydae
Research Abstract

The taeniids are of interest not only because of their disease roll in domestic animals, some species are also of immense importance to Public health.
To date, research on resistance to these cestodes has mainly focused on the intermediate host, and therefore on the larval cestode stage. The reasons for this were, that a suitable definitive host model has not been established, and experiments using the natural definitive host pose a grave threat to liuinan health, creating a barrier to safe investigative methods.
To overcome this, this laboratory has investigated the possibility of using as experimental hosts for the five taeniid species Echinococcus multilocularis(Em), E. granulosus(Eg), Taenia crassiceps(Tc), T. saginata(Ts) and T. hydatigena(Th), the rodent species golden hamster(GH), Mongolian gerbil(MG) and 10 species of wild carnivorous rodents obtained from New Mexico, U.S.A.
1) Tc/GH group. Adult worms developed in the small intestine of predonisolone treated and imtreated hamster … More s, and produced normal eggs.
2) TC/MG group. In the treatment group worm expulsion was hindered as in the GH. A marked impediment to egg formation was noted.
3) Em/GH group. Sexually mature worms were recovered from imtreated GH on day 25 post inoculation(PI). In inbred strains the presence of a defensive reaction to reinfection was suggested.
4) Em/MG group. Susceptibility varied with age of host, and high worm recovery rate showed that the eggs liad Iiigli infectivity in this 1-iost.
5) Em/Kangaroo rat etc. group. In tlie early stages of infection these rodents match the natural definitive host for worm recovery rate and worm development.
Also, a complete substitute definitive host model for Em and Tc was established for the first time, and we could begin to explain phenomena such as the association between worm expulsion and antibody response.
Apart from this, by achieving growth to sexual maturity of the human tapeworm T. saginata in treated Mongolian Gerbils, we have broken down the barriers to research in this field. Less

  • Research Products

    (41 results)

All Other

All Publications (41 results)

  • [Publications] 大林正士: "エキノコックス症とその広がり" メディアサ-クル. 33. 81-88 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] KAMIYA.M: "Infectious diseases transmitted by dogs to humans" Asian Medical Journal. 31. 87-93 (1988)

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      「研究成果報告書概要(和文)」より
  • [Publications] 神谷正男: "エキノコックス、特に多包虫の伝播における野生動物の位置付け." モダンメディア. 34. 343-351 (1988)

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      「研究成果報告書概要(和文)」より
  • [Publications] 神谷正男: "エキノコックスの現状について" ふぉ-なす. 8. 7-8 (1988)

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      「研究成果報告書概要(和文)」より
  • [Publications] 神谷正男: "エキノコックスに関する最近の知見、特に感染サイクルにおける動物ならびに防除のための国際協力" 環境衛生. 36(10). 6-18 (1989)

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  • [Publications] 神谷正男: "包条虫・エキノコックスの現状とその対策" 臨床と微生物. 16. 544-550 (1989)

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      「研究成果報告書概要(和文)」より
  • [Publications] 神谷正男: "被食者-捕食者相互関係で伝播する寄生虫・エキノコックスの防除" 学術月報印刷中. (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] SATO.H,&KAMIYA,M.: "viable egg production of Taenia crassiceps developed in the intestine of prednisolone-treated golden hamsters." Japanese Journal of Parasitology. 38. 46-53 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] SATO,H&KAMIYA,M.: "Deleterious effect of prednisolone on the attachment of Taenia crassiceps cysticerci to intestine of gerbils." Japanese Journal of Veterinary Science. 51. 1099-1101 (1989)

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      「研究成果報告書概要(和文)」より
  • [Publications] KAMIYA,M.&SATO,H.: "Survival,strobilation and sexual maturation of Echinococcus multilocularis in the small intestine of golden hamsters." Parasitology. 100. 125-130 (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] MIYAJI,S.,OKU,Y.,KAMIYA,M.,OKAMOTO,M.,OHBAYASHI,M.,UCHIODA,A.& RAUSCH,R,L.: "Growth of a Japanese isolate of Taenia crassiceps in intermediate and difinitive hosts" Parasitology Research(in press). (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] KITAOKA,M.,OKU,Y.,OKAMOTO,M.,& KAMIYA,M.: "Development and sexual maturation of Taenia crassiceps(Cestoda) in golden hamster" Journal of Parasitology(in press). (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] SATO,H.& KAMIYA,M.: "Establishment,development and fecundity of Taenia crassiceps in the intestine of predonisolone-treated Mongolian gerbils and inbred mice." Journal of Helminthology(in press). (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] SATO,H.& KAMIYA,M.: "Extraintestinal strobilar development of immature Echinococcus multilocularis in laboratory rodent following intra-tracheal inoculation of the protoscoleces." International Journal for Parasitology(in press). (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] SATO,H.,KAMIYA,Y.,YOKOHATA,Y.& MATSUZAKI,T.: "Experimental infections of shrews(Suncus murinus and Sorex unguiculatus)with Trichinella spp,.Taenia crassiceps and Echinococcus multilocularis." Journal of Wildife Diseases(sub mitted). (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] SAITOH,R.,OKU,Y.&KAMIYA,M.: "Survival of Tania crassiceps in mice and jirds following oral infection with metacestodes." (投稿予定). (1990)

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      「研究成果報告書概要(和文)」より
  • [Publications] 黒野博之、佐藤宏、奥祐三郎、岡本宗裕、神谷正男: "多包条虫の非許容宿主腸管における原頭節の動態、宿主の病理学的変化および腸管粘膜透過性" (投稿予定). (1990)

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  • [Publications] 山田岳彦、奥祐三郎、岡本宗裕、佐藤宏、神谷正男: "Taenia crassiceps成虫に対する代替終宿主ゴ-ルデンハムスタ-の再感染防御、抗体産生および組織反応" (投稿予定). (1990)

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  • [Publications] 神谷正男: "エキノコックスの分類・生活環・分布ならびに種分化.62-74 上本・和田編、病気の生物地理学" 東海大学出版会東京, 183 (1989)

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      「研究成果報告書概要(和文)」より
  • [Publications] OHBAYASHI, M.: "Echinococcosis and its spreading condition." Media Circle, 33, 81-88, 1988.

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      「研究成果報告書概要(欧文)」より
  • [Publications] KAMIYA, M.: "Role of wild animals in transmission of Echinococcus species, especially E. multilocularis." Modern Media, 34, 343-351, 1988.

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      「研究成果報告書概要(欧文)」より
  • [Publications] KAMIYA, M.: "Present status of Echinococcus." Faunus, 8, 7-8, 1988.

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      「研究成果報告書概要(欧文)」より
  • [Publications] KAMIYA, M.: "Latest information on hydatid diseases especially on the international cooperation-program for their control." Kankyo-Eisei, 36(10), 6-18, 1989.

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      「研究成果報告書概要(欧文)」より
  • [Publications] KAMIYA, M.: "Current status and control of Echinococcus infection." Clin. Microbiol., 16, 544-550, 1989.

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      「研究成果報告書概要(欧文)」より
  • [Publications] KAMIYA, M.: "Echinococcus being transmitted through prey-predator interaction." Japanese Scientific Monthly, 43,(5), in press, 1990.

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      「研究成果報告書概要(欧文)」より
  • [Publications] SATO, H. & KAMIYA, M.: "Viable egg production of Taenia crassiceps developed in the intestine of predonisolone-treated golden hamsters." Jpn. J. Parasitol., 38 46-53, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] SATO, H. & KAMIYA, M.: "Deleterious effect of prednisolone on the attachment of Taenia crassiceps cysticerci to the intestine of gerbils." Jpn. J. Vet. Sci., 51, 1099-1101, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] KAMIYA, M. & SATO, H.: "Survival, strobilation and sexual maturation of Echinococcus multilocularis in the small intestine of golden hamsters." Parasitology, 100, 125-130, 1990.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] KAMIYA, M., SATO, H.: "Complete life-cycle of a canid tapeworm, Echinococcus multilocularis, in laboratory rodents." FASEB Journal, 1990.

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      「研究成果報告書概要(欧文)」より
  • [Publications] KITAOKA, M., OKU, Y., OKAMOTO, M. & KAMIYA, M.: "Development and sexual maturation of Taenia crassiceps (Cestoda) in golden hamster." J. Parasitol. 1990.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] MIYAJI, S., OKU, Y., KAMIYA, M., OKAMOTO, M., OHBAYASHI, M., UCHIDA, A. & RAUSCH, R. L.: "Growth of a Japanese isolate of Taenia crassiceps in intermediate and definitive hosts." Parasitol. Res. 1990.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] SATO, H. & KAMIYA, M.: "Establishment, development and fecundity of Taenia crassiceps in the intestine of predonisolon-treated Mongolian gerbils and inbred mice." J. Helminthol. 1990.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] SATO, H. & KAMIYA, M.: "Extraintestinal strobilar development of immature Echinococcus multilocularis in laboratory rodents following intra-tracheal inoculation of the protoscolexes." Int. J. Parasitol. 1990.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] SATO, H., KAMIYA, M., YOKOHATA, Y. & MATSUZAKI, T.: "Experimental infection of shrews ( Suncus murinus and Sorex unguiculatus ) with Trichinella spp., Taenia crassiceps and Echinococcus multilocularis." J. Wildlife Dise. 1990.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] FUJITA, O., OKU, Y., OOI, H. K., RAUSCH, R. L. & KAMIYA, M.: "Susceptibility of rodents to taenia polyacantha and their mortality along the course of infection." Jpn. J. Parasitol.

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      「研究成果報告書概要(欧文)」より
  • [Publications] ISHIWATA, K., OKU, Y., KAMIYA, M. & OHBAYASHI M.: "Phenotypic changes in hepatic mast cells accumulating around the metacestodes of Taenia taeniaeformis in rats." APMIS, 1990.

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      「研究成果報告書概要(欧文)」より
  • [Publications] KURONO, H., SATO, H., OKU, Y., OKAMOTO, M., & KAMIYA, M.: "Studies on the definitive host-specificity of Echinococcus multilocularis, especially on the kinetics of scoleces in non-permissive hosts."

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  • [Publications] MORISHITA, K.: "Development and characterization of murine monoclonal antibodies to larval Echinococcus."

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      「研究成果報告書概要(欧文)」より
  • [Publications] SAITOH, R., OKU, Y. & KAMIYA, M.: "Survival of Taenia crassiceps in mice and jirds following oral infection with metacestodes."

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] YAMADA, T., OKU, Y. OKAMMOTO, M., SATO, H. & KAMIYA, M.: "Acquired immunity against Taenia crassiceps in golden hamsters as alternative definitive hosts."

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      「研究成果報告書概要(欧文)」より
  • [Publications] KAMIYA, M.: Classification, life cycles, geographical distribution and speciation of Echinococcus spp. In: Biogeographyy of diseases, Eds. UEMOTO, K. & WADA, Y.62-74,. Tokai University Press, 183, 1989,

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Published: 1993-03-26  

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