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2018 Fiscal Year Annual Research Report

生命分子システムにおける動的秩序形成と高次機能発現の研究に関する総括

Compiling the Research Achievements

Project AreaDynamical ordering of biomolecular systems for creation of integrated functions
Project/Area Number 18H05203
Research InstitutionCenter for Novel Science Initatives, National Institutes of Natural Sciences

Principal Investigator

加藤 晃一  大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 教授 (20211849)

Co-Investigator(Kenkyū-buntansha) 佐藤 啓文  京都大学, 工学研究科, 教授 (70290905)
Project Period (FY) 2018-04-01 – 2019-03-31
Keywords動的秩序 / 生命分子 / 超分子 / 高次機能 / 集合離散
Outline of Annual Research Achievements

本申請課題は、本領域研究の成果を公開し広く発信するとともに、本領域研究で培ってきた異分野連携・融合を基軸とした学術の推進および学理の啓発を目的とした。本領域の研究成果に関して、領域ホームページやニュースレターでの発信、アウトリーチ活動、マスメディアへの掲載等を通じて社会に広く公開するとともに、主に以下の活動を通じて、異分野融合の推進と本領域研究の啓発に努めた。
1.国際シンポジウムの開催: Frontier Bioorganization Forum 2018を主催し、本領域の研究成果に基づく学理の啓発を行うとともに、日本・韓国・台湾の先端的研究者との交流を通じて、近年その重要性が謳われている国際共同研究の実施に対してインセンティブを与えた。本領域を基軸とした異分野間の有機的な研究ネットワークを構築し、更なる国際共同研究の発展に努めた。
2.出版物の刊行: 本領域の研究成果の集大成として総説を刊行し、国内外の研究者・研究領域に対して成果を発信した。昨年度までに、本領域研究を通じて進展した計測手法に関してはBiochimica et Biophysica Acta の特集号として既に刊行してきた。したがって、今年度は、理論・計算系アプローチの成果をまとめて、Journal of Computer Chemistry, Japanの特集号を刊行した。国内外の研究者に対して、領域活動と研究成果に関する情報発信を行うことができた。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

  • Research Products

    (27 results)

All 2018 Other

All Int'l Joint Research (5 results) Journal Article (18 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 18 results,  Open Access: 9 results) Presentation (2 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Remarks (1 results) Funded Workshop (1 results)

  • [Int'l Joint Research] National Institutes of Health/The Scripps Research/University of California(米国)

    • Country Name
      U.S.A.
    • Counterpart Institution
      National Institutes of Health/The Scripps Research/University of California
  • [Int'l Joint Research] Max Planck Institute/Free University of Berlin(ドイツ)

    • Country Name
      GERMANY
    • Counterpart Institution
      Max Planck Institute/Free University of Berlin
  • [Int'l Joint Research] National Chiao Tung University/Academia Sinica(台湾)

    • Country Name
      その他の国・地域
    • Counterpart Institution
      National Chiao Tung University/Academia Sinica
  • [Int'l Joint Research] Chimie Paris Teck(フランス)

    • Country Name
      FRANCE
    • Counterpart Institution
      Chimie Paris Teck
  • [Int'l Joint Research] University of Cambridge/University of Edinburgh(英国)

    • Country Name
      UNITED KINGDOM
    • Counterpart Institution
      University of Cambridge/University of Edinburgh
  • [Journal Article] Structural insights on the dynamics of proteasome formation2018

    • Author(s)
      Kato Koichi、Satoh Tadashi
    • Journal Title

      Biophysical Reviews

      Volume: 10 Pages: 597-604

    • DOI

      10.1007/s12551-017-0381-4

    • Peer Reviewed
  • [Journal Article] Exploration of Conformational Spaces of Oligosaccharides byCombining Molecular Dynamics Simulation and NMR Spectroscopy2018

    • Author(s)
      YAMAGUCHI Takumi、WATANABE Tokio、YAGI Hirokazu、KATO Koichi
    • Journal Title

      Journal of Computer Chemistry, Japan

      Volume: 17 Pages: 1-7

    • DOI

      10.2477/jccj.2018-0011

    • Peer Reviewed / Open Access
  • [Journal Article] 常磁性NMR法と計算科学を組み合わせた糖鎖の動的コンホメーション解析2018

    • Author(s)
      矢木 宏和、加藤 晃一
    • Journal Title

      生化学

      Volume: 90 Pages: 198-202

    • DOI

      10.14952/SEIKAGAKU.2018.900198

    • Peer Reviewed
  • [Journal Article] Molecular Dynamics of Gangliosides2018

    • Author(s)
      Yamaguchi Takumi、Kato Koichi
    • Journal Title

      Gangliosides (S.Sonnino and A.Prinetti ed.), Methods in Molecular Biology, Humana Press (New York)

      Volume: 1804 Pages: 411-417

    • DOI

      10.1007/978-1-4939-8552-4_20

    • Peer Reviewed
  • [Journal Article] NMR Characterization of the Dynamic Conformations of Oligosaccharides2018

    • Author(s)
      Kato Koichi、Yagi Hirokazu、Yamaguchi Takumi
    • Journal Title

      Modern Magnetic Resonance, 2nd Edition,

      Volume: - Pages: 737-754

    • DOI

      10.1007/978-3-319-28388-3_35

    • Peer Reviewed
  • [Journal Article] Structural Aspects of ER Glycoprotein Quality-Control System Mediated by Glucose Tagging2018

    • Author(s)
      Satoh Tadashi、Kato Koichi
    • Journal Title

      Glycobiophysics

      Volume: - Pages: 149-169

    • DOI

      10.1007/978-981-13-2158-0_8

    • Peer Reviewed
  • [Journal Article] Structure and Dynamics of Immunoglobulin G Glycoproteins2018

    • Author(s)
      Yagi Hirokazu、Yanaka Saeko、Kato Koichi
    • Journal Title

      Glycobiophysics

      Volume: - Pages: 219-235

    • DOI

      10.1007/978-981-13-2158-0_11

    • Peer Reviewed
  • [Journal Article] 集合シャペロンを介したプロテアソーム形成機構2018

    • Author(s)
      佐藤匡史,加藤晃一
    • Journal Title

      医学のあゆみ

      Volume: 276 Pages: 949-953

    • Peer Reviewed
  • [Journal Article] Effects of a Hydrophilic/Hydrophobic Interface on Amyloid-β Peptides Studied by Molecular Dynamics Simulations and NMR Experiments2018

    • Author(s)
      Itoh Satoru G.、Yagi-Utsumi Maho、Kato Koichi、Okumura Hisashi
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 123 Pages: 160-169

    • DOI

      10.1021/acs.jpcb.8b11609

    • Peer Reviewed
  • [Journal Article] A kinetics study of ligand substitution reaction on dinuclear platinum complexes: Stochastic versus deterministic approach2018

    • Author(s)
      Iioka Tatsuya、Takahashi Satoshi、Yoshida Yuichiro、Matsumura Yoshihiro、Hiraoka Shuichi、Sato Hirofumi
    • Journal Title

      Journal of Computational Chemistry

      Volume: 40 Pages: 279-285

    • DOI

      10.1002/jcc.25588

    • Peer Reviewed
  • [Journal Article] Theoretical Study on Oligomerization of Cytochrome c2018

    • Author(s)
      MOTOKI Hideyoshi、YOSHIDA Norio、HIROTA Shun、HIGASHI Masahiro
    • Journal Title

      Journal of Computer Chemistry, Japan

      Volume: 17 Pages: 8-13

    • DOI

      10.2477/jccj.2018-0006

    • Peer Reviewed / Open Access
  • [Journal Article] Modeling of Cells which Migrate and Proliferate on a Substrate2018

    • Author(s)
      YAMAMOTO Ryoichi、MOLINA John J.、SCHNYDER Simon K.
    • Journal Title

      Journal of Computer Chemistry, Japan

      Volume: 17 Pages: 14-19

    • DOI

      10.2477/jccj.2018-0003

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Visualization of Protein Dynamics using High-Speed Atomic Force Microscopy and Image Analysis2018

    • Author(s)
      UCHIHASHI Takayuki
    • Journal Title

      Journal of Computer Chemistry, Japan

      Volume: 17 Pages: 20-30

    • DOI

      10.2477/jccj.2018-0001

    • Peer Reviewed / Open Access
  • [Journal Article] Theoretical Study on Substituent and Solvent Effectsfor Nanocubes Formed with Gear-shaped Amphiphile Molecules2018

    • Author(s)
      MASHIKO Takako、HIRAOKA Shuichi、NAGASHIMA Umpei、TACHIKAWA Masanori
    • Journal Title

      Journal of Computer Chemistry, Japan

      Volume: 17 Pages: 31-37

    • DOI

      10.2477/jccj.2018-0010

    • Peer Reviewed / Open Access
  • [Journal Article] Cryo-electron Microscopy for Structural Analysis of Dynamic Biological Macromolecules2018

    • Author(s)
      SONG Chihong、MURATA Kazuyoshi
    • Journal Title

      Journal of Computer Chemistry, Japan

      Volume: 17 Pages: 38-45

    • DOI

      10.2477/jccj.2018-0007

    • Peer Reviewed / Open Access
  • [Journal Article] Development of μ-fluidics Based Auto Sampling System Designed for Continuous Titration SAXS Experiments2018

    • Author(s)
      KAMIKUBO Hironari
    • Journal Title

      Journal of Computer Chemistry, Japan

      Volume: 17 Pages: 57-64

    • DOI

      10.2477/jccj.2018-0008

    • Peer Reviewed / Open Access
  • [Journal Article] Classical Molecular Dynamics Simulation to Understand Role of a Zinc Ion for Aggregation of Amyloid-β Peptides2018

    • Author(s)
      NISHIZAWA Hiroaki、OKUMURA Hisashi
    • Journal Title

      Journal of Computer Chemistry, Japan

      Volume: 17 Pages: 76-79

    • DOI

      10.2477/jccj.2018-0005

    • Peer Reviewed / Open Access
  • [Journal Article] Basic Cell Size Dependence of Displacement for a Solvation Motor in a Lennard-Jones Solvent2018

    • Author(s)
      TOKUNAGA Ken、AKIYAMA Ryo
    • Journal Title

      Journal of Computer Chemistry, Japan

      Volume: 17 Pages: 80-84

    • DOI

      10.2477/jccj.2018-0004

    • Peer Reviewed / Open Access
  • [Presentation] What is life? What is ExCELLS?2018

    • Author(s)
      Koichi Kato
    • Organizer
      Frontier Bioorganization Forum 2018
    • Int'l Joint Research / Invited
  • [Presentation] In situ structural characterization of antibody interactions2018

    • Author(s)
      Koichi Kato
    • Organizer
      The 18th KIAS Conference on Protein Structure and Function
    • Int'l Joint Research / Invited
  • [Remarks] 生命分子システムにおける動的秩序形成と高次機能発現

    • URL

      http://seimei.ims.ac.jp/

  • [Funded Workshop] Frontier Bioorganization Forum 2018: Dynamical ordering and integrated functions of biomolecular systems2018

URL: 

Published: 2019-12-27   Modified: 2022-08-18  

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