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Biosynthetic machinery: Deciphering and regulating the system for creating structural diversity of baioactive metabolites

Administrative Group

Project AreaBiosynthetic machinery: Deciphering and regulating the system for bioactive metabolite diversification
Project/Area Number 22108001
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionHokkaido University

Principal Investigator

OIKAWA Hideaki  北海道大学, 理学(系)研究科(研究院), 教授 (00185175)

Co-Investigator(Kenkyū-buntansha) 齊藤 和季 (斉藤 和季)  千葉大学, 薬学研究科(研究院), 教授 (00146705)
石川 淳  国立感染症研究所, 真菌部第四室, 室長 (40202957)
阿部 郁朗  東京大学, 薬学研究科(研究院), 教授 (40305496)
江口 正  東京工業大学, 理工学研究科, 教授 (60201365)
五味 勝也  東北大学, (連合)農学研究科(研究院), 教授 (60302197)
池田 治生 (池田 治男)  北里大学, 大学院感染制御科学府・北里生命科学研究所, 教授 (90159632)
金谷 重彦  奈良先端科学技術大学院大学, 情報科学研究科, 教授 (90224584)
大利 徹  北海道大学, 工学(系)研究科(研究院), 教授 (70264679)
Co-Investigator(Renkei-kenkyūsha) EGUCHI Tadashi  東京工業大学, 大学院理工学研究科, 教授 (60201365)
ABE Ikuro  東京大学, 大学院薬学研究科, 教授 (40305496)
KUZUYAMA Tomohisa  東京大学, 生物生産工学研究センター, 准教授 (30280952)
DAIRI Tohru  北海道大学, 大学院工学研究科, 教授 (70264679)
IKEDA Haruo  北里大学, 感染制御科学府, 教授 (90159632)
GOMI Katsuya  東北大学, 大学院農学研究科, 教授 (60302197)
SAITO Kazuki  千葉大学, 大学院薬学研究科, 教授 (00146705)
KANAYA Shigehiko  奈良先端科学技術大学院大学, 情報科学研究科, 教授 (90224584)
ISHIKAWA Jun  国立感染症研究所, 生物活性物質部, 室長 (40202957)
Project Period (FY) 2010-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥57,720,000 (Direct Cost: ¥44,400,000、Indirect Cost: ¥13,320,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2013: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2012: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords生合成 / ゲノム情報 / 物質生産 / バイオインフォマティクス / メタボローム / 二次代謝産物 / 抗生物質 / 抗腫瘍性物質 / ゲノム / 天然物 / ペプチド合成酵素 / 大腸菌 / 化学酵素合成
Outline of Annual Research Achievements

新学術領域領域代表者と8名の計画研究代表者(江口、大利、阿部、池田、五味、斉藤、金谷、石川)、5名の評価委員の意見を取りまとめ、新学術領域研究「生合成マシナリー」の成果報告シンポジウムを、聴衆が期待できる週末のアクセスが良い場所という観点から、東京都港区のコクヨホールに決定した。6月21日の日曜日には、100名近い企業からの出席者や一般参加者に対し、5年間の研究成果を、A01,A02,A03班の班長および指名された顕著な成果を挙げた合計7名の講演者が、判りやすく説明した。

最終の文部科学省へ提出する成果報告書は、3班構成の各班長が、班員個人より事務局に提出された5年間の領域活動で得られた成果に関する資料をもとにデータを整理し、論文発表、学会発表、シンポジウムや講演会での依頼講演、新聞・テレビなどのメディアでの公表状況、各賞の受賞状況、さらには領域内での共同研究など各班の成果を取りまとめた後、事後評価ヒアリング、さらには一般公開用資料としてデータファイルを作成した。これをベースに冊子体も作成し、公的な研究機関や関連研究者に送付した。

6月から10月オープンキャンパスや夏休み期間中には、領域代表が所属する北海道大学や班員が所属する研究機関で、中高生を対象にオープンラボなどの企画で、研究活動を疑似体験してもらうために、実験を撮影したビデオの上映、さらに実験室の見学を行なった。さらに11月14-15日(土・日)、東京都江東区にある日本科学未来館で開かれた大規模なサイエンスコミュニケーションのイベント、サイエンスアゴラに出展し、総括班でアウトリーチ用に作成した領域活動の広報用アニメーションやクイズ形式の説明用プレゼンファイルを利用して、来場者に研究成果を説明した。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Report

(7 results)
  • 2015 Annual Research Report
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (84 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article (33 results) (of which Peer Reviewed: 33 results,  Acknowledgement Compliant: 9 results) Presentation (36 results) (of which Invited: 18 results) Book (12 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Reconstitution of biosynthetic machinery for highly elaborated indole diterpene penitrem2015

    • Author(s)
      C. W. Liu, K. Tagami, A. Minami, T. Matsumoto, J. C. Frisvad, H. Suzuki, J. Ishikawa, K. Gomi, and H. Oikawa
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 2015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A Peptide Ligase and the Ribosome Cooperate to Synthesize the Peptide Pheganomycin2015

    • Author(s)
      M. Noike, T. Matsui, K. Ooya, I. Sasaki, S. Ohtaki, Y. Hamano, C. Maruyama, J. Ishikawa, Y. Satoh, H. Ito, H. Morita, and T. Dairi
    • Journal Title

      Nat. Chem. Biol.

      Volume: 11 Pages: 71-71

    • NAID

      120005619608

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Terpene synthases are widely distributed in bacteria.2015

    • Author(s)
      Y. Yamada, T. Kuzuyama, M. Komatsu, K. Shin-ya, S. Omura, D.E. Cane, H. Ikeda
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 112 Pages: 857-857

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Characterization of a Radical Adenosyl-L-methionine Epimerase, NeoN, in the Last Step of Neomycin B Biosynthesis2014

    • Author(s)
      F. Kudo, S. Hoshi, T. Kawashima, T. Kamachi, and T. Eguchi
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 136 Pages: 13909-13909

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A Methyltransferase Initiates Terpene Cyclization in Teleocidin B Biosynthesis2014

    • Author(s)
      T. Awakawa, L. H. Zhang, T. Wakimoto, S. Hoshino, T. Mori, T. Ito, J. Ishikawa, M. E. Tanner and I. Abe
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 136 Pages: 9910-9910

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont2014

    • Author(s)
      T. Wakimoto, Y. Egami, Y. Nakashima, Y. Wakimoto, T. Mori, T. Awakawa, T. Ito, H. Kenmoku, Y. Asakawa, J. Piel and I. Abe
    • Journal Title

      Nat. Chem. Biol.

      Volume: 10 Pages: 648-648

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A flavonoid 3-O-glucoside: 2 ''-O-glucosyltransferase responsible for terminal modification of pollen-specific flavonols in Arabidopsis thaliana2014

    • Author(s)
      K. Yonekura-Sakakibara, R. Nakabayashi, S. Sugawara, T. Tohge, T. Ito, M. Koyanagi, M. Kitajima, H. Takayama and K. Saito
    • Journal Title

      Plant J.

      Volume: 79 Pages: 769-769

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Clustering of 3D-Structure Similarity Based Network of Secondary Metabolites Reveals Their Relationships with Biological Activities2014

    • Author(s)
      S. Kanaya, T. Shirai
    • Journal Title

      Mol. Inf.

      Volume: 33 Pages: 780-780

    • NAID

      130005146305

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Draft genome sequence of Rhodococcus erythropolis JCM 6824, an aurachin RE antibiotic producer2014

    • Author(s)
      Kitagawa, W., Hata, M., Sekizuka, T., Kuroda, M., and Ishikawa, J.
    • Journal Title

      Genome Announcement

      Volume: 2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Allosteric Regulation of Epoxide Opening Cascades by a Pair of Epoxide Hydrolases in Monensin Biosynthesis,2014

    • Author(s)
      A. Minami, T. Ose, K. Sato, A. Oikawa, K. Kuroki, K.Maenaka, H.Oguri and H. Oikawa
    • Journal Title

      ACS Chem. Biol.

      Volume: 9 Issue: 2 Pages: 562-569

    • DOI

      10.1021/cb4006485

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of oxidative and drought tolerance in Arabidopsis by overaccumulation of antioxidant flavonoids2014

    • Author(s)
      R. Nakabayashi, K. Yonekura-Sakakibara, K. Urano, M. Suzuki, Y. Yamada, T. Nishizawa, F. Matsuda, M. Kojima, H. Sakakibara, K. Shinozaki, A. J. Michael, T. Tohge, M. Yamazaki, and K. Saito
    • Journal Title

      Plant J.

      Volume: 77 Issue: 3 Pages: 367-379

    • DOI

      10.1111/tpj.12388

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Core Assembly Mechanism of Quinocarcin/Sf-1739: Bimodular Complex Nonribosomal Peptide Synthetases for Sequential Mannich-Type Reactions2013

    • Author(s)
      T. Hiratsuka, K. Koketsu, A. Minami, S. Kaneko, C. Yamazaki, K. Watanabe, H. Oguri, and H. Oikawa
    • Journal Title

      Chem. Biol.

      Volume: 20 Issue: 12 Pages: 1523-1535

    • DOI

      10.1016/j.chembiol.2013.10.011

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spiro-ring formation is catalyzed by a multifunctional dioxygenase in austinol biosynthesis2013

    • Author(s)
      Y. Matsuda, T. Awakawa, T. Wakimoto, and I. Abe
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 135 Issue: 30 Pages: 10962-10965

    • DOI

      10.1021/ja405518u

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Menaquinone Biosynthesis: Formation of Aminofutalosine Requires a Unique Radical SAM Enzyme2013

    • Author(s)
      N. Mahanta, D. Fedoseyenko, T. Dairi, and T. P. Begley
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 135 Issue: 41 Pages: 15318-15321

    • DOI

      10.1021/ja408594p

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Engineered Streptomyces Avermitilis Host for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites2013

    • Author(s)
      M. Komatsu, K. Komatsu, H. Koiwai, Y. Yarnada, I. Kozone, M. Izumikawa, J. Hashimoto, M. Takagi, S. Omura, K. Shin-ya, D. E. Cane, and H. Ikeda
    • Journal Title

      ACS Synth. Biol.

      Volume: 2 Issue: 7 Pages: 384-396

    • DOI

      10.1021/sb3001003

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systematization of the protein sequence diversity in enzymes related to secondary metabolic pathways in plants, in the context of big data biology inspired by the KNApSAcK motorcycle database,2013

    • Author(s)
      S. Ikeda, Abe T, Y. Nakamura, N. Kibinge, A. Hirai Morita, A. Nakatani, N. Ono, T. Ikemura, K. Nakamura, M. Altaf-Ul-Amin, S. Kanaya
    • Journal Title

      Plant Cell Physiol.

      Volume: 54 Issue: 5 Pages: 711-727

    • DOI

      10.1093/pcp/pct041

    • NAID

      10031177050

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reconstitution of biosynthetic machinery for indole-diterpene paxilline in Aspergillus oryzae.2013

    • Author(s)
      K. Tagami, C. Liu, A. Minami, M. Noike, T. Isaka, S. Fueki, Y. Shichijo, H. Toshima, K, T. Dairi, and H. Oikawa.
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 135 Issue: 4 Pages: 1260-1263

    • DOI

      10.1021/ja3116636

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Product-Mediated Regulation of Pentalenolactone Biosynthesis in Streptomyces by the MarR/SlyA Family Activators PenR and PntR.2013

    • Author(s)
      Zhu, D.
    • Journal Title

      J. Bacteriol.

      Volume: 195 Issue: 6 Pages: 1255-1266

    • DOI

      10.1128/jb.02079-12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Last Step of Kanamycin Biosynthesis : A Unique Deamination Reaction Catalyzed by an α-Ketoglutarate-dependent Nonheme Iron Dioxygenase KanJ and an NADPH Dependent Reductase KanK2012

    • Author(s)
      Hilda Sucipto, Fumitaka Kudo, Tadashi Eguchi
    • Journal Title

      Angew.Chem.Int.Ed

      Volume: (印刷中) Issue: 14 Pages: 3428-3431

    • DOI

      10.1002/anie.201108122

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modified Cre-loxP recombination in Aspergillus oryzae by direct introduction of Cre recombinase for marker gene rescue2012

    • Author(s)
      Mizutani, et al
    • Journal Title

      Appl.Environ.Microbiol.

      Volume: (未定)(in press) Issue: 12 Pages: 4126-4133

    • DOI

      10.1128/aem.00080-12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lysine decarboxylase catalyzes the first step of quinolizidine alkaloid biosynthesis and coevolved with alkaloid production in Leguminosae2012

    • Author(s)
      Somnuk Bunsupa, Kae Katayama, Emi Ikeura, Akira Oikawa, Kiminori Toyooka, Kazuki Saito, Mami Yamazaki.
    • Journal Title

      Plant Cell

      Volume: 24 Issue: 3 Pages: 1202-1216

    • DOI

      10.1105/tpc.112.095885

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of operon-like gene clusters in the Arabidopsis thaliana genome based on co-expression analysis of neighboring genes2012

    • Author(s)
      Wada M, Takahashi H, Altaf-Ul-Amin M, Nakamura K, Hirai MY, Ohta D, Kanaya S.
    • Journal Title

      Gene

      Volume: 503(1) Issue: 1 Pages: 56-64

    • DOI

      10.1016/j.gene.2012.04.043

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enzymatic Catalysis of Anti-Baldwin Ring-Closure in Polyether Biosynthesis2012

    • Author(s)
      K.Hotta, X.Chen, R.S.Paton, A.Minami, H.Li, K.Swamina-than, I.Mathews, K.Watanabe, H.Oikawa, K.N.Houk, K.C.-Y.
    • Journal Title

      Nature

      Volume: 483 No.7389 Pages: 355-358

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two glycosyltransferases involved in anthocyanin modification delineated by transcriptome independent component analysis in Arabidopsis thaliana2012

    • Author(s)
      Keiko Yonekura-Sakakibara, Atsushi Fukushima, Ryo Nakabayashi, Kousuke Hanada, Fumio Matsuda, Satoko Sugawara, Eri Inoue, Takashi Kuromori, Takuya Ito, Kazuo Shinozaki, Bunyapa Wangwattana, Mami Yamazaki, Kazuki Saito
    • Journal Title

      Plant J

      Volume: 69 Issue: 1 Pages: 154-167

    • DOI

      10.1111/j.1365-313x.2011.04779.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Natural Protecting Group Strategy To Carry an Amino Acid Starter Unit in the Biosynthesis of Macrolactam Polyketide Antibiotics2011

    • Author(s)
      Y.Shinohara, F.Kudo, T.Eguchi
    • Journal Title

      J.Am.Chem.Soc.

      Volume: Vol.133, No.45 Issue: 45 Pages: 18134-18137

    • DOI

      10.1021/ja208927r

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase2011

    • Author(s)
      Morita, H., Yamashita, M., Shi, S.-P., Wakimoto, T., Kondo, S., Kato, R., Sugio, S., Kohno, T., Abe, I.
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 108 Issue: 33 Pages: 13504-13509

    • DOI

      10.1073/pnas.1107782108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dioxygenases, key enzymes to determine the aglycon structures of fusicoccin and brassicicene, diterpene compounds produced by fungi2011

    • Author(s)
      Y.Ono, A.Minami, M.Noike, Y.Higuchi, T.Toyomasu, T.Sassa, N.Kato, T.Dairi
    • Journal Title

      J.Am.Chem.Soc.

      Volume: Vol.133 Issue: 8 Pages: 18134-18137

    • DOI

      10.1021/ja107785u

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome mining in Streptomyces. Discovery of an unprecedented P450-catalyzed oxidative rearrangement that is the final step in the biosynthesis of pentalenolactone2011

    • Author(s)
      Zhu, D.Seo, M-J.Ikeda, H.Cane, D.E.
    • Journal Title

      J.Am.Chem.Soc.

      Volume: 133 Issue: 7 Pages: 2128-2131

    • DOI

      10.1021/ja111279h

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Biosynthesis of Diterpene Aphidicolin, a Specific Inhibitor of DNA Polymerase .ALPHA.: Heterologous Expression of Four Biosynthetic Genes in Aspergillus oryzae2011

    • Author(s)
      R.Fujii, A.Minami, T.Tsukagoshi, N.Sato, T.Sahara, S.Ohgiya, K.Gomi, H.Oikawa
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 75 Issue: 9 Pages: 1813-1817

    • DOI

      10.1271/bbb.110366

    • NAID

      10029757547

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reconstruction of the Saframycin Core Scaffold Defines Dual Pictet-Spengler Mechanisms2010

    • Author(s)
      K.Koketsu, K.Watanabe, H.Suda, H.Oguri, H.Oikawa
    • Journal Title

      Nat.Chem.Biol.

      Volume: Vol 6, No 6 Pages: 408-410

    • NAID

      120002646838

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cloning and Characterization of the Biosynthetic Gene Cluster of 16-Membered Macrolide Antibiotic FD-891 : Involvement of a Dual Functional Cytochrome P450 Monooxygenase Catalyzing Epoxidation and Hydroxylation2010

    • Author(s)
      F.Kudo, A.Motegi, K.Mizoue, T.Eguchi
    • Journal Title

      ChemBioChem

      Volume: Vol.11 Pages: 1574-1582

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Structure-Based Mechanism for Benzalacetone Synthase from Rheum palmatum2010

    • Author(s)
      H.Morita, Y.Shimokawa, M.Tanio, R.Kato, H.Noguchi, S.Sugio, T.Kohno, I.Abe
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 107 Pages: 669-673

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway2010

    • Author(s)
      Okamura E, Tomita T, Sawa R, Nishiyama M, Kuzuyama T
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 107 Pages: 11265-11270

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effects of α -1,3-glucan synthase gene knockout on α -amylase adsorption onto the cell wall and productivity of enzymes and metabolites in Aspergillus oryzae2015

    • Author(s)
      Katsuya Gomi
    • Organizer
      12th International Aspergillus meeting (Asperfest12)
    • Place of Presentation
      Asilomar, USA
    • Year and Date
      2015-03-16 – 2015-03-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Crystal Structure of a Menaquinone Biosynthetic Enzyme, MqnD, Complexed with its Substrate and Product2014

    • Author(s)
      Tohru Dairi
    • Organizer
      15th IUBMB Conference
    • Place of Presentation
      Academia Sinica, Taipei, Taiwan
    • Year and Date
      2014-10-21 – 2014-10-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 2ndFind: a web-based support tool to find secondary metabolite biosynthetic gene cluster2014

    • Author(s)
      Ishikawa, J. and Hoshino, Y.
    • Organizer
      17th International Symposium on the Biology of Actinomycetes
    • Place of Presentation
      Kusadasi, Turkey
    • Year and Date
      2014-10-08 – 2014-10-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Total Biosynthesis of Bioactive Fungal Metabolites2014

    • Author(s)
      Hideaki Oikawa
    • Organizer
      24th French-Japanese Symposium on Medicinal and Fine Chemistry
    • Place of Presentation
      Lyon, France
    • Year and Date
      2014-09-14 – 2014-09-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Biosynthesis of fungal meroterpenoids2014

    • Author(s)
      Ikuro Abe
    • Organizer
      97th Canadian Chemistry Conference and Exhibition
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2014-06-01 – 2014-06-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Metabolomics-based functional genomics from Arabidopsis to crops and medicinal plants2014

    • Author(s)
      Kazuki Saito
    • Organizer
      ICREA Workshop: From model systems to crops, challenge for a new era in plant biology
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-05-07 – 2014-05-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Biosynthetic studies on fungal meroterpenoids derived from 3,5-dimethylorsellinic acid2014

    • Author(s)
      Ikuro Abe
    • Organizer
      Gordon Research Conference on Marine Natural Products
    • Place of Presentation
      Four Points Sheraton / Holiday Inn Express, Ventura, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Self-excising Cre/mutant lox marker recycling system for multiple gene integrations and consecutive gene deletions in Aspergillus oryzae2014

    • Author(s)
      Katsuya Gomi
    • Organizer
      11th International Aspergillus meeting (Asperfest11)
    • Place of Presentation
      Hotel Silken-Al Andalus, Seville, Spain
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Subcellular localization of aphidicolin biosynthesis enzymes from Phoma betae expressed heterologously in Aspergillus oryzae.2013

    • Author(s)
      Katsuya Gomi
    • Organizer
      27th Fungal Genetics Conference
    • Place of Presentation
      Asilomar Conference Grounds (USA)
    • Year and Date
      2013-03-12
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Origin of metabolomic diversity.2013

    • Author(s)
      Kazuki Saito
    • Organizer
      Evolution of Plant Metabolic Diversity
    • Place of Presentation
      The Banbury Center, Cold Spring Harbor Laboratory, New York, US.
    • Year and Date
      2013-03-03
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Genomic data-based synthesis of fungal natural products2013

    • Author(s)
      Hideaki Oikawa
    • Organizer
      International Symposium on Natural Products Chemistry and Chemical Biology 2013
    • Place of Presentation
      Hotel Ohzan, Aichi-ken
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Functional Analysis of Prenyltransferses Responsible for Diterpene Biosynthesis in Fungi2013

    • Author(s)
      C. W. Liu, M. Noike, A. Minami, H. Oikawa, and T. Dairi,
    • Organizer
      11th TERPNET meeting
    • Place of Presentation
      Kolymvari, Crete, Greece
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Second version of versatile hosts for heterologous expression of biosynthetic gene(s) for secondary metabolites2013

    • Author(s)
      Haruo Ikeda
    • Organizer
      1st European Conference on Natural Products: Research and Applications
    • Place of Presentation
      DECHEMA-Haus, Frankfurt, Germany.
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Metabolomics finds a new class of plant lipid essential for protection against phosphorus depletion2013

    • Author(s)
      K. Saito, Y. Okazaki
    • Organizer
      7th EPSO Conference
    • Place of Presentation
      Porto Heli (AKS Hotel), Greece
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Metabolomics-based functional genomics in plants2013

    • Author(s)
      K. Saito
    • Organizer
      Molecular Life Sciences 2013 Interntional Symposium of the Germany Society for Bioehcmistry and Molecular Biology
    • Place of Presentation
      Campus Westend Goethe University in Frankfurt/Main, Germany
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Expanding the Catalytic Repertoires of Biosynthetic Enzymes2012

    • Author(s)
      Ikuro Abe
    • Organizer
      Directing Biosynthesis III
    • Place of Presentation
      The University of Nottingham (UK)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Recent Progress on Biosynthesis of Fungal and Bacterial Metabolites2012

    • Author(s)
      Hideaki Oikawa
    • Organizer
      9th Asia-Pacific Marine Biotechnology Conference (APMBC2012)
    • Place of Presentation
      高知市文化プラザ かるぽーと(高知県)
    • Year and Date
      2012-07-13
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Metabolome quantitative trait loci analysis for investigation of genotype#8211;phenotype associations in rice.2012

    • Author(s)
      F. Matsuda
    • Organizer
      Metabolomics 2012 8th International Conference of the Metabolomics Society
    • Place of Presentation
      Marriot Wardman Park Hotel (USA)
    • Year and Date
      2012-06-25
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Multiple gene expression system by means of Cre/loxP-mediated marker recycling with mutated loxP sites in Aspergillus oryzae2012

    • Author(s)
      katsuya Gomi
    • Organizer
      9th International Aspergillus meeting (Asperfest9)
    • Place of Presentation
      Marburg University, (Germany)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Elucidation of the Catalytic Mechanism on Non-ribosomal Peptide Synthetase Involving Biosynthesis of Saframycin-Type Antitumor Agent2012

    • Author(s)
      Hideaki Oikawa
    • Organizer
      6th Korea-Japan Young Scientists Meeting on Bioorganic and Natural Products Chemistry
    • Place of Presentation
      Seoul University(韓国)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Biosynthesis of Peptide and Polyether Antibiotics 7th US-Japan Seminar on Marine Natural Products2011

    • Author(s)
      Hideaki Oikawa
    • Organizer
      7th US-Japan Seminar on Marine Natural Products, Cross-Disciplinary Expansions in Marine Bioorganic Chemistry
    • Place of Presentation
      沖縄コンベンションセンター(那覇市)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Engineering Plant Polyketide Synthases2011

    • Author(s)
      Ikuro Abe
    • Organizer
      Phytochemical Society of North America 50th Anniversary Symposium
    • Place of Presentation
      North America Convention Center, (USA)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] An alternative menaquinone biosynthetic pathway : an attractive target for drug discovery to Helicobacter pylori2011

    • Author(s)
      Tohru Dairi
    • Organizer
      The Third International Conference on Cofactors 03 (ICC-03)
    • Place of Presentation
      The Univ.of Turku, (Finland)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] The genome-minimized Streptomyces hosts for the secondary metabolism2011

    • Author(s)
      Haruo Ikeda
    • Organizer
      BIT'S 4th Annual World Congress of Industrial Biotechnology
    • Place of Presentation
      Hanzou University, (China)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of plant metabolomics from Arabidopsis to crops2011

    • Author(s)
      Kazuki Saito
    • Organizer
      International Conference of the Metabolomics Society
    • Place of Presentation
      Sidney Convention Center, (Australia)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Metabolomics-based Phytochemical Genomics-Beyond Arabidopsis to Crop Biotechnology2011

    • Author(s)
      Kazuki Saito
    • Organizer
      Gordon Research Conferences, Plant Metabolic Engineering
    • Place of Presentation
      Dubrin Institute of Technology, (Ireland)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Species metabolite Relation KNApSAcK and Its Multifaceted Retrieval System, KNApSAcK Family2011

    • Author(s)
      Shigehiko Kanaya
    • Organizer
      26th Philippine Chemistry Congress
    • Place of Presentation
      Manila Convention Center, (Filippin)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Marker recycling in Aspergillus oryzae by application of the Cre/loxP system with direct introduction of Cre recombinase2011

    • Author(s)
      Katsuya Gomi
    • Organizer
      26th Fungal Genetics Conference
    • Place of Presentation
      Asilomar Convention Center, (USA)(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functional characterization of Streptomyces ABBA prenyltransferases in the biosyntheses of naphthoquinone derivatives and novobiocin2010

    • Author(s)
      Tomohisa Kuzuyama
    • Organizer
      60^<th> SIM Annual Meeting
    • Place of Presentation
      San Francisco Convention Center (USA)(招待講演)
    • Year and Date
      2010-08-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Highly unusual iterative use of NRPS involved in the biosynthesis of saframycin2010

    • Author(s)
      Hideaki Oikawa
    • Organizer
      Directed Biosynthesis II
    • Place of Presentation
      Durham University (UK)(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Recent progress on the biosynthesis of peptide antitumor antibiotics2010

    • Author(s)
      Hideaki Oikawa
    • Organizer
      Pacifichem 2010 Symposium on Recent Advances in Natural Products as Anticancer Agents
    • Place of Presentation
      Hilton Hawaiian Village Hotel (USA)(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular Analysis of Glycosyltransferase VinC2010

    • Author(s)
      Tadashi Eguchi
    • Organizer
      Pacifichem 2010 Symposium on Biosynthesis of Natural Products
    • Place of Presentation
      Hilton Hawaiian Village Hotel (USA)(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Engineered Biosynthesis of Plant Polyketide2010

    • Author(s)
      Ikuro Abe
    • Organizer
      Japan-Finland Biotechnology Symposium 2010
    • Place of Presentation
      The Univ.of Turku, Finland(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genome Minimization of an Industrial Microorganism Streptomyces avermitilis2010

    • Author(s)
      Haruo Ikeda
    • Organizer
      11^<th> International Symposium on the Genetics of Industrial Microorganisms
    • Place of Presentation
      Melbourne Convention Center (Australia)(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Plant metabolomics for systems biology and crop biotechnology2010

    • Author(s)
      Kazuki Saito
    • Organizer
      Cold Spring Harbor Asia conference From Plant Biology to Crop Biotechnology
    • Place of Presentation
      Suzhou Convention Center, (China)(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular/cellular regulation of sulfate uptake and assimilation-what we know and what we should know2010

    • Author(s)
      Kazuki Saito
    • Organizer
      8^<th> International Workshop on Plant Sulphur Metabolism
    • Place of Presentation
      Creswick Convention Center, (Australia)(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Book] Biotechnology for Medicinal Plants2013

    • Author(s)
      S. Bunsupa, K. Saito and M. Yamazaki
    • Total Pages
      462
    • Publisher
      Springer-Verlag, Berlin Heidelberg
    • Related Report
      2013 Annual Research Report
  • [Book] Metabolite analyses of single cells2012

    • Author(s)
      Akira Oikawa
    • Publisher
      Plant J.
    • Related Report
      2012 Annual Research Report
  • [Book] Enzymatic Synthesis of Unnatural Cyclic Triterpenes” In Isoprenoid Synthesis in Plants and Microorganisms2012

    • Author(s)
      I. Abe
    • Publisher
      T. Bach, M. Rohmer, Eds.; Springer
    • Related Report
      2012 Annual Research Report
  • [Book] The Diels-Alderase never ending story2011

    • Author(s)
      A.Minami, H.Oikawa(共著)
    • Publisher
      Wiley-VCH, New York
    • Related Report
      2011 Annual Research Report
  • [Book] Plant Metabolism ana Biotechnology Hiroshi Ashihara, Alan Crozier, Atsushi Komamine2011

    • Author(s)
      Yozo Okazaki, Akira Oikawa, Miyako Kusano, Fumio Matsuda, Kazuki Saito(共著)
    • Publisher
      Wiley
    • Related Report
      2011 Annual Research Report
  • [Book] Species-Metabolite Relation Database KNApSAcK and Its Multifaceted Retrieval System, KNApSAcK Family2011

    • Author(s)
      Hiroki Takahashi, Aki Hirai, Masayuki Shojyo, Kaori Matsuda, Aziza Kawsar Parvin, Hiroko Asahi, Kensuke Nakamura, Md.Altaf-Ul-Amin, Shigehiko Kanaya(共著)
    • Publisher
      Handbook of Systems Toxicology
    • Related Report
      2011 Annual Research Report
  • [Book] "Chapter 8 Chemical Difence and Toxins of Plant," In Comprehensive Natural Products II : Chemistry and Biology2010

    • Author(s)
      H.Yamane, K.Konno, M.Sabelis, J.Takabayashi, T.Sassa, H.Oikawa(共著)
    • Total Pages
      47
    • Publisher
      Elsevier
    • Related Report
      2010 Annual Research Report
  • [Book] "Chapter 8 Diels-Alderases," In Comprehensive Natural Products II : Chemistry and Biology ; Mander2010

    • Author(s)
      Oikawa, H.
    • Total Pages
      38
    • Publisher
      Elsevier
    • Related Report
      2010 Annual Research Report
  • [Book] 天然薬物の生合成工学創薬科学の魅力:東京大学大学院薬学系研究科からの発信2010

    • Author(s)
      阿部郁朗
    • Total Pages
      16
    • Publisher
      廣川書店
    • Related Report
      2010 Annual Research Report
  • [Book] "Plant Polyketide Synthase," In Comprehensive Natural Products II : Chemistry and Biology, Vol.12010

    • Author(s)
      H.Morita, I.Abe, H.Noguchi(共著)
    • Total Pages
      55
    • Publisher
      Elsevier
    • Related Report
      2010 Annual Research Report
  • [Book] "Chapter 12 Mevalonate Pathway in Archaea and Bacteria." In Comprehensive Natural Products II. Chemistry & Biology2010

    • Author(s)
      Kuzuyama T., H.Hemmi, S.Takahashi(共著)
    • Total Pages
      24
    • Publisher
      Elsevier
    • Related Report
      2010 Annual Research Report
  • [Book] Production of Pharmaceuticals by Plant Tissue Cultures. In "Comprehensive Natural Products II Chemistry and Biology"2010

    • Author(s)
      Toshiya Muranaka, Kazuki Saito(共著)
    • Total Pages
      14
    • Publisher
      Elsevier
    • Related Report
      2010 Annual Research Report
  • [Remarks] 2ndFind

    • URL

      http://biosyn.nih.go.jp/2ndfind/

    • Related Report
      2013 Annual Research Report
  • [Remarks] Motorcycle

    • URL

      http://kanaya.naist.jp/motorcycle/top2.html

    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 1. 新規テルペノイド化合物およびその製造方法2013

    • Inventor(s)
      池田治生
    • Industrial Property Rights Holder
      池田治生
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-168230
    • Filing Date
      2013-06-18
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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