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Development of Novel Treatment Strategies Targeting Cancer Stem Cells

Administrative Group

Project AreaDevelopment of Novel Treatment Strategies Targeting Cancer Stem Cells
Project/Area Number 22130001
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyushu University

Principal Investigator

AKASHI Koichi  九州大学, 医学(系)研究科(研究院), 教授 (80380385)

Co-Investigator(Kenkyū-buntansha) GOTO Noriko  金沢大学, がん進展制御研究所, 教授 (10251448)
KITABAYASHI Issei  国立がん研究センター, 研究所, 分野長 (20261175)
TANAKA Shinji  東京医科歯科大学, 医歯学総合研究科, 教授 (30253420)
TAGA Tetsuya  東京医科歯科大学, 難治疾患研究所, 教授 (40192629)
SUDA Toshio  慶應義塾大学, 医学部, 教授 (60118453)
CHIBA Shigeru  筑波大学, 医学医療系, 教授 (60212049)
SAYA Hideyuki  慶應義塾大学, 医学部, 教授 (80264282)
NAKAYAMA Keiichi  九州大学, 生体防御医学研究所, 主幹教授 (80291508)
Co-Investigator(Renkei-kenkyūsha) MORI Masaki  大阪大学, 医学系研究科, 教授 (70190999)
UEDA Ryuzo  愛知医科大学, 医学部, 教授 (20142169)
NODA Tetsuo  癌研究会, 癌研究所, 所長 (10183550)
CLARKE Michael F.  Stanford School of Medicine, Professor
TENEN Daniel G.  Harvard Stem Cell Institute, Professor
NOMURA Hideaki  協和キリン富士フィルムバイオロジクス株式会社, 代表取締役社長
TAKAGO Toru  医薬基盤研究所
Project Period (FY) 2010-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥38,350,000 (Direct Cost: ¥29,500,000、Indirect Cost: ¥8,850,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Keywords癌 / 細胞・組織 / 生体分子 / 癌幹細胞 / 幹細胞ニッチ / 分子標的治療
Outline of Annual Research Achievements

新学術領域研究「癌幹細胞を標的とする腫瘍根絶技術の新構築」(平成22-26年度)の研究成果と波及効果を、多面的に評価することを目的として、成果の取りまとめを行った。本領域研究から創出された学術論文や知的財産をもとに、計画研究および公募研究の達成度を評価し、さらに領域内での有機的な連携が計れていたかについて検証した。特に、がん幹細胞標的治療を実現するシーズ探索における成果を精査し、がん幹細胞研究が新しい学術領域として広く社会に認知されたことへの貢献を評価した。具体的には、以下の項目について調査・評価を行った。
(1)計画研究8題と公募研究23題について、研究期間内に発表あるいは発表予定の学術論文および知的財産を調査した。(2)(1)をもとに、それぞれの研究課題の達成度を評価した。特に、今後の課題を明確にすることに重点を置いて精査した。(3)領域内共同研究の実施状況、研究資源共有の状況を調査し、領域内連携の達成度を評価した。(4)本領域研究によって、がん幹細胞標的治療を可能にするシーズ探索がどの程度進んだかを調査した。(5)国内外におけるがん幹細胞研究の成果を調査し、本領域研究の貢献度を評価した。(6)関連学会において、がん幹細胞研究が取り上げられた状況、テレビ・新聞等での報道状況を調査し、本領域研究の認知度と波及効果について評価した。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Report

(7 results)
  • 2015 Annual Research Report
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report

Research Products

(257 results)

All 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article (187 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 186 results,  Open Access: 13 results,  Acknowledgement Compliant: 20 results) Presentation (53 results) (of which Int'l Joint Research: 2 results,  Invited: 23 results) Book (7 results) Remarks (10 results)

  • [Journal Article] Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes.2015

    • Author(s)
      Izumi K, Mine K, Inoue Y, Teshima M, Ogawa S, Kai Y, Kurafuji T, Hirakawa K, Miyakawa D, Ikeda H, Inada A, Hara M, Yamada H, Akashi K, Niho Y, Ina K, Kobayashi T, Yoshikai Y, Anzai K, Yamashita T, Minagawa H, Fujimoto S, Kurisaki H, Shimoda K, Katsuta H, Nagafuchi S.
    • Journal Title

      Nat Commun

      Volume: 6 Pages: 1-10

    • DOI

      10.1038/ncomms7748

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased CD226 Expression on CD8+ T Cells Is Associated with Upregulated Cytokine Production and Endothelial Cell Injury in Patients with Systemic Sclerosis.2015

    • Author(s)
      Ayano M, Tsukamoto H, Kohno K, et al.
    • Journal Title

      J Immunol.

      Volume: 195 Pages: 892-900

    • DOI

      10.4049/jimmunol.1403046

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Expression of programmed cell death ligand 1 is associated with poor overall survival in patients with diffuse large B-cell lymphoma.2015

    • Author(s)
      Kiyasu J, Miyoshi H, Hirata A, Arakawa F, Ichikawa A, Niino D, Sugita Y, Yufu Y, Choi I, Abe Y, Uike N, Nagafuji K, Okamura T, Akashi K, Takayanagi R, Shiratsuchi M, Ohshima K.
    • Journal Title

      Blood.

      Volume: 126 Pages: 2193-2201

    • DOI

      10.1182/blood-2015-02-629600

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natural killer cells regulate T cell immune responses in primary biliary cirrhosis.2015

    • Author(s)
      Shimoda S, Hisamoto S, Harada K, Iwasaka S, Chong Y, Nakamura M, Bekki Y, Yoshizumi T, Shirabe K, Ikegami T, Maehara Y, He XS, Gershwin ME, Akashi K.
    • Journal Title

      Hepatology

      Volume: 62 Pages: 1817-1827

    • DOI

      10.1002/hep.28122

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression.2015

    • Author(s)
      Kikushige Y, Miyamoto T, Yuda J, Jabbarzadeh-Tabrizi S, Shima T, Takayanagi S, Niiro H, Yurino A, Miyawaki K, Takenaka K, Iwasaki H, Akashi K
    • Journal Title

      Cell Stem Cell

      Volume: 17 Pages: 341-341

    • DOI

      10.1016/j.stem.2015.07.011

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Prognostic role of Child-Pugh score 5 and 6 in hepatocellular carcinoma patients who underwent curative hepatic resection.2015

    • Author(s)
      Okajima C, Arii S, Tanaka S, Matsumura S, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Tanabe M.
    • Journal Title

      American Journal of Surgery

      Volume: 209 Pages: 199-205

    • DOI

      10.1016/j.amjsurg.2014.03.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria.2014

    • Author(s)
      Yonekawa A, Saijo S, Hoshino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M, Oh-Hora M, Akashi K, Yamasaki S.
    • Journal Title

      Immunity.

      Volume: 41 Pages: 402-13

    • DOI

      10.1016/j.immuni.2014.08.005

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell.2014

    • Author(s)
      Shima T, Miyamoto T, Kikushige Y, Yuda J, Tochigi T, Yoshimoto G, Kato K, Takenaka K, Iwasaki H, Mizuno S, Goto N, Akashi K.
    • Journal Title

      Exp. Hematol

      Volume: 42 Pages: 955-65

    • DOI

      10.1016/j.exphem.2014.07.267

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment.2014

    • Author(s)
      Iwamoto C
    • Journal Title

      Exp. Hematol

      Volume: 42 Pages: 163-171

    • DOI

      10.1016/j.exphem.2013.11.005

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation.2014

    • Author(s)
      Nobusue H
    • Journal Title

      Nature Communications

      Volume: 5 Pages: 3368-3368

    • DOI

      10.1038/ncomms4368

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress2014

    • Author(s)
      Shimizu T, Sugihara E, Yamaguchi-Iwai S, Tamaki S, Koyama Y, Kamel W, Ueki A, Ishikawa T, Chiyoda T, Osuka S, Onishi N, Ikeda H, Kamei J, Matsuo K, Fukuchi Y, Nagai T, Toguchida J, Toyama Y, Muto A, Saya H
    • Journal Title

      Cancer Research

      Volume: 74 Pages: 6531-41

    • DOI

      10.1158/0008-5472.can-14-0914

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] p57 regulates T-cell development and prevents lymphomagenesis by balancing p53 activity and pre-TCR signaling.2014

    • Author(s)
      Matsumoto, A., Takeishi, S., Nakayama, K. I.
    • Journal Title

      Blood

      Volume: 123 Pages: 1-11

    • DOI

      10.1182/blood-2013-10-532390

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.2014

    • Author(s)
      Yamauchi, T., Nishiyama, M., Moroishi, T., Yumimoto, K., Nakayama, K. I.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 289 Pages: 16430-16441

    • DOI

      10.1074/jbc.m113.541490

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Nuclear export signal within CALM is necessary for CALM-AF10-induced leukemia.2014

    • Author(s)
      鈴木 麻衣
    • Journal Title

      Cancer Sci.

      Volume: 105 Pages: 315-23

    • DOI

      10.1111/cas.12347

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bromodomain-PHD finger protein 1 is critical for leukemogenesis associated with MOZ-TIF2 fusion.2014

    • Author(s)
      Shima H, Yamagata K, Aikawa Y, Shino M, Koseki H, Shimada H, Kitabayashi I.
    • Journal Title

      Int J Hematol.

      Volume: 99 Pages: 21-31

    • DOI

      10.1007/s12185-013-1466-x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] MicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancer.2014

    • Author(s)
      Hasegawa S, Eguchi H, Nagano H, Konno M, Tomimaru Y, Wada H, Hama N, Kawamoto K, Kobayashi S, Nishida N, Koseki J, Nishimura T, Gotoh N, Ohno S, Yabuta N, Nojima H, Mori M, Doki Y, Ishii H.
    • Journal Title

      B.r J. Cancer

      Volume: 111 Pages: 1572-1580

    • DOI

      10.1038/bjc.2014.454

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Epiregulin enhances tumorigenicity by activating the ERK/MAPK pathway in glioblastoma.2014

    • Author(s)
      Kohsaka S, Hinohara K, Wang L, Nishimura T, Urushido M, Yachi K, Tsuda M, Tanino M, Kimura T, Nishihara H, Gotoh N, Tanaka S.
    • Journal Title

      Neuro Oncol.

      Volume: 16 Pages: 960-70

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frs2α and Shp2 signal independently of Gab to mediate FGF signaling in lens development.2014

    • Author(s)
      Li H, Tao C, Cai Z, Hertzler-Schaefer K, Collins TN, Wang F, Feng GS, Gotoh N, Zhang X.
    • Journal Title

      J. Cell Sci.

      Volume: 127 Pages: 571-582

    • DOI

      10.1242/jcs.134478

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Megakaryocytes are essential for HSC quiescence through the production of thrombopoietin.2014

    • Author(s)
      Nakamura-Ishizu A, Takubo K, Fujioka M, Suda T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 454 Pages: 353-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurons limit angiogenesis by titrating VEGF in retina.2014

    • Author(s)
      Okabe K, Kobayashi S, Yamada T, Kurihara T, Tai-Nagara I, Miyamoto T, Mukouyama YS, Sato TN, Suda T, Ema M, Kubota Y
    • Journal Title

      Cell

      Volume: 159 Pages: 584-596

    • DOI

      10.1016/j.cell.2014.09.025

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling.2014

    • Author(s)
      Kobayashi I, Kobayashi-Sun J, Kim AD, Pouget C, Fujita N, Suda T, Traver D.
    • Journal Title

      Nature

      Volume: 512 Pages: 319-23

    • DOI

      10.1038/nature13623

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The IL-2/CD25 Axis Maintains Distinct Subsets of Chronic M yeloid Leukemia-initiating Cells.2014

    • Author(s)
      Kobayashi CI, Takubo K, Kobayashi H, Nakamura-Ishizu A, Honda H, Kataoka K, Kumano K, Akiyama H, Sudo T, Kurokawa M, Suda T.
    • Journal Title

      Blood.doi: 10.1182/blood-2013-07-517847

      Volume: 123 Pages: 2540-2549

    • DOI

      10.1182/blood-2013-07-517847

    • NAID

      40020385227

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Alcohol consumption and recurrence of non-B or non-C hepatocellular carcinoma after hepatectomy: a propensity score analysis.2014

    • Author(s)
      Kudo A, Tanaka S, Ban D, Matsumura S, Irie T, Ochiai T, Nakamura N, Arii S, Tanabe M.
    • Journal Title

      Journal of Gastroenterology

      Volume: 49 Pages: 1352-1361

    • DOI

      10.1007/s00535-013-0899-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sox17-ediated Maintenance of Fetal Intra-ortic Hematopoietic Cell Clusters2014

    • Author(s)
      Nobuhisa. Ikuo., Ozawa. M., Uemura. M., Kishikawa. Y., Azumi. M. Harada K. Takagi M Saito. K., Kanai-Azuma M. Kanai. Y Iwama. A. Tetsuya.
    • Journal Title

      Mol Cell Biol

      Volume: (印刷中) Pages: 1975-1990

    • DOI

      10.1128/mcb.01485-13

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A growth-promoting signaling component cyclin D1 in neural stem cells has anti-astrogliogenic function to execute self-renewal.2014

    • Author(s)
      Bizen N
    • Journal Title

      Stem Cells.

      Volume: Epub ahead of print] Pages: 1602-15

    • DOI

      10.1002/stem.1613

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.2014

    • Author(s)
      Nagamachi A
    • Journal Title

      Cancer Cell.

      Volume: 24 Pages: 305-17

    • DOI

      10.1016/j.ccr.2013.08.011

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.2014

    • Author(s)
      Lu Z
    • Journal Title

      Nat. Commun.

      Volume: 5 Pages: 3463-3463

    • DOI

      10.1038/ncomms4463

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ink4a/Arf –/– and HRAS(G12V) transform mouse mammary cells into triple-negative breast cancer containing tumorigenic CD49f – quiescent cells.2014

    • Author(s)
      Kai K
    • Journal Title

      Oncogene.

      Volume: 33 Pages: 440-448

    • DOI

      10.1038/onc.2012.609

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TNF-a/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells2014

    • Author(s)
      Oshima H, Ishikawa T, Yoshida GJ, et al.
    • Journal Title

      Oncogene

      Volume: 33 Pages: 1-10

    • DOI

      10.1038/onc.2013.356

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] TNFα promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state.2014

    • Author(s)
      Mori T
    • Journal Title

      Oncogene

      Volume: Epub ahead of print Pages: 4236-4241

    • DOI

      10.1038/onc.2013.545

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Fgfr1-Frs2/3 Signalling Maintains Sensory Progenitors during Inner Ear Hair Cell Formation.2014

    • Author(s)
      Ono K
    • Journal Title

      PLoS Genet.

      Volume: 10

    • DOI

      10.1371/journal.pgen.1004118

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epiregulin enhances tumorigenicity activating ERK/MAPK pathway in glioblastoma.2014

    • Author(s)
      Kohsaka S
    • Journal Title

      Neuro Oncol

      Volume: Epub ahead of print

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EpCAM-Targeted therapy for human hepatocellular carcinoma.2014

    • Author(s)
      Katsuta E
    • Journal Title

      Oncol. Rep.

      Volume: 21 Pages: 1133-1138

    • DOI

      10.3892/or.2013.2952

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment.2013

    • Author(s)
      Yamauchi T
    • Journal Title

      Blood

      Volume: 121 Pages: 1316-1325

    • DOI

      10.1182/blood-2012-06-440354

    • NAID

      40019873170

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E2 regulates murine hematopoietic stem/progenitorcells directly via EP4 receptor and indirectly through mesenchymal progenitor cells.2013

    • Author(s)
      Ikushima YM. Arai F, Hosokawa K, Toyama H, Takubo K, Furuyashiki T, Narumiya S, Suda T
    • Journal Title

      Blood.

      Volume: 121(11) Pages: 1995-2007

    • DOI

      10.1182/blood-2012-06-437889

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.2013

    • Author(s)
      Takubo K
    • Journal Title

      Cell Stem Cell.

      Volume: 12 Pages: 49-61

    • DOI

      10.1016/j.stem.2012.10.011

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes2013

    • Author(s)
      Arisa Hirano, Kanae Yumimoto, Ryosuke Tsunematsu, Masaki Matsumoto, Masaaki Oyama, Hiroko Kozuka-Hata, Tomoki Nakagawa, Darin Lanjakornsiripan, Keiichi I. Nakayama, and Yoshitaka Fukada
    • Journal Title

      Cell Stem Cell

      Volume: 152 Pages: 1106-1118

    • DOI

      10.1016/j.cell.2013.01.054

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ablation of fbxw7 eliminates leukemia-initiating cells by preventing quiescence.2013

    • Author(s)
      Takeishi S
    • Journal Title

      Cancer Cell

      Volume: 23 Pages: 347-361

    • DOI

      10.1016/j.ccr.2013.01.026

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression.2013

    • Author(s)
      Reavie L
    • Journal Title

      Cancer Cell

      Volume: 23 Pages: 347-361

    • DOI

      10.1016/j.ccr.2013.01.025

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors.2013

    • Author(s)
      Zhao H
    • Journal Title

      Cancer Cell

      Volume: 24 Pages: 645-659

    • DOI

      10.1016/j.ccr.2013.09.021

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies.2013

    • Author(s)
      Iwanami A
    • Journal Title

      Proc Natl Acad Sci

      Volume: 110 Pages: 4339-4344

    • DOI

      10.1073/pnas.1217602110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MOZ increases p53 acetylation and premature senescence through its complex formation with PML.2013

    • Author(s)
      Rokudai S
    • Journal Title

      Proc Natl Acad Sci

      Volume: 110 Pages: 3895-3900

    • DOI

      10.1073/pnas.1300490110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of PML nuclear body disruption in APL: PML-RARa inhibits PML oligomerization and its phosphorylation restores PML NBs.2013

    • Author(s)
      Shima Y
    • Journal Title

      Cancer Res.

      Volume: 73 Pages: 4278-4288

    • DOI

      10.1158/0008-5472.can-12-3814

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cleary ML MLL becomes functional through intra-molecular interaction not by proteolytic processing.2013

    • Author(s)
      Yokoyama A, Ficara F, Murphy M, Meisel C, Hatanaka C, Kitabayashi I,
    • Journal Title

      PLoS One

      Volume: 8(9)

    • DOI

      10.1371/journal.pone.0073649

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acquired expression of NFATc1 downregulates E-cadherin and promotes cancer cell invasion.2013

    • Author(s)
      Oikawa T
    • Journal Title

      Cancer Res.

      Volume: 73 Pages: 5100-5109

    • DOI

      10.1158/0008-5472.can-13-0274

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein.2013

    • Author(s)
      Kano Y
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 432 Pages: 175-181

    • DOI

      10.1016/j.bbrc.2013.01.034

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma.2013

    • Author(s)
      Cai Z
    • Journal Title

      Development

      Volume: 140 Pages: 2711-2723

    • DOI

      10.1242/dev.089987

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Visualization of stem cell features in human hepatocellular carcinoma enlightened in vivo significance of tumor-host interaction and clinical implication.2013

    • Author(s)
      Muramatsu S
    • Journal Title

      Hepatology

      Volume: 58 Pages: 218-228

    • DOI

      10.1002/hep.26345

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contrast-enhanced intraoperative ultrasonography for vascular imaging of hepatocellular carcinoma; clinical and biological significance.2013

    • Author(s)
      Sato K
    • Journal Title

      Hepatology

      Volume: 57 Pages: 1436-1447

    • DOI

      10.1002/hep.26122

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Tumor-suppressive mir-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma.2013

    • Author(s)
      Furuta M
    • Journal Title

      PLOS One

      Volume: 8

    • DOI

      10.1371/journal.pone.0060155

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Engulfment of hematopoietic stem cel ls caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis2013

    • Author(s)
      Kuriyama T, Takenaka K 他12名
    • Journal Title

      Blood

      Volume: 120巻 Pages: 4058-4067

    • DOI

      10.1182/blood-2012-02-408864

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantification of hematogones at the time of engraftment is a useful prognostic indicator in allogeneic stem cell transplantation.2013

    • Author(s)
      Shima T
    • Journal Title

      Blood.

      Volume: 121 Pages: 840-848

    • DOI

      10.1182/blood-2012-02-409607

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial metabolism in the noncancerous liver determine the occurrence of hepatocellular carcinoma: a prospective study.2013

    • Author(s)
      Kudo A
    • Journal Title

      J Gastroenterol

      Volume: Epub ahead of print

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ErbB/NF-kB signaling controls mammosphere formation in human breast cancer2012

    • Author(s)
      Hinohara, K.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: (in press) Pages: 6584-6589

    • DOI

      10.1073/pnas.1113271109

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.2012

    • Author(s)
      Yae T, Tsuchihashi K, Ishimoto T, Motohara T, Yoshikawa M, Yoshida GJ, Wada T, Masuko T,Mogushi K, Tanaka H, Osawa T, Kanki Y, et al
    • Journal Title

      Nat Commun

      Volume: 6;3 Pages: 883-883

    • DOI

      10.1038/ncomms1892

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD45 low c-Kit high cells have hematopoietic properties in the mouse aorta-gonad-mesonephros region2012

    • Author(s)
      Ikuo Nobuhisa
    • Journal Title

      Exp.Cell Res.

      Volume: 318 Pages: 705-715

    • DOI

      10.1016/j.yexcr.2012.01.017

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells.2012

    • Author(s)
      Satow R
    • Journal Title

      Gastroenterology.

      Volume: 142 Pages: 572-581

    • DOI

      10.1053/j.gastro.2011.11.041

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Corneal antifibrotic switch identified in genetic and pharmacological deficiency of vimentin2012

    • Author(s)
      Bargagna-Mohan P, et al
    • Journal Title

      J.Biol.Chem

      Volume: 287 Pages: 989-1006

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-beta-catenin signaling pathway2012

    • Author(s)
      Nishiyama M, et al
    • Journal Title

      Mol.Cell.Biol

      Volume: 32 Pages: 501-512

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteome-wide identification of uUbiquitylation sites by conjugation of engineered lysine-less ubiquitin2012

    • Author(s)
      Oshikawa K, et al
    • Journal Title

      J.Proteome Res

      Volume: 11 Pages: 796-807

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation2012

    • Author(s)
      Kanie T, et al
    • Journal Title

      Mol.Cell.Biol

      Volume: 32 Pages: 590-605

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, Herceptin sensitivity and tumorigenesis2012

    • Author(s)
      Chan C.-H, et al
    • Journal Title

      Cell

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] odulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells2012

    • Author(s)
      Tamada M, et al
    • Journal Title

      Cancer Research

      Volume: 72 Pages: 1438-1448

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibroblast growth factor-2 (Fgf2) is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma2012

    • Author(s)
      Shimizu T, et al
    • Journal Title

      Molecular Cancer Research

      Volume: 10 Pages: 454-468

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor2012

    • Author(s)
      Sugihara E, et al
    • Journal Title

      Oncogene

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-renewing hematopoietic stem cell is the primary target in pathogenesis ofhuman chronic lymphocytic leukemia. Cancer Cell2011

    • Author(s)
      Kikushige Y, et al
    • Journal Title

      Cancer Cell

      Volume: 20-2 Pages: 246-259

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells2011

    • Author(s)
      Takashima S, et al
    • Journal Title

      J Exp Med

      Volume: 208-2 Pages: 285-294

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regenerating islet-derived 3-alpha is a biomarker ofgastrointestinal graft-versus-host disease2011

    • Author(s)
      Ferrara L, et al
    • Journal Title

      Blood

      Volume: 118-25 Pages: 6702-6708

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The classification of mRNA expression levels by the phosphorylation state of RNAPII CTD based on a combined genome-wide approach2011

    • Author(s)
      Odawara J, et al
    • Journal Title

      BMC Genomics

      Volume: 12 Pages: 516-516

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different risk factors related to adenovirus- or BK virus-associated hemorrhagic cystitis following allogeneic stem cell transplantation2011

    • Author(s)
      Mori Y, et al
    • Journal Title

      Biol Blood Marrow Transplant

      Volume: 18-3 Pages: 458-465

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clonal origin of Epstein-Barr virus (EBV)-infected T/NK-cell subpopulations in EBV-positive T/NK-cell lymphoproliferative disorders of childhood2011

    • Author(s)
      Ohga S, et al
    • Journal Title

      J Clin Virol

      Volume: 51-1 Pages: 31-37

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of autotransplantation in the treatment of acute promyelocytic leukemia patients in remission : Fukuoka BMT Group observations and a literature review2011

    • Author(s)
      Kamimura T, et al
    • Journal Title

      Bone Marrow Transplant

      Volume: 46-6 Pages: 820-826

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27kip1, KPC1, and SOCS-12011

    • Author(s)
      Lu, C., Huang, et al
    • Journal Title

      Blood

      Volume: 117 Pages: 4293-4303

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells2011

    • Author(s)
      Matsumoto A, et al
    • Journal Title

      J.Biol.Chem

      Volume: 286 Pages: 13754-13764

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fbxw7beta resides in the endoplasmic reticulum membrane and protects cells from oxidative stress2011

    • Author(s)
      Matsumoto A, et al
    • Journal Title

      Cancer Sci

      Volume: 102 Pages: 749-755

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteome of ubiquitin/MVB pathway : possible involvement of iron-induced ubiquitylation of transferrin receptor in lysosomal degradation2011

    • Author(s)
      Tachiyama R, et al
    • Journal Title

      Genes Cells

      Volume: 16 Pages: 448-466

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional analyses of the activation loop of phototropin2 in Arabidopsis2011

    • Author(s)
      Inoue S, et al
    • Journal Title

      Plant Physiol

      Volume: 156 Pages: 117-128

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired ovarian development and reduced fertility in female mice deficient in Skp22011

    • Author(s)
      Fotovati A, et al
    • Journal Title

      J.Anat

      Volume: 218 Pages: 668-677

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of APC/C(Cdc20) activity by RASSF1A-APC/C(Cdc20) circuitry2011

    • Author(s)
      Chow C, et al
    • Journal Title

      Oncogene

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Four mood stabilizers commonly induce FEZ1 expression in human astrocytes2011

    • Author(s)
      Yu Z, et al
    • Journal Title

      Bipolar Disord

      Volume: 13 Pages: 486-499

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cellquiescence through interactions with Hsc702011

    • Author(s)
      Zou P, et al
    • Journal Title

      Cell Stem Cell

      Volume: 9 Pages: 247-261

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p57 is required for quiescence and maintenance of adult hematopoietic stem cells2011

    • Author(s)
      Matsumoto A, et al
    • Journal Title

      Cell Stem Cell

      Volume: 9 Pages: 262-271

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo2011

    • Author(s)
      Moroishi T, et al
    • Journal Title

      Cell Metab

      Volume: 14 Pages: 339-351

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deregulation of the p57-E2F1-p53 axis results in nonobstructive hydrocephalus and cerebellar malformation in mice2011

    • Author(s)
      Matsumoto A, et al
    • Journal Title

      Mol.Cell.Biol

      Volume: 31 Pages: 4176-4192

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRIM8 regulates Nanog via Hsp90beta-mediated nuclear translocation of STAT3 in embryonic stem cells2011

    • Author(s)
      Okumura F, et al
    • Journal Title

      Biochim.Biophys.Acta

      Volume: 1813 Pages: 1784-1792

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficient p27 phosphorylation at serine 10 increases macrophage foam cell formation and aggravates atherosclerosis through a proliferation-independent mechanism2011

    • Author(s)
      Fuster J.J, et al
    • Journal Title

      Arterioscler.Thromb.Vasc.Biol

      Volume: 31 Pages: 2455-2463

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation2011

    • Author(s)
      Matsuzaki F, et al
    • Journal Title

      Mol.Biol.Cell

      Volume: 22 Pages: 4602-4620

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The SKP2 E3 Ligase regulates basal homeostasis and stress-induced regeneration of hematopoietic stem cells2011

    • Author(s)
      Rodriguez S, et al
    • Journal Title

      Blood

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The pathophysiological role of the PKCdelta pathway in the intervertebral disc : In vitro, ex vivo and in vivo studies2011

    • Author(s)
      Ellman M.B, et al
    • Journal Title

      Arthritis Rheuma

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rodriguez-Puebla, M.L. : Skp2 is necessary for Myc-induced keratinocyte proliferation but dispensable for Myc oncogenic activity in the oral epithelium2011

    • Author(s)
      Sistrunk h, et al
    • Journal Title

      Am.J.Pathol

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere independent mechanism2011

    • Author(s)
      Nitta Eriko
    • Journal Title

      Blood

      Volume: 117 Pages: 4169-4180

    • DOI

      10.1182/blood-2010-08-297390

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero2011

    • Author(s)
      Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Sano K, Murakami M, Ema M, Omatsu Y, Takahashi S, Nagasawa T, Shibuya M, Okano H, Suda T
    • Journal Title

      J. Exp. Med

      Volume: 208 Pages: 949-960

    • DOI

      10.1084/jem.20102187

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow-derived cells serve : as pro-angiogenic macrophages but not endothelial cells in wound healing2011

    • Author(s)
      Okuno Y, et al
    • Journal Title

      Blood

      Volume: 117 Pages: 5264-5272

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p57^<Kip2> and p27^<Kip1> cooperate to maintain hematopoietic stem cell quiescence through interaction with Hsc702011

    • Author(s)
      Zou P, et al
    • Journal Title

      Cell Stem Cell

      Volume: 9 Pages: 247-261

    • DOI

      10.1016/j.stem.2011.07.003

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoclasts are dispensable for haematopoietic stem cell maintenance and mobilization2011

    • Author(s)
      Miyamoto K, et al
    • Journal Title

      J Exp Med.

      Volume: 208 Pages: 2175-2181

    • DOI

      10.1084/jem.20101890

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic regulation of hematopoietic stem cells in the hypoxic niche2011

    • Author(s)
      Suda T, et al
    • Journal Title

      Cell Stem Cell

      Volume: 9 Pages: 298-310

    • DOI

      10.1016/j.stem.2011.09.010

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a yolk sac cell population with hematopoietic activity in view of CD45/c-Kit expression2011

    • Author(s)
      Shoutarou Yamasaki
    • Journal Title

      Develop. Growth Differ

      Volume: 53 Pages: 870-877

    • DOI

      10.1111/j.1440-169x.2011.01293.x

    • NAID

      10030403633

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アストロサイトの発生・分化2011

    • Author(s)
      鹿川哲史
    • Journal Title

      Clinical Neuroscience

      Volume: 29 Pages: 1239-1242

    • Related Report
      2011 Annual Research Report
  • [Journal Article] The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells2011

    • Author(s)
      Takashima S, Kadowaki M, Aoyama K, Koyama M, Oshima T, Tomizuka K, Akashi K, Teshima T
    • Journal Title

      J Exp Med

      Volume: 208(2) Pages: 285-94

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine2011

    • Author(s)
      Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito TI, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, Chiba S
    • Journal Title

      Blood

      Volume: 117(1) Pages: 128-34

    • NAID

      120007137632

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7&alpha ; overexpression2011

    • Author(s)
      Iriuchishima H, Takubo K, Matsuoka S, Onoyama I, Nakayama KI, Nojima Y, Suda T
    • Journal Title

      Blood

      Volume: 117(8) Pages: 2373-7

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip12011

    • Author(s)
      Katagiri K, Ueda Y, Tomiyama T, Yasuda K, Toda Y, Ikehara S, Nakayama KI, Kinashi T
    • Journal Title

      Immunity

      Volume: 34(1) Pages: 24-38

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p532011

    • Author(s)
      Wu H, Pomeroy SL, Ferreira M, Teider N, Mariani J, Nakayama KI, Hatakeyama S, Tron VA, Saltibus LF, Spyracopoulos L, Leng RP
    • Journal Title

      Nat Med

      Volume: 17(3) Pages: 347-55

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction2011

    • Author(s)
      Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, De Pinho RA, Wei W
    • Journal Title

      Nature

      Volume: 471(7336) Pages: 104-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fbxw7 controls lipid metabolism and cell fate decision in the liver in mice2011

    • Author(s)
      Onoyama I, Suzuki A, Matsumoto A, Tomita K, Katagiri H, Oike Y, Nakayama K, Nakayama KI
    • Journal Title

      J Clin Invest

      Volume: 121(1) Pages: 342-354

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc(-) and Thereby Promotes Tumor Growth2011

    • Author(s)
      Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, Oshima M, Ikeda T, Asaba R, Yagi H, Masuko T, Shimizu T, Ishikawa T, Kai K, Takahashi E, Imamura Y, Baba Y, Ohmura M, Suematsu M, Baba H, Saya H
    • Journal Title

      Cancer Cell

      Volume: 19(3) Pages: 387-400

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NKX2.2 suppresses self-renewal of glioma-initiating cells2011

    • Author(s)
      Muraguchi T, Tanaka S, Yamada D, Tamase A, Nakada M, Nakamura H, Hoshii T, Ooshio T, Tadokoro Y, Naka K, Ino Y, Todo T, Kuratsu J, Saya H, Hamada J, Hirao A
    • Journal Title

      Cancer Res

      Volume: 71(3) Pages: 1135-45

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells2010

    • Author(s)
      Kikushige Y, Shima T, Takayanagi SI, Urata S, Miyamoto T, Iwasaki H, Takenaka K, Teshima T, Tanaka T, Inagaki Y, Akashi K
    • Journal Title

      Cell Stem Cell

      Volume: 7(6) Pages: 708-717

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation2010

    • Author(s)
      Oku S, Takenaka K, Kuriyama T, Shide K, Kumano T, Kikushige Y, Urata S, Yamauchi T, Iwamoto C, Shimoda HK, Miyamoto T, Nagafuji K, Kishimoto J, Shimoda K, Akashi K
    • Journal Title

      Br J Haematol

      Volume: 150(3) Pages: 334-344

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice2010

    • Author(s)
      Asakura S, Hashimoto D, Takashima S, Sugiyama H, Maeda Y, Akashi K, Tanimoto M, Teshima T
    • Journal Title

      J Clin Invest

      Volume: 120(7) Pages: 2370-2378

    • NAID

      130004505744

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced expression of PCAF endows apoptosis resistance in cisplatin-resistant cells2010

    • Author(s)
      Hirano G, Izumi H, Kidani A, Yasuniwa Y, Han B, Kusaba H, Akashi K, Kuwano M, Kohno K
    • Journal Title

      Mol Cancer Res

      Volume: 8(6) Pages: 864-872

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp12010

    • Author(s)
      Parmar K, Kim J, Sykes SM, Shimamura A, Stuckert P, Zhu K, Hamilton A, Deloach MK, Kutok JL, Akashi K, Gilliland DG, D'andrea A
    • Journal Title

      Stem Cells

      Volume: 28(7) Pages: 1186-1195

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia2010

    • Author(s)
      Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S
    • Journal Title

      Blood

      Volume: 115(14) Pages: 2872-2881

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress2010

    • Author(s)
      Hayakawa H, Fujikane A, Ito R, Matsumoto M, Nakayama KI, Sekiguchi M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 403(2) Pages: 220-4

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1^<+/-> mice2010

    • Author(s)
      Wang H, Bauzon F, Ji P, Xu X, Sun D, Locker J, Sellers RS, Nakayama K, Nakayama KI, Cobrinik D, Zhu L
    • Journal Title

      Nature Genet

      Volume: 42 Pages: 83-88

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development2010

    • Author(s)
      Tsukada Y, Ishitani T, Nakayama KI
    • Journal Title

      Genes Dev

      Volume: 24 Pages: 432-437

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis2010

    • Author(s)
      Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY, Wu J, Nakayama KI, Kang HY, Huang HY, Hung MC, Pandolfi PP, Lin HK
    • Journal Title

      Nature Cell Biol

      Volume: 12 Pages: 457-467

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence2010

    • Author(s)
      Lin HK, Chen Z, Wang G, Nardella C, Lee SW, Chan CH, Yang WL, Wang J, Egia A, Nakayama KI, Cordon-Cardo C, Teruya-Feldstein J, Pandolfi PP
    • Journal Title

      Nature

      Volume: 464 Pages: 374-379

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative Analysis of Human Src-family Kinase Substrate Specificity in vitro2010

    • Author(s)
      Takeda H, Kawamura Y, Miura A, Mori M, Wakamatsu A, Yamamoto JI, Isogai T, Matsumoto M, Nakayama KI, Natsume T, Nomura N, Goshima N
    • Journal Title

      J Proteome Res

      Volume: 9(11) Pages: 5982-93

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro histone demethylase assay2010

    • Author(s)
      Tsukada Y, Nakayama KI
    • Journal Title

      Cold Spring Harb Protoc

      Volume: 2010(10)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc42010

    • Author(s)
      Benirschke RC, Thompson JR, Nomine Y, Wasielewski E, Juranic N, Macura S, Hatakeyama S, Nakayama KI, Botuyan MV, Mer G
    • Journal Title

      Structure

      Volume: 18 Pages: 955-965

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression : role of protein phosphatases2010

    • Author(s)
      Ma H, Yu L, Byra EA, Hu N, Kitagawa K, Nakayama KI, Kawamoto T, Ren J
    • Journal Title

      J Mol Cell Cardiol

      Volume: 49 Pages: 322-329

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRIM8 modulates STAT3 activity through negative regulation of PIAS32010

    • Author(s)
      Okumura F, Matsunaga Y, Katayama Y, Nakayama KI, Hatakeyama S
    • Journal Title

      J Cell Sci

      Volume: 123 Pages: 2238-2245

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GABA(A) receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout mice2010

    • Author(s)
      Mizokami A, Tanaka H, Ishibashi H, Umebayashi H, Fukami K, Takenawa T, Nakayama KI, Yokoyama T, Nabekura J, Kanematsu T, Hirata M
    • Journal Title

      J Neurochem

      Volume: 114 Pages: 302-310

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of the chromodomain changes the binding specificity of Cbx2 for methylated histone H32010

    • Author(s)
      Hatano A, Matsumoto M, Higashinakagawa T, Nakayama KI
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 397 Pages: 93-99

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nedd4-interacting protein 2, a short half-life membrane protein degraded in lysosomes, negatively controls down-regulation of connexin432010

    • Author(s)
      Ohzono C, Etoh S, Matsumoto M, Nakayama KI, Hirota Y, Tanaka Y, Fujita H
    • Journal Title

      Biol Pharm Bull

      Volume: 33 Pages: 951-957

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity2010

    • Author(s)
      Susaki E, Kaneko-Oshikawa C, Miyata K, Tabata M, Yamada T, Oike Y, Katagiri H, Nakayama KI
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 15538-15547

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer : clinical significance2010

    • Author(s)
      Iwatsuki M, Mimori K, Ishii H, Yokobori T, Takatsuno Y, Sato T, Toh H, Onoyama I, Nakayama KI, Baba H, Mori M
    • Journal Title

      Int J Cancer

      Volume: 126 Pages: 1828-1837

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts2010

    • Author(s)
      Masuda K, Ishikawa Y, Onoyama I, Unno M, de Alboran IM, Nakayama KI, Nakayama K
    • Journal Title

      Oncogene

      Volume: 29 Pages: 1798-1809

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis2010

    • Author(s)
      Old JB, Kratzat S, Hoellein A, Graf S, Nilsson JA, Nilsson L, Nakayama KI, Peschel C, Clevel, JL, Keller UB
    • Journal Title

      Mol Cancer Res

      Volume: 8 Pages: 353-362

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acquisition of G□ state by CD34-positive cord blood cells after bone marrow transplantation2010

    • Author(s)
      Shima H, Takubo K, Tago N, Iwasaki H, Arai F, Takahashi T, Suda T
    • Journal Title

      Exp Hematol

      Volume: 38(12) Pages: 1231-40

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool2010

    • Author(s)
      Nakajima H, Ito M, Smookler DS, Shibata F, Fukuchi Y, Morikawa Y, Ikeda Y, Arai F, Suda T, Khokha R, Kitamura T
    • Journal Title

      Blood

      Volume: 116(22) Pages: 4474-82

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB12010

    • Author(s)
      Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D
    • Journal Title

      Nature

      Volume: 466(7309) Pages: 941-6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis2010

    • Author(s)
      Shimizu T, Ishikawa T, Sugihara E, Kuninaka S, Miyamoto T, Mabuchi Y, Matsuzaki Y, Tsunoda T, Miya F, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Kawai A, Ichikawa H, Hasegawa T, Okada S, Ito T, Ikeda Y, Suda T, Saya H
    • Journal Title

      Oncogene

      Volume: 29(42) Pages: 5687-99

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hematopoietic Stem Cells and Their Niche2010

    • Author(s)
      Iwasaki H, Suda T
    • Journal Title

      Hematopoietic Stem Cell Biology

      Pages: 37-55

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells2010

    • Author(s)
      Kobayashi I, Ono H, Moritomo T, Kano K, Nakanishi T, Suda T
    • Journal Title

      Blood

      Volume: 115 Pages: 1-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver2010

    • Author(s)
      Iwasaki H, Arai F, Kubota Y, Suda T
    • Journal Title

      Blood

      Volume: 116 Pages: 544-553

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors2010

    • Author(s)
      Fujii M, Kanematsu T, Ishibashi H, Fukami K, Takenawa T, Nakayama KI, Moss SJ, Nabekura J, Hirata M
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 4837-4846

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fbxo45, a novel ubiquitin ligase, regulates synaptic activity2010

    • Author(s)
      Tada H, Okano HJ, Takagi H, Shibata S, Yao I, Matsumoto M, Saiga T, Nakayama KI, Kashima H, Takahashi T, Setou M, Okano H
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 3840-3849

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of osteoclast apoptosis by bcl-2 family protein bim and caspase-32010

    • Author(s)
      Tanaka S, Wakeyama H, Akiyama T, Takahashi K, Amano H, Nakayama KI, Nakamura K
    • Journal Title

      Adv Exp Med Biol

      Volume: 658 Pages: 111-116

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cadherin-based adhesion is a potential target for niche manipulation to protect hematopoietic stem cells in adult bone marrow2010

    • Author(s)
      Hosokawa K, Arai F, Yoshihara H, Iwasaki H, Hembree M, Yin T, Nakamura N, Gomei Y, Takubo K, Shiama H, Matsuoka S, Li L, Suda T
    • Journal Title

      Cell Stem Cell

      Volume: 6 Pages: 194-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells2010

    • Author(s)
      Hosokawa K, Arai F, Yoshihara H, Iwasaki H, Nakamura Y, Gomei Y, Suda T
    • Journal Title

      Blood

      Volume: 116 Pages: 554-563

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells2010

    • Author(s)
      Nakamura Y, Arai F, Iwasaki H, Hosokawa K, Kobayashi I, Gomei Y, Matsumoto Y, Yoshihara H, Suda T
    • Journal Title

      Blood

      Volume: 116 Pages: 1422-1432

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of the HIF-1alpha level is essential for hematopoietic stem cells2010

    • Author(s)
      Takubo K, Goda N, Yamada W, Iriuchishima H, Ikeda E, Kubota Y, Shima H, Johnson RS, Hirao A, Suematsu M, Suda T
    • Journal Title

      Cell Stem Cell

      Volume: 7 Pages: 391-402

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina2010

    • Author(s)
      Kurihara T, Kubota Y, Ozawa Y, Ta kubo K, Noda K, Simon MC, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H
    • Journal Title

      Development

      Volume: 137 Pages: 1563-1571

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone hemostasis2010

    • Author(s)
      Miyauchi Y, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, Miyamoto K, Hao W, Yoshida S, Morioka H, Chiba K, Kato S, Tokuhisa T, Saitou M, Toyama Y, Suda T, Miyamoto T
    • Journal Title

      J Exp Med

      Volume: 207 Pages: 751-762

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression phenotypes for vascular invasiveness of hepatocellular carcinomas2010

    • Author(s)
      Tanaka S, Mogushi K, Yasen M, Noguchi N, Kudo A, Nakamura N, Ito K, Miki Y, Inazawa J, Tanaka H, Arii S
    • Journal Title

      Surgery

      Volume: 147(3) Pages: 405-414

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The selective Aurora B kinase inhibitor AZD1152 as a novel treatment for hepatocellular carcinoma2010

    • Author(s)
      Aihara A, Tanaka S, Yasen M, Matsumura S, Mitsunori Y, Murakata A, Noguchi N, Kudo A, Nakamura N, Ito K, Arii S
    • Journal Title

      Journal of Hepatology

      Volume: 52(1) Pages: 63-71

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma2010

    • Author(s)
      Furuta M, Kozaki KI, Tanaka S, Arii S, Imoto I, Inazawa J
    • Journal Title

      Carcinogenesis

      Volume: 31(5) Pages: 766-76

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analogy between sphere forming ability and stemness of human hepatoma cells2010

    • Author(s)
      Uchida U, Tanaka S, Aihara A, Adikrisna R, Yoshitake K, Matsumura S, Mitsunori Y, Murakata A, Noguchi N, Irie K, Kudo A, Nakamura N, Lai PB, Arii S
    • Journal Title

      Oncology Reports

      Volume: 24 Pages: 1147-51

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD13 is a therapeutic target in human liver cancer stem cells2010

    • Author(s)
      Haraguchi N, Ishii H, Mimori K, Tanaka F, Ohkuma M, Kim HM, Akita H, Takiuchi D, Hatano H, Nagano H, Barnard GF, Doki Y, Mori M
    • Journal Title

      J Clin Invest

      Volume: 120(9) Pages: 3326-3339

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defined factors induce reprogramming of gastrointestinal cancer cells2010

    • Author(s)
      Miyoshi N, Ishii H, Nagai K, Hoshino H, Mimori K, Tanaka F, Nagano H, Sekimoto M, Doki Y, Mori M
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 107(1) Pages: 40-45

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF22010

    • Author(s)
      Aikawa Y, Katsumoto T, Zhang P, Shima H, Shino M, Terui K, Ito E, Ohno H, Stanley ER, Singh H, Tenen DG, Kitabayashi I
    • Journal Title

      Nat Med

      Volume: 16(5) Pages: 580-585

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription2010

    • Author(s)
      Yokoyama A, Lin M, Naresh A, Kitabayashi I, Cleary ML
    • Journal Title

      Cancer Cell

      Volume: 17(2) Pages: 198-212

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mad2 inhibits the mitotic kinesin MKlp22010

    • Author(s)
      Lee SH, McCormick F, Saya H
    • Journal Title

      J Cell Biol

      Volume: 191(6) Pages: 1069-77

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of CD44 as a cell surface marker for Muller glia precursor cells2010

    • Author(s)
      Shinoe T, Kuribayashi H, Saya H, Seiki M, Aburatani H, Watanabe S
    • Journal Title

      J Neurochem

      Volume: 115(6) Pages: 1633-42

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation2010

    • Author(s)
      Naoe H, Araki K, Nagano O, Kobayashi Y, Ishizawa J, Chiyoda T, Shimizu T, Yamamura K, Sasaki Y, Saya H, Kuninaka S
    • Journal Title

      Mol Cell Biol

      Volume: 30(16) Pages: 3994-4005

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteome profiling reveals gender differences in the composition of human serum2010

    • Author(s)
      Miike K, Aoki M, Yamashita R, Takegawa Y, Saya H, Miike T, Yamamura K
    • Journal Title

      Proteomics

      Volume: 10(14) Pages: 2678-91

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Experimental therapies : Investigator-initiated cancer trials with INDs for approval in Japan2010

    • Author(s)
      Imamura CK, Takebe N, Nakamura S, Saya H, Ueno NT
    • Journal Title

      Nat Rev Clin Oncol

      Volume: 7(3) Pages: 127-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties2010

    • Author(s)
      Nagahama Y, Ueno M, Miyamoto S, Morii E, Minami T, Mochizuki N, Saya H, Takakura N
    • Journal Title

      Cancer Res

      Volume: 70(3) Pages: 1215-24

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteopontin-mediated enhanced hyaluronan binding induces multidrug resistance in mesothelioma cells2010

    • Author(s)
      Tajima K, Ohashi R, Sekido Y, Hida T, Nara T, Hashimoto M, Iwakami S, Minakata K, Yae T, Takahashi F, Saya H, Takahashi K
    • Journal Title

      Oncogene

      Volume: 29(13) Pages: 1941-51

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myristoylated alanine-rich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase C-dependent pathway2010

    • Author(s)
      Techasen A, Loilome W, Namwat N, Takahashi E, Sugihara E, Puapairoj A, Miwa M, Saya H, Yongvanit P
    • Journal Title

      Cancer Sci

      Volume: 101(3) Pages: 658-65

    • NAID

      10026589391

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis2010

    • Author(s)
      Ishimoto T, Oshima H, Oshima M, Kai K, Torii R, Masuko T, Baba H, Saya H, Nagano O
    • Journal Title

      Cancer Sci

      Volume: 101(3) Pages: 673-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased expression of neurofibromin contributes to epithelial-mesenchymal transition in neurofibromatosis type 12010

    • Author(s)
      Arima Y, Hayashi H, Kamata K, Goto TM, Sasaki M, Kuramochi A, Saya H
    • Journal Title

      Exp Dermatol

      Volume: 19(8)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD 44-moesin interaction2010

    • Author(s)
      Takahashi E, Nagano O, Ishimoto T, Yae T, Suzuki Y, Shinoda T, Nakamura S, Niwa S, Ikeda S, Koga H, Tanihara H, Saya H
    • Journal Title

      J Biol Chem

      Volume: 285(6) Pages: 4060-73

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Breast cancer stem cells2010

    • Author(s)
      Kai K, Arima Y, Kamiya T, Saya H
    • Journal Title

      Breast Cancer

      Volume: 17(2) Pages: 80-5

    • NAID

      10027255296

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks2010

    • Author(s)
      Tabu K, Kimura T, Sasai K, Wang L, Bizen N, Nishihara H, Taga T, Tanaka S
    • Journal Title

      Mol Cancer

      Volume: 9 Pages: 39-53

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrated quantitative analysis of the phosphoproteome and transcriptome in tamoxifen-resistant breast cancer2010

    • Author(s)
      Oyama M, Nagashima T, Suzuki T, Kozuka-Hata H, Yumoto N, Shiraishi Y, Ikeda K, Kuroki Y, Gotoh N, Ishida T, Inoue S, Kitano H, Okada-Hatakeyama M
    • Journal Title

      J.Biol.Chem

      Volume: 286 Pages: 818-829

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling2010

    • Author(s)
      Tasaki S, Nagasaki M, Kozuka-Hata H, Semba K, Gotoh N, Hattori S, Inoue J, Yamamoto T, Miyano S, Sugano S, Oyama M
    • Journal Title

      PLoS ONE

      Volume: 5(11)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Collocation-based sparse estimation for constructing dynamic gene networks2010

    • Author(s)
      Shimamura T, Imoto S, Nagasaki M, Yamauchi M, Yamaguchi R, Fujita A, Tamada Y, Gotoh N, Miyano S
    • Journal Title

      Genome Inform

      Volume: 24 Pages: 164-178

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory signaling pathways in self-renewing breast cancer stem cells2010

    • Author(s)
      Hinohara K, Gotoh N
    • Journal Title

      Curr Opin Pharmacol

      Volume: 10 Pages: 650-654

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FGF-FRS2a-Erk axis controls a self-renewal target Hes1 and growth of neural stem/progenitor cells2010

    • Author(s)
      Sato T, Shimazaki T, Naka H, Fukami S, Okano H, Lax I, Schlessinger J, Gotoh N
    • Journal Title

      Stem Cells

      Volume: 28 Pages: 1661-1672

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A state space representation of VAR models with sparse learning for dynamic gene networks2010

    • Author(s)
      Kojima K, Yamaguchi R, Imoto S, Yamauchi M, Nagasaki M, Yoshida R, Shimamura T, Ueno K, Higuchi T, Gotoh N, Miyano S
    • Journal Title

      Genome Inform

      Volume: 22 Pages: 56-68

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FRS2b, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor for EGF receptor family members via ERK binding2010

    • Author(s)
      Iejima D, Minegichi Y, Takenaka K, Siswanto A, Watanabe M, Huang L, Watanabe T, Tanaka F, Kuroda M, Gotoh N
    • Journal Title

      Oncogene

      Volume: 29 Pages: 3087-3099

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene set enrichment analysis provides insight into novel signaling pathways in breast cancer stem cells2010

    • Author(s)
      Murohashi M, Hinohara K, Kuroda M, Isagawa T, Tsuji S, Kobayashi S, Umezawa K, Tojo A, Aburatani H, Gotoh N
    • Journal Title

      British J Cancer

      Volume: 102 Pages: 206-212

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An FGF4-FRS2a-Cdx2 axis-in trophoblast stem cells induces BMP4 to regulate proper growth of early mouse embryos2010

    • Author(s)
      Murohashi M, Nakamura T, Tanaka S, Ichise T, Yoshida N, Yamamoto T, Shibuya M, Schlessinger J, Gotoh N
    • Journal Title

      Stem Cells

      Volume: 28 Pages: 113-121

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clonal origin of Epstein-Barr virus (EBV)-infected T/NK-cell subpopulations in EBV-positive T/NK-cell lymphoproliferative disorders of childhood

    • Author(s)
      Ohga S, Ishimura M, Yoshimoto G, Miyamoto T, Takada H, Tanaka T, Ohshima K, Ogawa Y, Imadome KI, Abe Y, Akashi K, Hara T
    • Journal Title

      J Clin Virol

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fbxw7-dependent degradation of Notch is required for control of stemness and neuronal-glial differentiation in neural stem cells

    • Author(s)
      Matsumoto A, Onoyama I, Sunabori, T, Kageyama R, Okano H, Nakayama KI
    • Journal Title

      J Biol Chem

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MiR-221 and miR-155 regulate human dendritic cell development, apoptosis and IL-12 production through targeting of p27kip1, KPC1 and SOCS-1

    • Author(s)
      Lu C, Huang X, Zhang X, Roensch K, Cao Q, Nakayama KI, Blazar BR, Zeng Y, Zhou X
    • Journal Title

      Blood

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow-derived cells serve as pro-angiogenic macrophages but not endothelial cells in wound healing

    • Author(s)
      Okuno Y, Kishi K, Suda T, Kubota Y
    • Journal Title

      Blood

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells

    • Author(s)
      Kinoshita T, Nagamatsu G, Kosaka T, Takubo K, Hotta A, Ellis J, Suda T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere independent mechanism

    • Author(s)
      Nitta E, Yamashita M, Hosokawa K, Xian M, Takubo K, Arai F, Nakada S, Suda T
    • Journal Title

      Blood

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A germ cell specific gene, Prmt5 works as somatic cell reprogramming

    • Author(s)
      Nagamatsu G, Kosaka T, Kawasumi M, Kinoshita T, Takubo K, Akiyama H, Sudo T, Kobayashi T, Oya M, Suda T
    • Journal Title

      J Biol.Chem

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression signature of the gross morphology in hepatocellular carcinoma

    • Author(s)
      Murakata A, Tanaka S, Mogushi K, Yasen M, Noguchi N, Irie T, Kudo A, Nakamura N, Tanaka H, Arii S
    • Journal Title

      Annals of Surgery

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress

    • Author(s)
      Ishizawa J, Kuninaka S, Sugihara E, Naoe H, Kobayashi Y, Chiyoda T, Ueki A, Araki K, Yamamura KI, Matsuzaki Y, Nakajima H, Ikeda Y, Okamoto S, Saya H
    • Journal Title

      Cancer Sci.

      Volume: (in press)

    • NAID

      10029293305

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FRS2

    • Author(s)
      Gotoh N
    • Journal Title

      Encyclopedia of Signaling Molecules

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible signaling pathways in cancer stem cells in breast cancer

    • Author(s)
      Gotoh N
    • Journal Title

      Cancer Stem Cells

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] TIM-3 and its ligand, galectin-9, constitute an autocrine loop critical for development of human myeloid leukemia stem cells.2016

    • Author(s)
      Koichi Akashi
    • Organizer
      JSPS-NUS Joint Symposium New Horizons in Normal and Cancer Stem Cell Research
    • Place of Presentation
      Singapore
    • Year and Date
      2016-01-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] TIM-3 and its ligand, galectin-9 constitute an autocrine loop to maintain stem cells in most human myeloid malignancies.2015

    • Author(s)
      Koichi Akashi
    • Organizer
      2015 ISEH Annual Meeting
    • Place of Presentation
      Kyoto
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 骨髄系白血病幹細胞における共通の鍵分子TIM-3とその臨床応用2015

    • Author(s)
      赤司浩一
    • Organizer
      第39回阿蘇シンポジウム
    • Place of Presentation
      阿蘇
    • Year and Date
      2015-08-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] TIM-3 Signaling and Human Myeloid Leukemia Stem Cell Development2015

    • Author(s)
      Koichi Akashi
    • Organizer
      KEYSTONE SYMPOSIA
    • Place of Presentation
      Keystone, Colorado USA
    • Year and Date
      2015-02-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 白血病幹細胞研究のすゝめ2014

    • Author(s)
      赤司 浩一
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 造血器腫瘍幹細胞2014

    • Author(s)
      赤司 浩一
    • Organizer
      第101回近畿血液学地方会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] TIM-3, as a Target for Eradication of Cancer Stem Cells2014

    • Author(s)
      Koichi Akashi
    • Organizer
      The Uehara Memorial Foundation Symposium
    • Place of Presentation
      東京
    • Year and Date
      2014-06-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 造血器腫瘍幹細胞2014

    • Author(s)
      赤司 浩一
    • Organizer
      第3回日本血液学会東海地方会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cancer Stem Cell2014

    • Author(s)
      赤司 浩一
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-04-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Hematopoietic stem cells in the hypoxic niche2014

    • Author(s)
      Toshio Suda
    • Organizer
      Keystone Symposia conference 2014: Sensing and Signaling of Hypoxia: Interfaces with Biology and Medicine
    • Place of Presentation
      Colorado, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Transcription Factor Regulation of Normal and Malignant Hematopoiesis2013

    • Author(s)
      Akashi K
    • Organizer
      2013USA-Japan Science Conference
    • Place of Presentation
      Maui,Hawaii
    • Year and Date
      2013-03-26
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Niche regulation for hematopoietic stem cells2013

    • Author(s)
      Toshio Suda
    • Organizer
      1st Shanghai International Workshop on Stem Cells in Cancer
    • Place of Presentation
      Shanghai, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Hematopoiesis under the stress2013

    • Author(s)
      Toshio Suda
    • Organizer
      Collaborative Meeting of the European and the Spanish Societies for Gene and Cell Therapy
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 悪性造血器腫瘍における癌幹細胞の病理2012

    • Author(s)
      赤司浩一
    • Organizer
      第71回日本癌学会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-21
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 慢性リンパ性白血病幹細胞の特性と治療応用2012

    • Author(s)
      赤司浩一
    • Organizer
      第10回日本臨床腫瘍学会
    • Place of Presentation
      大阪
    • Year and Date
      2012-07-28
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 造血器悪性幹細胞の成立機構2012

    • Author(s)
      赤司浩一
    • Organizer
      第101回日本病理学会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-26
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Hematopoietic stem cell metabolism2012

    • Author(s)
      Suda T
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology, The life of a Stem Cell : From Birth to Death
    • Place of Presentation
      Olympic Valley, USA(招待講演)
    • Year and Date
      2012-03-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Maintenance of C6 glioma side population with stemness by the cellular and synthetic niche2011

    • Author(s)
      Kouichi Tabu
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川県
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Transcription factor regulation in normal and malignant hematopoiesis2011

    • Author(s)
      Koichi Akashi
    • Organizer
      米国血液学会
    • Place of Presentation
      San Diego,米国
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 癌幹細胞の自己複製戦略2011

    • Author(s)
      田賀哲也
    • Organizer
      第56回日本人類遺伝学会
    • Place of Presentation
      千葉市(招待講演)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Niche for hematopoietic stem cells in bone marrow2011

    • Author(s)
      Suda T
    • Organizer
      The 2^<nd> Pacific Meeting for Angiogensis and Lymphangiogenesis
    • Place of Presentation
      Jeju, Korea(招待講演)
    • Year and Date
      2011-10-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Glycolytic metabolism of hematopoietic stem cells2011

    • Author(s)
      Suda T
    • Organizer
      2011 Cold Spring Harbor Asia Conference : Cellular Programs and Reprogramming
    • Place of Presentation
      Suzhou, China(招待講演)
    • Year and Date
      2011-10-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Control of glioma stem cells by the synthetic polymers2011

    • Author(s)
      Kouichi Tabu
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of CD44 in cancer stem cells and metastasis2011

    • Author(s)
      Saya H
    • Organizer
      8^<th> International Symposium on Minmal Residual Cancer
    • Place of Presentation
      Osaka International Convention Center, Osaka
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Origin of leukemic stem cells2011

    • Author(s)
      Koichi Akashi
    • Organizer
      ドイツ造血幹細胞学会
    • Place of Presentation
      Tubingen、ドイツ
    • Year and Date
      2011-09-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] The cellular and synthetic niches for C6 glioma stem cells2011

    • Author(s)
      椨康一
    • Organizer
      平成23年度がん若手研究者ワークショップ
    • Place of Presentation
      長野県
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regulation of quiescent hematopoietic stem cells2011

    • Author(s)
      Suda T
    • Organizer
      ISEH 40^<th> Annual Scientific Meeting
    • Place of Presentation
      Vancouver, Canada(招待講演)
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regulation of quiescent hematopoietic stem cells2011

    • Author(s)
      Suda T
    • Organizer
      Heidelberg-Kyoto Joint Symposium "Crossing Boundaries : Stem Cells, Materials, and Mesoscopic Sciences"
    • Place of Presentation
      Heidelberg, Germany(招待講演)
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 神経幹細胞の分化制御シグナル2011

    • Author(s)
      田賀哲也
    • Organizer
      第96回医工学フォーラム
    • Place of Presentation
      京都市(招待講演)
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子宮体癌幹細胞形質獲得機構におけるdbpC/contrinの関与2011

    • Author(s)
      楠木総司
    • Organizer
      第10回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      松江市
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Leukemic stem cells2011

    • Author(s)
      Koichi Akashi
    • Organizer
      ヨーロッパ血液学会
    • Place of Presentation
      London、英国(招待講演)
    • Year and Date
      2011-06-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hypoxic niche for hematopoietic stem cells and cancer stem cells2011

    • Author(s)
      Suda T
    • Organizer
      The 52nd Spring Meeting of the Korean Society of Hematology
    • Place of Presentation
      Seoul, Korea(招待講演)
    • Year and Date
      2011-05-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Normal haematopoietic stem cells and the stem cell niche2011

    • Author(s)
      Suda T
    • Organizer
      The 11^<th> International Symposium on Myelodysplastic Syndromes
    • Place of Presentation
      Edinburgh, UK(招待講演)
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 幹細胞維持機構の考察による癌の生存戦略解明へのアプローチ2011

    • Author(s)
      田賀哲也
    • Organizer
      第316回情報計算化学生物学会研究講演会
    • Place of Presentation
      東京都(招待講演)
    • Year and Date
      2011-04-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of SoxF family proteins in the maintenance of immature phenotype of hematopoietic progenitors in the aorta-gonad-mesonephros region2011

    • Author(s)
      Ikuo Nobuhisa
    • Organizer
      The 9^<th> Stem Cell Research Symposium
    • Place of Presentation
      Tokyo
    • Related Report
      2011 Annual Research Report
  • [Presentation] The role of cyclin D1 in inhibition of astrocyte differentiation from neural stem/progenitor cells2011

    • Author(s)
      Norihisa Bizen
    • Organizer
      The 9^<th> Stem Cell Research Symposium
    • Place of Presentation
      Tokyo
    • Related Report
      2011 Annual Research Report
  • [Presentation] External cues and intrinsic properties regulating neural stem cell fate2011

    • Author(s)
      Tetsuya Taga
    • Organizer
      KEY Forum in Developmental Biology and Regenerative Medicine
    • Place of Presentation
      Kumamoto(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] SoxF family proteins have roles in maintenance of immature phenotype of hematopoietic progenitors in the aorta-gonad-mesonephros region2011

    • Author(s)
      Ikuo Nobuhisa
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉県
    • Related Report
      2011 Annual Research Report
  • [Presentation] Maintenance of immature phenotype of the hematopoietic cell clusters in the aorta-gonad-mesonephros region by SoxF family proteins2011

    • Author(s)
      Ikuo Nobuhisa
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川県
    • Related Report
      2011 Annual Research Report
  • [Presentation] 白血病幹細胞を考える2010

    • Author(s)
      赤司浩一
    • Organizer
      第72回日本血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 造血幹細胞と造血器癌幹細胞

    • Author(s)
      赤司浩一
    • Organizer
      第110回日本内科学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Epigenetic landscape of hematopoiesis visualized by histone H3.3 incorporation is deregulated in acute myeloid leukemia

    • Author(s)
      Koichi Akashi
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Cancer Stem Cells in Human Hematological Malignancies

    • Author(s)
      Koichi Akashi
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 造血器癌幹細胞  Malignant hematopoietic stem cell

    • Author(s)
      赤司浩一
    • Organizer
      第55回日本小児血液・がん学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 治療標的としてのヒト白血病幹細胞

    • Author(s)
      赤司浩一
    • Organizer
      「がん研究分野の特性等を踏まえた支援活動」公開シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 肝細胞癌に対する分子標的薬の現状と展望

    • Author(s)
      田中真二
    • Organizer
      第75回日本臨床外科学会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Cell cycle and cancer stem cells: Abrogation of quiescence by Fbw7 ablation eliminates leukemia stem cells.

    • Author(s)
      Keiichi Nakayama
    • Organizer
      ISEH 42nd Annual Scientific Meeting
    • Place of Presentation
      Vienna
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Absolute quantification oh human proteome by large-scale targeted proteomics

    • Author(s)
      Keiichi Nakayama
    • Organizer
      HUPO 2013 12th Annual World Congress
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 急性骨髄性白血病における幹細胞の制御と治療戦略

    • Author(s)
      北林一生
    • Organizer
      第72回日本癌学会学術総会シンポジウム
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Roles of CD44 in cancer stem cells.

    • Author(s)
      Hideyuki Saya
    • Organizer
      The American Association for Cancer Research (AACR) Annual Meeting 2013
    • Place of Presentation
      Washington, DC, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Novel Therapeutic Strategies for Cancer Stem Cells.

    • Author(s)
      Hideyuki Saya
    • Organizer
      Weatherall Institute of Molecular Medicine (WIMM) Seminar
    • Place of Presentation
      University of Oxford, UK
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 増殖因子制御遺伝子による予後予測診断と癌幹細胞の分子標的

    • Author(s)
      後藤典子
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Glioma stem cell survival strategy in view of niche involving immune/inflammatory cells.

    • Author(s)
      Tetsuya Taga
    • Organizer
      11th World Congress on Inflammation
    • Place of Presentation
      Natal, Brazil
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia. Chapter 1 Identification and Biology of CML Stem Cells.2016

    • Author(s)
      Hiromi Iwasaki and Koichi Akashi
    • Total Pages
      193
    • Publisher
      Springer Japan
    • Related Report
      2015 Annual Research Report
  • [Book] Notch2 and immune function. Current Topics in Microbiology and Immunology2012

    • Author(s)
      Sakata-Yanagimoto M
    • Publisher
      Springer
    • Related Report
      2012 Annual Research Report
  • [Book] サイトカインのすべて2012

    • Author(s)
      備前典久、田賀哲也
    • Publisher
      科学評論社(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Book] Molecular Targets of CNS Tumors2011

    • Author(s)
      Kouichi Tabu
    • Total Pages
      26
    • Publisher
      InTech
    • Related Report
      2011 Annual Research Report
  • [Book] Stem Cells and Cancer Stem Cells : Therapeutic Applications in Disease and Injury2011

    • Author(s)
      Kouichi Tabu
    • Total Pages
      9
    • Publisher
      Springer
    • Related Report
      2011 Annual Research Report
  • [Book] ものづくり技術からみる再生医療-細胞研究・創薬・治療-2011

    • Author(s)
      田賀哲也
    • Total Pages
      7
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Annual Research Report
  • [Book] Hematopoietic Stem Cell Biology(Motonari Kondo ed.)2010

    • Author(s)
      Iwasaki H, Suda T
    • Total Pages
      251
    • Publisher
      Hematopoietic Stem Cells and Their Niche
    • Related Report
      2010 Annual Research Report
  • [Remarks] 九州大学医学部第一内科(病態修復内科)

    • URL

      http://www.1nai.med.kyushu-u.ac.jp

    • Related Report
      2015 Annual Research Report
  • [Remarks] 新学術領域研究「癌幹細胞を標的とする腫瘍根絶技術の新構築」

    • URL

      http://www.cancer-stem-cell.com

    • Related Report
      2014 Annual Research Report
  • [Remarks] 新学術領域研究「癌幹細胞を標的とする腫瘍根絶技術の新構築」

    • URL

      http://www.cancer-stem-cell.com

    • Related Report
      2013 Annual Research Report
  • [Remarks] 新学術領域研究「癌幹細胞を標的とする腫瘍根絶技術の新構築」

    • URL

      http://www.cancer-stem-cell.com/

    • Related Report
      2012 Annual Research Report
  • [Remarks] 九州大学医学部第一内科

    • URL

      http://www.1nai.med.kyushu-u.ac.jp/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.1nai.med.kyushu-u.ac.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.cancer-stem-cell.com/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.genereg.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/mri/scr/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.cancer-stem-cell.com/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-22   Modified: 2019-07-29  

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