KAKEN — Research Projects | Researcher Number: 60585058

Search Results: 9 results / Researcher Number: 60585058

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1. Investigating the mechanism of intestinal colonization of enteric pathogens by dynamically regulated functions of type IV pili

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 49050:Bacteriology-related
Research Institution	Osaka University
Principal Investigator	河原一樹大阪大学, 大学院薬学研究科, 助教
Project Period (FY)	2024-04-01 – 2027-03-31Granted
Keywords	腸管系病原菌 / 薬剤耐性菌 / 定着 / IV型線毛システム
Outline of Research at the Start	病原細菌が産生する病原因子を標的とした治療法は、薬剤耐性菌問題解決へ向けた魅力的なアプローチであり、細菌の定着に関与する線毛は重要な創薬標的である。腸管毒素原性大腸菌やコレラ菌などの腸管系病原細菌は、IV型に分類される線毛を産生し、その長さをダイナミックに制御しながら定着因子を分泌し、腸管定着を達成 ...

2. Investigating the roles of type IV pilus system in regulating enteric infection of bacterial pathogens

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 49050:Bacteriology-related
Research Institution	Osaka University
Principal Investigator	Kawahara Kazuki 大阪大学, 大学院薬学研究科, 助教
Project Period (FY)	2021-04-01 – 2024-03-31Completed
Keywords	腸管系病原菌 / 定着 / IV型線毛 / 分泌タンパク質 / X線単結晶構造解析 / ETEC / IV型線毛システム / 構造生物学
Outline of Research at the Start	薬剤耐性菌問題が深刻化する中、病原細菌が産生する病原因子を標的とした治療法が注目されている。これまでの腸管毒素原性大腸菌(ETEC)の病原因子の研究から、ETECはIV型に分類される線毛を菌体上に産生し、アドへシンとして機能する分泌タンパク質と相互作用することで腸管定着を成し遂げることを明らかにした ...
Outline of Final Research Achievements	In the post-antibiotic era, there has been an increasing interest in developing novel therapeutics targeting bacterial infection processes involving a ...

Research Products of this project	Journal Article (1 results, of which Peer Reviewed: 1 results, Open Access: 1 results) Presentation (15 results, of which Int'l Joint Research: 4 results, Invited: 1 results) Remarks (1 results)

3. Genomic survey of enteric pathogens in India for developing anti-adhesion therapies

Research Project

Research Category	Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
Review Section	Medium-sized Section 49:Pathology, infection/immunology, and related fields
Research Institution	Osaka University
Principal Investigator	Iida Tetsuya 大阪大学, 微生物病研究所, 教授
Project Period (FY)	2020-10-27 – 2024-03-31Completed
Keywords	コレラ / メタゲノム解析 / IV型線毛 / コレラ菌 / 次世代シーケンサー / インド / 腸管病原体 / 下痢症
Outline of Research at the Start	世界的に公衆衛生の改善による感染症の制御が進められているが、腸管感染症は未だ乳幼児や高齢者の死亡要因の上位に位置しており、喫緊の課題である。代表的な腸管疾患であるコレラは、年間およそ10万人の死亡が推定され、自然災害や交通網発達などにより流行地からの感染拡大が認められており、先進国も例外ではない。本 ...
Outline of Final Research Achievements	Metagenomic analysis revealed that some citizens of Kolkata have a small number of V. cholerae in their intestines as a subclinical infection. In orde ...

Research Products of this project	Journal Article (1 results, of which Peer Reviewed: 1 results, Open Access: 1 results) Presentation (6 results, of which Int'l Joint Research: 2 results)

4. Interplay of a secreted protein with type IV pilus for efficient adhesion of enteric pathogens

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 49050:Bacteriology-related
Research Institution	Osaka University
Principal Investigator	Kawahara Kazuki 大阪大学, 薬学研究科, 助教
Project Period (FY)	2018-04-01 – 2021-03-31Completed
Keywords	腸管系病原菌 / 定着 / ETEC / IV型線毛 / X線単結晶構造解析 / リポソーム / X線結晶構造解析 / 構造生物学
Outline of Final Research Achievements	For efficient attachment and subsequent colonization of the host-cell surface, enteric pathogens have evolved numerous surface organelles, with filame ...

Research Products of this project	Journal Article (5 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 5 results, Open Access: 2 results) Presentation (16 results, of which Int'l Joint Research: 3 results) Remarks (1 results)

5. Oversea's Research on Archaeological Proteins as Molecular Markers of Ancient Culture and Civilization

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Biomolecular chemistry
Research Institution	Nara Women's University
Principal Investigator	Nakazawa Takashi 奈良女子大学, 自然科学系, 教授
Project Period (FY)	2016-04-01 – 2020-03-31Completed
Keywords	タンパク質 / コラーゲン / 質量分析 / アミノ酸配列解析 / 新石器時代 / 旧石器時代 / タンパク質の分解 / タンパク質科学 / 質量分析学 / 動物考古学 / 西アジア / 分子古生物学 / 考古学 / 構造生物科学 / 有機化学 / 翻訳後修飾 / 文化財科学 / タンパク質考古学 / 動物骨 / 環境分析化学 / 古代文明 / エジプト / 古代技術 / 環境化学分析
Outline of Final Research Achievements	The purpose of our project is to apply "protein archaeology" to proteins preserved in Paleolithic and Neolithic animal remains from archaeological sit ...

Research Products of this project	Int'l Joint Research (8 results) Journal Article (16 results, of which Peer Reviewed: 14 results, Open Access: 9 results) Presentation (22 results, of which Int'l Joint Research: 9 results, Invited: 1 results) Book (1 results) Remarks (3 results)

6. プロテオミクス技術による古代タンパク質分析

Publicly Offered Research

Research Category	Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Review Section	Humanities and Social Sciences
Research Institution	Osaka University
Principal Investigator	河原一樹大阪大学, 薬学研究科, 特任助教(常勤)
Project Period (FY)	2015-04-01 – 2017-03-31Completed
Keywords	西アジア / 文化遺産 / プロテオミクス / 質量分析 / タンパク質
Outline of Annual Research Achievements	タンパク質は、骨や動物遺存体などの生物由来の発掘試料だけでなく、壁画や絵画などの彩色材料、毛皮で作られた衣類、更には食物残滓が付着した土器など多岐に渡る文化財に残存する素材であり、古代DNAと同様に重要な研究対象である。本研究では、発掘又は保存環境により汚染された試料を含む文化財から採取した極微量片 ...
Project Area	Ancient West Asian Civilization as the foundation of all modern civilizations: A counter to the 'Clash of Civilizations' theory.

Research Products of this project	Int'l Joint Research (1 results) Journal Article (7 results, of which Int'l Joint Research: 1 results, Open Access: 1 results, Acknowledgement Compliant: 2 results) Presentation (5 results, of which Int'l Joint Research: 2 results, Invited: 1 results) Remarks (2 results)

7. Research on the animal glue production in ancient East Asia

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Archaeology
Research Institution	Nara Women's University
Principal Investigator	MIYAJI ATSUKO 奈良女子大学, 人文科学系, 教授
Project Period (FY)	2014-04-01 – 2018-03-31Completed
Keywords	動物考古学 / プロテオミクス / タンパク質考古学 / 動物資源 / 考古学 / 膠生産 / 膠流通 / 古代東アジア / 膠 / 文化財 / タンパク質 / 質量分析 / 東アジア / 墨
Outline of Final Research Achievements	In this study, we focused on fiber proteins (collagen) contained in glue used in cultural properties, and based on their accurate analysis using prote ...

Research Products of this project	Journal Article (8 results, of which Peer Reviewed: 1 results) Presentation (4 results, of which Int'l Joint Research: 1 results) Book (6 results) Remarks (1 results)

8. Amino acid sequencing of animal glues remained in cultural properties by proteomic techniques

Research Project

Research Category	Grant-in-Aid for Young Scientists (B)
Research Field	Cultural assets study and museology
Research Institution	Osaka University
Principal Investigator	KAWAHARA KAZUKI 大阪大学, 薬学研究科(研究院), 助教
Project Period (FY)	2013-04-01 – 2016-03-31Completed
Keywords	考古学 / 膠 / コラーゲン / プロテオミクス / 質量分析
Outline of Final Research Achievements	Animal glue, mainly constituted of collagen, is one of the oldest materials used as the adhesive and binder of cultural properties. Identifying its an ...

Research Products of this project	Int'l Joint Research (1 results) Journal Article (21 results, of which Int'l Joint Research: 1 results, Acknowledgement Compliant: 2 results, Peer Reviewed: 7 results) Presentation (15 results, of which Invited: 2 results) Remarks (2 results)

9. Identification of Animal Species of Collagen Used as Glues in Archaeological Materials Utilizing MALDI Mass Spectrometry

Research Project

Research Category	Grant-in-Aid for Research Activity Start-up
Research Field	Archaeology
Research Institution	Nara Women's University
Principal Investigator	KAWAHARA Kazuki 奈良女子大学, 古代学学術研究センター, 特任助教
Project Period (FY)	2010 – 2011Completed
Keywords	考古学 / 膠 / コラーゲン / プロテオミクス / 質量分析
Research Abstract	Collagen, the most abundant protein in animals, has often been found as animal glue in a wide variety of archaeological materials. In this research pr ...

Research Products of this project	Journal Article (9 results, of which Peer Reviewed: 7 results) Presentation (13 results) Remarks (3 results)