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Frontiers in brain and life sciences on active information gain in an uncertain environment

Administrative Group

Project AreaFrontiers in brain and life sciences on active information gain in an uncertain environment
Project/Area Number 21H05167
Research Category

Grant-in-Aid for Transformative Research Areas (B)

Allocation TypeSingle-year Grants
Review Section Transformative Research Areas, Section (IV)
Research InstitutionNagoya University

Principal Investigator

Osakada Fumitaka  名古屋大学, 創薬科学研究科, 准教授 (60455334)

Co-Investigator(Kenkyū-buntansha) 雨森 賢一  京都大学, 高等研究院, 特定拠点准教授 (70344471)
本田 直樹  広島大学, 統合生命科学研究科(理), 教授 (30515581)
Project Period (FY) 2021-08-23 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2023: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords自由エネルギー原理 / 予測符号化 / 能動的推論 / 限定合理性 / David Marr / 神経回路 / 葛藤 / 認知 / データ駆動的解読 / 数理モデル / ベイズ推定 / 知覚 / 意思決定 / 好奇心 / AI / 新FEP理論 / 神経科学 / 情報獲得
Outline of Research at the Start

本領域「あいまい脳」では、脳・生命体の情報獲得過程に学び、予測があいまいな場合の意思決定を統一的に説明できる理論(新自由エネルギー理論)を新たに提唱し、その理論によって提唱される神経メカニズムを実験によって実証することを目的とする。学術変革(B)の3年間では、最先端の神経活動計測技術を導入し、脳・生命体の情報獲得戦略の本質に迫る。一連の脳機能の実験・理論研究は、自ら情報を求めて学習していく自律アルゴリズムなどの工学応用のみならず、精神疾患、生命科学の数理・実験モデルへの発展が期待される。本領域研究により、人工知能、臨床精神医学、システム生物学などの既存の学問分野に革新的な変革・転換をもたらす。

Outline of Final Research Achievements

The free energy principle, which evolves under perfect rationality, has limitations in modeling living organisms, including humans. Unlike AI, which has unlimited computational resources, it is in principle difficult for living organisms with limited knowledge and computational capacity to achieve perfect rationality. We overcame the problems of the free energy principle and clarified how a system with bounded rationality can optimize predictions and generate behavioral strategies from the perspective of Marr's three levels: computational, algorithmic, and implementational levels. The core group was responsible for organizing the Osakada, Amemori, and Honda groups, promoting collaboration and the exchange of knowledge and techniques among them, and translating our research results into the real world. We invited advisors and researchers related to our research to regular group meetings and reflected their comments to the research and group management.

Academic Significance and Societal Importance of the Research Achievements

我々は、限定合理性のもとでの脳内計算原理の一端を明らかにし、柔軟で自律的な知性を実現するための手がかりを得た。神経疾患や精神疾患は、予測や葛藤の脳内情報処理のバランス異常として捉えることができる。本領域の研究は、神経疾患や精神疾患の診断法や新たな治療戦略の創出に貢献できると期待される。さらに、自らの予測のあいまいさに基づいて、目的志向の行動を切り替え、自律的・能動的に情報獲得を行う「あいまい脳」を有するAIの計算原理が導けると期待される。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (101 results)

All 2024 2023 2022 2021 Other

All Journal Article (32 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 26 results,  Open Access: 20 results) Presentation (68 results) (of which Int'l Joint Research: 9 results,  Invited: 33 results) Remarks (1 results)

  • [Journal Article] Evolutionary engineering and characterization of Sendai virus mutants capable of persistent infection and autonomous production2024

    • Author(s)
      Iwata Moe、Kawabata Ryoko、Morimoto Nao、Takeuchi Ryosuke F.、Sakaguchi Takemasa、Irie Takashi、Osakada Fumitaka
    • Journal Title

      Frontiers in Virology

      Volume: 4 Pages: 1363092-1363092

    • DOI

      10.3389/fviro.2024.1363092

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cingulate microstimulation induces negative decision-making via reduced top-down influence on primate fronto-cingulo-striatal network2024

    • Author(s)
      Satoko Amemori, Ann M Graybiel, Ken-ichi Amemori
    • Journal Title

      Nature Communications

      Volume: in press Issue: 1 Pages: 1-1

    • DOI

      10.1038/s41467-024-48375-1

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multi-scale Neural Circuit Analysis with Rabies Viral Vectors2023

    • Author(s)
      Kamaguchi Riki、Osakada Fumitaka
    • Journal Title

      The Brain & Neural Networks

      Volume: 30 Issue: 2 Pages: 56-65

    • DOI

      10.3902/jnns.30.56

    • ISSN
      1340-766X, 1883-0455
    • Year and Date
      2023-06-05
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modeling the marmoset brain using embryonic stem cell-derived cerebral assembloids2023

    • Author(s)
      Tomoki Kodera, Ryosuke F. Takeuchi, Sara Takahashi, Keiichiro Suzuki, Hidetoshi Kassai, Atsu Aiba, Seiji Shiozawa, Hideyuki Okano, Fumitaka Osakada
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 657 Pages: 119-127

    • DOI

      10.1016/j.bbrc.2023.03.019

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経回路機能解析のための細胞種特異的な標識と光学イメージング2023

    • Author(s)
      竹内 遼介, 小坂田 文隆
    • Journal Title

      医学のあゆみ

      Volume: 286 Pages: 372-379

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal expression patterns of anxiety disorder-associated genes2023

    • Author(s)
      Karunakaran Kalyani B.、Amemori Ken-ichi
    • Journal Title

      Translational Psychiatry

      Volume: 13 Issue: 1 Pages: 385-385

    • DOI

      10.1038/s41398-023-02693-y

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decoding reward?curiosity conflict in decision-making from irrational behaviors2023

    • Author(s)
      Konaka Yuki、Naoki Honda
    • Journal Title

      Nature Computational Science

      Volume: 3 Issue: 5 Pages: 418-432

    • DOI

      10.1038/s43588-023-00439-w

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adaptive discrimination between harmful and harmless antigens in the immune system by predictive coding2023

    • Author(s)
      Yoshido Kana、Naoki Honda
    • Journal Title

      iScience

      Volume: 26 Issue: 1 Pages: 105754-105754

    • DOI

      10.1016/j.isci.2022.105754

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intercellular exchange of Wnt ligands reduces cell population heterogeneity during embryogenesis2023

    • Author(s)
      Yudai Hatakeyama, Nen Saito, Yusuke Mii, Ritsuko Takada, Takuma Shinozuka, Tatsuya Takemoto, Naoki Honda & Shinji Takada
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 1-16

    • DOI

      10.1038/s41467-023-37350-x

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dopamine error signal to actively cope with lack of expected reward2023

    • Author(s)
      Ishino Seiya、Kamada Taisuke、Sarpong Gideon A.、Kitano Julia、Tsukasa Reo、Mukohira Hisa、Sun Fangmiao、Li Yulong、Kobayashi Kenta、Naoki Honda、Oishi Naoya、Ogawa Masaaki
    • Journal Title

      Science Advances

      Volume: 9 Issue: 10 Pages: 1-19

    • DOI

      10.1126/sciadv.ade5420

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multidimensional fractal scaling analysis using higher order moving average polynomials and its fast algorithm2023

    • Author(s)
      Ju Hanqiu、Honda Naoki、Yoshimura Shige H.、Kaneko Miki、Shigematsu Taiki、Kiyono Ken
    • Journal Title

      Signal Processing

      Volume: 208 Pages: 108997-108997

    • DOI

      10.1016/j.sigpro.2023.108997

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optimal COVID-19 testing strategy on limited resources2023

    • Author(s)
      Tatsuki Onishi、Naoki Honda、Igarashi Yasunobu
    • Journal Title

      PLOS ONE

      Volume: 18 Issue: 2 Pages: e0281319-e0281319

    • DOI

      10.1371/journal.pone.0281319

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation and Application of Engineered Rabies Viral Vectors for Neural Circuit Research2023

    • Author(s)
      Yamaguchi Masahiro、Iwata Moe、Kamaguchi Riki、Osakada Fumitaka
    • Journal Title

      Vectorology for Optogenetics and Chemogenetics

      Volume: - Pages: 51-75

    • DOI

      10.1007/978-1-0716-2918-5_4

    • ISBN
      9781071629178, 9781071629185
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒトiPS細胞由来網膜色素上皮細胞を薬にするために ー細胞医薬品におけるバラつきの克服ー2023

    • Author(s)
      小坂田 文隆
    • Journal Title

      ファルマシア

      Volume: 11 Pages: 1046-1050

    • Related Report
      2022 Annual Research Report
  • [Journal Article] 異分野融合が切り拓く脳オルガノイド生物学2023

    • Author(s)
      小坂田 文隆
    • Journal Title

      日本薬理学雑誌

      Volume: 158 Pages: 64-70

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Stem cell homeostasis regulated by hierarchy and neutral competition2022

    • Author(s)
      Nakamuta Asahi、Yoshido Kana、Naoki Honda
    • Journal Title

      Communications Biology

      Volume: 5 Issue: 1

    • DOI

      10.1038/s42003-022-04218-7

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of male germline transmission patterns by the Trp53-Cdkn1a pathway2022

    • Author(s)
      Kanatsu-Shinohara Mito、Naoki Honda、Tanaka Takashi、Tatehana Misako、Kikkawa Takako、Osumi Noriko、Shinohara Takashi
    • Journal Title

      Stem Cell Reports

      Volume: 17 Issue: 9 Pages: 1924-1941

    • DOI

      10.1016/j.stemcr.2022.07.007

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Monosynaptic rabies virus tracing from projection-targeted single neurons2022

    • Author(s)
      Masaki Yuji、Yamaguchi Masahiro、Takeuchi Ryosuke F.、Osakada Fumitaka
    • Journal Title

      Neuroscience Research

      Volume: 178 Pages: 20-32

    • DOI

      10.1016/j.neures.2022.01.007

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fast z-focus controlling and multiplexing strategies for multiplane two-photon imaging of neural dynamics2022

    • Author(s)
      Ito Kei N.、Isobe Keisuke、Osakada Fumitaka
    • Journal Title

      Neuroscience Research

      Volume: - Pages: 15-23

    • DOI

      10.1016/j.neures.2022.03.007

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiplexed action-outcome representation by striatal striosome-matrix compartments detected with a mouse cost-benefit foraging task2022

    • Author(s)
      Bloem Bernard、Huda Rafiq、Amemori Ken-ichi、Abate Alex S.、Krishna Gayathri、Wilson Anna L.、Carter Cody W.、Sur Mriganka、Graybiel Ann M.
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 1541-1541

    • DOI

      10.1038/s41467-022-28983-5

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multiple types of navigational information are independently encoded in the population activities of the dentate gyrus neurons2022

    • Author(s)
      Murano Tomoyuki、Nakajima Ryuichi、Nakao Akito、Hirata Nao、Amemori Satoko、Murakami Akira、Kamitani Yukiyasu、Yamamoto Jun、Miyakawa Tsuyoshi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 119 Issue: 32

    • DOI

      10.1073/pnas.2106830119

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] あいまい環境に対峙する脳・生命体の情報獲得戦略の解明2022

    • Author(s)
      小坂田文隆
    • Journal Title

      Neuroscience News

      Volume: - Pages: 31-33

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 脳機能の理解と中枢神経系疾患の克服を目指した多分野融合薬理学研究2022

    • Author(s)
      小坂田文隆
    • Journal Title

      最先端ナノライフシステム研究

      Volume: - Pages: 138-146

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 背側視覚経路の機能と回路構造2022

    • Author(s)
      佐藤 彰典, 竹内 遼介, 小坂田 文隆
    • Journal Title

      Clinical Neuroscience

      Volume: - Pages: 21-25

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Generation and Application of Engineered Rabies Viral Vectors for Neural Circuit Research2022

    • Author(s)
      Masahiro Yamaguchi, Moe Iwata, Riki Kamaguchi, Fumitaka Osakada
    • Journal Title

      Neuromethods

      Volume: -

    • Related Report
      2021 Annual Research Report
  • [Journal Article] The Role of the Dorsal?Lateral Prefrontal Cortex in Reward Sensitivity During Approach?Avoidance Conflict2021

    • Author(s)
      Rolle Camarin E、Pedersen Mads L、Johnson Noriah、Amemori Ken-ichi、Ironside Maria、Graybiel Ann M、Pizzagalli Diego A、Etkin Amit
    • Journal Title

      Cerebral Cortex

      Volume: - Issue: 6 Pages: 1269-1285

    • DOI

      10.1093/cercor/bhab292

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficient and robust induction of retinal pigment epithelium cells by tankyrase inhibition regardless of the differentiation propensity of human induced pluripotent stem cells2021

    • Author(s)
      Ito Arisa、Ye Ke、Onda Masanari、Morimoto Nao、Osakada Fumitaka
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 552 Pages: 66-72

    • DOI

      10.1016/j.bbrc.2021.03.012

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporally multiplexed dual-plane imaging of neural activity with four-dimensional precision2021

    • Author(s)
      Onda Masanari、Takeuchi Ryosuke F.、Isobe Keisuke、Suzuki Toshiaki、Masaki Yuji、Morimoto Nao、Osakada Fumitaka
    • Journal Title

      Neuroscience Research

      Volume: - Pages: 9-18

    • DOI

      10.1016/j.neures.2021.02.001

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes2021

    • Author(s)
      Karunakaran Kalyani B.、Amemori Satoko、Balakrishnan N.、Ganapathiraju Madhavi K.、Amemori Ken-ichi
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 18392-18392

    • DOI

      10.1038/s41598-021-97418-w

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Causal Evidence for Induction of Pessimistic Decision-Making in Primates by the Network of Frontal Cortex and Striosomes2021

    • Author(s)
      Amemori Satoko、Graybiel Ann M.、Amemori Ken-ichi
    • Journal Title

      Frontiers in Neuroscience

      Volume: 15 Pages: 649167-649167

    • DOI

      10.3389/fnins.2021.649167

    • NAID

      120007141959

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Computational phenotyping of brain-behavior dynamics underlying approach-avoidance conflict in major depressive disorder2021

    • Author(s)
      Pedersen Mads L.、Ironside Maria、Amemori Ken-ichi、McGrath Callie L.、Kang Min S.、Graybiel Ann M.、Pizzagalli Diego A.、Frank Michael J.
    • Journal Title

      PLOS Computational Biology

      Volume: 17 Issue: 5 Pages: 1008955-1008955

    • DOI

      10.1371/journal.pcbi.1008955

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Model-based prediction of spatial gene expression via generative linear mapping2021

    • Author(s)
      Okochi Yasushi、Sakaguchi Shunta、Nakae Ken、Kondo Takefumi、Naoki Honda
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1

    • DOI

      10.1038/s41467-021-24014-x

    • NAID

      120007089251

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] オルガノイドを用いた大脳皮質神経回路の構成的理解に向けて2024

    • Author(s)
      小坂田文隆
    • Organizer
      第101回日本生理学大会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] リスク選択行動における認識の歪みとしての楽観・悲観バイアスのデータ駆動的解読2024

    • Author(s)
      東野伊織, 横山寛, 伊東諒, 加藤利佳子, 雨森賢一, 本田直樹
    • Organizer
      定量生物の会第十一回年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] データ駆動的アプローチによってリスク選択行動における楽観・悲観バイアスを読み解く2024

    • Author(s)
      東野伊織, 横山寛, 伊東諒, 加藤利佳子, 雨森賢一, 本田直樹
    • Organizer
      CPSY TOKYO
    • Related Report
      2023 Annual Research Report
  • [Presentation] Adaptive discrimination between harmful and harmless antigens by predictive coding in immune system2024

    • Author(s)
      Kana Yoshido, Honda Naoki
    • Organizer
      Winter q-bio 2024
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 予測情報処理の脳内メカニズムの解明に向けて2023

    • Author(s)
      小坂田文隆
    • Organizer
      Neuroscience Institute セミナー
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Rabies viral tracing in the mouse visual system and human brain organoids2023

    • Author(s)
      小坂田文隆
    • Organizer
      The 16th Annual Meeting of Chinese Neuroscience Society & The 2nd CJK International Meeting
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 予測情報処理の脳内基盤の解明に向けて2023

    • Author(s)
      小坂田文隆
    • Organizer
      第 73 回脳の医学・生物学研究会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] あいまい環境に対峙する 脳・生命体の情報獲得戦略の解明2023

    • Author(s)
      小坂田文隆
    • Organizer
      第33回日本神経回路学会全国大会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 高次脳機能研究の最先端:新時代の研究手法と多角的な理解2023

    • Author(s)
      小坂田文隆
    • Organizer
      第15回 脳科学若手の会 関西部会セミナー
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Electrophysiological Recordings and Electrical Microstimulation in Monkey pACC and cOFC During Approach-Avoidance Behavior2023

    • Author(s)
      Georgios K. Papageorgiou, Daniel J. Gibson, Ken Amemori, Helen N. Schwerdt, Michelle C. Wang, Ann M. Graybiel
    • Organizer
      Biological Psychiatry
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 霊長類の不安と葛藤の制御のための 生理学的・遺伝学的アプローチ2023

    • Author(s)
      雨森賢一
    • Organizer
      京都大学ヒト行動進化研究センター 国際脳科学シンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 不安と葛藤の制御のための生理学的・遺伝学的アプローチ2023

    • Author(s)
      雨森賢一
    • Organizer
      生理研 セミナー
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 4.Orbitofrontal and anterior cingulate circuits in primates: complementary roles in cost-benefit decision-making and learning2023

    • Author(s)
      G. K. PAPAGEORGIOU, D. GIBSON, K.-I. AMEMORI, H. SCHWERDT, M. C. WANG, J. SHARMA, A. M. GRAYBIEL
    • Organizer
      Society for Neuroscience
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reduced top-down influence in the primate fronto-cingulo-striatal network underlying negative bias in conflict decision-making2023

    • Author(s)
      S. AMEMORI, A. M. GRAYBIEL, K. AMEMORI
    • Organizer
      Society for Neuroscience
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 6.Selective silencing of the ventral striatum-ventral pallidum pathway enhances approach choices and motivational states under approach-avoidance conflict in nonhuman primates2023

    • Author(s)
      J. N. OH, S. AMEMORI, K.-I. INOUE, K. KIMURA, M. TAKADA, K.-I. AMEMORI
    • Organizer
      Society for Neuroscience
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 不安の2つの次元:価値・意欲を区別して制御する霊長類大脳基底2023

    • Author(s)
      雨森賢一
    • Organizer
      第7回ヒト脳イメージング研究会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Neuromodulationの基礎研究と未来2023

    • Author(s)
      雨森賢一
    • Organizer
      第46回日本神経科学大会, 産学連携シンポジウム「信頼される脳科学技術による社会への貢献を考える」
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 機械学習による「心の揺れ・葛藤」の解読 -報酬をとるか好奇心に従うか-2023

    • Author(s)
      本田直樹
    • Organizer
      若手・中堅脳科学研究者のオンライン勉強会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 機械学習による「心の揺れ・葛藤」の解読:報酬をとるか好奇心をに従うか2023

    • Author(s)
      本田直樹
    • Organizer
      第53回日本神経精神薬理学会年会 シンポジウム「ひきこもりの意思決定の基礎・臨床・理論によるトランスレーショナルリサーチ」
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 神経回路形成・意思決定のデータ駆動生物学2023

    • Author(s)
      本田直樹
    • Organizer
      第8回サロン・ド・脳
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] データ駆動生物学 -遺伝子から細胞、臓器、心まで-2023

    • Author(s)
      本田直樹
    • Organizer
      第8回OUバイオインフォマティクスセンターセミナー
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] リスク選択行動時における過去の経験と現在の観測の間の心理的葛藤2023

    • Author(s)
      東野伊織, 横山寛, 伊東諒, 加藤利佳子, 雨森賢一, 本田直樹
    • Organizer
      第33回日本神経回路学会全国大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 自由エネルギー原理に基づいた楽観・悲観バイアスのデータ駆動的解読2023

    • Author(s)
      東野伊織, 横山寛, 伊東諒, 加藤利佳子, 雨森賢一, 本田直樹
    • Organizer
      第26回情報論的学習理論ワークショップ(IBIS2023)
    • Related Report
      2023 Annual Research Report
  • [Presentation] リスク選択行動における楽観・悲観のバイアスのデータから読み解く2023

    • Author(s)
      東野伊織, 横山寛, 伊東諒, 加藤利佳子, 雨森賢一, 本田直樹
    • Organizer
      第5回共調的社会脳研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 免疫系における予測符号化に基づく適応的な抗原の有害/無害識別2023

    • Author(s)
      吉戸香奈, 本田直樹
    • Organizer
      2023年度日本数理生物学会年会 企画シンポジウム「理論免疫学による免疫システムの統合的な理解 -基礎から臨床まで-」
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Adaptive immune discrimination of antigen risks by predictive coding2023

    • Author(s)
      Kana Yoshido, Honda Naoki
    • Organizer
      2023 International Congress on Industrial and Applied Mathematics
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 視覚運動連関を担う神経回路と予測符号化2023

    • Author(s)
      小坂田 文隆
    • Organizer
      あいまい脳第3回領域会議
    • Related Report
      2022 Annual Research Report
  • [Presentation] 脳機能の理解と新規治療戦略の創出を目指し2023

    • Author(s)
      小坂田 文隆
    • Organizer
      量子制御生命研究会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 視覚運動連関を担う神経回路と予測符号化2023

    • Author(s)
      小坂田 文隆
    • Organizer
      日本医学会連合Rising Starリトリート
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 認知・辺縁系における予測符号化と不安のトップダウン制御2023

    • Author(s)
      雨森賢一
    • Organizer
      あいまい脳ワークショップ
    • Related Report
      2022 Annual Research Report
  • [Presentation] 霊長類腹側線条体-腹側淡蒼球の経路選択的抑制による接近回避葛藤時の意欲の変化2023

    • Author(s)
      雨森賢一
    • Organizer
      第4回サル脳新技術研究会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Primate-Genomics interdisciplinary research for developing new primate models2023

    • Author(s)
      Ken-ichi Amemori
    • Organizer
      ASHBi Flagship報告会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Silencing of the projection from the ventral striatum to the ventral pallidum modulates motivational states under conflict decision-making in nonhuman primates2023

    • Author(s)
      Jungmin OH, Satoko Amemori, Ken-ichi Inoue, Kei Kimura, Masahiko Takada, Ken-ichi Amemori
    • Organizer
      3施設合同シンポジウム
    • Related Report
      2022 Annual Research Report
  • [Presentation] Spatiotemporal expression patterns of anxiety disorder-associated genes2023

    • Author(s)
      Kalyani B. Karunakaran, Ken-ichi Amemori
    • Organizer
      The 21st Takeda Science Foundation Symposium on Bioscience
    • Related Report
      2022 Annual Research Report
  • [Presentation] バルーンアナログリスク課題遂行中の非ヒト霊長類の損失回避傾向の計算論的解読2023

    • Author(s)
      伊東諒、加藤利佳子、石井信、雨森賢一
    • Organizer
      日本生理学会第100回記念大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Exploring the neural pathway of anxiety and depression in non-human primates2023

    • Author(s)
      Ken-ichi Amemori
    • Organizer
      Mental Health Challenge Area (MHCA) at Wellcome Trust
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳を知り、作り、操ることで、新たな治療を目指す2022

    • Author(s)
      小坂田 文隆
    • Organizer
      基盤生物化学特論Ⅱ
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 脳機能の理解と新規治療法の開発を目指して2022

    • Author(s)
      小坂田 文隆
    • Organizer
      iGCOREセミナー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 視覚運動連関を担う予測処理の解明2022

    • Author(s)
      小坂田 文隆
    • Organizer
      リエゾンラボ炎症シンポジウム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] サルおよびヒトの多能性幹細胞を用いた脳オルガノイド研究2022

    • Author(s)
      小坂田 文隆
    • Organizer
      動物実験代替法学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 視覚運動予測誤差を処理する大脳皮質の階層ネットワーク2022

    • Author(s)
      小坂田 文隆
    • Organizer
      次世代脳プロジェクト 冬のシンポジウム2022
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] An in vitro non-human primate brain model using assembloids derived from embryonic stem cells2022

    • Author(s)
      Tomoki Kodera, Taiki Hara, Nao Morimoto, Ryosuke Takeuchi, Fumitaka Osakada
    • Organizer
      Neuro2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] The dynamics of acetylcholine in the whole cortex of the mouse during visual decision-making2022

    • Author(s)
      佐藤 彰典、竹内 遼介、伊藤 慶、山口 真広、小坂田 文隆
    • Organizer
      Neuro2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] マウス後部帯状皮質におけるサブドメインの同定; マクロ機能イメージングと狂犬病ウイルスベクターによるアプローチ2022

    • Author(s)
      竹内 遼介、上田 瑠南、正木 佑治、伊藤 慶、山口 真広、小坂田 文隆
    • Organizer
      Neuro2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] 視覚予測誤差情報処理における抑制性神経細胞を介した神経回路メカニズムの解明2022

    • Author(s)
      宮田零士, 伊藤慶, 山口真広, 佐藤彰典, 竹内遼介, 小坂田文隆
    • Organizer
      視覚科学フォーラム
    • Related Report
      2022 Annual Research Report
  • [Presentation] センダイウイルスの持続感染性獲得メカニズムの解明2022

    • Author(s)
      岩田萌,川端涼子,坂口剛正,入江崇,小坂田文隆
    • Organizer
      第69回日本ウイルス学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Construction of a novel Sendai virus vector for neural circuit analysis.2022

    • Author(s)
      Kazuyoshi Miwa, Moe iwata, Ryosuke F. Takeuchi, Fumitaka Osakada
    • Organizer
      日本薬理学会関東部会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 視覚刺激検出課題遂行中および学習過程におけるマウスの全皮質のアセチルコリン動態.2022

    • Author(s)
      佐藤 彰典, 竹内 遼介, 伊藤 慶, 山口 真広, 小坂田 文隆.
    • Organizer
      日本生理学会第100回記念大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Emotion regulation and depression: Reduced coupling of the fronto-limbic system was associated with stimulation-induced anxiety states2022

    • Author(s)
      雨森賢一
    • Organizer
      第 33 回 ASHBi Colloquium
    • Related Report
      2022 Annual Research Report
  • [Presentation] 不安に伴う認知・辺縁系の階層ネットワークの変化2022

    • Author(s)
      雨森賢一
    • Organizer
      システム神経科学研究会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 刺激誘導の不安に伴う認知・辺縁系の階層ネットワークの変化2022

    • Author(s)
      雨森賢一
    • Organizer
      次世代脳シンポジウム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Silencing of the projection from the ventral striatum to the ventral pallidum increases motivational states under approach-avoidance conflict in nonhuman primates2022

    • Author(s)
      Jungmin OH, Satoko Amemori, Ken-ichi Inoue, Kei Kimura, Masahiko Takada, Ken-ichi Amemori
    • Organizer
      Neuro2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] Computational and Physiological Approaches to the Primate Anxiety Connectome2022

    • Author(s)
      Ken-ichi Amemori
    • Organizer
      SPP2041 Status Meeting
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of a novel Brain-Machine Interface by wide-field microscopy.2022

    • Author(s)
      Kentaro Ibuka, Ryosuke F. Takeuchi, Akinori Y. Sato, Kei N. Ito, Masahiro Yamaguchi and Fumitaka Osakada
    • Organizer
      第95回日本薬理学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Anatomical identification of segregated network modules of the retrosplenial cortex along the cingulate cortex2022

    • Author(s)
      Rumina Ueda, Yuji Masaki, Masahiro Yamaguchi, Ryosuke Takeuchi, Fumitaka Osakada.
    • Organizer
      第95回日本薬理学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] An in vitro model of thalamocortical and corticothalamic interactions using human induced pluripotent stem cells.2022

    • Author(s)
      Masatoshi Nishimura, Tomoki Kodera, Fumitaka Osakada.
    • Organizer
      第95回日本薬理学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Monosynaptic rabies virus tracing from projection-targeted single neurons2022

    • Author(s)
      Yuji Masaki, Masahiro Yamaguchi, Ryosuke Takeuchi, Fumitaka Osakada
    • Organizer
      日本生理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] The dynamics of acetylcholine in the whole cortex of the mouse performing the visual detection task2022

    • Author(s)
      Akinori Y. Sato, Ryosuke F. Takeuchi, Kei N. Ito, Masahiro Yamguchi, Fumitaka Osakada
    • Organizer
      日本生理学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 標的受容体発現ニューロンに特異的なウイルスベクター標識法の開発2022

    • Author(s)
      釜口力、田村朋則、森本菜央、浜地格、小坂田文隆
    • Organizer
      日本薬学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 空間視知覚を担う視覚背側経路の予測処理2022

    • Author(s)
      小坂田文隆
    • Organizer
      第39回埼玉認知症研究会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Imaging, viral, and machine learning approaches in stem cell biology2022

    • Author(s)
      小坂田文隆
    • Organizer
      第95回日本薬理学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Evaluation of cell products and brain functions with optical imaging2022

    • Author(s)
      小坂田文隆
    • Organizer
      日本再生医療学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 低毒化G欠損狂犬病ウイルスベクターの開発2021

    • Author(s)
      山口真広、恩田将成、正木佑治、竹内遼介、森本菜央、小坂田文隆
    • Organizer
      第139回日本薬理学会近畿部会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Distributed encoding of visuomotor mismatch signals through posterior cortical circuits2021

    • Author(s)
      竹内遼介、伊藤慶、上田るみな、山口真広、小坂田文隆
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Posterior cortical networks hierarchically encode visuomotor error signals2021

    • Author(s)
      竹内遼介、伊藤慶、上田るみな、山口真広、小坂田文隆
    • Organizer
      生理研研究会『大脳皮質を中心とした神経回路:構造と機能、その作動原理』
    • Related Report
      2021 Annual Research Report
  • [Presentation] 視覚と運動の統合メカニズムの解明と再生医療等製品の開発を目指して2021

    • Author(s)
      小坂田文隆
    • Organizer
      iSeminar
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 新規治療戦略の創出を目指した幹細胞および神経回路研究2021

    • Author(s)
      小坂田文隆
    • Organizer
      医歯学総合研究科大学院セミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Hierarchical processing of visuomotor error signals in posterior cortical networks2021

    • Author(s)
      小坂田文隆
    • Organizer
      遺伝研研究会「哺乳類脳の機能的神経回路の構築メカニズム」
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Remarks] 「あいまい脳」領域HP

    • URL

      https://sites.google.com/view/aimai-brain/

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report 2021 Annual Research Report

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Published: 2021-10-22   Modified: 2025-01-30  

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