1989 Fiscal Year Final Research Report Summary
Inhibition of tumor neovascularizatuon in the experimental brain tumors by hydrocortisone.
| Project/Area Number |
63570692
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
SUZUKI Yasuo Kawasaki Medical School, Department of Neurosurgery, Assistant Professor, 脳神経外科, 助教授 (90143809)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Akira Kawasaki Medical School, Department of Neurosurgery, Lecturer, 脳神経外科, 講師 (20192437)
ISHII Ryoji Kawasaki Medical School, Department of Neurosurgery, Professor, 脳神経外科, 教授 (40111710)
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| Project Period (FY) |
1988 – 1989
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| Keywords | Microvascular architecture / Corrosion cast / Experimental brain tumor / Bromodeoxyuridine / Anti-angiogenesis |
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| Research Abstract |
Tumor microcirculation is of crucial importance not only for the metabolism and behavior of tumor tissue but also for tumor therapy. Scanning electron microscopy of vascular corrosion casts and immuno- cytochemical study was undertaken to demonstrate the inhibition of the tumor neovasucularization by hydrocortisone in ethyinitrosourea induced brain tumors. Although a reduction in tumor developmental rate was observed in rats treated with hydrocotisone, microvascular architecture and bromodeoxyuridine(BrdU) labeled endothelial cells did not varied with or without hydrocortisone. In tumors less than 2mm in diameter no tumor vessels and BrdU labeled endothelial cells were observed, indicating an avascular phase of tumor growth. On the other hand, in tumors more than 2 mm in diameter, various vascular phases were observed. In particular, the peripheral zone of the tumors consisted of dilated and tortuous vessels and rich BrdU labeled endothelial cells which may be characteristic of angiogenesis.
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