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Establishment of a community platform for primate developmental biolgoy

Administrative Group

Project AreaA new foundation for primate developmental biology
Project/Area Number 20H05760
Research Category

Grant-in-Aid for Transformative Research Areas (B)

Allocation TypeSingle-year Grants
Review Section Transformative Research Areas, Section (III)
Research InstitutionKyoto University

Principal Investigator

Nakamura Tomonori  京都大学, 白眉センター, 特定准教授 (90648429)

Project Period (FY) 2020-10-02 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2022: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords霊長類 / 発生学 / PDB seminar / コミュニティ基盤 / オンライン講演会
Outline of Research at the Start

①領域研究サポートでは、毎年研究成果/進捗発表会を領域内で開催し、各々の計画研究者間で闊達な議論を行う。研究の遅延や更なる進展が見込まれる場合には、様々な研究者から助言と情報を得る。
②研究成果は、論文や学会発表を中心にwebや、ミニシンポジウムや所属組織での研究会や講演会の開催、関連学会におけるセッション開催など、様々な形で積極的に発信していく。また一般社会へも、所属する大学や組織の本部広報のお力添えをいただきつつ、広く発信していく。
③コミュニティ基盤の形成に関しては、我々自身において霊長類着床後胚研究に興味のある/携わる研究者のための小さな学会グループのような研究会の運営を検討する。

Outline of Final Research Achievements

We aimed to establish a research platform that brings innovative advancements to primate developmental biology, specifically focusing on the early implantation stage. For this purpose, we have proposed four research objectives. In A01, we successfully obtained comprehensive biological information using in-utero embryonic samples. In A02, we enabled the induction of placental constituent cells to enhance our understanding of embryo-uterus interactions. Furthermore, in B01, we achieved the generation of mosaic-free transgenic primates, and in B02, we successfully induced epigenome reprogramming of male germ cells derived from primate pluripotent stem cells.

Academic Significance and Societal Importance of the Research Achievements

本領域研究では、それまで長きにわたり進展の乏しかった霊長類着床期胚発生学の創出を見据え、in vitroでの胚培養系の構築と子宮内発生環境の構築、また霊長類個体に最適化した遺伝子改変技術の開発と幹細胞からの生殖細胞誘導研究を行ってきた。そしてそれぞれの研究計画において、確かな実験結果や論文発表など一定の成果を得ることができた。近年、世界中で霊長類を用いた発生学研究が盛んになってきているが、我々の成果は今後の霊長類発生学研究に大きな貢献をすると期待される。そして、今後も世界に後れを取らぬよう尽力するとともに、強力な資金力を背景に躍進する中国らとは一線を画した発想や角度からの研究を発展させていく。

Report

(3 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • Research Products

    (34 results)

All 2023 2022 2021 2020 Other

All Journal Article (13 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 12 results,  Open Access: 12 results) Presentation (11 results) (of which Int'l Joint Research: 6 results,  Invited: 5 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results) Funded Workshop (7 results)

  • [Journal Article] Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys2023

    • Author(s)
      Gyobu‐Motani Sayuri、Yabuta Yukihiro、Mizuta Ken、Katou Yoshitaka、Okamoto Ikuhiro、Kawasaki Masanori、Kitamura Ayaka、Tsukiyama Tomoyuki、Iwatani Chizuru、Tsuchiya Hideaki、Tsujimura Taro、Yamamoto Takuya、Nakamura Tomonori、Saitou Mitinori
    • Journal Title

      The EMBO Journal

      Volume: - Issue: 9

    • DOI

      10.15252/embj.2022112962

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mesothelial fusion mediates chorioallantoic membrane formation2022

    • Author(s)
      Nagai Hiroki、Tanoue Yuki、Nakamura Tomonori、Chan Christopher J. J.、Yamada Shigehito、Saitou Mitinori、Fukuda Takaichi、Sheng Guojun
    • Journal Title

      Philosophical Transactions of the Royal Society B: Biological Sciences

      Volume: 377 Issue: 1865 Pages: 20210263-20210263

    • DOI

      10.1098/rstb.2021.0263

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] <i>Ex vivo</i> reconstitution of fetal oocyte development in humans and cynomolgus monkeys2022

    • Author(s)
      Mizuta Ken、Katou Yoshitaka、Nakakita Baku、Kishine Aoi、Nosaka Yoshiaki、Saito Saki、Iwatani Chizuru、Tsuchiya Hideaki、Kawamoto Ikuo、Nakaya Masataka、Tsukiyama Tomoyuki、Nagano Masahiro、Kojima Yoji、Nakamura Tomonori、Yabuta Yukihiro、Horie Akihito、Mandai Masaki、Ohta Hiroshi、Saitou Mitinori
    • Journal Title

      The EMBO Journal

      Volume: 41 Issue: 18

    • DOI

      10.15252/embj.2022110815

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Conformational change of RNA-helicase DHX30 by ALS/FTD-linked FUS induces mitochondrial dysfunction and cytosolic aggregates2022

    • Author(s)
      Hikiami R, Morimura T, Ayaki T, Tsukiyama T, Morimura N, Kusui M, Wada H, Minamiyama S, Shodai A, Asada-Utsugi M, Muramatsu SI, Ueki T, Takahashi R, Urushitani M.
    • Journal Title

      Scxeintific Reports

      Volume: 12 Issue: 1 Pages: 16030-16046

    • DOI

      10.1038/s41598-022-20405-2

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Essential Roles of Exocyst Complex Component 3-like 2 on Cardiovascular Development in Mice2022

    • Author(s)
      Watanabe C., Shibuya H., Ichiyama Y., Okamura E., Tsukiyama-Fujii S., Tsukiyama T., Matsushita J., Azami T., Kubota Y., Ohji M., Sugiyama F., Takahashi S., Mizuno S., Tamura M., Mizutani K. & Ema M.
    • Journal Title

      Life

      Volume: 12 Issue: 11 Pages: 1730-1730

    • DOI

      10.3390/life12111730

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Resolution of the curse of dimensionality in single-cell RNA sequencing data analysis2022

    • Author(s)
      Yusuke Imoto, Tomonori Nakamura, Emerson G Escolar, Michio Yoshiwaki, Yoji Kojima, Yukihiro Yabuta, Yoshitaka Katou, Takuya Yamamoto, Yasuaki Hiraoka, Mitinori Saitou
    • Journal Title

      Life Science Alliance

      Volume: 5 Issue: 12 Pages: 202201591-202201591

    • DOI

      10.26508/lsa.202201591

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Circadian protection against bacterial skin infection by epidermal CXCL14-mediated innate immunity2022

    • Author(s)
      Tsujihana Kojiro、Tanegashima Kosuke、Santo Yasuko、Yamada Hiroyuki、Akazawa Sota、Nakao Ryuta、Tominaga Keiko、Saito Risa、Nishito Yasumasa、Hata Ryu-Ichiro、Nakamura Tomonori、Murai Iori、Kono Yuka、Sugawa Maho、Tanioka Miki、Egawa Gyohei、Doi Masao、Isa Tadashi、Kabashima Kenji、Hara Takahiko、Okamura Hitoshi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 119 Issue: 25 Pages: 25-25

    • DOI

      10.1073/pnas.2116027119

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] mRNA-based generation of marmoset PGCLCs capable of differentiation into gonocyte-like cells2022

    • Author(s)
      Kubiura-Ichimaru Musashi、Penfold Christopher、Kojima Kazuaki、Dollet Constance、Yabukami Haruka、Semi Katsunori、Takashima Yasuhiro、Boroviak Thorsten、Kawaji Hideya、Woltjen Knut、Minoda Aki、Sasaki Erika、Watanabe Toshiaki
    • Journal Title

      BioRxiv

      Volume: N/A

    • DOI

      10.1101/2022.09.20.508677

    • Related Report
      2022 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Journal Article] Capturing human trophoblast development with naive pluripotent stem cells in vitro2021

    • Author(s)
      S Io M Kabata Y Lemura N Morone A Minagawa B Wong I Okamoto T Nakamura Y Kojima C Iwatani H Tsuchiya B Kawswandy E KondohS Kaneko K Woltjen M Saitou T Yamanoto M Mandai Y Takashima
    • Journal Title

      Cell Stem Cell

      Volume: 21 Issue: 6 Pages: 10-10

    • DOI

      10.1016/j.stem.2021.03.013

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficient Induction of Primate iPS Cells Using a Combination of RNA Transfection and Chemical Compounds2021

    • Author(s)
      Watanabe Toshiaki、Sasaki Erika
    • Journal Title

      Methods in Molecular Biology

      Volume: 1 Pages: 10-10

    • DOI

      10.1007/7651_2021_373

    • ISBN
      9781071621189, 9781071621196
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pluripotent stem cells for the study of early human embryology2021

    • Author(s)
      Semi Katsunori、Takashima Yasuhiro
    • Journal Title

      Development, Growth & Differentiation

      Volume: 63 Issue: 2 Pages: 104-115

    • DOI

      10.1111/dgd.12715

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program2021

    • Author(s)
      Kojima Yoji、Yamashiro Chika、Murase Yusuke、Yabuta Yukihiro、Okamoto Ikuhiro、Iwatani Chizuru、Tsuchiya Hideaki、Nakaya Masataka、Tsukiyama Tomoyuki、Nakamura Tomonori、Yamamoto Takuya、Saitou Mitinori
    • Journal Title

      Life Science Alliance

      Volume: 4 Issue: 5 Pages: 202000974-202000974

    • DOI

      10.26508/lsa.202000974

    • NAID

      120006979739

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-human primates as a model for human development2021

    • Author(s)
      Tomonori Nakamura, Kohei Fujiwara, Mitinori Saitou, Tomonyuki Tsukiyama
    • Journal Title

      Stem Cell Reports

      Volume: 1 Pages: 10-10

    • NAID

      120007037861

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] A comprehensive high-resolution transcriptomic profiling of primate embryogenesis just after implantation2023

    • Author(s)
      Tomonori Nakamura
    • Organizer
      第21回 武田科学振興財団生命科学シンポジウム
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 多能性幹細胞からのマーモセット初期生殖細胞発生系の構築2023

    • Author(s)
      渡部聡朗
    • Organizer
      マーモセット研究会
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] piggyBacトランスポゾンシステムを利用したトランスジェニックカニクイザルの作出2022

    • Author(s)
      中家 雅隆, 築山 智之
    • Organizer
      日本繁殖生物学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] カニクイザルを用いた霊長類着床直後の胚発生研究2022

    • Author(s)
      中村友紀
    • Organizer
      第76回日本人類学会、第38回日本霊長類学会、連合大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] “次元の呪い”からの解放 ~ シングルセル解析の真の力を解き放つ ~2022

    • Author(s)
      中村友紀
    • Organizer
      新学術領域研究「配偶子インテグリティ」オンラインセミナー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Marmoset germ cell differentiation from pluripotent cells2022

    • Author(s)
      Toshiaki Watanabe
    • Organizer
      55th Society for the Study of Reproduction annual conference
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 霊長類コモンマーモセット及びカニクイザルの雄性生殖細胞における DNA メチル化確立過程のシングルセル解析2022

    • Author(s)
      小島一晃、近藤洋介、小原実穂、Dollet Constance、山海直、仲木竜、渡部聡朗
    • Organizer
      日本実験動物学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] mRNA-based generation of marmoset PGCLCs capable of differentiation into gonocyte-like cells2022

    • Author(s)
      Kubiura-Ichimaru M. and Watanabe T.
    • Organizer
      Totipotency and germ cell development
    • Related Report
      2022 Annual Research Report
  • [Presentation] Identifying cells hidden by curse of dimensionality2020

    • Author(s)
      Tomonori Nakamura
    • Organizer
      1st ASHBi SignAC Workshop
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ナイーブ型多能性幹細胞を用いた着床期モデルの構築2020

    • Author(s)
      髙島 康弘、大久保 巧
    • Organizer
      第10回日本マーモセット研究会大会
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マーモセット iPS 細胞からの始原生殖細胞様細胞の誘導2020

    • Author(s)
      渡部 聡朗, Christopher Penfold, 蝉 克憲, 岩崎 師壽江, 篠原 晴香, 髙島 康弘, Thorsten Boroviak, Knut Woltjen, 佐々木 えりか
    • Organizer
      第10回日本マーモセット研究会大会
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 霊長類発生学研究の基盤構築

    • URL

      https://www.primate-dev-biol.ashbi.kyoto-u.ac.jp/home

    • Related Report
      2022 Annual Research Report
  • [Remarks] 2020年度学術変革領域研究(B)「霊長類発生学研究の基盤構築」

    • URL

      https://www.primate-dev-biol.ashbi.kyoto-u.ac.jp/

    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] 観測ノイズ削減法の開発2020

    • Inventor(s)
      井元祐介、中村友紀、平岡裕章、斎藤通紀
    • Industrial Property Rights Holder
      井元祐介、中村友紀、平岡裕章、斎藤通紀
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Acquisition Date
      2022
    • Related Report
      2022 Annual Research Report
  • [Funded Workshop] PDB seminar #09, Dr Ikuo Suzuki2023

    • Related Report
      2022 Annual Research Report
  • [Funded Workshop] PDB seminar #04, Dr Ikuhiro Okamoto2022

    • Related Report
      2022 Annual Research Report
  • [Funded Workshop] PDB seminar #05, Dr Masaki Kinoshita2022

    • Related Report
      2022 Annual Research Report
  • [Funded Workshop] PDB seminar #06, Dr Yukiko Abe2022

    • Related Report
      2022 Annual Research Report
  • [Funded Workshop] PDB seminar #07, Dr Masatoshi Ohgushi2022

    • Related Report
      2022 Annual Research Report
  • [Funded Workshop] PDB seminar #08, Dr Vincent Pasque2022

    • Related Report
      2022 Annual Research Report
  • [Funded Workshop] PDB seminar #12020

    • Related Report
      2020 Annual Research Report

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Published: 2020-10-30   Modified: 2024-01-30  

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