2014 Fiscal Year Final Research Report
Identification of genetic determinant for individual radiosensitivity
Project/Area Number |
24310043
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Risk sciences of radiation/Chemicals
|
Research Institution | Hiroshima University |
Principal Investigator |
MATSUURA SHINYA 広島大学, 原爆放射線医科学研究所, 教授 (90274133)
|
Co-Investigator(Kenkyū-buntansha) |
MIYAMOTO Tatsuo 広島大学, 原爆放射線医科学研究所, 講師 (40452627)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | 放射線感受性 / 個人差 |
Outline of Final Research Achievements |
The current system of radiological protection is uniformly established to the public, and it is important for the radiation risk communication to evaluate the individual radiosensitivity. We studied radiation-induced micronucleus formation in peripheral blood lymphocytes from normal individuals, and found that individual differences of radiosensitivity exist in human populations. We also found that cells from the heterozygous carriers for radiation hypersensitive disorders exhibited an increase of micronucleus formation, suggesting that the DNA repair gene variants are indeed involved in individual radiosensitivity.
|
Free Research Field |
放射線生物学
|