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Comprehensive understanding of neo-self generation, function, and structure

Administrative Group

Project AreaCreation, function and structure of neo-self
Project/Area Number 16H06495
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokushima

Principal Investigator

MATSUMOTO Mitsuru  徳島大学, 先端酵素学研究所, 教授 (60221595)

Co-Investigator(Kenkyū-buntansha) 横須賀 忠  東京医科大学, 医学部, 主任教授 (10359599)
Project Period (FY) 2016-06-30 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥38,220,000 (Direct Cost: ¥29,400,000、Indirect Cost: ¥8,820,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2016: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Keywordsネオ・セルフ / 免疫学的自己 / 総括班 / 研究支援 / 抗原認識機構 / 免疫的自己 / 連携強化 / 分子イメージング / 自己免疫疾患 / MHC / アレルギー / 構造生物学
Outline of Final Research Achievements

The general team strengthened the research cooperation of the group members, and the international activity support group worked on training young researchers and building an international network through overseas dispatch. The open recruitment group was attended by 19 (first phase) and 20 (second phase) members, including proposals from different fields that would lead to the elucidation of neo-self from different perspectives. Worked on the functional elucidation of the self-generation/recognition mechanism (Research Item A01). In addition, researchers who propose the latest technology for elucidating the structure of neo-self participated in research item A02 (2 people: 1st stage and 3 people: 2nd stage), and the diversity of open recruitment team members in immunology. It contributed to the activation of research not only in academic fields but also in medical science in general.

Academic Significance and Societal Importance of the Research Achievements

総括班では、計画班開始年度のキックオフシンポジウム、定期の研究進捗状況の総括のための班員全員参加の全体班会議を計4回開催した。また、計画班員による計画班運営を適切に行うため、アドバイザー、文部科学省学術調査官も交えて助言を仰ぎながら総括班会議を計9回開催した。同様に、総括班の役割としての若手研究者の育成を目的に、若手の会を計3回開催した。また、国内研究者へのネオ・セルフの発信のためにニュースレターを合計4号発刊した。さらに国内外に向けたアウトリーチ活動、日本語/英語の領域ホームページ作成などの広報活動にも積極的に取り組み、その学術的・社会的意義は十分に大きなものであったと考える。

Report

(6 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (104 results)

All 2022 2021 2019 2018 2017 2016 Other

All Int'l Joint Research (11 results) Journal Article (20 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 17 results,  Open Access: 14 results,  Acknowledgement Compliant: 2 results) Presentation (63 results) (of which Int'l Joint Research: 14 results,  Invited: 21 results) Book (5 results) Remarks (4 results) Funded Workshop (1 results)

  • [Int'l Joint Research] ワシントン大学/NIH(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] モナッシュ大学(オーストラリア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ポルト大学(ポルトガル)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] タルトゥー大学(エストニア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ワシントン大学(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] モナッシュ大学(オーストラリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ワシントン大学(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ミュンヘン大学(ドイツ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] タルトゥー大学(エストニア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ヘルシンキ大学(フィンランド)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] モナッシュ大学(オーストラリア)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Development of organ-specific autoimmunity by dysregulated Aire expression2022

    • Author(s)
      Nishijima H, Sugita M, Umezawa N, Kimura N, Sasaki H, Kawano H, Nishioka Y, Matsumoto M, Oya T, Tsuneyama K, Morimoto J, Matsumoto M.
    • Journal Title

      Immunology & Cell Biology

      Volume: - Issue: 5 Pages: 1-7

    • DOI

      10.1111/imcb.12546

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] No major impact of two homologous Ly6C1 and Ly6C2 on immune homeostasis2022

    • Author(s)
      Morimoto J, Matsumoto M, Miyazawa R, Oya T, Taneyama K, Matsumoto M.
    • Journal Title

      Immunohorizons

      Volume: 9 Issue: 3 Pages: 202-210

    • DOI

      10.4049/immunohorizons.2100114

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aire suppresses CTLA-4 expression from the thymic storm to control autoimmunity2022

    • Author(s)
      Morimoto J, Matsumoto M, Miyazawa R, Yoshida H, Tsuneyama K, Matsumoto M.
    • Journal Title

      Cell Reports

      Volume: 15 Issue: 7 Pages: 110384-110384

    • DOI

      10.1016/j.celrep.2022.110384

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aire controls heterogeneity of medullary thymic epithelial cells for the expression of self-antigens2022

    • Author(s)
      Nishijima H, Matsumoto M, Morimoto J, Hosomichi K, Akiyama N, Akiyama T, Oya T, Tsuneyama K, Yoshida H, Matsumoto M.
    • Journal Title

      The Journal of Immunology

      Volume: 15 Issue: 2 Pages: 303-320

    • DOI

      10.4049/jimmunol.2100692

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PD-L2 suppresses T cell signaling via coinhibitory microcluster formation and SHP2 phosphatase recruitment2021

    • Author(s)
      Tomohiro Takehara, Ei Wakamatsu, Hiroaki Machiyama, Wataru Nishi, Katsura Emoto, Miyuki Azuma, Kenzo Soejima, Koichi Fukunaga, Tadashi Yokosuka
    • Journal Title

      Communications Biology

      Volume: 4 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s42003-021-02111-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tissue-specific autoimmunity controlled by Aire in thymic and peripheral tolerance mechanisms2019

    • Author(s)
      Matsumoto Minoru、Tsuneyama Koichi、Morimoto Junko、Hosomichi Kazuyoshi、Matsumoto Mitsuru、Nishijima Hitoshi
    • Journal Title

      International Immunology

      Volume: 32 Issue: 2 Pages: 117-131

    • DOI

      10.1093/intimm/dxz066

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a new monoclonal antibody specific to mouse Vg6 chain2019

    • Author(s)
      Hatano S, Tun X, Noguchi N, Yue D, Yamada H, Sun X, Matsumoto M, Yoshikai Y.
    • Journal Title

      Life Sci Alliance

      Volume: 2 Issue: 3 Pages: 1-12

    • DOI

      10.26508/lsa.201900363

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ヒトAIREを発現させたNODマウスに認められる自己免疫応答2019

    • Author(s)
      西嶋 仁、松本 満
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 71 Pages: 490-496

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Inhibition of T cell activation and function by the adaptor protein CIN85.2019

    • Author(s)
      Kong Mei S*., Hashimoto-Tane A*., Kawashima Y., Sakuma M., Yokosuka T., Kometani K., Onishi R., Carpino N., Ohara O., Kurosaki T., Phua K.K. and Saito, T.
    • Journal Title

      Science Signaling

      Volume: 12 Issue: 567 Pages: 1609-1625

    • DOI

      10.1126/scisignal.aav4373

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] AIRE - The Autoimmune Regulator2019

    • Author(s)
      Matsumoto Minoru、Nishijima Hitoshi、Morimoto Junko、Tsuneyama Koichi、Matsumoto Mitsuru
    • Journal Title

      eLS

      Volume: 1 Pages: 1-8

    • DOI

      10.1002/9780470015902.a0027281

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE)2018

    • Author(s)
      Nishijima Hitoshi、Kajimoto Tatsuya、Matsuoka Yoshiki、Mouri Yasuhiro、Morimoto Junko、Matsumoto Minoru、Kawano Hiroshi、Nishioka Yasuhiko、Uehara Hisanori、Izumi Keisuke、Tsuneyama Koichi、Okazaki Il-mi、Okazaki Taku、Hosomichi Kazuyoshi、Shiraki Ayako、Shibutani Makoto、Mitsumori Kunitoshi、Matsumoto Mitsuru
    • Journal Title

      Journal of Autoimmunity

      Volume: 86 Pages: 75-92

    • DOI

      10.1016/j.jaut.2017.09.006

    • NAID

      120006532435

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aire Controls in Trans the Production of Medullary Thymic Epithelial Cells Expressing Ly-6C/Ly-6G2018

    • Author(s)
      Morimoto Junko、Nishikawa Yumiko、Kakimoto Takumi、Furutani Kohei、Kihara Naoki、Matsumoto Minoru、Tsuneyama Koichi、Kozono Yuko、Kozono Haruo、Hozumi Katsuto、Hosomichi Kazuyoshi、Nishijima Hitoshi、Matsumoto Mitsuru
    • Journal Title

      The Journal of Immunology

      Volume: 201 Issue: 11 Pages: 3244-3257

    • DOI

      10.4049/jimmunol.1800950

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mode of Tolerance Induction and Requirement for Aire Are Governed by the Cell Types That Express Self-Antigen and Those That Present Antigen.2017

    • Author(s)
      Mouri Y, Ueda Y, Yamano T, Matsumoto M, Tsuneyama K, Kinashi T, and Matsumoto M.
    • Journal Title

      The Journal of Immunology

      Volume: 199 Issue: 12 Pages: 3959-3971

    • DOI

      10.4049/jimmunol.1700892

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Analyzing the Dynamics of Signaling Microclusters2017

    • Author(s)
      Hashimoto-Tane A, Yokosuka T, Saito T.
    • Journal Title

      The Immune Synapse

      Volume: 1584 Pages: 5-64

    • DOI

      10.1007/978-1-4939-6881-7_4

    • ISBN
      9781493968794, 9781493968817
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells.2017

    • Author(s)
      Okada M, Chikuma S et al.
    • Journal Title

      Cell Reports

      Volume: 20 Issue: 5 Pages: 1017-1028

    • DOI

      10.1016/j.celrep.2017.07.027

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 細胞膜脂質成分によるT細胞シグナルソームと活性化の制御機構2017

    • Author(s)
      横須賀忠、古畑昌枝、豊田博子、秦喜久美、矢那瀬紀子、町山裕亮
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 67 Pages: 321-326

    • NAID

      40021132650

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator.2016

    • Author(s)
      Akiyama N, Takizawa N, Miyauchi M, Yanai H, Tateishi R, Shinzawa M, Yoshinaga R, Kurihara M, Demizu Y, Yasuda H, Yagi S, Wu G, Matsumoto M, Sakamoto R, Yoshida N, Penninger JM, Kobayashi Y, Inoue J, Akiyama T.
    • Journal Title

      The Journal of Experimental Medicine

      Volume: 213 Issue: 8 Pages: 1441-1458

    • DOI

      10.1084/jem.20151780

    • NAID

      120006532434

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Micro-adhesion rings surrounding TCR microclusters are essential for T cell activation2016

    • Author(s)
      Hashimoto-Tane A, Sakuma M, Ike H, Yokosuka T, Kimura Y, Ohara O, Saito T.
    • Journal Title

      J. Exp. Med.

      Volume: 213 Issue: 8 Pages: 1609-1625

    • DOI

      10.1084/jem.20151088

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Multifaceted Role of PD-1 in Health and Disease2016

    • Author(s)
      Badr MEISG, Hata K, Furuhata M, Toyoda H, Yokosuka T.
    • Journal Title

      Choronic Inflammation

      Volume: 1 Pages: 441-457

    • DOI

      10.1007/978-4-431-56068-5_34

    • ISBN
      9784431560661, 9784431560685
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 最先端イメージング技術によるTCRシグナル研究の進歩2016

    • Author(s)
      横須賀忠、古畑昌枝、豊田博子、秦喜久美、矢那瀬紀子、町山裕亮
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 66 Pages: 169-176

    • NAID

      40020941348

    • Related Report
      2016 Annual Research Report
  • [Presentation] 胸腺内Treg誘導における胸腺髄質上皮細胞と樹状細胞の機能的差異2022

    • Author(s)
      森本 純子、松本 満
    • Organizer
      第41回日本胸腺研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 胸腺癌におけるAIRE発現と胸腺髄質上皮細胞との類似性2022

    • Author(s)
      松本 穣、松本 満、尾矢剛志
    • Organizer
      第41回日本胸腺研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Aire suppresses CTLA-4 expression from medullary thymic epithelial cells to avoid autoimmunity.2021

    • Author(s)
      Junko Morimoto , Minoru Matsumoto , Ryuichiro Miyazawa , Hideyuki Yoshida , Mitsuru Matsumoto.
    • Organizer
      第50回日本免疫学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 分子イメージングによるT細胞活性化機構の解明とがん免疫2021

    • Author(s)
      横須賀忠、若松英、西嶋仁、竹内新、竹原朋宏、西航、西川哲史、Maksim Mamokin、Malcolm K. Brenner、町山裕亮
    • Organizer
      第61回日本リンパ網内系学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] CAR-T細胞の抗原認識と活性化を担うCARマイクロクラスターの分子イメージング解析2021

    • Author(s)
      横須賀忠
    • Organizer
      第25回日本がん免疫学会総会シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] LAG-3発現CD4+ T細胞はMHC class IIのトロゴサイトーシスを介して間接的にCD4+ T細胞の活性化を抑制する2021

    • Author(s)
      若松英、町山裕亮、豊田博子、古畑昌枝、西嶋仁、竹内新、横須賀忠
    • Organizer
      第30回 Kyoto T Cell Conference
    • Related Report
      2020 Annual Research Report
  • [Presentation] The kinase Lck activate CAR-T cells independently upon co-receptor association2021

    • Author(s)
      Hiroaki Machiyama, Ei Wakamatsu, Masae Furuhata, Hiroko Toyota, Mamonkin Maksim, Brenner K. Malcom, Tadashi Yokosuka
    • Organizer
      第50回日本免疫学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] LAG-3-mediated trogoytosis of MHC class II indirectly regulates CD4+ T cell actibation2021

    • Author(s)
      Ei Wakamatsu, Hiroaki Machiyama, Hiroko Toyota, Masae Furuhata, Hitoshi Nishijima, Arata Takeuchi, Tadashi Yokosuka
    • Organizer
      第50回日本免疫学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Human T cells illustrate TCR microclusters by triggering with bispecific antibodies, blinatumomab2021

    • Author(s)
      Hitoshi Nishijima, Arata Takeuchi, Ei Wakamatsu, Wataru Nishi, Hiroaki Machiyama, Tadashi Yokosuka
    • Organizer
      第50回日本免疫学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Establishment of a molecular imaging system to evaluate the T cell exhaustion releasing function of human PD-1/PD-L1 antibodies2021

    • Author(s)
      Wataru Nishi,Ei Wakamatsu, Masae Furuhata, Hiroaki Machiyama, Hiroaki Machiyama, Hitoshi Nishijima, Arata Takeuchi, Miyuki Azuma, Tadashi Yokosuka
    • Organizer
      第50回日本免疫学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Aire-dependent establishment of self-tolerance studied by genetically modified mice2019

    • Author(s)
      Mitsuru Matsumoto, Junko Morimoto, Minoru Matsumoto, Koichi Tsuneyama, Ryuichiro Miyazawa, Hitoshi Nishijima
    • Organizer
      EMBO Workshop ThymE
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Tissue-specific autoimmunity controlled by Aire in thymic and peripheral tolerance mechanisms2019

    • Author(s)
      Minoru Matsumoto, Mitsuru Matsumoto
    • Organizer
      The 18th Awaji International Forum on Infection and Immunity
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aire-dependent establishment of self-tolerance2019

    • Author(s)
      Matsumoto M, Morimoto J, Matsumoto M, Tsuneyama K, Miyazawa R, Nishijima H
    • Organizer
      The 17th International Congress of Immunology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Programmed cell death 2 forms coinhibitory microclusters that directly attenuate T cell receptor signaling by recruiting phosphatase SHP22019

    • Author(s)
      Takehara T, Wakamatsu E, Machiyama H, Yanase N, Hata K, Toyoda H, Furuhata M, Yasuda H, Soejima K, Yokosuka T.
    • Organizer
      American Association for Cancer Research
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 分子イメージングが拓くがん免疫応答とT細胞活性化メカニズムの解明2019

    • Author(s)
      横須賀忠
    • Organizer
      第75回日本口腔科学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 末梢T細胞ではLckと共受容体CD4/CD8との協調的クラスター形成よって初期のTCRシグナルが惹起される2019

    • Author(s)
      町山裕亮、若松英、秦喜久美、矢那瀬紀子、古畑昌枝、豊田博子、横須賀忠
    • Organizer
      Kyot T cell Conference 第29回学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] CARマイクロクラスターによる腫瘍抗原の認識とCAR-T細胞活性化の時空間的制御機構2019

    • Author(s)
      横須賀忠、若松英、矢那瀬紀子、秦喜久美、竹原朋宏、西航、町山裕亮
    • Organizer
      第23回日本がん免疫学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 胸腺におけるネオ・セルフ生成機構2019

    • Author(s)
      松本 満
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 多様なT細胞シグナルソームによる腫瘍およびネオ・セルフ抗原認識の分子機構2019

    • Author(s)
      横須賀忠、若松英、矢那瀬紀子、秦喜久美、竹原朋宏、西航、町山裕亮
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 胸腺髄質上皮細胞に発現する転写調節因子Aireを用いた自己免疫病態の解析2019

    • Author(s)
      松本 満
    • Organizer
      第29回日本内分泌学会臨床内分泌代謝Update
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Aireを高発現する胸腺髄質上皮細胞の免疫学的機能とトランスクリプトーム解析2019

    • Author(s)
      西嶋 仁、杉田瑞季、森本純子、松本 穣、松本 満
    • Organizer
      第42回日本分子生物学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 分子イメージングが拓くT細胞活性化機構の解明とがん免疫療法2019

    • Author(s)
      横須賀忠
    • Organizer
      第81回日本血液学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 分子イメージングが拓くT細胞活性化機構の解明とがん免疫療法~免疫チェックポイント分子とキメラ抗原受容体のシグナルソーム~2019

    • Author(s)
      横須賀忠
    • Organizer
      Scientific Exchange Meeting in 北九州2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Antigen transfer from thymic epithelial cells to DCs contributes to the production of thymic Tregs2019

    • Author(s)
      Junko Morimoto, Hitoshi Nishijima, Minoru Matsumoto, Mitsuru Matsumoto
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Characterization of Aire-expressing DCs with a high-sensitivity and high-fidelity Aire-reporter strain2019

    • Author(s)
      Minoru Matsumoto, Hitoshi Nishijima, Ryuichiro Miyazawa, Junko Morimoto, Koichi Tsuneyama, Mitsuru Matsumoto
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Extrinsic and intrinsic inhibition of T cell response by co-inhibitory receptors, TIGIT and CD96.2019

    • Author(s)
      Yanase N, Machiyama H, Toyota H, Furuhata M, Hata K, Takehara T, Wakamatsu E, Yokosuka T
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Programmed cell death 2 forms coinhibitory microclusters that directly attenuate T cell receptor signaling by recruiting the phosphatase SHP2.2019

    • Author(s)
      Takehara T, Wakamatsu E, Machiyama H, Yanase N, Toyota H, Furuhata M, Koichi F, Soejima K, Yokosuka T
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Indirect suppression of CD4+ T cell activation by LAG3-mediated trogocytosis of MHC Class II.2019

    • Author(s)
      Wakamatsu E, Machiyama H, Toyota H, Furuhata M, Hata K, Yanase N, Yokosuka T
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Different requirement of the coreceptors CD4 and CD8 for initiation of T cell activation.2019

    • Author(s)
      Machiyama H Wakamatsu E, Hata K, Yanase N, Furuhata M, Toyota H, Yokosuka T
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 分子イメージングが拓くT細胞活性化機構の解明とがん免疫応答ーチェックポイント分子とキメラ抗原受容体CARのシグナルソーム形成ー2019

    • Author(s)
      横須賀忠
    • Organizer
      Immuno-Oncology Forum in Ehime
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells2018

    • Author(s)
      Junko Morimoto, Yumiko Nishikawa, Naoki Kihara, Kazuyoshi Hosomichi, Hitoshi Nishijima, Mitsuru Matsumoto
    • Organizer
      Immunology 2018 - AAI Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Manipulation of thymic and peripheral tolerance by AIRE defines distinct tissue-specific autoimmunity2018

    • Author(s)
      Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama and Mitsuru Matsumoto
    • Organizer
      11th International Congress on Autoimmunity
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Amelioration of diabetes development in NOD by the transgenic human AIRE expression in DCs2018

    • Author(s)
      Mitsuru Matsumoto
    • Organizer
      第47回 日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 免疫チェックポイント阻害剤と癌治療の進歩ー臨床と基礎の視点からー2018

    • Author(s)
      横須賀忠
    • Organizer
      第22回日本がん分子標的治療学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] チェックポイントから学ぶことー科学的思考は疫学や過去の結論から新天地を築くー2018

    • Author(s)
      横須賀忠
    • Organizer
      第35回日本呼吸器外科学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 免疫チェックポイント療法はなぜ効くのか?分子イメージングが明らかにするT細胞活性化の時空間的制御機構2018

    • Author(s)
      横須賀忠
    • Organizer
      国立がんセンター東がん免疫セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 胸腺ダブルポジティブT細胞におけるc-Cblのシグナルソーム形成と胸腺選択との相関2018

    • Author(s)
      秦喜久美、町山裕亮、若松英、豊田博子、古畑昌枝、矢那瀬紀子、横須賀忠
    • Organizer
      Kyot T cell Conference 第28回学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 分子イメージングによる免疫チェックポイント療法によるT細胞の疲弊解除とその分子メカニズムの解明2018

    • Author(s)
      横須賀忠、若松英、矢那瀬紀子、竹原朋宏、秦喜久美、町山裕亮
    • Organizer
      第22回日本がん免疫学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] がん免疫と分子イメージング先端的研究ー免疫チェックポイント分子とキメラ抗原受容体CARの分子メカニズムー2018

    • Author(s)
      横須賀忠
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 分子イメージングが拓くT細胞活性化機構の解明とがん免疫応答ー;免疫チェックポイント分子とキメラ抗原受容体CARのシグナルソーム形成ー2018

    • Author(s)
      横須賀忠
    • Organizer
      三重大学院医学研究科セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 分子イメージングが解明する免疫チェックポイント療法によるT細胞の疲弊解除とその分子メカニズム2018

    • Author(s)
      横須賀忠
    • Organizer
      中外製薬株式会社セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 分子イメージングが明らかにするT細胞活性化の時空間的制御機構ー免疫チェックポイント分子とCARー2018

    • Author(s)
      横須賀忠
    • Organizer
      第59回日本肺癌学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 分子イメージングが明らかにするマイクロクラスターによるT細胞活性化制御機構ー免疫チェックポイント受容体とCARのマイクロクラスターー2018

    • Author(s)
      横須賀忠
    • Organizer
      第一三共株式会社細胞治療研究所講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Dynamics of the PI3K signaling pathway induced by a T cell costimulator, ICOS.2018

    • Author(s)
      Yokosuka Tadashi, Wakamatsu Ei, Yanase Noriko, Toyota Hiroko, Furuhata Masae, Hata Kikumi, Machiyama Hiroaki
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cooperative regulation of thymic selection by receptor endocytosis and signal strength through TCR and E3 ubiquitin ligase c-Cbl microcluster formation.2018

    • Author(s)
      Kikumi Hata, Hiroaki Machiyama, Noriko Yanase, Masae Furuhata, Hiroko Toyota, Ei Wakamatsu, Tadashi Yokosuka
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Molecular imaging of the hCD19 CAR signalosomes, “CAR microclusters”.2018

    • Author(s)
      Yanase Noriko, Machiyama Hiroaki, Wakamatsu Ei, Toyota Hiroko, Furuhata Masae, Hata Kikumi, Mamonkin Maksim, Brenner Malcolm K, Yokosuka Tadashi
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Single molecule imaging unveils a distinct difference in Lck-dynamics between CD4+ and CD8+ T cells.2018

    • Author(s)
      Hiroaki Machiyama, Ei Wakamatsu, Noriko Yanase, Kikumi Hata, Masae Furuhata, Hiroko Toyota, Tadashi Yokosuka
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Molecular imaging unveils a mechanism of T cell activation regulation by immune checkpoint microclusters.2018

    • Author(s)
      Tadashi Yokosuka, Ei Wakamatsu, Tomohiro Takehara, Kikumi Hata, Noriko Yanase,Hiroaki Machiyama
    • Organizer
      The 23rd JFCR-ISCC New Antitumor Agents under Development in the US, Europe and Japan
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aire-dependent subset of mTECs with tolerogenic functions is defined by Ly6 family protein expression.2018

    • Author(s)
      Mitsuru Matsumoto, Junko Morimoto, Minoru Matsumoto, Koichi Tsuneyama, Hitoshi Nishijima
    • Organizer
      ThymOz8
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acquisition of the resistance to autoimmune diabetes by the expression of human AIRE in BM-derived APCs in NOD2018

    • Author(s)
      Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama, Mitsuru Matsumoto
    • Organizer
      ThymOz8
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular imaging unveils spatiotemporal regulation of T cell activation by immune checkpoint receptors2018

    • Author(s)
      Yokosuka T
    • Organizer
      The 1st International Cancer Research Symposium of Training Plan for Oncology Professionals
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Expression of Ly6C/6G defines a novel Aire-dependent subset of medullary thymic epithelial cells with tolerogenic function2017

    • Author(s)
      Morimoto, J., Nishikawa, Y., Nishijima, H., Matsumoto, M.
    • Organizer
      12th International Congress on SLE
    • Place of Presentation
      Melbourne (Australia)
    • Year and Date
      2017-03-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Paradoxical development of polymyositis-like autoimmunity through augmented expression of AIRE2017

    • Author(s)
      Nishijima, H., Mouri, Y., Morimoto, J., Matsumoto, M.
    • Organizer
      7th International Workshop of Kyoto T Cell Conference
    • Place of Presentation
      芝蘭会館(京都府・京都市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microclusters as a signaling unit for T cell receptor endocytosis2017

    • Author(s)
      Machiyama H, Hata K, Yanase N, Hashimoto-Tane A, Saito T, Yokosuka T.
    • Organizer
      The 7th International Symposium of Kyoto T Cell Conference
    • Place of Presentation
      京都大学(京都府・京都市)
    • Year and Date
      2017-03-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] Paradoxical development of polymyositis-like autoimmunity through augmented expression of human AIRE in mice2017

    • Author(s)
      Nishijima, H., Mouri, Y., Morimoto, J., Matsumoto, M.
    • Organizer
      Controversies in Rheumatology and Autoimmunity 2017
    • Place of Presentation
      Bologna (Italy)
    • Year and Date
      2017-03-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] イメージングが拓く免疫チェックポイント分子によるT細胞活性化の時空間的制御機構2017

    • Author(s)
      横須賀忠
    • Organizer
      第14回日本免疫治療学研究会学術集会
    • Place of Presentation
      東京大学(東京都・文京区)
    • Year and Date
      2017-02-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells.2017

    • Author(s)
      Junko Morimoto, Yumiko Nishikawa, Naoki Kihara, Kazuyoshi Hosomichi, Hitoshi Nishijima, Mitsuru Matsumoto
    • Organizer
      5th Annual Meeting of the International Cytokine and Interferon Society(国際学会)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tissue-specific autoimmune response controlled by Aire.2017

    • Author(s)
      Mitsuru Matsumoto
    • Organizer
      第46回日本免疫学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] イメージンブが拓くT細胞活性化の時空間的制御機構2017

    • Author(s)
      横須賀忠
    • Organizer
      Expert Seminar of Immunology
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Possible defect in the Treg production in mice overexpressing AIRE/Aire which exhibit muscle-specific autoimmunity2016

    • Author(s)
      Nishijima, H., Matsuoka, Y., Mouri, Y., Morimoto, J., Matsumoto, M.
    • Organizer
      第45回日本免疫学会総会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県・宜野湾市)
    • Year and Date
      2016-12-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Microclusters as a functional unit for the endocytosis of TCRs2016

    • Author(s)
      Yokosuka T, Machiyama H, Hata K, Yanase N, Hashimoto-Tane A, Saito T.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県・宜野湾市)
    • Year and Date
      2016-12-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Immunological tolerance mediated by Aire2016

    • Author(s)
      Matsumoto, M.
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Massive infiltration of macrophages and eosinophils in the muscle of mice overexpressing Aire in thymic and peripheral antigen-presenting cells2016

    • Author(s)
      Nishijima, H., Matsumoto, M.
    • Organizer
      Cell Symposia
    • Place of Presentation
      Sicily (Italy)
    • Year and Date
      2016-09-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Book] Transcriptomics in Health and Disease2022

    • Author(s)
      Yoshida H, Matsumoto M, Matsumoto M.
    • Total Pages
      23
    • Publisher
      Springer
    • ISBN
      9783030878207
    • Related Report
      2020 Annual Research Report
  • [Book] Thymus Transcriptome and Cell Biology2019

    • Author(s)
      Minoru Matsumoto, Pedro M. Rodrigues, Laura Sousa, Koichi Tsuneyama, Mitsuru Matsumoto, Nuno L. Alves.
    • Total Pages
      31
    • Publisher
      Springer International Publishing
    • ISBN
      9783030120399
    • Related Report
      2019 Annual Research Report
  • [Book] 実験医学増刊号「新・腫瘍免疫学」免疫チェックポイント分子の分子作用機序2019

    • Author(s)
      横須賀忠、若松英、秦喜久美、竹原朋宏、西航、矢那瀬紀子、町山裕亮
    • Total Pages
      268
    • Publisher
      羊土社
    • Related Report
      2019 Annual Research Report
  • [Book] 「膜タンパク質工学ハンドブック」 第7章 第2節 免疫チェックポイント受容体PD-1とCTLA-42019

    • Author(s)
      横須賀忠、若松英、町山裕亮
    • Total Pages
      624
    • Publisher
      (株)NTS
    • Related Report
      2019 Annual Research Report
  • [Book] Janeway's免疫生物学原著第9版 第7章リンパ球レセプターシグナル2019

    • Author(s)
      横須賀忠、西川博嘉
    • Total Pages
      884
    • Publisher
      南江堂
    • Related Report
      2018 Annual Research Report
  • [Remarks] 文部科学省科学研究費補助金 新学術領域研究:ネオ・セルフの生成・機能・構造

    • URL

      http://www.tokyo-med.ac.jp/neoself/

    • Related Report
      2020 Annual Research Report 2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] 徳島大学先端酵素学研究所免疫病態学分野ホームページ

    • URL

      https://www.tokushima-autoimmunity.com

    • Related Report
      2020 Annual Research Report
  • [Remarks] 文部科学省科学研究費補助金新学術領域研究:ネオ・セルフの生成・機能・構造

    • URL

      http://www.tokyo-med.ac.jp/neoself/

    • Related Report
      2019 Annual Research Report
  • [Remarks] ネオ・セルフの生成・機能・構造

    • URL

      http://www.tokyo-med.ac.jp/neoself/index.html

    • Related Report
      2016 Annual Research Report
  • [Funded Workshop] The 1st International Symposium on NEO-SELF2018

    • Related Report
      2018 Annual Research Report

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Published: 2016-07-04   Modified: 2023-01-30  

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