KAKEN — Research Projects | Researcher Number: 10233743

Search Results: 14 results / Researcher Number: 10233743

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1. Establishment of PDX model of malignant salivary gland tumors and investigation of malignant transformation mechanism

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 57060:Surgical dentistry-related
Research Institution	Tokyo Dental College
Principal Investigator	菅原圭亮東京歯科大学, 歯学部, 准教授
Project Period (FY)	2024-04-01 – 2027-03-31Granted
Keywords	口腔扁平上皮癌 / PDXマウス / 唾液腺腫瘍
Outline of Research at the Start	悪性唾液腺腫瘍は薬物療法や放射線治療への治療抵抗性が高く、肺などへの遠隔転移が多く長期予後が不良である。本申請研究では、悪性唾液腺腫瘍原発巣および転移巣切除組織からPDXモデルを樹立し、それぞれの腫瘍間あるいは腫瘍内の不均一性を考慮する上で重要な癌微小環境を再現した腫瘍モデル基盤を構築する。そこで間 ...

2. 唾液中のcholine transporter-like protein(CTL1)は上皮異形成を反映する

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 57060:Surgical dentistry-related
Research Institution	Tokyo Dental College
Principal Investigator	片倉朗東京歯科大学, 歯学部, 教授
Project Period (FY)	2023-04-01 – 2027-03-31Granted
Keywords	口腔扁平上皮癌 / コリン / コリントランスポーター / 細胞増殖 / バイオマーカー / 扁平上皮癌 / メタボローム解析 / OPMDｓ / liquid biopsy
Outline of Research at the Start	本研究はこれまでの研究の中で最も特徴的な発現が確認されたコリンとそのトランスポーターであるcholine transporter-like protein(CTL1)に注目し、口腔癌患者の検体を用いて、各種免疫染色、イメージング技術を用いて、その結果を多重ロジスティクス解析で早期口腔癌や上皮異形成症 ...
Outline of Annual Research Achievements	がん研究分野でコリンと細胞増殖能の関連性が注目されている。我々は以前に、健常者と比較して口腔扁平上皮がん患者の唾液中にコリンが有意に多く含まれることをメタボローム解析により明らかにいる。コリンは細胞膜の合成に必須であり、コリントランスポーター (cholinetransporter-like pro ...
Current Status of Research Progress	2: Research has progressed on the whole more than it was originally planned.

Research Products of this project	Presentation (2 results)

3. Development of a new treatment for fibrodysplasia using active genomics and high-throughput analysis

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Review Section	Basic Section 57060:Surgical dentistry-related
Research Institution	Tokyo Dental College
Principal Investigator	AZUMA TOSHIFUMI 東京歯科大学, 歯学部, 教授
Project Period (FY)	2021-04-01 – 2024-03-31Completed
Keywords	iPS細胞 / GNAS / Gタンパク質 / 悪性腫瘍 / 遺伝子編集 / 骨芽細胞分化 / Hedghog / 骨異形成症 / 線維化 / 骨芽細胞 / 線維性骨異形成症 / 遺伝性稀少疾患 / 骨芽細胞分化誘導 / FGFG2 / McCuneAlbright 症候群 / シングルセル解析 / ゴーリン症候群
Outline of Research at the Start	ゲノム機能解析、ハイスループット解析、遺伝子改変動物開発を用い、①FDモデルマウス開発　②GNASR201H -iPS細胞由来骨芽細胞分化過程のシングルセル解析、③骨芽細胞分化抑制にかかわる新規non-coding RNA同定と遺伝子治療応用、④薬剤ライブラリーを応用したDrug Repositio ...
Outline of Final Research Achievements	We generated iPS cells artificially transfected with the R201H mutation of MacCuneAlbright syndrome-specific iPS (MA). First, a highly specific site w ...

Research Products of this project	Journal Article (16 results, of which Peer Reviewed: 14 results, Open Access: 5 results) Presentation (7 results)

4. Comprehensive understanding of fibrous dysplasia of the jaw based on the mechanism of FGF23 production and abnormal phosphorus metabolism.

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Review Section	Basic Section 57060:Surgical dentistry-related
Research Institution	Tokyo Dental College
Principal Investigator	Yamaguchi Akira 東京歯科大学, 歯学部, 客員教授
Project Period (FY)	2020-04-01 – 2023-03-31Completed
Keywords	線維性骨異形成症 / FGF23 / Notch / 線維性異形成症 / Fibrous dysplasia / GNAS / リン代謝
Outline of Research at the Start	McCune-Albright症候群(MAS)/線維性骨異形成症(FD)は、FGF23を過剰産生し、低リン血症を呈する疾患の一つであるが、顎骨に発症するFDのFGF23産生とリン代謝は十分に解析されていない。我々はNotchシグナルが骨細胞のFGF23産生を制御することを世界に先駆けて報告した。その ...
Outline of Final Research Achievements	In this study, we aimed to clarify the involvement of Notch signaling in FGF23 production in fibrodysplasia (FD) and obtained the following results: 1 ...

Research Products of this project	Journal Article (14 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 14 results, Open Access: 7 results)

5. Validation of oral cancer biomarkers applied to saliva testing with metabolome analysis and multiplex fluorescence staining

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 57060:Surgical dentistry-related
Research Institution	Tokyo Dental College
Principal Investigator	Katakura Akira 東京歯科大学, 歯学部, 教授
Project Period (FY)	2019-04-01 – 2024-03-31Completed
Keywords	口腔癌 / バイオマーカー / コリン / コリントランスポーター / 口腔扁平上皮癌 / 細胞増殖 / 扁平上皮癌 / メタボローム解析 / OPMDｓ / liquid biopsy / 唾液 / プロテオーム解析 / 多重蛍光染色 / 多重染色 / メタボローム
Outline of Research at the Start	a.口腔癌患者の唾液中に特徴的に発現する代謝物の再現性の検証、b.患者の口腔癌（舌癌・歯肉癌）の切除標本からの組織採取と保管、c. TSA多重染色による癌組織におけるバイオマーカー候補物質の共局在の観察、d.バイオマーカー候補とする代謝物質の組み合わせによる口腔癌識別能力の多重ロジスチィック解析、e ...
Outline of Final Research Achievements	In recently, the association between cholinetransporter-like protein 1 (CTL1) and cell proliferative potential associated with hypermetabolism of chol ...

Research Products of this project	Journal Article (1 results, of which Peer Reviewed: 1 results) Presentation (2 results, of which Int'l Joint Research: 1 results) Book (1 results) Remarks (2 results)

6. Establishment of tongue cancer PDX model and study on preclinical application

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 57060:Surgical dentistry-related
Research Institution	Tokyo Dental College
Principal Investigator	Sugahara Keisuke 東京歯科大学, 歯学部, 准教授
Project Period (FY)	2018-04-01 – 2023-03-31Completed
Keywords	口腔がん / 舌癌 / PDXモデル / CAFs / 口腔扁平上皮癌 / PDXマウス / 頸部リンパ節転移 / 口腔癌 / 扁平上皮癌 / 臨床応用
Outline of Final Research Achievements	For the development of novel tongue cancer therapies, we have been working to establish a PDX model using patient tongue cancer surgical specimens. We ...

Research Products of this project	Journal Article (7 results, of which Peer Reviewed: 7 results, Open Access: 2 results) Presentation (12 results, of which Int'l Joint Research: 5 results)

7. Screening examination of the dysplasia of the oral mucosa by the metabolic loam analysis of saliva

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Surgical dentistry
Research Institution	Tokyo Dental College
Principal Investigator	Katakura Akira 東京歯科大学, 歯学部, 教授
Project Period (FY)	2016-04-01 – 2019-03-31Completed
Keywords	口腔癌 / メタボローム解析 / 唾液 / スクリーニング / バイオマーカー / 口腔がん / トランスレーショナルリサーチ
Outline of Final Research Achievements	We searched saliva of the oral cancer patient by capillary electrophoresis - mass spectrometry (CE-MS) metabolic analysis , and went ahead through the ...

Research Products of this project	Journal Article (2 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 2 results, Open Access: 2 results)

8. A profiling for oral cancer using saliva samples: metabolome analysis of oral cancer-related protein in whole saliva

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Surgical dentistry
Research Institution	Tokyo Dental College
Principal Investigator	KATAKURA AKIRA 東京歯科大学, 歯学部, 教授
Project Period (FY)	2012-04-01 – 2016-03-31Completed
Keywords	唾液 / メタボローム解析 / 口腔癌 / バイオマーカー / タンパク
Outline of Final Research Achievements	The purpose of this study was to characterize metabolic systems in oral squamous cell carcinoma (OSCC) using Capillary Electrophoresis / Mass Spectrom ...

Research Products of this project	Journal Article (2 results, of which Peer Reviewed: 2 results, Open Access: 1 results) Presentation (3 results, of which Invited: 1 results)

9. Prediction of cancerization in leukoplakia of the oral cavity based on cancer suppressor gene product Doc-1

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Surgical dentistry
Research Institution	Tokyo Dental College
Principal Investigator	YAMAUCHI Tomohoro TOKYO DENTAL COLLEGE, DEPARTMENT OF DENTISTRY, ASSISTANT PROFFESSOR
Project Period (FY)	2002 – 2004Completed
Keywords	Oral Cancer / Precancerous resion / Leukoplakia / Doc-1
Research Abstract	I.Expression of Doc-1 protein

Research Products of this project	Journal Article (5 results)

10. Reduced expression and hypermethylation of HEADPIN, a serine proteinase inhibitor (serpin) in human squamous cell carcinoma

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Surgical dentistry
Research Institution	Tokyo Dental College
Principal Investigator	TAKEDA Eizo (2003) TOKYO DENTAL COLLEGE, DEPARTMENT OF DENTISTRY, ASSISTANT 片倉朗 (2001-2002) 東京歯科大学, 歯学部, 講師
Project Period (FY)	2001 – 2003Completed
Keywords	HEADPIN gene / oral squamous cell carcinoma
Research Abstract	Our in-house cDNA microarray system, which carries cDNAs derived from oligo-capped eDNA library of human oral cavity cancer cell lines, identified red ...

11. Effect of Angiogenesis Inhibitors on Tongue Carcinoma Induced by 4-Nitroquinoline 1-Oxide (4NQO) on Rats

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	病態科学系歯学(含放射線系歯学)
Research Institution	TOKYO DENTAL COLLEGE
Principal Investigator	KATAKURA Akira Tokyo Dental College, Department of Dentistry, Lecturer
Project Period (FY)	1999 – 2000Completed
Keywords	4-Nitroquino 1-Oxide (4NQO) / Tongue Carcinoma / Angiogenesis Inhibitors / Vessel Stracture
Research Abstract	Ever since we established 4-nitroquinoline 1-oxide-induced rat tongue cancer models, we have been actively conducting research on vascularity. This ti ...

Research Products of this project	Publications (4 results)

12. The relationship between the carcinoma of the tongue and the muscle by 3D imageing.

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Surgical dentistry
Research Institution	TOKYO DENTAL COLLEGE
Principal Investigator	TAKAKI Takashi Tokyo Dental College Department of Dentistry Lecturer
Project Period (FY)	1995 – 1996Completed
Keywords	carcinoma of the tongue / growth pattern / tongue muscle / three dimentional imaging
Research Abstract	This study removed primary squamous-cell carcinoma on the lingual margin, and visualized the sequential samples from the border area between the tumor ...

13. 頭頸部癌における重粒子線治療の抗腫瘍効果に関する実験的研究

Research Project

Research Category	Grant-in-Aid for Encouragement of Young Scientists (A)
Research Field	Surgical dentistry
Research Institution	Tokyo Dental College
Principal Investigator	片倉朗東京歯科大学, 口腔外科学第一講座, 助手
Project Period (FY)	1994 – 1995Completed
Research Abstract	発癌剤4Nitroquinoline1-oxideをラットの体重が200gに達した時点で投与を開始した。開始後7ケ月目には肉眼的に舌背部に癌と認識できる病変が発生した。これを生検により扁平上皮癌であることを病理組織学的に確認した。

14. 舌癌に対する抗癌剤CDDPおよびTegafurの効果に関する研究

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	外科・放射線系歯学
Research Institution	Tokyo Dental College
Principal Investigator	高木多加志東京歯科大学, 歯学部, 講師
Project Period (FY)	1992Completed
Keywords	CDDP / FT207 / 舌癌 / 4NQO / 抗腫瘍効果
Research Abstract	S-D系ラットに対して4-nitroguinoline1-oxideを7ヶ月間経口投与し,舌背に発生した扁平上皮癌に対し以下の実験を行った。(1)CDDP単独投与群(CDDP単独群)(2)FT207単独投与群(FT207単独群)(3)CDDP+FT207併用投与群(併用群)(4)無処置対照群(対照群 ...