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1990 Fiscal Year Final Research Report Summary

Study on Neuromagnetic Imaging and Modeling of MEG Activities

Research Project

Project/Area Number 63850090
Research Category

Grant-in-Aid for Developmental Scientific Research (B).

Allocation TypeSingle-year Grants
Research Field 計測・制御工学
Research InstitutionDepartment of Electronics, Faculty of Engineering, Kyushu University

Principal Investigator

UENO Shoogo  Kyushu University, Electronics, Professor, 工学部, 教授 (00037988)

Co-Investigator(Kenkyū-buntansha) MATSUOKA Shigaaki  University of Occupational and Environmental Health, Neurosurgery, Professor, 脳神経外科, 教授 (10122855)
KATO Motohiro  Kyushu University, Neurophysiology, Professor, 医学部, 教授 (90038638)
HARADA Koosuke  Kyushu University, Electronics, Professor, 工学部, 教授 (90037705)
ENPUKU Keiji  Kyushu University, Electronics, Associate Professor, 工学部, 助教授 (20150493)
YOSHIDA Keiji  Kyshu University, Electronics, Associate Professor, 工学部, 助教授 (80108670)
Project Period (FY) 1988 – 1990
KeywordsMagnetoencephalogram / Inverse problem / Neuromagnetic imaging / Current dipole / Flux reversal / SQUID / K-complex / Delta wave
Research Abstract

During the past decade, substantial advances in the understanding of the functional organization of the human brain have been made through the technique of MEG topographic mapping. Most of these investigations were concerned with the estimation and localization of sources which were modeled as single current dipoles positioned in a semi infinite volume conductor with homogeneous conductivities. However, the sources in the brain are complex, and the head as a volume conductor consisits of different materials with different electrical conductivities. The influence of these inhomogeneities on the MEG topography is studied by a computer simulation, modeling the sources as single or multiple dipoles located in inhomogeneous volume conductors. The computer simulation suggests some important aspects in estimation of source localization. (1) Flux reversal phenomena can be observed in MEG to pographic patterns in special cases where conductivities of the inhomogeneous regions change with pathol … More ogical conditions. The flux reversal can be caused by the change of flow patterns of currents which flow on the surface of boundary between different inhomogeneous regions in the head. (2) Radially oriented dipoles produced magnetic fields outside the sphere due to the effects of inhomogeneities. Normal components of magnetic fields perpendicular to the surface of the sphere generated by the effects of inhomogeneities were determined by volume current. The sources of MEG activities in human subject during sleep were also studied, The following results were obtained ; (3) Sources of K-complexes can be modeled by two current dipoles positioned in the deeper parts of the head. (4) Delta activities in sleep stages 3 and 4 have many sources with different frequencies. Some of these sources can be detected by MEG measurements, but are difficult to detect with EEG measurements. The MEG technique has a potential advantage to provide important information concerning brain function which cannot be obtained using the EEG measurements. Less

  • Research Products

    (36 results)

All Other

All Publications (36 results)

  • [Publications] S.Ueno: "Simulation study on temporal and spatial properties of electric and magnetic fields in auditory brainstem responses" BIOMAGNETISM´87:Proceedings of the 6th International Conference on Biomagnetism. 114-117 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Iramina: "Spatial properties of magnetic fields produced by radially oriented dipole inhomogeneous sphere" BIOMAGNETISM´87:Proceedings of the 6th International Conference on Biomagnetism. 106-109 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 上野 照剛: "動径方向を向く脳内電源がつくる脳磁図分布について" 日本応用磁気学会誌. Vol.13. 457-460 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 上野 照剛: "生体と磁気" 日本ME学会誌 月刊BME. Vol.2. 643-650 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Ueno: "Estimation of both conduction velocities and the number of firing nerve fibers from magnetic fields outside a volume conductor" Advances in Biomagnetism:Proceedings of the 7th International Conference on Biomagnetism,Plenum Press,New York. 145-148 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Iramina: "Mechanism of Flux reversal phenomena in spatial distributions of the magnetoencephalograms" Advances in Biomagnetism:Proceedings of the 7th International Conference on Biomagnetism,Plenum Press,New York. 619-622 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Ueno: "Modeling and Source Localization of MEG Activities" Brain Topography,Journal of Functional Neurophysiology HUMAN SCIENCES PRESS,INC.,New York. Vol.3. 151-165 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Ueno: "Chaotic Dynamics in Abnormal EEG Activities Related to Parkinson´s Disease" Brain Topography,Journal of Functional Neurophysiology HUMAN SCIENCES PRESS,INC.,New York. Vol.3. 287-288 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Iramina: "Spatial Distributions of the Magnetoencephalograms and Electroencephalograms Produced by Multiple Dipoles" Brain Topography,Journal of Functional Neurophysiology HUMAN SCIENCES PRESS,INC.,New York. Vol.3. 234-235 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Iramina: "Source Localization of Kーcomplexes and Vertex Waves during Sleep Using MEG and EEG Activities" Brain Topography,Journal of Functional Neurophysiology HUMAN SCIENCES PRESS,INC.,New York. Vol.3. 243-245 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Iramina: "Spatial Patterns of Magnetic Fields Produced by Multiple dipoles in an Inhomogeneous volume Conductor" J.Appl.phys.Vol.67. 5835-5837 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kohjiro: "Conversion efficiency of a largeーβ DCーSQUID with a resistively shunted inductance" Japanese Journal of Applied Physics. Vol.27. 214-218 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kohjiro: "Experimental study of noise characteristics of largeーβ DCーSQUID with resistively shunted inductance" Japanese Journal of Applied physics. Vol.27. 1871-1874 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Enpuku: "Low noise operation of a DC SQUID in a large β regime and its application to the design of a high Tc SQUID" IEEE Trans.Mag.Vol.25. 1154-1157 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] I.Sasada: "Effective shielding for lowーlevel magnetic fields" Journal of Applied physics. Vol.64. 5696-5968 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Wada: "Quantitative analysis of reversible dysfunction of brainーstem midline structures caused by disturbance of basilar artery blood flow with the auditory brainーstam responces" Electroenceph.clin.Neurophysiol.Vol.69. 148-159 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Urasaki: "Absence of spinal N_<13>ーP_<13> and normal scalp far field P_<14> in a patient with syringomyelia" Electroenceph.clin.Neurophysiol.Vol.71. 400-404 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Matsuoka: "Theta rhythms:state of consciousness" Brain Topography;Journal of Functional Neurophysiology,HUMAN SCIENCES PRESS,INC.,New York. Vol.3. 203-208 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Morioka: "Origin and distribution of thalamic somatosensory evoked potentials in humans" Electroenceph.clin.Neurophysiol.Vol.74. 186-193 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S. Ueno, K. Maekawa, K. Iramina, K. Harada, S. Wada and S. Matsuoka: ""Simulation study on temporal and spatial properties of electric and magnetic fields in auditory brainstem responses"" Biomagnetism '87 : Proceedings of the 6th International Conference on Biomagnetism, edited by K. Atsumi, M. Kotani, S. Ueno, T. Katila and S. J. Williamson, Tokyo Denki University Press, Tokyo. 114-117 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Iramina and S. Ueno: ""Spatial properties of magnetic fields produced by radially oriented dipole in inhomogeneous sphere"" Biomagnetism '87 : Proceedings of the 6th International Conference on Biomagnetism, edited by K. Atsumi, M. Kotani, S. Ueno, T. Katila and S. J. Williamson, Tokyo Denki University Press, Tokyo. 106-109 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Ueno and S. Suzuki: ""Estimation of both conduction velocities and the number of firing nerve fibers from magnetic fields outside a volume conductor"" Advances in Biomagnetism : Proceedings of the 7th International Conference on Biomagnetism, edited by S. J. Williamson, M. Hoke, G. Stroink and M. Kotani, Plenum Press, New York. 145-148 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iramina and S. Ueno: ""Mechanism of flux reversal phenomena in spatial distributions of the magnetoencephalograms"" Advances in Biomagnetism : Proceedings of the 7th International Conference on Biomagnetism, edited by S. J. Williamson, M. Hoke, G. Stroink and M. Kotani, Plenum Press, New York. 619-622 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Ueno and K. Iramina: ""Modeling and source localization of MEG activities"" Brain Topography ; Journal of Functional Neurophysiology, Human Scuences Press, Inc., New York. Vol. 3. 151-165 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Ueno Y. Takada, T. Mizoguchi K. Hirakawa and M. Tomonaga: ""Chaotic dynamics in abnormal neural activities related to Parkinson's disease"" Brain Topography ; Journal of Functional Neurophysiology, Human Sciences Press, Inc., New York. Vol. 3. 287-288 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Iramina and S. Ueno: ""Spatial distributions of the magnetoencephalograms and electroencephalograms produced by multiple dipoles"" Brain Topography ; Journal of Functional Neurophysiology, f Human Sciences Press, Inc., New York. Vol. 3. 234-235 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Iramina and S. Ueno: ""Source Localization of K-complexes and vertex waves during sleep using MEG and EEG activities"" Brain Topography ; Journal of Functional Neurophysiology, f Human Sciences Press, Inc., New York. Vol. 3. 243-245 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Iramina and S. Ueno: ""Spatial patterns of magnetic fields produced by multiple dipoles in inhomogeneous volume conductor"" Journal of Applied Physics. Vol. 67 (9). 5835-5837 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Kohjiro, K. Enpuku, K. Yoshida and K. Yamafuji: ""Conversion efficiency of a Large-beta DC-SQUID with a resistively shunted inductance"" Japanese Journal of Applied physics. Vol. 27 (2). 214-218 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Kohjiro, K. Enpuku, K. Yoshida and K. Yamafuji: ""Experimental study of noise characteristics of large-beta DC-SQUID with resistively shunted inductance"" Japanese Journal of Applied physics. Vol. 27 (10). 1871-1874 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Enpuku, S. Kohjiro and K. Yoshida: ""Low noise operation of a DC SQUID in a large beta regime and its application to the design of a high Tc SQUID"" IEEE Trans. Mag.Vol. 25. 1154-1157 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] I. Sasada, S. Kudo and K. Harada: ""Effective shielding for low-level magnetic fields"" Journal of Applied physics. Vol. 64 (10). 5696-5698 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Wada, S. Matsuoka, E. Urasaki and C. Yadomi: ""Quantitative analysis of reversibe dysfunction of brain-stem midline structures caused by disturbance of basilar artery blood flow with the auditory brain stem responses"" Electroencephchlin Neurophysoil.69. 148-159 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E. Urasaki, S. Wada, C. Kadoya, H. Matsuzaki, A. Yokota and S. Matsuoka: ""Absence of spinal N_<13>-P_<13> and normal scalp far field P_<14> in a patient with syringomyelia"" Electroenceph. clin. Neurophysiol.71. 400-404 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Matsuoka: ""Theta rhythms : state of consciousness"" Brain Topography ; Journal of Functional Neurophysiology, Human Scences Press, Inc.Vol. 3. 203-208 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Morioka, F. Shima, M. Kato and M. Fukui: ""Origin and distribution of thalamic somatosensory evoked potentials in humans"" Electroenceph. clin. Neurophysiol.74. 186-193 (1989)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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