The function of linker histones and the epigenetics of chromatin regulation in mammalian early development.

• Project/Area Number: 21592109
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Keio University
• Principal Investigator: TANAKA Mamoru 慶應義塾大学, 医学部, 講師 (20207145)
• Co-Investigator(Kenkyū-buntansha): MIYAKOSHI Kei 慶應義塾大学, 医学部, 講師 (70265883)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: リンカーヒストン / クロマチン / 卵子

Research Abstract

H1foo KO mice revealed that H1foo has no effect of oogenesis and fertility. This may result from the existence of compensatory mechanism for H1foo.

Research Products

• [Journal Article] Expression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization (2010)
  • Author(s): Mizusawa Y, Kuji N, Tanaka Y, Tanaka M, Ikeda E, Komatsu S, Kato S, Yoshimura Y
  • Journal Title: Fertil Steril Volume: 93(4) Pages: 1134-41
  • Peer Reviewed
• [Journal Article] Expression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization. (2010)
  • Author(s): Mizusawa S, et al.
  • Journal Title: Fertility and Sterility Volume: 93 Pages: 1134-41
  • Peer Reviewed
• [Journal Article] Expression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization (2010)
  • Author(s): Mizusawa, Y, et al
  • Journal Title: Fertil Steril 93 Pages: 1134-1141
  • Peer Reviewed
• [Journal Article] Expression of ovary-specific acidic protein in steroidogenic tissues : a possible role in steroidogenesis (2009)
  • Author(s): Matsumoto, T, et al
  • Journal Title: Endocrinology 150 Pages: 3352-3359
  • Peer Reviewed
• [Presentation] ノックアウトマウスを用いた卵子特異的リンカーヒストンH1FOOの卵子形成における機能解析 (2012)
  • Author(s): 古谷正敬、田中守、浅井哲、松本直、峰岸一宏、宮越敬、青木大輔、村泰典
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸