Identification of genetic determinant for individual radiosensitivity
Project/Area Number |
24310043
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Risk sciences of radiation/Chemicals
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Research Institution | Hiroshima University |
Principal Investigator |
MATSUURA SHINYA 広島大学, 原爆放射線医科学研究所, 教授 (90274133)
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Co-Investigator(Kenkyū-buntansha) |
MIYAMOTO Tatsuo 広島大学, 原爆放射線医科学研究所, 講師 (40452627)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
|
Keywords | 放射線感受性 / 個人差 / 微小核形成法 / GWAS / 遺伝子標的法 |
Outline of Final Research Achievements |
The current system of radiological protection is uniformly established to the public, and it is important for the radiation risk communication to evaluate the individual radiosensitivity. We studied radiation-induced micronucleus formation in peripheral blood lymphocytes from normal individuals, and found that individual differences of radiosensitivity exist in human populations. We also found that cells from the heterozygous carriers for radiation hypersensitive disorders exhibited an increase of micronucleus formation, suggesting that the DNA repair gene variants are indeed involved in individual radiosensitivity.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS (MVA) syndrome.2014
Author(s)
Ochiai H, Miyamoto T, Kanai A, Hosoba K, Sakuma T, Kudo Y, Asami K, Ogawa A, Watanabe A, Kajii T, Yamamoto T, Matsuura S.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 111(4)
Issue: 4
Pages: 1461-6
DOI
Related Report
Peer Reviewed
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[Journal Article] Exome sequencing reveals a novel MRE11 mutation in a patient with progressive myoclonic ataxia.2014
Author(s)
Miyamoto R, Morino H, Yoshizawa A, Miyazaki Y, Maruyama H, Murakami N, Fukada K, Izumi Y, Matsuura S, Kaji R, Kawakami H.
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Journal Title
J Neurol Sci.
Volume: 337
Issue: 1-2
Pages: 219-223
DOI
Related Report
Peer Reviewed
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[Journal Article] Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity.2013
Author(s)
Sakuma T, Ochiai H, Kaneko T, Mashimo T, Tokumasu D, Sakane Y, Suzuki K, Miyamoto T, Sakamoto N, Matsuura S, Yamamoto T
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Journal Title
Sci Rep.
Volume: 3
Issue: 1
Pages: 3379-3379
DOI
Related Report
Peer Reviewed
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[Journal Article] Efficient TALEN construction and evaluation methods for human cell and animal applications.2013
Author(s)
Sakuma T, Hosoi S, Woltjen K, Suzuki KI, Kashiwagi K, Wada H, Ochiai H, Miyamoto T, Kawai N, Sasakura Y, Matsuura S, Okada Y, Kawahara A, Hayashi S, Yamamoto T.
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Journal Title
Genes to Cells
Volume: (In press)
Issue: 4
Pages: 315-326
DOI
Related Report
Peer Reviewed
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[Presentation] Kinetics of radiation-induced DNA double strand break rejoining in DNA repair deficient cells2013
Author(s)
Ohara, M., Sakamoto, Y., Fukasaku, J., Komatsu, K., Matsuura, S., Tauchi, H.
Organizer
The 3rd international symposium of RIRBM, Hiroshima University
Place of Presentation
広島
Related Report
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[Presentation] Artificial nuclease-based targeted DSB introduction and its application2013
Author(s)
Ochiai, H., Miyamoto, T., Kanai, A., Hosoba, K., Sakuma, T., Yamamoto, T., Matsuura, S.
Organizer
The 3rd international symposium of RIRBM, Hiroshima University
Place of Presentation
広島
Related Report
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[Presentation] Establishment of human disease model cell lines by introduction of intergenic single nucleotide mutation using artificial nucleases2012
Author(s)
Ochiai, H., Miyamoto, T., Kanai, A., Hosoba, K., Sakuma, T., Noji, S., Yamamoto, T., Matsuura, S.
Organizer
第35回日本分子生物学会年会
Place of Presentation
福岡(招待講演)
Related Report
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[Presentation] Role of MRE11/RAD50/NBS1 complex in regulation of ATM activation2012
Author(s)
Kobayashi, J., Fujimoto, H., Okui, M., Kato, T., Matsuura, S., Komatsu, K.
Organizer
第35回日本分子生物学会年会
Place of Presentation
福岡
Related Report