Development of Novel Treatment Strategies Targeting Cancer Stem Cells

• Project Area: Development of Novel Treatment Strategies Targeting Cancer Stem Cells
• Project/Area Number: 22130001
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyushu University
• Principal Investigator: AKASHI Koichi 九州大学, 医学(系)研究科(研究院), 教授 (80380385)
• Co-Investigator(Kenkyū-buntansha): GOTO Noriko 金沢大学, がん進展制御研究所, 教授 (10251448) ; KITABAYASHI Issei 国立がん研究センター, 研究所, 分野長 (20261175) ; TANAKA Shinji 東京医科歯科大学, 医歯学総合研究科, 教授 (30253420) ; TAGA Tetsuya 東京医科歯科大学, 難治疾患研究所, 教授 (40192629) ; SUDA Toshio 慶應義塾大学, 医学部, 教授 (60118453) ; CHIBA Shigeru 筑波大学, 医学医療系, 教授 (60212049) ; SAYA Hideyuki 慶應義塾大学, 医学部, 教授 (80264282) ; NAKAYAMA Keiichi 九州大学, 生体防御医学研究所, 主幹教授 (80291508)
• Co-Investigator(Renkei-kenkyūsha): MORI Masaki 大阪大学, 医学系研究科, 教授 (70190999) ; UEDA Ryuzo 愛知医科大学, 医学部, 教授 (20142169) ; NODA Tetsuo 癌研究会, 癌研究所, 所長 (10183550) ; CLARKE Michael F. Stanford School of Medicine, Professor ; TENEN Daniel G. Harvard Stem Cell Institute, Professor ; NOMURA Hideaki 協和キリン富士フィルムバイオロジクス株式会社, 代表取締役社長 ; TAKAGO Toru 医薬基盤研究所
• Project Period (FY): 2010-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥38,350,000 (Direct Cost: ¥29,500,000、Indirect Cost: ¥8,850,000); Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000); Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
• Keywords: 癌 / 細胞・組織 / 生体分子 / 癌幹細胞 / 幹細胞ニッチ / 分子標的治療

Outline of Annual Research Achievements

新学術領域研究「癌幹細胞を標的とする腫瘍根絶技術の新構築」（平成22-26年度）の研究成果と波及効果を、多面的に評価することを目的として、成果の取りまとめを行った。本領域研究から創出された学術論文や知的財産をもとに、計画研究および公募研究の達成度を評価し、さらに領域内での有機的な連携が計れていたかについて検証した。特に、がん幹細胞標的治療を実現するシーズ探索における成果を精査し、がん幹細胞研究が新しい学術領域として広く社会に認知されたことへの貢献を評価した。具体的には、以下の項目について調査・評価を行った。
(1)計画研究8題と公募研究23題について、研究期間内に発表あるいは発表予定の学術論文および知的財産を調査した。(2)(1)をもとに、それぞれの研究課題の達成度を評価した。特に、今後の課題を明確にすることに重点を置いて精査した。(3)領域内共同研究の実施状況、研究資源共有の状況を調査し、領域内連携の達成度を評価した。(4)本領域研究によって、がん幹細胞標的治療を可能にするシーズ探索がどの程度進んだかを調査した。(5)国内外におけるがん幹細胞研究の成果を調査し、本領域研究の貢献度を評価した。(6)関連学会において、がん幹細胞研究が取り上げられた状況、テレビ・新聞等での報道状況を調査し、本領域研究の認知度と波及効果について評価した。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes. (2015)
  • Author(s): Izumi K, Mine K, Inoue Y, Teshima M, Ogawa S, Kai Y, Kurafuji T, Hirakawa K, Miyakawa D, Ikeda H, Inada A, Hara M, Yamada H, Akashi K, Niho Y, Ina K, Kobayashi T, Yoshikai Y, Anzai K, Yamashita T, Minagawa H, Fujimoto S, Kurisaki H, Shimoda K, Katsuta H, Nagafuchi S.
  • Journal Title: Nat Commun Volume: 6 Pages: 1-10
  • DOI: 10.1038/ncomms7748
  • Peer Reviewed / Open Access
• [Journal Article] Increased CD226 Expression on CD8+ T Cells Is Associated with Upregulated Cytokine Production and Endothelial Cell Injury in Patients with Systemic Sclerosis. (2015)
  • Author(s): Ayano M, Tsukamoto H, Kohno K, et al.
  • Journal Title: J Immunol. Volume: 195 Pages: 892-900
  • DOI: 10.4049/jimmunol.1403046
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Expression of programmed cell death ligand 1 is associated with poor overall survival in patients with diffuse large B-cell lymphoma. (2015)
  • Author(s): Kiyasu J, Miyoshi H, Hirata A, Arakawa F, Ichikawa A, Niino D, Sugita Y, Yufu Y, Choi I, Abe Y, Uike N, Nagafuji K, Okamura T, Akashi K, Takayanagi R, Shiratsuchi M, Ohshima K.
  • Journal Title: Blood. Volume: 126 Pages: 2193-2201
  • DOI: 10.1182/blood-2015-02-629600
  • Peer Reviewed
• [Journal Article] Natural killer cells regulate T cell immune responses in primary biliary cirrhosis. (2015)
  • Author(s): Shimoda S, Hisamoto S, Harada K, Iwasaka S, Chong Y, Nakamura M, Bekki Y, Yoshizumi T, Shirabe K, Ikegami T, Maehara Y, He XS, Gershwin ME, Akashi K.
  • Journal Title: Hepatology Volume: 62 Pages: 1817-1827
  • DOI: 10.1002/hep.28122
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression. (2015)
  • Author(s): Kikushige Y, Miyamoto T, Yuda J, Jabbarzadeh-Tabrizi S, Shima T, Takayanagi S, Niiro H, Yurino A, Miyawaki K, Takenaka K, Iwasaki H, Akashi K
  • Journal Title: Cell Stem Cell Volume: 17 Pages: 341-341
  • DOI: 10.1016/j.stem.2015.07.011
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Prognostic role of Child-Pugh score 5 and 6 in hepatocellular carcinoma patients who underwent curative hepatic resection. (2015)
  • Author(s): Okajima C, Arii S, Tanaka S, Matsumura S, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Tanabe M.
  • Journal Title: American Journal of Surgery Volume: 209 Pages: 199-205
  • DOI: 10.1016/j.amjsurg.2014.03.009
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria. (2014)
  • Author(s): Yonekawa A, Saijo S, Hoshino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M, Oh-Hora M, Akashi K, Yamasaki S.
  • Journal Title: Immunity. Volume: 41 Pages: 402-13
  • DOI: 10.1016/j.immuni.2014.08.005
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell. (2014)
  • Author(s): Shima T, Miyamoto T, Kikushige Y, Yuda J, Tochigi T, Yoshimoto G, Kato K, Takenaka K, Iwasaki H, Mizuno S, Goto N, Akashi K.
  • Journal Title: Exp. Hematol Volume: 42 Pages: 955-65
  • DOI: 10.1016/j.exphem.2014.07.267
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment. (2014)
  • Author(s): Iwamoto C
  • Journal Title: Exp. Hematol Volume: 42 Pages: 163-171
  • DOI: 10.1016/j.exphem.2013.11.005
  • Peer Reviewed
• [Journal Article] Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation. (2014)
  • Author(s): Nobusue H
  • Journal Title: Nature Communications Volume: 5 Pages: 3368-3368
  • DOI: 10.1038/ncomms4368
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress (2014)
  • Author(s): Shimizu T, Sugihara E, Yamaguchi-Iwai S, Tamaki S, Koyama Y, Kamel W, Ueki A, Ishikawa T, Chiyoda T, Osuka S, Onishi N, Ikeda H, Kamei J, Matsuo K, Fukuchi Y, Nagai T, Toguchida J, Toyama Y, Muto A, Saya H
  • Journal Title: Cancer Research Volume: 74 Pages: 6531-41
  • DOI: 10.1158/0008-5472.can-14-0914
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] p57 regulates T-cell development and prevents lymphomagenesis by balancing p53 activity and pre-TCR signaling. (2014)
  • Author(s): Matsumoto, A., Takeishi, S., Nakayama, K. I.
  • Journal Title: Blood Volume: 123 Pages: 1-11
  • DOI: 10.1182/blood-2013-10-532390
  • Peer Reviewed
• [Journal Article] HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism. (2014)
  • Author(s): Yamauchi, T., Nishiyama, M., Moroishi, T., Yumimoto, K., Nakayama, K. I.
  • Journal Title: The Journal of Biological Chemistry Volume: 289 Pages: 16430-16441
  • DOI: 10.1074/jbc.m113.541490
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Nuclear export signal within CALM is necessary for CALM-AF10-induced leukemia. (2014)
  • Author(s): 鈴木 麻衣
  • Journal Title: Cancer Sci. Volume: 105 Pages: 315-23
  • DOI: 10.1111/cas.12347
  • Peer Reviewed
• [Journal Article] Bromodomain-PHD finger protein 1 is critical for leukemogenesis associated with MOZ-TIF2 fusion. (2014)
  • Author(s): Shima H, Yamagata K, Aikawa Y, Shino M, Koseki H, Shimada H, Kitabayashi I.
  • Journal Title: Int J Hematol. Volume: 99 Pages: 21-31
  • DOI: 10.1007/s12185-013-1466-x
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] MicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancer. (2014)
  • Author(s): Hasegawa S, Eguchi H, Nagano H, Konno M, Tomimaru Y, Wada H, Hama N, Kawamoto K, Kobayashi S, Nishida N, Koseki J, Nishimura T, Gotoh N, Ohno S, Yabuta N, Nojima H, Mori M, Doki Y, Ishii H.
  • Journal Title: B.r J. Cancer Volume: 111 Pages: 1572-1580
  • DOI: 10.1038/bjc.2014.454
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Epiregulin enhances tumorigenicity by activating the ERK/MAPK pathway in glioblastoma. (2014)
  • Author(s): Kohsaka S, Hinohara K, Wang L, Nishimura T, Urushido M, Yachi K, Tsuda M, Tanino M, Kimura T, Nishihara H, Gotoh N, Tanaka S.
  • Journal Title: Neuro Oncol. Volume: 16 Pages: 960-70
  • Peer Reviewed
• [Journal Article] Frs2α and Shp2 signal independently of Gab to mediate FGF signaling in lens development. (2014)
  • Author(s): Li H, Tao C, Cai Z, Hertzler-Schaefer K, Collins TN, Wang F, Feng GS, Gotoh N, Zhang X.
  • Journal Title: J. Cell Sci. Volume: 127 Pages: 571-582
  • DOI: 10.1242/jcs.134478
  • Peer Reviewed
• [Journal Article] Megakaryocytes are essential for HSC quiescence through the production of thrombopoietin. (2014)
  • Author(s): Nakamura-Ishizu A, Takubo K, Fujioka M, Suda T.
  • Journal Title: Biochem Biophys Res Commun. Volume: 454 Pages: 353-7
  • Peer Reviewed
• [Journal Article] Neurons limit angiogenesis by titrating VEGF in retina. (2014)
  • Author(s): Okabe K, Kobayashi S, Yamada T, Kurihara T, Tai-Nagara I, Miyamoto T, Mukouyama YS, Sato TN, Suda T, Ema M, Kubota Y
  • Journal Title: Cell Volume: 159 Pages: 584-596
  • DOI: 10.1016/j.cell.2014.09.025
  • Peer Reviewed / Open Access
• [Journal Article] Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling. (2014)
  • Author(s): Kobayashi I, Kobayashi-Sun J, Kim AD, Pouget C, Fujita N, Suda T, Traver D.
  • Journal Title: Nature Volume: 512 Pages: 319-23
  • DOI: 10.1038/nature13623
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The IL-2/CD25 Axis Maintains Distinct Subsets of Chronic M yeloid Leukemia-initiating Cells. (2014)
  • Author(s): Kobayashi CI, Takubo K, Kobayashi H, Nakamura-Ishizu A, Honda H, Kataoka K, Kumano K, Akiyama H, Sudo T, Kurokawa M, Suda T.
  • Journal Title: Blood.doi: 10.1182/blood-2013-07-517847 Volume: 123 Pages: 2540-2549
  • DOI: 10.1182/blood-2013-07-517847
  • NAID: 40020385227
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Alcohol consumption and recurrence of non-B or non-C hepatocellular carcinoma after hepatectomy: a propensity score analysis. (2014)
  • Author(s): Kudo A, Tanaka S, Ban D, Matsumura S, Irie T, Ochiai T, Nakamura N, Arii S, Tanabe M.
  • Journal Title: Journal of Gastroenterology Volume: 49 Pages: 1352-1361
  • DOI: 10.1007/s00535-013-0899-6
  • Peer Reviewed
• [Journal Article] Sox17-ediated Maintenance of Fetal Intra-ortic Hematopoietic Cell Clusters (2014)
  • Author(s): Nobuhisa. Ikuo., Ozawa. M., Uemura. M., Kishikawa. Y., Azumi. M. Harada K. Takagi M Saito. K., Kanai-Azuma M. Kanai. Y Iwama. A. Tetsuya.
  • Journal Title: Mol Cell Biol Volume: (印刷中) Pages: 1975-1990
  • DOI: 10.1128/mcb.01485-13
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A growth-promoting signaling component cyclin D1 in neural stem cells has anti-astrogliogenic function to execute self-renewal. (2014)
  • Author(s): Bizen N
  • Journal Title: Stem Cells. Volume: Epub ahead of print] Pages: 1602-15
  • DOI: 10.1002/stem.1613
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. (2014)
  • Author(s): Nagamachi A
  • Journal Title: Cancer Cell. Volume: 24 Pages: 305-17
  • DOI: 10.1016/j.ccr.2013.08.011
  • Peer Reviewed
• [Journal Article] Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity. (2014)
  • Author(s): Lu Z
  • Journal Title: Nat. Commun. Volume: 5 Pages: 3463-3463
  • DOI: 10.1038/ncomms4463
  • Peer Reviewed / Open Access
• [Journal Article] Ink4a/Arf –/– and HRAS(G12V) transform mouse mammary cells into triple-negative breast cancer containing tumorigenic CD49f – quiescent cells. (2014)
  • Author(s): Kai K
  • Journal Title: Oncogene. Volume: 33 Pages: 440-448
  • DOI: 10.1038/onc.2012.609
  • Peer Reviewed
• [Journal Article] TNF-a/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells (2014)
  • Author(s): Oshima H, Ishikawa T, Yoshida GJ, et al.
  • Journal Title: Oncogene Volume: 33 Pages: 1-10
  • DOI: 10.1038/onc.2013.356
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] TNFα promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state. (2014)
  • Author(s): Mori T
  • Journal Title: Oncogene Volume: Epub ahead of print Pages: 4236-4241
  • DOI: 10.1038/onc.2013.545
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Fgfr1-Frs2/3 Signalling Maintains Sensory Progenitors during Inner Ear Hair Cell Formation. (2014)
  • Author(s): Ono K
  • Journal Title: PLoS Genet. Volume: 10
  • DOI: 10.1371/journal.pgen.1004118
  • Peer Reviewed
• [Journal Article] Epiregulin enhances tumorigenicity activating ERK/MAPK pathway in glioblastoma. (2014)
  • Author(s): Kohsaka S
  • Journal Title: Neuro Oncol Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] EpCAM-Targeted therapy for human hepatocellular carcinoma. (2014)
  • Author(s): Katsuta E
  • Journal Title: Oncol. Rep. Volume: 21 Pages: 1133-1138
  • DOI: 10.3892/or.2013.2952
  • Peer Reviewed
• [Journal Article] Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment. (2013)
  • Author(s): Yamauchi T
  • Journal Title: Blood Volume: 121 Pages: 1316-1325
  • DOI: 10.1182/blood-2012-06-440354
  • NAID: 40019873170
  • Peer Reviewed
• [Journal Article] Prostaglandin E2 regulates murine hematopoietic stem/progenitorcells directly via EP4 receptor and indirectly through mesenchymal progenitor cells. (2013)
  • Author(s): Ikushima YM. Arai F, Hosokawa K, Toyama H, Takubo K, Furuyashiki T, Narumiya S, Suda T
  • Journal Title: Blood. Volume: 121(11) Pages: 1995-2007
  • DOI: 10.1182/blood-2012-06-437889
  • Peer Reviewed
• [Journal Article] Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. (2013)
  • Author(s): Takubo K
  • Journal Title: Cell Stem Cell. Volume: 12 Pages: 49-61
  • DOI: 10.1016/j.stem.2012.10.011
  • Peer Reviewed
• [Journal Article] FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes (2013)
  • Author(s): Arisa Hirano, Kanae Yumimoto, Ryosuke Tsunematsu, Masaki Matsumoto, Masaaki Oyama, Hiroko Kozuka-Hata, Tomoki Nakagawa, Darin Lanjakornsiripan, Keiichi I. Nakayama, and Yoshitaka Fukada
  • Journal Title: Cell Stem Cell Volume: 152 Pages: 1106-1118
  • DOI: 10.1016/j.cell.2013.01.054
  • Peer Reviewed
• [Journal Article] Ablation of fbxw7 eliminates leukemia-initiating cells by preventing quiescence. (2013)
  • Author(s): Takeishi S
  • Journal Title: Cancer Cell Volume: 23 Pages: 347-361
  • DOI: 10.1016/j.ccr.2013.01.026
  • Peer Reviewed
• [Journal Article] Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression. (2013)
  • Author(s): Reavie L
  • Journal Title: Cancer Cell Volume: 23 Pages: 347-361
  • DOI: 10.1016/j.ccr.2013.01.025
  • Peer Reviewed
• [Journal Article] Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors. (2013)
  • Author(s): Zhao H
  • Journal Title: Cancer Cell Volume: 24 Pages: 645-659
  • DOI: 10.1016/j.ccr.2013.09.021
  • Peer Reviewed
• [Journal Article] PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies. (2013)
  • Author(s): Iwanami A
  • Journal Title: Proc Natl Acad Sci Volume: 110 Pages: 4339-4344
  • DOI: 10.1073/pnas.1217602110
  • Peer Reviewed
• [Journal Article] MOZ increases p53 acetylation and premature senescence through its complex formation with PML. (2013)
  • Author(s): Rokudai S
  • Journal Title: Proc Natl Acad Sci Volume: 110 Pages: 3895-3900
  • DOI: 10.1073/pnas.1300490110
  • Peer Reviewed
• [Journal Article] Mechanism of PML nuclear body disruption in APL: PML-RARa inhibits PML oligomerization and its phosphorylation restores PML NBs. (2013)
  • Author(s): Shima Y
  • Journal Title: Cancer Res. Volume: 73 Pages: 4278-4288
  • DOI: 10.1158/0008-5472.can-12-3814
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cleary ML MLL becomes functional through intra-molecular interaction not by proteolytic processing. (2013)
  • Author(s): Yokoyama A, Ficara F, Murphy M, Meisel C, Hatanaka C, Kitabayashi I,
  • Journal Title: PLoS One Volume: 8(9)
  • DOI: 10.1371/journal.pone.0073649
  • Peer Reviewed
• [Journal Article] Acquired expression of NFATc1 downregulates E-cadherin and promotes cancer cell invasion. (2013)
  • Author(s): Oikawa T
  • Journal Title: Cancer Res. Volume: 73 Pages: 5100-5109
  • DOI: 10.1158/0008-5472.can-13-0274
  • Peer Reviewed
• [Journal Article] The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein. (2013)
  • Author(s): Kano Y
  • Journal Title: Biochem Biophys Res Commun Volume: 432 Pages: 175-181
  • DOI: 10.1016/j.bbrc.2013.01.034
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. (2013)
  • Author(s): Cai Z
  • Journal Title: Development Volume: 140 Pages: 2711-2723
  • DOI: 10.1242/dev.089987
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Visualization of stem cell features in human hepatocellular carcinoma enlightened in vivo significance of tumor-host interaction and clinical implication. (2013)
  • Author(s): Muramatsu S
  • Journal Title: Hepatology Volume: 58 Pages: 218-228
  • DOI: 10.1002/hep.26345
  • Peer Reviewed
• [Journal Article] Contrast-enhanced intraoperative ultrasonography for vascular imaging of hepatocellular carcinoma; clinical and biological significance. (2013)
  • Author(s): Sato K
  • Journal Title: Hepatology Volume: 57 Pages: 1436-1447
  • DOI: 10.1002/hep.26122
  • Peer Reviewed
• [Journal Article] The Tumor-suppressive mir-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma. (2013)
  • Author(s): Furuta M
  • Journal Title: PLOS One Volume: 8
  • DOI: 10.1371/journal.pone.0060155
  • Peer Reviewed
• [Journal Article] Engulfment of hematopoietic stem cel ls caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis (2013)
  • Author(s): Kuriyama T, Takenaka K 他12名
  • Journal Title: Blood Volume: 120巻 Pages: 4058-4067
  • DOI: 10.1182/blood-2012-02-408864
  • Peer Reviewed
• [Journal Article] Quantification of hematogones at the time of engraftment is a useful prognostic indicator in allogeneic stem cell transplantation. (2013)
  • Author(s): Shima T
  • Journal Title: Blood. Volume: 121 Pages: 840-848
  • DOI: 10.1182/blood-2012-02-409607
  • Peer Reviewed
• [Journal Article] Mitochondrial metabolism in the noncancerous liver determine the occurrence of hepatocellular carcinoma: a prospective study. (2013)
  • Author(s): Kudo A
  • Journal Title: J Gastroenterol Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] ErbB/NF-kB signaling controls mammosphere formation in human breast cancer (2012)
  • Author(s): Hinohara, K.
  • Journal Title: Proc Natl Acad Sci USA Volume: (in press) Pages: 6584-6589
  • DOI: 10.1073/pnas.1113271109
  • Peer Reviewed
• [Journal Article] Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell. (2012)
  • Author(s): Yae T, Tsuchihashi K, Ishimoto T, Motohara T, Yoshikawa M, Yoshida GJ, Wada T, Masuko T,Mogushi K, Tanaka H, Osawa T, Kanki Y, et al
  • Journal Title: Nat Commun Volume: 6;3 Pages: 883-883
  • DOI: 10.1038/ncomms1892
  • Peer Reviewed
• [Journal Article] CD45 low c-Kit high cells have hematopoietic properties in the mouse aorta-gonad-mesonephros region (2012)
  • Author(s): Ikuo Nobuhisa
  • Journal Title: Exp.Cell Res. Volume: 318 Pages: 705-715
  • DOI: 10.1016/j.yexcr.2012.01.017
  • Peer Reviewed
• [Journal Article] β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells. (2012)
  • Author(s): Satow R
  • Journal Title: Gastroenterology. Volume: 142 Pages: 572-581
  • DOI: 10.1053/j.gastro.2011.11.041
  • Peer Reviewed
• [Journal Article] Corneal antifibrotic switch identified in genetic and pharmacological deficiency of vimentin (2012)
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  • Journal Title: J.Biol.Chem Volume: 287 Pages: 989-1006
  • Peer Reviewed
• [Journal Article] Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-beta-catenin signaling pathway (2012)
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  • Journal Title: Mol.Cell.Biol Volume: 32 Pages: 501-512
  • Peer Reviewed
• [Journal Article] Proteome-wide identification of uUbiquitylation sites by conjugation of engineered lysine-less ubiquitin (2012)
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  • Peer Reviewed
• [Journal Article] Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation (2012)
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  • Journal Title: Mol.Cell.Biol Volume: 32 Pages: 590-605
  • Peer Reviewed
• [Journal Article] The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, Herceptin sensitivity and tumorigenesis (2012)
  • Author(s): Chan C.-H, et al
  • Journal Title: Cell Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] odulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells (2012)
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  • Journal Title: Cancer Research Volume: 72 Pages: 1438-1448
  • Peer Reviewed
• [Journal Article] Fibroblast growth factor-2 (Fgf2) is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma (2012)
  • Author(s): Shimizu T, et al
  • Journal Title: Molecular Cancer Research Volume: 10 Pages: 454-468
  • Peer Reviewed
• [Journal Article] Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor (2012)
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  • Journal Title: Oncogene Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Self-renewing hematopoietic stem cell is the primary target in pathogenesis ofhuman chronic lymphocytic leukemia. Cancer Cell (2011)
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  • Journal Title: Cancer Cell Volume: 20-2 Pages: 246-259
  • Peer Reviewed
• [Journal Article] The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells (2011)
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  • Peer Reviewed
• [Journal Article] Regenerating islet-derived 3-alpha is a biomarker ofgastrointestinal graft-versus-host disease (2011)
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  • Peer Reviewed
• [Journal Article] The classification of mRNA expression levels by the phosphorylation state of RNAPII CTD based on a combined genome-wide approach (2011)
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  • Journal Title: BMC Genomics Volume: 12 Pages: 516-516
  • Peer Reviewed
• [Journal Article] Different risk factors related to adenovirus- or BK virus-associated hemorrhagic cystitis following allogeneic stem cell transplantation (2011)
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  • Journal Title: Biol Blood Marrow Transplant Volume: 18-3 Pages: 458-465
  • Peer Reviewed
• [Journal Article] Clonal origin of Epstein-Barr virus (EBV)-infected T/NK-cell subpopulations in EBV-positive T/NK-cell lymphoproliferative disorders of childhood (2011)
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  • Journal Title: J Clin Virol Volume: 51-1 Pages: 31-37
  • Peer Reviewed
• [Journal Article] Role of autotransplantation in the treatment of acute promyelocytic leukemia patients in remission : Fukuoka BMT Group observations and a literature review (2011)
  • Author(s): Kamimura T, et al
  • Journal Title: Bone Marrow Transplant Volume: 46-6 Pages: 820-826
  • Peer Reviewed
• [Journal Article] miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27kip1, KPC1, and SOCS-1 (2011)
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  • Peer Reviewed
• [Journal Article] Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells (2011)
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  • Peer Reviewed
• [Journal Article] Fbxw7beta resides in the endoplasmic reticulum membrane and protects cells from oxidative stress (2011)
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  • Journal Title: Cancer Sci Volume: 102 Pages: 749-755
  • Peer Reviewed
• [Journal Article] Proteome of ubiquitin/MVB pathway : possible involvement of iron-induced ubiquitylation of transferrin receptor in lysosomal degradation (2011)
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  • Journal Title: Genes Cells Volume: 16 Pages: 448-466
  • Peer Reviewed
• [Journal Article] Functional analyses of the activation loop of phototropin2 in Arabidopsis (2011)
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  • Journal Title: Plant Physiol Volume: 156 Pages: 117-128
  • Peer Reviewed
• [Journal Article] Impaired ovarian development and reduced fertility in female mice deficient in Skp2 (2011)
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  • Journal Title: J.Anat Volume: 218 Pages: 668-677
  • Peer Reviewed
• [Journal Article] Regulation of APC/C(Cdc20) activity by RASSF1A-APC/C(Cdc20) circuitry (2011)
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  • Journal Title: Oncogene Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Four mood stabilizers commonly induce FEZ1 expression in human astrocytes (2011)
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  • Journal Title: Bipolar Disord Volume: 13 Pages: 486-499
  • Peer Reviewed
• [Journal Article] p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cellquiescence through interactions with Hsc70 (2011)
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  • Journal Title: Cell Stem Cell Volume: 9 Pages: 247-261
  • Peer Reviewed
• [Journal Article] p57 is required for quiescence and maintenance of adult hematopoietic stem cells (2011)
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  • Journal Title: Cell Stem Cell Volume: 9 Pages: 262-271
  • Peer Reviewed
• [Journal Article] The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo (2011)
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  • Journal Title: Cell Metab Volume: 14 Pages: 339-351
  • Peer Reviewed
• [Journal Article] Deregulation of the p57-E2F1-p53 axis results in nonobstructive hydrocephalus and cerebellar malformation in mice (2011)
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  • Journal Title: Mol.Cell.Biol Volume: 31 Pages: 4176-4192
  • Peer Reviewed
• [Journal Article] TRIM8 regulates Nanog via Hsp90beta-mediated nuclear translocation of STAT3 in embryonic stem cells (2011)
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  • Journal Title: Biochim.Biophys.Acta Volume: 1813 Pages: 1784-1792
  • Peer Reviewed
• [Journal Article] Deficient p27 phosphorylation at serine 10 increases macrophage foam cell formation and aggravates atherosclerosis through a proliferation-independent mechanism (2011)
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  • Journal Title: Arterioscler.Thromb.Vasc.Biol Volume: 31 Pages: 2455-2463
  • Peer Reviewed
• [Journal Article] Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation (2011)
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  • Journal Title: Mol.Biol.Cell Volume: 22 Pages: 4602-4620
  • Peer Reviewed
• [Journal Article] The SKP2 E3 Ligase regulates basal homeostasis and stress-induced regeneration of hematopoietic stem cells (2011)
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  • Journal Title: Blood Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] The pathophysiological role of the PKCdelta pathway in the intervertebral disc : In vitro, ex vivo and in vivo studies (2011)
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  • Journal Title: Arthritis Rheuma Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Rodriguez-Puebla, M.L. : Skp2 is necessary for Myc-induced keratinocyte proliferation but dispensable for Myc oncogenic activity in the oral epithelium (2011)
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  • Journal Title: Am.J.Pathol Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere independent mechanism (2011)
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  • Journal Title: Blood Volume: 117 Pages: 4169-4180
  • DOI: 10.1182/blood-2010-08-297390
  • Peer Reviewed
• [Journal Article] Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero (2011)
  • Author(s): Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Sano K, Murakami M, Ema M, Omatsu Y, Takahashi S, Nagasawa T, Shibuya M, Okano H, Suda T
  • Journal Title: J. Exp. Med Volume: 208 Pages: 949-960
  • DOI: 10.1084/jem.20102187
  • Peer Reviewed
• [Journal Article] Bone marrow-derived cells serve : as pro-angiogenic macrophages but not endothelial cells in wound healing (2011)
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  • Journal Title: Blood Volume: 117 Pages: 5264-5272
  • Peer Reviewed
• [Journal Article] p57^<Kip2> and p27^<Kip1> cooperate to maintain hematopoietic stem cell quiescence through interaction with Hsc70 (2011)
  • Author(s): Zou P, et al
  • Journal Title: Cell Stem Cell Volume: 9 Pages: 247-261
  • DOI: 10.1016/j.stem.2011.07.003
  • Peer Reviewed
• [Journal Article] Osteoclasts are dispensable for haematopoietic stem cell maintenance and mobilization (2011)
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  • DOI: 10.1084/jem.20101890
  • Peer Reviewed
• [Journal Article] Metabolic regulation of hematopoietic stem cells in the hypoxic niche (2011)
  • Author(s): Suda T, et al
  • Journal Title: Cell Stem Cell Volume: 9 Pages: 298-310
  • DOI: 10.1016/j.stem.2011.09.010
  • Peer Reviewed
• [Journal Article] Identification of a yolk sac cell population with hematopoietic activity in view of CD45/c-Kit expression (2011)
  • Author(s): Shoutarou Yamasaki
  • Journal Title: Develop. Growth Differ Volume: 53 Pages: 870-877
  • DOI: 10.1111/j.1440-169x.2011.01293.x
  • NAID: 10030403633
  • Peer Reviewed
• [Journal Article] アストロサイトの発生・分化 (2011)
  • Author(s): 鹿川哲史
  • Journal Title: Clinical Neuroscience Volume: 29 Pages: 1239-1242
• [Journal Article] The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells (2011)
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  • Peer Reviewed
• [Journal Article] Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine (2011)
  • Author(s): Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito TI, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, Chiba S
  • Journal Title: Blood Volume: 117(1) Pages: 128-34
  • NAID: 120007137632
  • Peer Reviewed
• [Journal Article] Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7&alpha ; overexpression (2011)
  • Author(s): Iriuchishima H, Takubo K, Matsuoka S, Onoyama I, Nakayama KI, Nojima Y, Suda T
  • Journal Title: Blood Volume: 117(8) Pages: 2373-7
  • Peer Reviewed
• [Journal Article] Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip1 (2011)
  • Author(s): Katagiri K, Ueda Y, Tomiyama T, Yasuda K, Toda Y, Ikehara S, Nakayama KI, Kinashi T
  • Journal Title: Immunity Volume: 34(1) Pages: 24-38
  • Peer Reviewed
• [Journal Article] UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53 (2011)
  • Author(s): Wu H, Pomeroy SL, Ferreira M, Teider N, Mariani J, Nakayama KI, Hatakeyama S, Tron VA, Saltibus LF, Spyracopoulos L, Leng RP
  • Journal Title: Nat Med Volume: 17(3) Pages: 347-55
  • Peer Reviewed
• [Journal Article] SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction (2011)
  • Author(s): Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, De Pinho RA, Wei W
  • Journal Title: Nature Volume: 471(7336) Pages: 104-9
  • Peer Reviewed
• [Journal Article] Fbxw7 controls lipid metabolism and cell fate decision in the liver in mice (2011)
  • Author(s): Onoyama I, Suzuki A, Matsumoto A, Tomita K, Katagiri H, Oike Y, Nakayama K, Nakayama KI
  • Journal Title: J Clin Invest Volume: 121(1) Pages: 342-354
  • Peer Reviewed
• [Journal Article] CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc(-) and Thereby Promotes Tumor Growth (2011)
  • Author(s): Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, Oshima M, Ikeda T, Asaba R, Yagi H, Masuko T, Shimizu T, Ishikawa T, Kai K, Takahashi E, Imamura Y, Baba Y, Ohmura M, Suematsu M, Baba H, Saya H
  • Journal Title: Cancer Cell Volume: 19(3) Pages: 387-400
  • Peer Reviewed
• [Journal Article] NKX2.2 suppresses self-renewal of glioma-initiating cells (2011)
  • Author(s): Muraguchi T, Tanaka S, Yamada D, Tamase A, Nakada M, Nakamura H, Hoshii T, Ooshio T, Tadokoro Y, Naka K, Ino Y, Todo T, Kuratsu J, Saya H, Hamada J, Hirao A
  • Journal Title: Cancer Res Volume: 71(3) Pages: 1135-45
  • Peer Reviewed
• [Journal Article] TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells (2010)
  • Author(s): Kikushige Y, Shima T, Takayanagi SI, Urata S, Miyamoto T, Iwasaki H, Takenaka K, Teshima T, Tanaka T, Inagaki Y, Akashi K
  • Journal Title: Cell Stem Cell Volume: 7(6) Pages: 708-717
  • Peer Reviewed
• [Journal Article] JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation (2010)
  • Author(s): Oku S, Takenaka K, Kuriyama T, Shide K, Kumano T, Kikushige Y, Urata S, Yamauchi T, Iwamoto C, Shimoda HK, Miyamoto T, Nagafuji K, Kishimoto J, Shimoda K, Akashi K
  • Journal Title: Br J Haematol Volume: 150(3) Pages: 334-344
  • Peer Reviewed
• [Journal Article] Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice (2010)
  • Author(s): Asakura S, Hashimoto D, Takashima S, Sugiyama H, Maeda Y, Akashi K, Tanimoto M, Teshima T
  • Journal Title: J Clin Invest Volume: 120(7) Pages: 2370-2378
  • NAID: 130004505744
  • Peer Reviewed
• [Journal Article] Enhanced expression of PCAF endows apoptosis resistance in cisplatin-resistant cells (2010)
  • Author(s): Hirano G, Izumi H, Kidani A, Yasuniwa Y, Han B, Kusaba H, Akashi K, Kuwano M, Kohno K
  • Journal Title: Mol Cancer Res Volume: 8(6) Pages: 864-872
  • Peer Reviewed
• [Journal Article] Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1 (2010)
  • Author(s): Parmar K, Kim J, Sykes SM, Shimamura A, Stuckert P, Zhu K, Hamilton A, Deloach MK, Kutok JL, Akashi K, Gilliland DG, D'andrea A
  • Journal Title: Stem Cells Volume: 28(7) Pages: 1186-1195
  • Peer Reviewed
• [Journal Article] Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia (2010)
  • Author(s): Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S
  • Journal Title: Blood Volume: 115(14) Pages: 2872-2881
  • Peer Reviewed
• [Journal Article] Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress (2010)
  • Author(s): Hayakawa H, Fujikane A, Ito R, Matsumoto M, Nakayama KI, Sekiguchi M
  • Journal Title: Biochem Biophys Res Commun Volume: 403(2) Pages: 220-4
  • Peer Reviewed
• [Journal Article] Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1^<+/-> mice (2010)
  • Author(s): Wang H, Bauzon F, Ji P, Xu X, Sun D, Locker J, Sellers RS, Nakayama K, Nakayama KI, Cobrinik D, Zhu L
  • Journal Title: Nature Genet Volume: 42 Pages: 83-88
  • Peer Reviewed
• [Journal Article] KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development (2010)
  • Author(s): Tsukada Y, Ishitani T, Nakayama KI
  • Journal Title: Genes Dev Volume: 24 Pages: 432-437
  • Peer Reviewed
• [Journal Article] Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis (2010)
  • Author(s): Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY, Wu J, Nakayama KI, Kang HY, Huang HY, Hung MC, Pandolfi PP, Lin HK
  • Journal Title: Nature Cell Biol Volume: 12 Pages: 457-467
  • Peer Reviewed
• [Journal Article] Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence (2010)
  • Author(s): Lin HK, Chen Z, Wang G, Nardella C, Lee SW, Chan CH, Yang WL, Wang J, Egia A, Nakayama KI, Cordon-Cardo C, Teruya-Feldstein J, Pandolfi PP
  • Journal Title: Nature Volume: 464 Pages: 374-379
  • Peer Reviewed
• [Journal Article] Comparative Analysis of Human Src-family Kinase Substrate Specificity in vitro (2010)
  • Author(s): Takeda H, Kawamura Y, Miura A, Mori M, Wakamatsu A, Yamamoto JI, Isogai T, Matsumoto M, Nakayama KI, Natsume T, Nomura N, Goshima N
  • Journal Title: J Proteome Res Volume: 9(11) Pages: 5982-93
  • Peer Reviewed
• [Journal Article] In vitro histone demethylase assay (2010)
  • Author(s): Tsukada Y, Nakayama KI
  • Journal Title: Cold Spring Harb Protoc Volume: 2010(10)
  • Peer Reviewed
• [Journal Article] Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4 (2010)
  • Author(s): Benirschke RC, Thompson JR, Nomine Y, Wasielewski E, Juranic N, Macura S, Hatakeyama S, Nakayama KI, Botuyan MV, Mer G
  • Journal Title: Structure Volume: 18 Pages: 955-965
  • Peer Reviewed
• [Journal Article] Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression : role of protein phosphatases (2010)
  • Author(s): Ma H, Yu L, Byra EA, Hu N, Kitagawa K, Nakayama KI, Kawamoto T, Ren J
  • Journal Title: J Mol Cell Cardiol Volume: 49 Pages: 322-329
  • Peer Reviewed
• [Journal Article] TRIM8 modulates STAT3 activity through negative regulation of PIAS3 (2010)
  • Author(s): Okumura F, Matsunaga Y, Katayama Y, Nakayama KI, Hatakeyama S
  • Journal Title: J Cell Sci Volume: 123 Pages: 2238-2245
  • Peer Reviewed
• [Journal Article] GABA(A) receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout mice (2010)
  • Author(s): Mizokami A, Tanaka H, Ishibashi H, Umebayashi H, Fukami K, Takenawa T, Nakayama KI, Yokoyama T, Nabekura J, Kanematsu T, Hirata M
  • Journal Title: J Neurochem Volume: 114 Pages: 302-310
  • Peer Reviewed
• [Journal Article] Phosphorylation of the chromodomain changes the binding specificity of Cbx2 for methylated histone H3 (2010)
  • Author(s): Hatano A, Matsumoto M, Higashinakagawa T, Nakayama KI
  • Journal Title: Biochem Biophys Res Commun Volume: 397 Pages: 93-99
  • Peer Reviewed
• [Journal Article] Nedd4-interacting protein 2, a short half-life membrane protein degraded in lysosomes, negatively controls down-regulation of connexin43 (2010)
  • Author(s): Ohzono C, Etoh S, Matsumoto M, Nakayama KI, Hirota Y, Tanaka Y, Fujita H
  • Journal Title: Biol Pharm Bull Volume: 33 Pages: 951-957
  • Peer Reviewed
• [Journal Article] Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity (2010)
  • Author(s): Susaki E, Kaneko-Oshikawa C, Miyata K, Tabata M, Yamada T, Oike Y, Katagiri H, Nakayama KI
  • Journal Title: J Biol Chem Volume: 285 Pages: 15538-15547
  • Peer Reviewed
• [Journal Article] Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer : clinical significance (2010)
  • Author(s): Iwatsuki M, Mimori K, Ishii H, Yokobori T, Takatsuno Y, Sato T, Toh H, Onoyama I, Nakayama KI, Baba H, Mori M
  • Journal Title: Int J Cancer Volume: 126 Pages: 1828-1837
  • Peer Reviewed
• [Journal Article] Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts (2010)
  • Author(s): Masuda K, Ishikawa Y, Onoyama I, Unno M, de Alboran IM, Nakayama KI, Nakayama K
  • Journal Title: Oncogene Volume: 29 Pages: 1798-1809
  • Peer Reviewed
• [Journal Article] Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis (2010)
  • Author(s): Old JB, Kratzat S, Hoellein A, Graf S, Nilsson JA, Nilsson L, Nakayama KI, Peschel C, Clevel, JL, Keller UB
  • Journal Title: Mol Cancer Res Volume: 8 Pages: 353-362
  • Peer Reviewed
• [Journal Article] Acquisition of G□ state by CD34-positive cord blood cells after bone marrow transplantation (2010)
  • Author(s): Shima H, Takubo K, Tago N, Iwasaki H, Arai F, Takahashi T, Suda T
  • Journal Title: Exp Hematol Volume: 38(12) Pages: 1231-40
  • Peer Reviewed
• [Journal Article] TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool (2010)
  • Author(s): Nakajima H, Ito M, Smookler DS, Shibata F, Fukuchi Y, Morikawa Y, Ikeda Y, Arai F, Suda T, Khokha R, Kitamura T
  • Journal Title: Blood Volume: 116(22) Pages: 4474-82
  • Peer Reviewed
• [Journal Article] Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1 (2010)
  • Author(s): Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D
  • Journal Title: Nature Volume: 466(7309) Pages: 941-6
  • Peer Reviewed
• [Journal Article] c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis (2010)
  • Author(s): Shimizu T, Ishikawa T, Sugihara E, Kuninaka S, Miyamoto T, Mabuchi Y, Matsuzaki Y, Tsunoda T, Miya F, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Kawai A, Ichikawa H, Hasegawa T, Okada S, Ito T, Ikeda Y, Suda T, Saya H
  • Journal Title: Oncogene Volume: 29(42) Pages: 5687-99
  • Peer Reviewed
• [Journal Article] Hematopoietic Stem Cells and Their Niche (2010)
  • Author(s): Iwasaki H, Suda T
  • Journal Title: Hematopoietic Stem Cell Biology Pages: 37-55
  • Peer Reviewed
• [Journal Article] Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells (2010)
  • Author(s): Kobayashi I, Ono H, Moritomo T, Kano K, Nakanishi T, Suda T
  • Journal Title: Blood Volume: 115 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver (2010)
  • Author(s): Iwasaki H, Arai F, Kubota Y, Suda T
  • Journal Title: Blood Volume: 116 Pages: 544-553
  • Peer Reviewed
• [Journal Article] Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors (2010)
  • Author(s): Fujii M, Kanematsu T, Ishibashi H, Fukami K, Takenawa T, Nakayama KI, Moss SJ, Nabekura J, Hirata M
  • Journal Title: J Biol Chem Volume: 285 Pages: 4837-4846
  • Peer Reviewed
• [Journal Article] Fbxo45, a novel ubiquitin ligase, regulates synaptic activity (2010)
  • Author(s): Tada H, Okano HJ, Takagi H, Shibata S, Yao I, Matsumoto M, Saiga T, Nakayama KI, Kashima H, Takahashi T, Setou M, Okano H
  • Journal Title: J Biol Chem Volume: 285 Pages: 3840-3849
  • Peer Reviewed
• [Journal Article] Regulation of osteoclast apoptosis by bcl-2 family protein bim and caspase-3 (2010)
  • Author(s): Tanaka S, Wakeyama H, Akiyama T, Takahashi K, Amano H, Nakayama KI, Nakamura K
  • Journal Title: Adv Exp Med Biol Volume: 658 Pages: 111-116
  • Peer Reviewed
• [Journal Article] Cadherin-based adhesion is a potential target for niche manipulation to protect hematopoietic stem cells in adult bone marrow (2010)
  • Author(s): Hosokawa K, Arai F, Yoshihara H, Iwasaki H, Hembree M, Yin T, Nakamura N, Gomei Y, Takubo K, Shiama H, Matsuoka S, Li L, Suda T
  • Journal Title: Cell Stem Cell Volume: 6 Pages: 194-8
  • Peer Reviewed
• [Journal Article] Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells (2010)
  • Author(s): Hosokawa K, Arai F, Yoshihara H, Iwasaki H, Nakamura Y, Gomei Y, Suda T
  • Journal Title: Blood Volume: 116 Pages: 554-563
  • Peer Reviewed
• [Journal Article] Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells (2010)
  • Author(s): Nakamura Y, Arai F, Iwasaki H, Hosokawa K, Kobayashi I, Gomei Y, Matsumoto Y, Yoshihara H, Suda T
  • Journal Title: Blood Volume: 116 Pages: 1422-1432
  • Peer Reviewed
• [Journal Article] Regulation of the HIF-1alpha level is essential for hematopoietic stem cells (2010)
  • Author(s): Takubo K, Goda N, Yamada W, Iriuchishima H, Ikeda E, Kubota Y, Shima H, Johnson RS, Hirao A, Suematsu M, Suda T
  • Journal Title: Cell Stem Cell Volume: 7 Pages: 391-402
  • Peer Reviewed
• [Journal Article] von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina (2010)
  • Author(s): Kurihara T, Kubota Y, Ozawa Y, Ta kubo K, Noda K, Simon MC, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H
  • Journal Title: Development Volume: 137 Pages: 1563-1571
  • Peer Reviewed
• [Journal Article] The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone hemostasis (2010)
  • Author(s): Miyauchi Y, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, Miyamoto K, Hao W, Yoshida S, Morioka H, Chiba K, Kato S, Tokuhisa T, Saitou M, Toyama Y, Suda T, Miyamoto T
  • Journal Title: J Exp Med Volume: 207 Pages: 751-762
  • Peer Reviewed
• [Journal Article] Gene expression phenotypes for vascular invasiveness of hepatocellular carcinomas (2010)
  • Author(s): Tanaka S, Mogushi K, Yasen M, Noguchi N, Kudo A, Nakamura N, Ito K, Miki Y, Inazawa J, Tanaka H, Arii S
  • Journal Title: Surgery Volume: 147(3) Pages: 405-414
  • Peer Reviewed
• [Journal Article] The selective Aurora B kinase inhibitor AZD1152 as a novel treatment for hepatocellular carcinoma (2010)
  • Author(s): Aihara A, Tanaka S, Yasen M, Matsumura S, Mitsunori Y, Murakata A, Noguchi N, Kudo A, Nakamura N, Ito K, Arii S
  • Journal Title: Journal of Hepatology Volume: 52(1) Pages: 63-71
  • Peer Reviewed
• [Journal Article] miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma (2010)
  • Author(s): Furuta M, Kozaki KI, Tanaka S, Arii S, Imoto I, Inazawa J
  • Journal Title: Carcinogenesis Volume: 31(5) Pages: 766-76
  • Peer Reviewed
• [Journal Article] Analogy between sphere forming ability and stemness of human hepatoma cells (2010)
  • Author(s): Uchida U, Tanaka S, Aihara A, Adikrisna R, Yoshitake K, Matsumura S, Mitsunori Y, Murakata A, Noguchi N, Irie K, Kudo A, Nakamura N, Lai PB, Arii S
  • Journal Title: Oncology Reports Volume: 24 Pages: 1147-51
  • Peer Reviewed
• [Journal Article] CD13 is a therapeutic target in human liver cancer stem cells (2010)
  • Author(s): Haraguchi N, Ishii H, Mimori K, Tanaka F, Ohkuma M, Kim HM, Akita H, Takiuchi D, Hatano H, Nagano H, Barnard GF, Doki Y, Mori M
  • Journal Title: J Clin Invest Volume: 120(9) Pages: 3326-3339
  • Peer Reviewed
• [Journal Article] Defined factors induce reprogramming of gastrointestinal cancer cells (2010)
  • Author(s): Miyoshi N, Ishii H, Nagai K, Hoshino H, Mimori K, Tanaka F, Nagano H, Sekimoto M, Doki Y, Mori M
  • Journal Title: Proc Natl Acad Sci USA Volume: 107(1) Pages: 40-45
  • Peer Reviewed
• [Journal Article] PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2 (2010)
  • Author(s): Aikawa Y, Katsumoto T, Zhang P, Shima H, Shino M, Terui K, Ito E, Ohno H, Stanley ER, Singh H, Tenen DG, Kitabayashi I
  • Journal Title: Nat Med Volume: 16(5) Pages: 580-585
  • Peer Reviewed
• [Journal Article] A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription (2010)
  • Author(s): Yokoyama A, Lin M, Naresh A, Kitabayashi I, Cleary ML
  • Journal Title: Cancer Cell Volume: 17(2) Pages: 198-212
  • Peer Reviewed
• [Journal Article] Mad2 inhibits the mitotic kinesin MKlp2 (2010)
  • Author(s): Lee SH, McCormick F, Saya H
  • Journal Title: J Cell Biol Volume: 191(6) Pages: 1069-77
  • Peer Reviewed
• [Journal Article] Identification of CD44 as a cell surface marker for Muller glia precursor cells (2010)
  • Author(s): Shinoe T, Kuribayashi H, Saya H, Seiki M, Aburatani H, Watanabe S
  • Journal Title: J Neurochem Volume: 115(6) Pages: 1633-42
  • Peer Reviewed
• [Journal Article] The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation (2010)
  • Author(s): Naoe H, Araki K, Nagano O, Kobayashi Y, Ishizawa J, Chiyoda T, Shimizu T, Yamamura K, Sasaki Y, Saya H, Kuninaka S
  • Journal Title: Mol Cell Biol Volume: 30(16) Pages: 3994-4005
  • Peer Reviewed
• [Journal Article] Proteome profiling reveals gender differences in the composition of human serum (2010)
  • Author(s): Miike K, Aoki M, Yamashita R, Takegawa Y, Saya H, Miike T, Yamamura K
  • Journal Title: Proteomics Volume: 10(14) Pages: 2678-91
  • Peer Reviewed
• [Journal Article] Experimental therapies : Investigator-initiated cancer trials with INDs for approval in Japan (2010)
  • Author(s): Imamura CK, Takebe N, Nakamura S, Saya H, Ueno NT
  • Journal Title: Nat Rev Clin Oncol Volume: 7(3) Pages: 127-8
  • Peer Reviewed
• [Journal Article] PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties (2010)
  • Author(s): Nagahama Y, Ueno M, Miyamoto S, Morii E, Minami T, Mochizuki N, Saya H, Takakura N
  • Journal Title: Cancer Res Volume: 70(3) Pages: 1215-24
  • Peer Reviewed
• [Journal Article] Osteopontin-mediated enhanced hyaluronan binding induces multidrug resistance in mesothelioma cells (2010)
  • Author(s): Tajima K, Ohashi R, Sekido Y, Hida T, Nara T, Hashimoto M, Iwakami S, Minakata K, Yae T, Takahashi F, Saya H, Takahashi K
  • Journal Title: Oncogene Volume: 29(13) Pages: 1941-51
  • Peer Reviewed
• [Journal Article] Myristoylated alanine-rich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase C-dependent pathway (2010)
  • Author(s): Techasen A, Loilome W, Namwat N, Takahashi E, Sugihara E, Puapairoj A, Miwa M, Saya H, Yongvanit P
  • Journal Title: Cancer Sci Volume: 101(3) Pages: 658-65
  • NAID: 10026589391
  • Peer Reviewed
• [Journal Article] CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis (2010)
  • Author(s): Ishimoto T, Oshima H, Oshima M, Kai K, Torii R, Masuko T, Baba H, Saya H, Nagano O
  • Journal Title: Cancer Sci Volume: 101(3) Pages: 673-8
  • Peer Reviewed
• [Journal Article] Decreased expression of neurofibromin contributes to epithelial-mesenchymal transition in neurofibromatosis type 1 (2010)
  • Author(s): Arima Y, Hayashi H, Kamata K, Goto TM, Sasaki M, Kuramochi A, Saya H
  • Journal Title: Exp Dermatol Volume: 19(8)
  • Peer Reviewed
• [Journal Article] Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD 44-moesin interaction (2010)
  • Author(s): Takahashi E, Nagano O, Ishimoto T, Yae T, Suzuki Y, Shinoda T, Nakamura S, Niwa S, Ikeda S, Koga H, Tanihara H, Saya H
  • Journal Title: J Biol Chem Volume: 285(6) Pages: 4060-73
  • Peer Reviewed
• [Journal Article] Breast cancer stem cells (2010)
  • Author(s): Kai K, Arima Y, Kamiya T, Saya H
  • Journal Title: Breast Cancer Volume: 17(2) Pages: 80-5
  • NAID: 10027255296
  • Peer Reviewed
• [Journal Article] Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks (2010)
  • Author(s): Tabu K, Kimura T, Sasai K, Wang L, Bizen N, Nishihara H, Taga T, Tanaka S
  • Journal Title: Mol Cancer Volume: 9 Pages: 39-53
  • Peer Reviewed
• [Journal Article] Integrated quantitative analysis of the phosphoproteome and transcriptome in tamoxifen-resistant breast cancer (2010)
  • Author(s): Oyama M, Nagashima T, Suzuki T, Kozuka-Hata H, Yumoto N, Shiraishi Y, Ikeda K, Kuroki Y, Gotoh N, Ishida T, Inoue S, Kitano H, Okada-Hatakeyama M
  • Journal Title: J.Biol.Chem Volume: 286 Pages: 818-829
  • Peer Reviewed
• [Journal Article] Phosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling (2010)
  • Author(s): Tasaki S, Nagasaki M, Kozuka-Hata H, Semba K, Gotoh N, Hattori S, Inoue J, Yamamoto T, Miyano S, Sugano S, Oyama M
  • Journal Title: PLoS ONE Volume: 5(11)
  • Peer Reviewed
• [Journal Article] Collocation-based sparse estimation for constructing dynamic gene networks (2010)
  • Author(s): Shimamura T, Imoto S, Nagasaki M, Yamauchi M, Yamaguchi R, Fujita A, Tamada Y, Gotoh N, Miyano S
  • Journal Title: Genome Inform Volume: 24 Pages: 164-178
  • Peer Reviewed
• [Journal Article] Inflammatory signaling pathways in self-renewing breast cancer stem cells (2010)
  • Author(s): Hinohara K, Gotoh N
  • Journal Title: Curr Opin Pharmacol Volume: 10 Pages: 650-654
  • Peer Reviewed
• [Journal Article] FGF-FRS2a-Erk axis controls a self-renewal target Hes1 and growth of neural stem/progenitor cells (2010)
  • Author(s): Sato T, Shimazaki T, Naka H, Fukami S, Okano H, Lax I, Schlessinger J, Gotoh N
  • Journal Title: Stem Cells Volume: 28 Pages: 1661-1672
  • Peer Reviewed
• [Journal Article] A state space representation of VAR models with sparse learning for dynamic gene networks (2010)
  • Author(s): Kojima K, Yamaguchi R, Imoto S, Yamauchi M, Nagasaki M, Yoshida R, Shimamura T, Ueno K, Higuchi T, Gotoh N, Miyano S
  • Journal Title: Genome Inform Volume: 22 Pages: 56-68
  • Peer Reviewed
• [Journal Article] FRS2b, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor for EGF receptor family members via ERK binding (2010)
  • Author(s): Iejima D, Minegichi Y, Takenaka K, Siswanto A, Watanabe M, Huang L, Watanabe T, Tanaka F, Kuroda M, Gotoh N
  • Journal Title: Oncogene Volume: 29 Pages: 3087-3099
  • Peer Reviewed
• [Journal Article] Gene set enrichment analysis provides insight into novel signaling pathways in breast cancer stem cells (2010)
  • Author(s): Murohashi M, Hinohara K, Kuroda M, Isagawa T, Tsuji S, Kobayashi S, Umezawa K, Tojo A, Aburatani H, Gotoh N
  • Journal Title: British J Cancer Volume: 102 Pages: 206-212
  • Peer Reviewed
• [Journal Article] An FGF4-FRS2a-Cdx2 axis-in trophoblast stem cells induces BMP4 to regulate proper growth of early mouse embryos (2010)
  • Author(s): Murohashi M, Nakamura T, Tanaka S, Ichise T, Yoshida N, Yamamoto T, Shibuya M, Schlessinger J, Gotoh N
  • Journal Title: Stem Cells Volume: 28 Pages: 113-121
  • Peer Reviewed
• [Journal Article] Clonal origin of Epstein-Barr virus (EBV)-infected T/NK-cell subpopulations in EBV-positive T/NK-cell lymphoproliferative disorders of childhood
  • Author(s): Ohga S, Ishimura M, Yoshimoto G, Miyamoto T, Takada H, Tanaka T, Ohshima K, Ogawa Y, Imadome KI, Abe Y, Akashi K, Hara T
  • Journal Title: J Clin Virol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Fbxw7-dependent degradation of Notch is required for control of stemness and neuronal-glial differentiation in neural stem cells
  • Author(s): Matsumoto A, Onoyama I, Sunabori, T, Kageyama R, Okano H, Nakayama KI
  • Journal Title: J Biol Chem Volume: (in press)
  • Peer Reviewed
• [Journal Article] MiR-221 and miR-155 regulate human dendritic cell development, apoptosis and IL-12 production through targeting of p27kip1, KPC1 and SOCS-1
  • Author(s): Lu C, Huang X, Zhang X, Roensch K, Cao Q, Nakayama KI, Blazar BR, Zeng Y, Zhou X
  • Journal Title: Blood Volume: (in press)
  • Peer Reviewed
• [Journal Article] Bone marrow-derived cells serve as pro-angiogenic macrophages but not endothelial cells in wound healing
  • Author(s): Okuno Y, Kishi K, Suda T, Kubota Y
  • Journal Title: Blood Volume: (in press)
  • Peer Reviewed
• [Journal Article] Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells
  • Author(s): Kinoshita T, Nagamatsu G, Kosaka T, Takubo K, Hotta A, Ellis J, Suda T
  • Journal Title: Biochem Biophys Res Commun Volume: (in press)
  • Peer Reviewed
• [Journal Article] Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere independent mechanism
  • Author(s): Nitta E, Yamashita M, Hosokawa K, Xian M, Takubo K, Arai F, Nakada S, Suda T
  • Journal Title: Blood Volume: (in press)
  • Peer Reviewed
• [Journal Article] A germ cell specific gene, Prmt5 works as somatic cell reprogramming
  • Author(s): Nagamatsu G, Kosaka T, Kawasumi M, Kinoshita T, Takubo K, Akiyama H, Sudo T, Kobayashi T, Oya M, Suda T
  • Journal Title: J Biol.Chem Volume: (in press)
  • Peer Reviewed
• [Journal Article] Gene expression signature of the gross morphology in hepatocellular carcinoma
  • Author(s): Murakata A, Tanaka S, Mogushi K, Yasen M, Noguchi N, Irie T, Kudo A, Nakamura N, Tanaka H, Arii S
  • Journal Title: Annals of Surgery Volume: (in press)
  • Peer Reviewed
• [Journal Article] The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress
  • Author(s): Ishizawa J, Kuninaka S, Sugihara E, Naoe H, Kobayashi Y, Chiyoda T, Ueki A, Araki K, Yamamura KI, Matsuzaki Y, Nakajima H, Ikeda Y, Okamoto S, Saya H
  • Journal Title: Cancer Sci. Volume: (in press)
  • NAID: 10029293305
  • Peer Reviewed
• [Journal Article] FRS2
  • Author(s): Gotoh N
  • Journal Title: Encyclopedia of Signaling Molecules Volume: (in press)
  • Peer Reviewed
• [Journal Article] Possible signaling pathways in cancer stem cells in breast cancer
  • Author(s): Gotoh N
  • Journal Title: Cancer Stem Cells Volume: (in press)
  • Peer Reviewed
• [Presentation] TIM-3 and its ligand, galectin-9, constitute an autocrine loop critical for development of human myeloid leukemia stem cells. (2016)
  • Author(s): Koichi Akashi
  • Organizer: JSPS-NUS Joint Symposium New Horizons in Normal and Cancer Stem Cell Research
  • Place of Presentation: Singapore
  • Year and Date: 2016-01-14
  • Int'l Joint Research / Invited
• [Presentation] TIM-3 and its ligand, galectin-9 constitute an autocrine loop to maintain stem cells in most human myeloid malignancies. (2015)
  • Author(s): Koichi Akashi
  • Organizer: 2015 ISEH Annual Meeting
  • Place of Presentation: Kyoto
  • Year and Date: 2015-09-17
  • Int'l Joint Research / Invited
• [Presentation] 骨髄系白血病幹細胞における共通の鍵分子TIM-3とその臨床応用 (2015)
  • Author(s): 赤司浩一
  • Organizer: 第39回阿蘇シンポジウム
  • Place of Presentation: 阿蘇
  • Year and Date: 2015-08-01
  • Invited
• [Presentation] TIM-3 Signaling and Human Myeloid Leukemia Stem Cell Development (2015)
  • Author(s): Koichi Akashi
  • Organizer: KEYSTONE SYMPOSIA
  • Place of Presentation: Keystone, Colorado USA
  • Year and Date: 2015-02-26
• [Presentation] 白血病幹細胞研究のすゝめ (2014)
  • Author(s): 赤司 浩一
  • Organizer: 第76回日本血液学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-11-02
• [Presentation] 造血器腫瘍幹細胞 (2014)
  • Author(s): 赤司 浩一
  • Organizer: 第101回近畿血液学地方会
  • Place of Presentation: 大阪
  • Year and Date: 2014-06-28
• [Presentation] TIM-3, as a Target for Eradication of Cancer Stem Cells (2014)
  • Author(s): Koichi Akashi
  • Organizer: The Uehara Memorial Foundation Symposium
  • Place of Presentation: 東京
  • Year and Date: 2014-06-17
• [Presentation] 造血器腫瘍幹細胞 (2014)
  • Author(s): 赤司 浩一
  • Organizer: 第3回日本血液学会東海地方会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-04-26
• [Presentation] Cancer Stem Cell (2014)
  • Author(s): 赤司 浩一
  • Organizer: 第87回日本内分泌学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2014-04-24
• [Presentation] Hematopoietic stem cells in the hypoxic niche (2014)
  • Author(s): Toshio Suda
  • Organizer: Keystone Symposia conference 2014: Sensing and Signaling of Hypoxia: Interfaces with Biology and Medicine
  • Place of Presentation: Colorado, USA
  • Invited
• [Presentation] Transcription Factor Regulation of Normal and Malignant Hematopoiesis (2013)
  • Author(s): Akashi K
  • Organizer: 2013USA-Japan Science Conference
  • Place of Presentation: Maui,Hawaii
  • Year and Date: 2013-03-26
  • Invited
• [Presentation] Niche regulation for hematopoietic stem cells (2013)
  • Author(s): Toshio Suda
  • Organizer: 1st Shanghai International Workshop on Stem Cells in Cancer
  • Place of Presentation: Shanghai, China
  • Invited
• [Presentation] Hematopoiesis under the stress (2013)
  • Author(s): Toshio Suda
  • Organizer: Collaborative Meeting of the European and the Spanish Societies for Gene and Cell Therapy
  • Place of Presentation: Madrid, Spain
  • Invited
• [Presentation] 悪性造血器腫瘍における癌幹細胞の病理 (2012)
  • Author(s): 赤司浩一
  • Organizer: 第71回日本癌学会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-21
  • Invited
• [Presentation] 慢性リンパ性白血病幹細胞の特性と治療応用 (2012)
  • Author(s): 赤司浩一
  • Organizer: 第10回日本臨床腫瘍学会
  • Place of Presentation: 大阪
  • Year and Date: 2012-07-28
  • Invited
• [Presentation] 造血器悪性幹細胞の成立機構 (2012)
  • Author(s): 赤司浩一
  • Organizer: 第101回日本病理学会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-26
  • Invited
• [Presentation] Hematopoietic stem cell metabolism (2012)
  • Author(s): Suda T
  • Organizer: Keystone Symposia on Molecular and Cellular Biology, The life of a Stem Cell : From Birth to Death
  • Place of Presentation: Olympic Valley, USA(招待講演)
  • Year and Date: 2012-03-14
• [Presentation] Maintenance of C6 glioma side population with stemness by the cellular and synthetic niche (2011)
  • Author(s): Kouichi Tabu
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 神奈川県
  • Year and Date: 2011-12-14
• [Presentation] Transcription factor regulation in normal and malignant hematopoiesis (2011)
  • Author(s): Koichi Akashi
  • Organizer: 米国血液学会
  • Place of Presentation: San Diego,米国
  • Year and Date: 2011-12-10
• [Presentation] 癌幹細胞の自己複製戦略 (2011)
  • Author(s): 田賀哲也
  • Organizer: 第56回日本人類遺伝学会
  • Place of Presentation: 千葉市(招待講演)
  • Year and Date: 2011-11-11
• [Presentation] Niche for hematopoietic stem cells in bone marrow (2011)
  • Author(s): Suda T
  • Organizer: The 2^<nd> Pacific Meeting for Angiogensis and Lymphangiogenesis
  • Place of Presentation: Jeju, Korea(招待講演)
  • Year and Date: 2011-10-30
• [Presentation] Glycolytic metabolism of hematopoietic stem cells (2011)
  • Author(s): Suda T
  • Organizer: 2011 Cold Spring Harbor Asia Conference : Cellular Programs and Reprogramming
  • Place of Presentation: Suzhou, China(招待講演)
  • Year and Date: 2011-10-26
• [Presentation] Control of glioma stem cells by the synthetic polymers (2011)
  • Author(s): Kouichi Tabu
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-04
• [Presentation] Role of CD44 in cancer stem cells and metastasis (2011)
  • Author(s): Saya H
  • Organizer: 8^<th> International Symposium on Minmal Residual Cancer
  • Place of Presentation: Osaka International Convention Center, Osaka
  • Year and Date: 2011-09-23
• [Presentation] Origin of leukemic stem cells (2011)
  • Author(s): Koichi Akashi
  • Organizer: ドイツ造血幹細胞学会
  • Place of Presentation: Tubingen、ドイツ
  • Year and Date: 2011-09-07
• [Presentation] The cellular and synthetic niches for C6 glioma stem cells (2011)
  • Author(s): 椨康一
  • Organizer: 平成23年度がん若手研究者ワークショップ
  • Place of Presentation: 長野県
  • Year and Date: 2011-09-02
• [Presentation] Regulation of quiescent hematopoietic stem cells (2011)
  • Author(s): Suda T
  • Organizer: ISEH 40^<th> Annual Scientific Meeting
  • Place of Presentation: Vancouver, Canada(招待講演)
  • Year and Date: 2011-08-27
• [Presentation] Regulation of quiescent hematopoietic stem cells (2011)
  • Author(s): Suda T
  • Organizer: Heidelberg-Kyoto Joint Symposium "Crossing Boundaries : Stem Cells, Materials, and Mesoscopic Sciences"
  • Place of Presentation: Heidelberg, Germany(招待講演)
  • Year and Date: 2011-07-22
• [Presentation] 神経幹細胞の分化制御シグナル (2011)
  • Author(s): 田賀哲也
  • Organizer: 第96回医工学フォーラム
  • Place of Presentation: 京都市(招待講演)
  • Year and Date: 2011-07-22
• [Presentation] 子宮体癌幹細胞形質獲得機構におけるdbpC/contrinの関与 (2011)
  • Author(s): 楠木総司
  • Organizer: 第10回日本婦人科がん分子標的研究会学術集会
  • Place of Presentation: 松江市
  • Year and Date: 2011-07-02
• [Presentation] Leukemic stem cells (2011)
  • Author(s): Koichi Akashi
  • Organizer: ヨーロッパ血液学会
  • Place of Presentation: London、英国(招待講演)
  • Year and Date: 2011-06-11
• [Presentation] Hypoxic niche for hematopoietic stem cells and cancer stem cells (2011)
  • Author(s): Suda T
  • Organizer: The 52nd Spring Meeting of the Korean Society of Hematology
  • Place of Presentation: Seoul, Korea(招待講演)
  • Year and Date: 2011-05-27
• [Presentation] Normal haematopoietic stem cells and the stem cell niche (2011)
  • Author(s): Suda T
  • Organizer: The 11^<th> International Symposium on Myelodysplastic Syndromes
  • Place of Presentation: Edinburgh, UK(招待講演)
  • Year and Date: 2011-05-19
• [Presentation] 幹細胞維持機構の考察による癌の生存戦略解明へのアプローチ (2011)
  • Author(s): 田賀哲也
  • Organizer: 第316回情報計算化学生物学会研究講演会
  • Place of Presentation: 東京都(招待講演)
  • Year and Date: 2011-04-18
• [Presentation] Role of SoxF family proteins in the maintenance of immature phenotype of hematopoietic progenitors in the aorta-gonad-mesonephros region (2011)
  • Author(s): Ikuo Nobuhisa
  • Organizer: The 9^<th> Stem Cell Research Symposium
  • Place of Presentation: Tokyo
• [Presentation] The role of cyclin D1 in inhibition of astrocyte differentiation from neural stem/progenitor cells (2011)
  • Author(s): Norihisa Bizen
  • Organizer: The 9^<th> Stem Cell Research Symposium
  • Place of Presentation: Tokyo
• [Presentation] External cues and intrinsic properties regulating neural stem cell fate (2011)
  • Author(s): Tetsuya Taga
  • Organizer: KEY Forum in Developmental Biology and Regenerative Medicine
  • Place of Presentation: Kumamoto(招待講演)
• [Presentation] SoxF family proteins have roles in maintenance of immature phenotype of hematopoietic progenitors in the aorta-gonad-mesonephros region (2011)
  • Author(s): Ikuo Nobuhisa
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉県
• [Presentation] Maintenance of immature phenotype of the hematopoietic cell clusters in the aorta-gonad-mesonephros region by SoxF family proteins (2011)
  • Author(s): Ikuo Nobuhisa
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 神奈川県
• [Presentation] 白血病幹細胞を考える (2010)
  • Author(s): 赤司浩一
  • Organizer: 第72回日本血液学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-24
• [Presentation] 造血幹細胞と造血器癌幹細胞
  • Author(s): 赤司浩一
  • Organizer: 第110回日本内科学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Epigenetic landscape of hematopoiesis visualized by histone H3.3 incorporation is deregulated in acute myeloid leukemia
  • Author(s): Koichi Akashi
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] Cancer Stem Cells in Human Hematological Malignancies
  • Author(s): Koichi Akashi
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 造血器癌幹細胞 Malignant hematopoietic stem cell
  • Author(s): 赤司浩一
  • Organizer: 第55回日本小児血液・がん学会学術集会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 治療標的としてのヒト白血病幹細胞
  • Author(s): 赤司浩一
  • Organizer: 「がん研究分野の特性等を踏まえた支援活動」公開シンポジウム
  • Place of Presentation: 東京
  • Invited
• [Presentation] 肝細胞癌に対する分子標的薬の現状と展望
  • Author(s): 田中真二
  • Organizer: 第75回日本臨床外科学会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] Cell cycle and cancer stem cells: Abrogation of quiescence by Fbw7 ablation eliminates leukemia stem cells.
  • Author(s): Keiichi Nakayama
  • Organizer: ISEH 42nd Annual Scientific Meeting
  • Place of Presentation: Vienna
  • Invited
• [Presentation] Absolute quantification oh human proteome by large-scale targeted proteomics
  • Author(s): Keiichi Nakayama
  • Organizer: HUPO 2013 12th Annual World Congress
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 急性骨髄性白血病における幹細胞の制御と治療戦略
  • Author(s): 北林一生
  • Organizer: 第72回日本癌学会学術総会シンポジウム
  • Place of Presentation: 横浜
  • Invited
• [Presentation] Roles of CD44 in cancer stem cells.
  • Author(s): Hideyuki Saya
  • Organizer: The American Association for Cancer Research (AACR) Annual Meeting 2013
  • Place of Presentation: Washington, DC, USA
  • Invited
• [Presentation] Novel Therapeutic Strategies for Cancer Stem Cells.
  • Author(s): Hideyuki Saya
  • Organizer: Weatherall Institute of Molecular Medicine (WIMM) Seminar
  • Place of Presentation: University of Oxford, UK
  • Invited
• [Presentation] 増殖因子制御遺伝子による予後予測診断と癌幹細胞の分子標的
  • Author(s): 後藤典子
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] Glioma stem cell survival strategy in view of niche involving immune/inflammatory cells.
  • Author(s): Tetsuya Taga
  • Organizer: 11th World Congress on Inflammation
  • Place of Presentation: Natal, Brazil
  • Invited
• [Book] Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia. Chapter 1 Identification and Biology of CML Stem Cells. (2016)
  • Author(s): Hiromi Iwasaki and Koichi Akashi
  • Total Pages: 193
  • Publisher: Springer Japan
• [Book] Notch2 and immune function. Current Topics in Microbiology and Immunology (2012)
  • Author(s): Sakata-Yanagimoto M
  • Publisher: Springer
• [Book] サイトカインのすべて (2012)
  • Author(s): 備前典久、田賀哲也
  • Publisher: 科学評論社(印刷中)
• [Book] Molecular Targets of CNS Tumors (2011)
  • Author(s): Kouichi Tabu
  • Total Pages: 26
  • Publisher: InTech
• [Book] Stem Cells and Cancer Stem Cells : Therapeutic Applications in Disease and Injury (2011)
  • Author(s): Kouichi Tabu
  • Total Pages: 9
  • Publisher: Springer
• [Book] ものづくり技術からみる再生医療-細胞研究・創薬・治療- (2011)
  • Author(s): 田賀哲也
  • Total Pages: 7
  • Publisher: シーエムシー出版
• [Book] Hematopoietic Stem Cell Biology(Motonari Kondo ed.) (2010)
  • Author(s): Iwasaki H, Suda T
  • Total Pages: 251
  • Publisher: Hematopoietic Stem Cells and Their Niche
• [Remarks] 九州大学医学部第一内科（病態修復内科）
  • URL: http://www.1nai.med.kyushu-u.ac.jp
• [Remarks] 新学術領域研究「癌幹細胞を標的とする腫瘍根絶技術の新構築」
  • URL: http://www.cancer-stem-cell.com
• [Remarks] 新学術領域研究「癌幹細胞を標的とする腫瘍根絶技術の新構築」
  • URL: http://www.cancer-stem-cell.com
• [Remarks] 新学術領域研究「癌幹細胞を標的とする腫瘍根絶技術の新構築」
  • URL: http://www.cancer-stem-cell.com/
• [Remarks] 九州大学医学部第一内科
  • URL: http://www.1nai.med.kyushu-u.ac.jp/
• [Remarks]
  • URL: http://www.1nai.med.kyushu-u.ac.jp/
• [Remarks]
  • URL: http://www.cancer-stem-cell.com/
• [Remarks]
  • URL: http://www.genereg.jp/
• [Remarks]
  • URL: http://www.tmd.ac.jp/mri/scr/index.html
• [Remarks]
  • URL: http://www.cancer-stem-cell.com/