Cell Proliferation Control

• Project Area: Cell Proliferation Control
• Project/Area Number: 19057004
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: KISHIMOTO Takeo 東京工業大学, 大学院・生命理工学研究科, 教授 (00124222)
• Co-Investigator(Kenkyū-buntansha): SAGATA Noriyuki 九州大学, 理学(系)研究科(研究院), 教授 (80142024) ; INAGAKI Masaki 愛知がんセンター(研究所), 発がん制御研究部, 部長 (30183007) ; TAKEUCHI Takashi 鳥取大学, 医学部, 教授 (70197268)
• Research Collaborator: ASAJIMA Makoto 東京大学, 大学院・総合文化研究科, 特任教授 ; YAMAMOTO Tadashi 東京大学, 医科学研究所, 教授 ; MASAI Hisao 東京都医学研究機構, 副参事研究員
• Project Period (FY): 2007 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥48,300,000 (Direct Cost: ¥48,300,000); Fiscal Year 2012: ¥3,000,000 (Direct Cost: ¥3,000,000); Fiscal Year 2011: ¥12,000,000 (Direct Cost: ¥12,000,000); Fiscal Year 2010: ¥7,400,000 (Direct Cost: ¥7,400,000); Fiscal Year 2009: ¥12,000,000 (Direct Cost: ¥12,000,000); Fiscal Year 2008: ¥7,400,000 (Direct Cost: ¥7,400,000); Fiscal Year 2007: ¥6,500,000 (Direct Cost: ¥6,500,000)
• Keywords: 細胞周期 / 細胞増殖 / 細胞分化 / チェックポイント / サイクリン / CDK / CDKインヒビター / 多細胞体制

Research Abstract

特定領域研究「細胞周期フロンティア-増殖と分化相関」(細胞増殖制御)は、平成19年度から5ヶ年計画で発足し、平成23年度末で終了を迎えた。本研究では、この特定領域研究の総括班業務を引き継ぎ、以下のように、領域終了にあたって領域としての研究成果をとりまとめ、その公開をはかった。
(1)「研究成果報告書」を、全班員(前期あるいは後期だけの公募班員や途中辞退者も含む、総計91名)をカバーした冊子体で作成した。本報告書は8章からなり、領域としての研究成果の概要だけでなく、各班員毎の研究成果の概要も掲載し、総頁数456頁の冊子となった。班員、関連研究者、文科省等に配付した。
(2)公開の領域終了シンポジウム「細胞増殖制御」を、平成24年8月30、31の両日、東京工業大学・蔵前会館(目黒区大岡山)で開催した。領域メンバーのうち、前後両期の参画者を中心として31名が講演発表した。参加者総数は約100名で、評価委員も出席した。領域としての主な研究成果を、概観できるシンポジウムとなった。
(3)領域の終了に伴う事後評価のためのヒアリングを、平成24年9月12日に文部科学省で受けた。後日、評価結果は「A」(研究領域の設定目的に照らして、期待どおりの成果があった)であるとの通知が届いた。
(4)領域ホームページで、上記の公開シンポジウムもアナウンスし、領域としての成果を発信した。
これらにより、本領域の設定によって得られた研究成果を周知するとともに、領域メンバー間の有機的な連携を再確認し、細胞周期制御関連分野の研究の今後の発展に資することができた。

Research Products

• [Journal Article] Greatwall kinase and cyclin B-Cdk1 are both critical constituents of M-phase promoting factor. (2012)
  • Author(s): Hara, M., …., Kishimoto, T.
  • Journal Title: Nat. Commun. Volume: 3 Issue: 1 Pages: 1059-1059
  • DOI: 10.1038/ncomms2062
  • Peer Reviewed
• [Journal Article] Cell cycle regulation in mouse heart during embryonic and postnatal stages. (2012)
  • Author(s): Ikenishi A, Okayama H, Iwamoto N, Yoshitome S, Tane S, Nakamura K, Obayashi T, Hayashi T, Takeuchi T.
  • Journal Title: Development, Growth & Differentiation Volume: 54 Issue: 8 Pages: 731-8
  • DOI: 10.1111/j.1440-169x.2012.01373.x
  • Peer Reviewed
• [Journal Article] Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells. (2012)
  • Author(s): Inoko, A., …., Inagaki, M.
  • Journal Title: J. Cell Biol. Volume: 197 Issue: 3 Pages: 391-405
  • DOI: 10.1083/jcb.201106101
  • Peer Reviewed
• [Journal Article] Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells (2012)
  • Author(s): Inoko, A., Matsuyama, M., Goto, H., Ohmuro-Matsuyama, Y., Hayashi, Y., Enomoto, M., Ibi, M., Urano, T., Yonemura, S., Kiyono, T., Izawa, I., and Inagaki, M.
  • Journal Title: J. Cell Biol. Volume: 197 Pages: 391-405
• [Journal Article] Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells (2012)
  • Author(s): Inoko, A., …, Inagaki, M
  • Journal Title: J.Cell Biol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Turn motif phosphorylation negatively regulates activation loop phosphorylation in Akt (2011)
  • Author(s): Hiraoka, D., Okumura, E., and Kishimoto, T.
  • Journal Title: Oncogene Volume: 30 Pages: 4487-4497
• [Journal Article] Dynamic regulation ofEmi2 by Emi2-bound Cdk1/Plk1/CK1 and PP2A-B56 in meiotic arrest of Xenopus eggs (2011)
  • Author(s): Isoda, M., Sako, K., Suzuki, K. Nishino, K., Nakajo, N., Ohe, M., Ezaki, T., Kanemori, Y., Inoue, D., Ueno, H., and Sagata, N.
  • Journal Title: Dev. Cell Volume: 21 Pages: 506-519
• [Journal Article] Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a Jumonji (Jarid2)-cyclinD1 pathway (2011)
  • Author(s): Nakajima, K., Inagawa, M., Uchida, C., Okada, K., Tane, S., Kojima, M., Kubota, M., Noda, M., Ogawa, S, Shirato, H., Sato, M., Suzuki-Migishima, R., Hino, T., Satoh, Y., Kitagawa, M., and Takeuchi, T.
  • Journal Title: Development Volume: 138 Pages: 1771-1782
• [Journal Article] Nuclear Chk1 prevents premature mitotic entry (2011)
  • Author(s): Matsuyama, M., Goto, H., Kasahara, K., Kawakami, Y., Nakanishi, M., Kiyono, T., Goshima, N., and Inagaki, M.
  • Journal Title: J. Cell Sci. Volume: 124 Pages: 2113-2119
• [Journal Article] A primer on meiotic resumption in starfish oocytes : The proposed signaling pathway triggered by maturation-inducing hormone (2011)
  • Author(s): Kishimoto, T
  • Journal Title: Mol.Reprod.Dev. Volume: 78 Pages: 704-707
  • Peer Reviewed
• [Journal Article] Dynamic regulation of Emi2 by Emi2-bound Cdk1/P1k1/CK1 and PP2A-B56 in meiotic arrest of Xenopus eggs (2011)
  • Author(s): Isoda, M., …, Sagata, N.
  • Journal Title: Dev.Cell Volume: 21 Pages: 506-519
  • Peer Reviewed
• [Journal Article] Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a Jumonji (Jarid2)-cyclin D1 pathway (2011)
  • Author(s): Nakajima, K., …, Takeuchi, T.
  • Journal Title: Development Volume: 138 Pages: 1771-1782
  • Peer Reviewed
• [Journal Article] Initiation of DNA replication after fertilization is regulated by p90Rsk at pre-RC/pre-IC transition in starfish eggs (2010)
  • Author(s): Tachibana, K., Mori, M., Matsuhira, T., Karino, T., Inagaki, T., Nagayama, A., Nishiyama, A., Hara, M., and Kishimoto, T.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 107 Pages: 5006-5011
• [Journal Article] Emi2 inhibition of the APC/C absolutely requires Emi2 binding via the C-terminal RL tail (2010)
  • Author(s): Ohe, M., Kawamura, Y., Ueno, H., Inoue, D., Kanemori, Y., Senoo, C., Isoda, M., Nakajo, N., and Sagata, N.
  • Journal Title: Mol. Biol. Cell Volume: 21 Pages: 905-913
• [Journal Article] 14-3-3γ mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage (2010)
  • Author(s): Kasahara, K., Goto, H., Enomoto, M., Tomono, Y., Kiyono, T., and Inagaki, M.
  • Journal Title: EMBO J. Volume: 29 Pages: 2802-2812
• [Journal Article] A single starfish Aurora kinase performs the combined functions of Aurora-A and Aurora-B in human cells. (2010)
  • Author(s): Abe, Y., 他
  • Journal Title: J.Cell Sci. Volume: 123 Pages: 3978-3988
  • Peer Reviewed
• [Journal Article] Emi2 inhibition of the APC/C absolutely requires Emi2 binding via the C-terminal RL tail. (2010)
  • Author(s): Ohe, M., 他
  • Journal Title: Mol.Biol.Cell Volume: 21 Pages: 905-913
  • Peer Reviewed
• [Journal Article] 14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage. (2010)
  • Author(s): Kasahara, K., 他
  • Journal Title: EMBO J Volume: 29 Pages: 2802-2812
  • Peer Reviewed
• [Journal Article] Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a JumonJi(Jarid2)-cyclin D1 pathway (2010)
  • Author(s): Nakajima, K., 他
  • Journal Title: Development Volume: 2011(in press)
  • Peer Reviewed
• [Journal Article] 14-3-3γmediates Cdc25A proteolysis to induce S and G2 arrest after DNA damage. (2010)
  • Author(s): Kasahara, H., Goto, H., Enomoto, M., Tomono, Y., Kiyono, T., Inagaki, M.
  • Journal Title: EMBO J. (in press)
  • Peer Reviewed
• [Journal Article] Initiation of DNA replication after fertilization is regulated by p90Rsk at pre-RC/pre-IC transition in starfish eggs. (2010)
  • Author(s): Tachibana, K., Mori, M., Matsuhira, T., Karino, T., Inagaki, T., Nagayama, A., Nishiyama, A., Hara, M., Kishimoto, T.
  • Journal Title: Proc. Natl. Acad. Sci. USA 107 Pages: 5006-5011
  • Peer Reviewed
• [Journal Article] Emi2 inhibition of the APC/C absolutely requires Emi2 binding via the C-terminal RL tail. (2010)
  • Author(s): Ohe, M., Kawamura, Y., Ueno, H., Inoue, D., Kanemori, Y., Senoo, C., Isoda, M., Nakajo, N., Sagata, N.
  • Journal Title: Mol. Biol. Cell 21 Pages: 905-913
  • Peer Reviewed
• [Journal Article] Initiation of DNA replication after fertilization is regulated by p90Rsk at pre-RC/pre-IC transition in starfish eggs (2010)
  • Author(s): Tachibana, K., 他
  • Journal Title: Proc.Natl.Acad.Sci.USA 107 Pages: 5006-5011
  • Peer Reviewed
• [Journal Article] Emi2 inhibition of the APC/C absolutely requires Emi2 binding via the C-terminal RL tail (2010)
  • Author(s): Ohe, M., 他
  • Journal Title: Mol.Biol.Cell 21 Pages: 905-913
  • Peer Reviewed
• [Journal Article] Start of theembryonic cell cycle is dually locked in unfertilized starfish eggs (2009)
  • Author(s): Hara, M., Mori, M., Wada, T., Tachibana, K., and Kishimoto, T.
  • Journal Title: Development Volume: 136 Pages: 1687-1696
• [Journal Article] The extracellular signal-regulated kinase-mitogen-activated protein kinase pathway phosphorylates and targets Cdc25A for SCF-TrCP-dependent degradation for cell-cycle arrest (2009)
  • Author(s): Isoda, M., Kanemori, Y., Nakajo, N., Uchida, S., Yamashita, K., Ueno, H., and Sagata, N.
  • Journal Title: Mol. Biol. Cell Volume: 20 Pages: 2186-2195
• [Journal Article] A Jumonji (Jarid2) Protein Complex Represses cyclin D1 Expression by Methylation of Histone H3-K9 (2009)
  • Author(s): Shirato, H., Ogawa, S., Nakajima, K., Inagawa, M., Kojima, M., Tachibana, M., Shinkai, Y., and Takeuchi, T.
  • Journal Title: J. Biol. Chem. Volume: 284 Pages: 733-739
• [Journal Article] Novel positive feedback loop between Cdk1 and Chk1 in the nucleus during the G2/M transition (2009)
  • Author(s): Enomoto, M., Goto, H., Tomono, Y., Kasahara, K., Tsujimura, K., Kiyono, T., and Inagaki, M.
  • Journal Title: J. Biol. Chem. Volume: 284 Pages: 34223-34230
• [Journal Article] A Jumonji (Jarid2) Protein Complex Represses cyclin D1 Expression by Methylation of Histone H3-K9. (2009)
  • Author(s): Shirato, H., Ogawa, S., Nakajima, K., Inagawa, M., Kojima, M., Tachibana, M., Shinkai, Y., Takeuchi, T.
  • Journal Title: J. Biol. Chem. 284 Pages: 733-739
  • Peer Reviewed
• [Journal Article] Novel positive feedback loop between Cdk1 and Chk1 in the nucleus during the G2/M transition (2009)
  • Author(s): Enomoto, M., 他
  • Journal Title: J.Biol.Chem. 284 Pages: 34223-34230
  • Peer Reviewed
• [Journal Article] Solution structure of the AT-rich interaction domain of Jumonji/JARID2 (2009)
  • Author(s): Kusunoki, H., 他
  • Journal Title: Proteins 76 Pages: 1023-1028
  • Peer Reviewed
• [Journal Article] Start of the embryonic cell cycle is dually locked in unfertilized starfish eggs (2009)
  • Author(s): Hara, M., 他
  • Journal Title: Development 136(in press)
  • Peer Reviewed
• [Journal Article] The ERK-MAPK pathway phosphorylates and targets Cdc25A for SCF-TrCP-dependent degradation for cell-cycle arrest (2009)
  • Author(s): Isoda, M., 他
  • Journal Title: Mol. Biol. Cell (in press)
  • Peer Reviewed
• [Journal Article] A Jumonji (Jarid2) protein complex represses cyclin DI expression by methylation of histone H3-K9 (2009)
  • Author(s): Shirato, H., 他
  • Journal Title: J. Biol. Chem. 284 Pages: 733-739
  • Peer Reviewed
• [Journal Article] Genetic connection of two contiguous Bacterial Artificial Chromosomes in the BGM vector (2009)
  • Author(s): Kaneko, S., 他
  • Journal Title: J. Biotech (in press)
  • Peer Reviewed
• [Journal Article] The keratin-binding protein Albatross regulates polarization of epithelial cells (2009)
  • Author(s): Sugimoto, M., 他
  • Journal Title: J. Cell Biol 183 Pages: 19-28
  • Peer Reviewed
• [Journal Article] Cyclin B-Cdk1 controls pronuclear union in interphase (2008)
  • Author(s): Tachibana, K., Hara, M., Hattori, Y., and Kishimoto, T.
  • Journal Title: Curr. Biol. Volume: 18 Pages: 1308-1313
• [Journal Article] FoxM1-driven cell division is required for neuronal differentiation in early Xenopus embryos (2008)
  • Author(s): Ueno, H., Nakajo, N., Watanabe, M., Isoda, M., and Sagata, N.
  • Journal Title: Development Volume: 135 Pages: 2023-2030
• [Journal Article] The keratin-binding protein Albatross regulates polarization of epithelial cells (2008)
  • Author(s): Sugimoto, M., Inoko, A., Shiromizu, T., Nakayama, M., Zou, P., Yonemura, S., Hayashi, Y., Izawa, I., Sasoh, M., Uji, Y., Kaibuchi, K., Kiyono, T., and Inagaki, M.
  • Journal Title: J. Cell Biol. Volume: 183 Pages: 19-28
• [Journal Article] Cyclin B-Cdkl controls pronuclear union in interphase (2008)
  • Author(s): Tachibana, K., 他
  • Journal Title: Curr. Biol 18 Pages: 1308-1313
  • Peer Reviewed
• [Journal Article] FoxMl-driven cell division is required for neuronal differentiation in early Xenopus embryos (2008)
  • Author(s): Ueno, H., 他
  • Journal Title: Development 135 Pages: 2023-2030
  • Peer Reviewed
• [Journal Article] Chkl phosphorylation at Ser286 and Ser301 occurs with both stalled DNA replication and damage checkpoint stimulation (2008)
  • Author(s): Ikegami. Y., 他
  • Journal Title: Biochem. Biophys. Res. Commun 377 Pages: 1227-1231
  • Peer Reviewed
• [Journal Article] Protein phosphatase 4 catalytic subunit regulates Cdkl activity and microtubule organization via NDELl dephosphorylation. (2008)
  • Author(s): K. Toyo-oka, 他
  • Journal Title: J. Cell Biol. 180 Pages: 1133-1147
  • Peer Reviewed
• [Journal Article] Transient activation of calcineurin is essential to initiate embryonic development in Xenopus laevis (2007)
  • Author(s): Nishiyama, T., Yoshizaki, N., Kishimoto, T. and Ohsumi, K.
  • Journal Title: Nature Volume: 449 Pages: 341-345
• [Journal Article] A direct link of the Mos- MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopus eggs (2007)
  • Author(s): Inoue, D., Ohe, M., Kanemori, Y., Nobui, T., and Sagata, N.
  • Journal Title: Nature Volume: 446 Pages: 1100-1104
• [Journal Article] Functions of a jumonji-cyclin D1 pathway in the coordination of cell cycle exit and migration during neurogenesis in the mouse hindbrain (2007)
  • Author(s): Takahashi, M., Kojima, M., Nakajima, K., Suzuki-Migishima, R., and Takeuchi, T.
  • Journal Title: Dev. Biol. Volume: 303 Pages: 549-560
• [Journal Article] Production of a site- and phosphorylation state-specific antibody (2007)
  • Author(s): Goto, H., and Inagaki, M.
  • Journal Title: Nat. Protoc. Volume: 2 Pages: 2574-2581
• [Journal Article] XErpl phosphorylation by p90Rsk is required for cytostatic factor arrest in Xenopus eggs. (2007)
  • Author(s): T. Nishiyama, 他
  • Journal Title: Nature 446 Pages: 1096-1099
  • Peer Reviewed
• [Journal Article] Transient activation of calcineurin is essential to initiate embryonic development in xenopus laevis. (2007)
  • Author(s): T. Nishiyama, 他
  • Journal Title: Nature 449 Pages: 341-345
  • Peer Reviewed
• [Journal Article] A direct link of the Mos-MAPK pathway to Erpl/Emi2 in meiotic arrest of xenopus eggs. (2007)
  • Author(s): D. Inoue, 他
  • Journal Title: Nature 446 Pages: 1100-1104
  • Peer Reviewed
• [Journal Article] Mechanism of degradation of CPEB during Xenopus oocyte maturation. (2007)
  • Author(s): D. Setoyama, 他
  • Journal Title: Proc. Natl. Acad. Sci. USA 104 Pages: 18001-18006
  • Peer Reviewed
• [Journal Article] The Drosophila jumonji gene encodes a JmjC-containing nuclear protein that is required for metamorphosis. (2007)
  • Author(s): N. Sasai, 他
  • Journal Title: FEBS J. 274 Pages: 6139-6151
  • Peer Reviewed
• [Journal Article] Functions of a jumonji-cyclin Dl pathway in the coordination of cell cycle exit and migration during neurogenesis in the mouse hindbrain. (2007)
  • Author(s): M. Takahashi, 他
  • Journal Title: Dev. Biol. 303 Pages: 549-560
  • Peer Reviewed
• [Journal Article] Production of a site and phosphorylation state-specific antibody. (2007)
  • Author(s): H. Goto, 他
  • Journal Title: Nature Protocols 2 Pages: 2574-2581
  • Peer Reviewed
• [Presentation] 再考MPF : MPFはcyclin B-Cdc2キナーゼとGreatwallキナーゼからなる. (2012)
  • Author(s): 岸本健雄
  • Organizer: 第83回日本動物学会大会シンポジウム「MPFとCSFの発見から40年 卵成熟再訪」
  • Place of Presentation: 大阪大学
• [Presentation] Cell proliferation of mammalian cardiomyocytes and cardiac generation (2011)
  • Author(s): Takeuchi, T
  • Organizer: The 21st CDB Meeting "From regeneration biology to regenerative medicine"
  • Place of Presentation: RIKEN CDB, Kobe
  • Year and Date: 2011-11-24
• [Presentation] Cell proliferation of mammalian cardiomyocytes and cardiac generation (2011)
  • Author(s): Takeuchi, T.
  • Organizer: The 21st CDB Meeting "From regeneration biology to regenerative medicine"
  • Place of Presentation: 理研CDB、神戸(招待講演)
  • Year and Date: 2011-11-24
• [Presentation] Cooperation of Greatwall kinase with cyclin B-Cdk1 in starfish oocytes (2011)
  • Author(s): Kishimoto, T.
  • Organizer: The 6th UK-Japan Cell Cycle Workshop
  • Place of Presentation: Ambleside(英国)(招待講演)
  • Year and Date: 2011-04-12
• [Presentation] Cooperation of Greatwall kinase with cyclin B-Cdk1 in starfish oocytes (2011)
  • Author(s): Kishimoto, T
  • Organizer: The 6th UK-Japan Cell Cycle Workshop
  • Place of Presentation: Ambleside, UK
• [Presentation] A novel mechanism for the activation of Notch signaling by the APC/C activator Cdh1 (2011)
  • Author(s): 出野結己、…、佐方功幸
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] ビメンチンの細胞周期特異的なリン酸化部位に変異を導入した遺伝子改変マウスは腫瘍形成や白内障を引き起こす (2011)
  • Author(s): 松山誠, 田中宏樹, 小堀恭子, 井澤一郎, 稲垣昌樹
  • Organizer: 第34回日本分子生物学会年会・ワークショップ
  • Place of Presentation: パシフィコ横浜(招待講演)
• [Presentation] The Cell Cycle Control: Lessons from Starfish Oocytes (2010)
  • Author(s): Kishimoto, T
  • Organizer: Czech-Japan Jpoint Symposium "Animal Reproduction: From Gametes to Stem Cells"
  • Place of Presentation: Liblice, Czech Republic
• [Presentation] Signaling pathway leading to meiotic maturation in starfish oocytes (2010)
  • Author(s): Kishimoto, T
  • Organizer: FHL International Symposium "Mechanisms of Egg Maturation and Fertilization: From Sea to Land"
  • Place of Presentation: Friday Harbor Laboratories, USA
• [Presentation] Signaling pathway leading to meiotic maturation in starfish oocytes. (2010)
  • Author(s): Kishimoto, T.
  • Organizer: FHL International Symposium Mechanisms of Egg Maturation and Fertilization : From Sea to Land
  • Place of Presentation: Friday Harbor Laboratories, USA
• [Presentation] The Cell Cycle Control : Lessons from Starfish Oocytes. (2010)
  • Author(s): Kishimoto, T.
  • Organizer: Czech-Japan Joint Symposium for Animal Reproduction : From Gametes to Stem Cells
  • Place of Presentation: Liblice, Czech Republic
• [Presentation] Dual lock for cell cycle arrest in unfertilized mature starfish eggs (2009)
  • Author(s): Kishimoto, T
  • Organizer: Les Treilles Conference "Meiotic Division in Oocytes"
  • Place of Presentation: Les Treilles, France
• [Presentation] Dual lock for cell cycle arrest in unfertilized mature starfish eggs. (2009)
  • Author(s): Kishimoto, T.
  • Organizer: Les Treilles Conference "Meiotic Division in Oocytes"
  • Place of Presentation: Les Treilles, France
• [Presentation] 卵減数分裂再開時におけるM期キナーゼの動態 (2009)
  • Author(s): 岸本健雄, 他
  • Organizer: 第32回日本分子生物学会年会ワークショップ「減数分裂の仕組み」
  • Place of Presentation: 横浜
• [Presentation] Revisit to MPF (2008)
  • Author(s): Kishimoto, T
  • Organizer: Jacques Monod Conference "The cell cycle and genomic instability"
  • Place of Presentation: Roscoff, France
• [Presentation] Roles of Jumonji in transcriptional control and development. (2008)
  • Author(s): Takeuchi, T.
  • Organizer: 第21回内藤コンファレンス
  • Place of Presentation: 北杜市
• [Presentation] Revisit to MPF. (2008)
  • Author(s): Kishimoto, T.
  • Organizer: Jacques Monod Conference "The cell cycle and genomic instability"
  • Place of Presentation: Roscoff, France
• [Presentation] 受精卵における雌雄両前核の接近と融合の制御 : 細胞周期制御因子の細胞周期制御とは別の機能 (2008)
  • Author(s): 岸本健雄, 他
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会シンポジウム「細胞周期制御と高次生命現象」
  • Place of Presentation: 神戸
• [Presentation] Undegradable xBora causes metaphase arrest in Xenopus oocytes (2008)
  • Author(s): 瀬戸山大樹、佐方功幸
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] Roles of Jumonji in transcriptional control and development (2008)
  • Author(s): Takeuchi, T.
  • Organizer: 第21回内藤コンファレンス
  • Place of Presentation: 北杜市
• [Presentation] Chkl phosphorylation by Cyclin-dependent kinases (Cdks) (2008)
  • Author(s): Goto, H. and Inagaki, M
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] The role of novel Chkl phosphorylation in carcinogenesis. (2007)
  • Author(s): Inagaki, M., 他
  • Organizer: 第66回日本癌学会学術総会シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-04
• [Presentation] Cell cycle start after fertilization (2007)
  • Author(s): Kishimoto, T
  • Organizer: EMBO Workshop "Molecular Mechanisms of Cell Cycle Control in Normal and Malignant Cells": XIV European Cell Cycle Conference
  • Place of Presentation: Spetses, Greece
• [Presentation] Cell cycle start after fertilization (2007)
  • Author(s): Kishimoto, T., 他
  • Organizer: EMBO Workshop & XIV European Cell Cycle Conference
  • Place of Presentation: Spetses, Greece
• [Presentation] 脊椎動物未受精卵のMeta-II停止の分子機構 (2007)
  • Author(s): 佐方功幸
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会ワークショップ
  • Place of Presentation: 横浜
• [Presentation] サイクリンD1-CDK4は心筋細胞の増殖と分化を同時に制御する (2007)
  • Author(s): 竹内 隆
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会ワークショップ
  • Place of Presentation: 横浜
• [Book] 実験医学(増刊号)「ヒトと医学のステージへ拡大する細胞周期2013:がん治療と生命現象の解明をめざして」(中山敬一編) (2013)
  • Author(s): 岸本健雄、佐方功幸、竹内隆、稲垣昌樹、他(それぞれ分担執筆)
  • Total Pages: 221
  • Publisher: 羊土社
• [Book] 実験医学増刊Vol.30-No.5「シグナル伝達研究最前線」チェックポイントキナーゼ1(Chk1)の新規制御機構とがん (2012)
  • Author(s): 後藤英仁、稲垣昌樹
  • Publisher: 羊土社
• [Book] c-Mosによる卵子染色体半数化と単為発生の抑制「卵子学」(森崇英編) (2011)
  • Author(s): 立花和則、岸本健雄
  • Publisher: 京都大学出版会
• [Book] 卵子学第VII章「c-Mosによる卵子染色体半数化と単為発生の抑制」(森崇英編) (2011)
  • Author(s): 立花和則、岸本健雄
  • Total Pages: 1195
  • Publisher: 京都大学出版会
• [Book] 実験医学29,Hot Press脊椎動物未受精卵の分裂停止因子Emi2の制御メカニズム (2011)
  • Author(s): 磯田道孝、迫洸佑、佐方功幸
  • Publisher: 羊土社
• [Book] Cytostatic arrest: Post-ovulation arrest until fertilization in metazoan oocytes. In "Oogenesis: The Universal Process" (ed. Verlhac, M.H.), Chapter 14 (2010)
  • Author(s): Nishiyama, T., Tachibana, K., and Kishimoto, T.
  • Publisher: Wiley-Blackwell, UK.
• [Book] 細胞周期フロンティア (2010)
  • Author(s): 佐方功幸・稲垣昌樹・岸本健雄(編集)
  • Total Pages: 252
  • Publisher: 共立出版
• [Book] Oogenesis: The Universal Process(ed. Verlhac, M.H., Cytostatic arrest: Post-ovulation arrest until fertilization in metazoan oocytes.) (2010)
  • Author(s): Nishiyama, T., Tachibana, K., Kishimoto, T.
  • Publisher: Wiley-Blackwell
• [Book] Oogenesis : The Universal Process(ed.Verlhac, M.H., Cytostatic arrest : Post-ovulation arrest until fertilization in metazoan oocytes., Chapter 14) (2010)
  • Author(s): Nishiyama, T., Tachibana, K., Kishimoto, T.
  • Publisher: Wiley-Blackwell
• [Book] 細胞工学(1月号)特集「細胞周期研究の新たなステージ」 (2009)
  • Author(s): 岸本健雄(監修)
  • Publisher: 秀潤社
• [Book] 細胞工学(1月号)特集「細胞周期研究の新たなステージ」 (2009)
  • Author(s): 岸本健雄
  • Publisher: 秀潤社
• [Book] 細胞工学(1月号)特集「細胞周期研究の新たなステージ」 (2009)
  • Author(s): 岸本健雄(監修)
  • Total Pages: 58
  • Publisher: 優潤社
• [Book] ベーシックマスター発生生物学(東中川徹他編集)「遺伝子ターゲティング法と遺伝子トラップ法」 (2008)
  • Author(s): 竹内隆
  • Publisher: オーム社
• [Book] 生化学辞典(第4版) (2007)
  • Author(s): 大島泰郎, 他(編集分担)
  • Total Pages: 1650
  • Publisher: 東京化学同人
• [Remarks]
  • URL: http://www.cellprolif.bio.titech.ac.jp/
• [Remarks] 特定領域「細胞増殖制御」ホームページ
  • URL: http://www.cellprolif.bio.titech.ac.jp/
• [Remarks]
  • URL: http://www.cellprolif.bio.titech.ac.jp/
• [Remarks]
  • URL: http://www.cellprolif.bio.titech.ac.jp/
• [Remarks] 特定領域「細胞増殖制御」
  • URL: http://www.cellprolif.bio.titech.ac.jp/
• [Remarks]
  • URL: http://www.cellprolif.bio.titech.ac.jp/
• [Remarks]
  • URL: http://www.cellprolif.bio.titech.ac.jp/
• [Remarks]
  • URL: http://www.cellprolif.bio.titech.ac.jp/