Analyses of membrane phospholipid quality

• Project Area: Quality of lipids in biological systems
• Project/Area Number: 15H05899
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tokyo Medical and Dental University (2018-2019); Akita University (2015-2017)
• Principal Investigator: Sasaki Takehiko 東京医科歯科大学, 難治疾患研究所, 教授 (50333365)
• Co-Investigator(Kenkyū-buntansha): 中西 広樹 秋田大学, 生体情報研究センター, 助教 (10466740) ; 青木 淳賢 東北大学, 薬学研究科, 教授 (20250219) ; 佐々木 純子 東京医科歯科大学, 難治疾患研究所, 准教授 (30333371) ; 江口 賢史 秋田大学, 医学系研究科, 助教 (70457117)
• Project Period (FY): 2015-06-29 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥118,300,000 (Direct Cost: ¥91,000,000、Indirect Cost: ¥27,300,000); Fiscal Year 2019: ¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000); Fiscal Year 2018: ¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000); Fiscal Year 2017: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000); Fiscal Year 2016: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000); Fiscal Year 2015: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
• Keywords: 膜リン脂質 / リン脂質代謝酵素 / 遺伝子改変マウス / イノシトールリン脂質 / 質量分析 / 病態モデル / 脂質代謝酵素 / 細胞膜 / リン脂質 / 基質特異性 / 炎症 / 脂肪酸 / イノシトール / キナーゼ / ホスファターゼ / 脂質 / 酵素 / シグナル伝達 / リン酸化 / 疾患モデル / がん

Outline of Final Research Achievements

To elucidate the biological significance of membrane phospholipid diversity, we focus on the action of hydrophilic and acyl groups of inositol phospholipids (PIPs) on the reaction characteristics of metabolic enzymes and the binding properties of target proteins. Considering the possibility that PIPs fingerprints are useful as biomarkers, we explore the composition of PIPs molecular species that are unique to physiological conditions and diseases. This study aimed to deepen the understanding of phospholipid quality's biological significance through more detailed analyses of lipid molecular species changes and to show new directions in drug discovery and diagnostic technology.

Academic Significance and Societal Importance of the Research Achievements

本研究で、PIPsとタンパク質の相互作用についての原子レベル、分子レベル、細胞レベルでの知見が得られた。さらに、相互作用の異常により生ずる病態について初の知見が得られた。マウス病態モデル、ヒト検体におけるPIPsプロファイルの変容と表現型の相関ならびに因果関係について、遺伝学的な手法によって新たな知見が得られた。すなわちリン脂質の分子解剖によって新たな研究の方法論を示すことができた。また、生体試料の脂質プロファイルによる特徴付けが、がんの予後予測、薬剤感受性予測に有用であることを示唆する知見が得られたことから、今後の開発によって医療への貢献も期待することができる。

Research Products

• [Int'l Joint Research] University of Edinburgh/University of Cambridge/University of Oxford(英国)
• [Int'l Joint Research] University of Toronto(カナダ)
• [Int'l Joint Research] Univ. of Michigan/Univ. of California Irvine/Weill Cornell Medical College(米国)
• [Int'l Joint Research] Babraham Institute(英国)
• [Int'l Joint Research] Cornell University/Harvard Med. Sch/UC Irvine(米国)
• [Int'l Joint Research] Babraham Inst/UCL Cancer Inst(英国)
• [Int'l Joint Research] IMBA(オーストリア)
• [Int'l Joint Research] UC Irvine/Cornell Univ/Harvard Medical School(米国)
• [Int'l Joint Research] Babraham Inst/University College London(英国)
• [Int'l Joint Research] IMBA(Austria)
• [Int'l Joint Research] Univ. of Harvard Medical School(米国)
• [Int'l Joint Research] University College London(英国)
• [Int'l Joint Research] Univ. of Toronto(Canada)
• [Int'l Joint Research] Univ. of Monash(Australia)
• [Int'l Joint Research] IMBA(Austria)
• [Int'l Joint Research]
• [Journal Article] Lysophosphatidylinositol‐acyltransferase‐1 is involved in cytosolic Ca2+ oscillations in macrophages (2019)
  • Author(s): Takemasu Shinya、Ito Masaki、Morioka Shin、Nigorikawa Kiyomi、Kofuji Satoshi、Takasuga Shunsuke、Eguchi Satoshi、Nakanishi Hiroki、Matsuoka Isao、Sasaki Junko、Sasaki Takehiko、Hazeki Kaoru
  • Journal Title: Genes to Cells Volume: - Issue: 5 Pages: 1-11
  • DOI: 10.1111/gtc.12681
  • Peer Reviewed / Open Access
• [Journal Article] A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites (2019)
  • Author(s): McCormick Barry, Craig Helen E., Chu Julia Y., Carlin Leo M., Canel Marta, Wollweber Florian, Toivakka Matilda, Michael Melina, Astier Anne L., Norton Laura, Lilja Johanna, Felton Jennifer M., Sasaki Takehiko, Ivaska Johanna, Hers Ingeborg, Dransfield Ian, Rossi Adriano G., Vermeren Sonja
  • Journal Title: JOURNAL OF IMMUNOLOGY Volume: 203 Issue: 6 Pages: 1579-1588
  • DOI: 10.4049/jimmunol.1900443
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency (2019)
  • Author(s): Nishio Miki、Miyachi Yousuke、Otani Junji、Tane Shoji、Omori Hirofumi、Ueda Fumihito、Togashi Hideru、Sasaki Takehiko、Mak Tak Wah、Nakao Kazuwa、Fujita Yasuyuki、Nishina Hiroshi、Maehama Tomohiko、Suzuki Akira
  • Journal Title: The FASEB Journal Volume: 33 Issue: 4 Pages: 5548-5560
  • DOI: 10.1096/fj.201802005r
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection (2019)
  • Author(s): Fujioka Y, Satoh AO, Horiuchi K, Fujioka M, Tsutsumi K, Sasaki J, Nepal P, Kashiwagi S, Paudel S, Nishide S, Nanbo A, Sasaki T, Ohba Y
  • Journal Title: Cell Structure and Function Volume: 44 Issue: 1 Pages: 61-74
  • DOI: 10.1247/csf.19001
  • NAID: 130007636814
  • ISSN: 0386-7196, 1347-3700
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression (2019)
  • Author(s): Koizumi Atsushi、Narita Shintaro、Nakanishi Hiroki、Ishikawa Masaki、Eguchi Satoshi、Kimura Hirotaka、Takasuga Shunsuke、Huang Mingguo、Inoue Takamitsu、Sasaki Junko、Yoshioka Toshiaki、Habuchi Tomonori、Sasaki Takehiko
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 13257-13257
  • DOI: 10.1038/s41598-019-49744-3
  • Peer Reviewed / Open Access
• [Journal Article] Polarized PtdIns(4,5)P2distribution mediated by a voltage-sensing phosphatase (VSP) regulates sperm motility (2019)
  • Author(s): Kawai Takafumi、Miyata Haruhiko、Nakanishi Hiroki、Sakata Souhei、Morioka Shin、Sasaki Junko、Watanabe Masahiko、Sakimura Kenji、Fujimoto Toyoshi、Sasaki Takehiko、Ikawa Masahito、Okamura Yasushi
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 116 Issue: 51 Pages: 26020-26028
  • DOI: 10.1073/pnas.1916867116
  • Peer Reviewed / Open Access
• [Journal Article] PIKfyve regulates melanosome biogenesis (2018)
  • Author(s): Liggins Marc C.、Flesher Jessica L.、Jahid Sohail、Vasudeva Priya、Eby Victoria、Takasuga Shunsuke、Sasaki Junko、Sasaki Takehiko、Boissy Raymond E.、Ganesan Anand K.
  • Journal Title: PLOS Genetics Volume: 14 Issue: 3 Pages: e1007290-e1007290
  • DOI: 10.1371/journal.pgen.1007290
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Metabolic determinants of sensitivity to phosphatidylinositol 3-kinase pathway inhibitor in small-cell lung carcinoma (2018)
  • Author(s): Makinoshima H et al.
  • Journal Title: Cancer Research Volume: - Issue: 9 Pages: 2179-2190
  • DOI: 10.1158/0008-5472.can-17-2109
  • Peer Reviewed / Open Access
• [Journal Article] TMEM55a localizes to macrophage phagosomes to downregulate phagocytosis (2018)
  • Author(s): Morioka Shin、Nigorikawa Kiyomi、Okada Eri、Tanaka Yoshimasa、Kasuu Yoshihiro、Yamada Miho、Kofuji Satoshi、Takasuga Shunsuke、Nakanishi Hiroki、Sasaki Takehiko、Hazeki Kaoru
  • Journal Title: Journal of Cell Science Volume: 131 Issue: 5 Pages: 213272-213272
  • DOI: 10.1242/jcs.213272
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fatty acid binding protein 4 enhances prostate cancer progression by upregulating matrix metalloproteinases and stromal cell cytokine production (2017)
  • Author(s): Huang Mingguo、Narita Shintaro、Inoue Takamitsu、Koizumi Atsushi、Saito Mitsuru、Tsuruta Hiroshi、Numakura Kazuyuki、Satoh Shigeru、Nanjo Hiroshi、Sasaki Takehiko、Habuchi Tomonori
  • Journal Title: Oncotarget Volume: 8 Issue: 67 Pages: 111780-111794
  • DOI: 10.18632/oncotarget.22908
  • Peer Reviewed / Open Access
• [Journal Article] PTEN Regulates PI(3,4)P 2 Signaling Downstream of Class I PI3K (2017)
  • Author(s): Malek M、Kielkowska A、Chessa T、Anderson K E.、Barneda D、Pir P、Nakanishi H、Eguchi S、Koizumi A、Sasaki J、Juvin V、Kiselev VY.、Niewczas I、Gray A、Valayer A、Spensberger D、Imbert M、Felisbino S、Habuchi T、Beinke S、Cosulich S、Le Novere N、Sasaki T、Clark J、Hawkins PT.、Stephens LR.
  • Journal Title: Molecular Cell Volume: 68 Issue: 3 Pages: 566-580
  • DOI: 10.1016/j.molcel.2017.09.024
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis (2017)
  • Author(s): Kimura Hirotaka、Matsuyama Yasushi、Araki Sachiko、Koizumi Atsushi、Kariya Yumi、Takasuga Shunsuke、Eguchi Satoshi、Nakanishi Hiroki、Sasaki Junko、Sasaki Takehiko
  • Journal Title: Modern Rheumatology Volume: 28 Issue: 3 Pages: 530-541
  • DOI: 10.1080/14397595.2017.1367116
  • Peer Reviewed / Open Access
• [Journal Article] Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells (2017)
  • Author(s): Shindou Hideo、Koso Hideto、Sasaki Junko、Nakanishi Hiroki、Sagara Hiroshi、Nakagawa Koh M.、Takahashi Yoshikazu、Hishikawa Daisuke、Iizuka-Hishikawa Yoshiko、Tokumasu Fuyuki、Noguchi Hiroshi、Watanabe Sumiko、Sasaki Takehiko、Shimizu Takao
  • Journal Title: Journal of Biological Chemistry Volume: 292 Issue: 29 Pages: 12054-12064
  • DOI: 10.1074/jbc.m117.790568
  • Peer Reviewed / Open Access
• [Journal Article] Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis (2017)
  • Author(s): Iizuka-Hishikawa Yoshiko、Hishikawa Daisuke、Sasaki Junko、Takubo Keiyo、Goto Motohito、Nagata Katsuyuki、Nakanishi Hiroki、Shindou Hideo、Okamura Tadashi、Ito Chizuru、Toshimori Kiyotaka、Sasaki Takehiko、Shimizu Takao
  • Journal Title: Journal of Biological Chemistry Volume: 292 Issue: 29 Pages: 12065-12076
  • DOI: 10.1074/jbc.m117.791277
  • Peer Reviewed / Open Access
• [Journal Article] Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia. (2017)
  • Author(s): Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Masaki N, Akatsu H, Hashizume Y, Yamamoto S, Sato S, Sasaki T, Setou M, Yabe H.
  • Journal Title: Sci Rep. Volume: 7 Issue: 7 Pages: 45050-45050
  • DOI: 10.1038/srep45050
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy. (2017)
  • Author(s): Kimura H, Eguchi S, Sasaki J, Kuba K, Nakanishi H, Takasuga S, Yamazaki M, Goto A, Watanabe H, Itoh H, Imai Y, Suzuki A, Mizushima N, Sasaki T
  • Journal Title: JCI Insight Volume: 2 Issue: 1 Pages: 89462-89478
  • DOI: 10.1172/jci.insight.89462
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model. (2016)
  • Author(s): Morioka S, Nigorikawa K, Sasaki J, Hazeki K, Kasuu Y, Sasaki T, Hazeki O
  • Journal Title: Innate Immun Volume: 6 Issue: 6 Pages: 444-444
  • DOI: 10.1177/1753425916652714
  • Peer Reviewed / Open Access
• [Journal Article] イノシトールリン脂質のがん転移への関与 : "invadopodia"の形成機構 (2016)
  • Author(s): 坂東 倫行、佐々木 雄彦
  • Journal Title: 医学のあゆみ Volume: 257 Pages: 1211-1215
• [Journal Article] Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment. (2015)
  • Author(s): Ip, LR., Poulogiannis, G., Viciano, FC., Sasaki, J., Kofuji, S., Spanswick, VJ., Hochhauser, D., Hartley, JA., Sasaki, T., Gewinner, CA.
  • Journal Title: Oncotarget Volume: 6 Pages: 10548-10562
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] INPP4B is a PtdIns(3,4,5)P3 phosphatase that can act as a tumor suppressor. (2015)
  • Author(s): Kofuji S, Kimura H, Nakanishi H, Nanjo H, Takasuga S, Liu H, Eguchi S, Nakamura R, Itoh R, Ueno N, Asanuma K, Huang M, Koizumi A, Habuchi T, Yamazaki M, Suzuki A, Sasaki J, Sasaki T
  • Journal Title: Cancer Discovery Volume: in press Issue: 7 Pages: 730-9
  • DOI: 10.1158/2159-8290.cd-14-1329
  • Peer Reviewed / Open Access
• [Journal Article] In vivo role of INPP4B in tumor and metastasis suppression through regulation of PI3K/AKT signaling at endosomes. (2015)
  • Author(s): Chew CL, Lunardi A, Gulluni F, Ruan DT, Chen M, Salmena L, Nishino M, Papa A, Ng C, Fung J, Clohessy JG, Sasaki J, Sasaki T, Bronson RT, Hirsch E, Pandolfi PP
  • Journal Title: Cancer Discovery Volume: in press Issue: 7 Pages: 740-751
  • DOI: 10.1158/2159-8290.cd-14-1347
  • Peer Reviewed
• [Journal Article] Inositol Polyphosphate-4-Phosphatase Type I Negatively (2015)
  • Author(s): Nigorikawa, K., Hazeki, K., Sasaki, J., Omori, Y., Miyake, M., Morioka, S., Guo, Y., Sasaki, T., Hazeki, O
  • Journal Title: PLoS One Volume: 10 Issue: 11 Pages: 740-751
  • DOI: 10.1371/journal.pone.0142091
  • Peer Reviewed / Open Access
• [Journal Article] The ML1Nx2 Phosphatidylinositol 3,5-Bisphosphate Probe Shows Poor Selectivity in Cells. (2015)
  • Author(s): Hammond GR, Takasuga S, Sasaki T, Balla T.
  • Journal Title: PLoS One Volume: 10 Issue: 10 Pages: e0139957-e0139957
  • DOI: 10.1371/journal.pone.0139957
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Localizing the lipid products of PI3Kγ in neutrophils (2015)
  • Author(s): Norton L, Lindsay Y, Deladeriere A, Chessa T, Guillou H, Suire S, Lucocq J, Walker S, Andrews S, Segonds-Pichon A, Rausch O, Finan P, Sasaki T, Du CJ, Bretschneider T, Ferguson GJ, Hawkins PT, Stephens L.
  • Journal Title: Adv Biol Regul Volume: 60 Pages: 36-45
  • DOI: 10.1016/j.jbior.2015.10.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dysregulated YAP1/TAZ and TGF signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice (2015)
  • Author(s): Nishio, M., Sugimachi, K., Goto, H., Wang, J., Morikawa, T., Miyachi, Y., Takano, Y., Hikasa, H., Itoh, T., Suzuki, S.O., Kurihara, H., Aishima, S., Leask, A., Sasaki, T., Nakano, T., Nishina, H., Nishikawa, Y., Sekido, Y., Nakao, K., Shin-ya, K., Mimori, K. and Suzuki, A.
  • Journal Title: PNAS Volume: 113 Issue: 1 Pages: 71-80
  • DOI: 10.1073/pnas.1517188113
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] INPP4BはPTEN欠損による発がんへのフェイルセーフ機構を担う (2015)
  • Author(s): 小藤智史，佐々木雄彦
  • Journal Title: 実験医学 Volume: 34 Pages: 450-453
• [Presentation] Lipoquality of phosphoinositides (2019)
  • Author(s): Takehiko Sasaki, Eiji Yamamoto, Toshiyoshi Yamamoto, Junko Sasaki
  • Organizer: 2nd International Conference on LipoQuality
  • Int'l Joint Research / Invited
• [Presentation] Molecular dissection of phosphoinositides (2019)
  • Author(s): Junko Sasaki, Eiji Yamamoto, Toshiyoshi Yamamoto, Takehiko Sasaki
  • Organizer: The 14th International Symposium of the Institute Network for Biomedical Sciences 2019
  • Int'l Joint Research / Invited
• [Presentation] Phosphoinositide Fingerprinting in Cancer (2019)
  • Author(s): Takehiko Sasaki, Eiji Yamamoto, Toshiyoshi Yamamoto, Junko Sasaki
  • Organizer: TOHOKU FORUM for CREATIVITY Thematic Program Cancer – from Biology to Acceptance International Symposium 2
  • Int'l Joint Research / Invited
• [Presentation] Molecular mechanisms of phosphoinositide signaling (2019)
  • Author(s): Junko Sasaki,Satoshi Eguchi,Hiroki Nakanishi,Takehiko Sasaki
  • Organizer: 9th Federation of the Asian and Oceanian Physiological Societies Congress
  • Int'l Joint Research / Invited
• [Presentation] The lipid phosphatase INPP4B is a tumor suppressor in the context of PTEN insufficiency (2018)
  • Author(s): Takehiko Sasaki, Satoshi Kofuji, Shunsuke Takasuga, Junko Sasaki
  • Organizer: Workshop on Frontiers in Phosphatase Research and Drug Discovery
  • Int'l Joint Research / Invited
• [Presentation] ホスホイノシタイドの異常と疾患 (2018)
  • Author(s): 佐々木雄彦
  • Organizer: 第176回 東京脂質談話会
  • Invited
• [Presentation] 細胞膜リン脂質動態の生理と病態：An overview (2018)
  • Author(s): 佐々木雄彦
  • Organizer: 第91回日本生化学会大会
  • Invited
• [Presentation] リポクオリティがプレクストリン相同ドメインと生体膜の相互作用に与える影響 (2018)
  • Author(s): 山本詠士、佐々木純子、Mark S.P. Sansom、佐々木雄彦
  • Organizer: 第60回 日本脂質生化学会
  • Invited
• [Presentation] 細胞膜リン脂質の動態と機能 (2017)
  • Author(s): 佐々木雄彦
  • Organizer: 東京工業大学科学技術創成研究院セミナー
  • Place of Presentation: 神奈川県・横浜市
  • Year and Date: 2017-03-31
  • Invited
• [Presentation] INPP4B is a tumor suppressor in the context of PTEN insufficiency by modulating the levels of PI3K lipid products (2017)
  • Author(s): Takehiko Sasaki
  • Organizer: International Symposium on Imaging Frontier 2017
  • Int'l Joint Research / Invited
• [Presentation] がんのリン脂質代謝制御 (2017)
  • Author(s): 佐々木 雄彦
  • Organizer: 第５回 がんと代謝制御研究会
  • Invited
• [Presentation] イノシトールリン脂質クオリティとシグナル伝達 (2017)
  • Author(s): 佐々木 雄彦
  • Organizer: 第69回 日本細胞生物学会大会
  • Invited
• [Presentation] Quality of phosphoinositide in disease (2017)
  • Author(s): 佐々木 雄彦
  • Organizer: 2017年度生命科学系学会合同年次大会（ConBio2017）
  • Invited
• [Presentation] 生体脂質を見る 、測る、理解する (2017)
  • Author(s): 佐々木 雄彦
  • Organizer: 第49回 日本臨床検査医学会東北支部総会第28回 日本臨床化学会東北支部総会
  • Invited
• [Presentation] 炎症性リン脂質シグナルを抑制する SHIP1 (2017)
  • Author(s): 佐々木 雄彦
  • Organizer: 第36回 日本認知症学会学術集会
  • Invited
• [Presentation] リン脂質のバイオロジー・疾患と質量分析 (2017)
  • Author(s): 佐々木 雄彦
  • Organizer: 第44回日本マススクリーニング学会
  • Invited
• [Presentation] イノシトールリン脂質のリポクオリティ解析 (2017)
  • Author(s): 佐々木 雄彦
  • Organizer: 第42回日本医用マススペクトル学会年会
  • Invited
• [Presentation] A method for studying quality of phosphoinositides (2016)
  • Author(s): Takehiko Sasaki, Hiroki Nakanishi, Satoshi Eguchi, Masaki Ishikawa, Akira Suzuki, Junko Sasaki
  • Organizer: 第３９回日本分子生物学会年会（MBSJ2016）
  • Place of Presentation: 神奈川県・横浜市
  • Year and Date: 2016-11-30
  • Invited
• [Presentation] イノシトールリン脂質代謝と病態 (2016)
  • Author(s): 佐々木雄彦
  • Organizer: 脂質栄養学会第２５回大会
  • Place of Presentation: 秋田県・秋田市
  • Year and Date: 2016-09-17
  • Invited
• [Presentation] ホスホイノシタイドによる生体調節機構 (2016)
  • Author(s): 佐々木雄彦
  • Organizer: 第28回高遠・分子細胞生物学シンポジウム
  • Place of Presentation: 長野県・伊那市
  • Year and Date: 2016-08-26
  • Invited
• [Presentation] ω3系脂肪酸代謝産物による肝庇護作用 (2016)
  • Author(s): 森井真也子、上野紀子、中西広樹、蛇口琢、渡部亮、吉野裕顕、佐々木雄彦
  • Organizer: 第15回生命科学研究会
  • Place of Presentation: 東京都・港区
  • Year and Date: 2016-06-17
• [Presentation] Measuring Phosphoinositides at Molecular Species Level (2015)
  • Author(s): Hiroki Nakanishi, Satoshi Eguchi, Masaki Ishikawa, Akira Suzuki, Junko Sasaki, Takehiko Sasaki
  • Organizer: 第38回日本分子生物学会年会・第88回生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-04
  • Invited
• [Presentation] 心肥大におけるホスホイノシタイド代謝酵素Vps34のタンパク質分解機構の役割 (2015)
  • Author(s): 木村洋貴、江口賢史、久場敬司、今井由美子、高須賀俊輔、伊藤玲悦、中村亮太郎、中西広樹、石川将己、佐々木純子、山崎正和、佐々木雄彦
  • Organizer: 第38回日本分子生物学会年会・第88回生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-03
  • Invited
• [Book] 脂質解析ハンドブック (2019)
  • Author(s): 新井 洋由、清水 孝雄、横山 信治
  • Total Pages: 310
  • Publisher: 羊土社
  • ISBN: 9784758122412
• [Book] 実験医学増刊 イノシトールリン脂質におけるリン酸化クオリティ制御の病態生理学的意義 (2018)
  • Author(s): 高須賀俊輔、佐々木雄彦
  • Total Pages: 246
  • Publisher: 羊土社
• [Remarks] 東京医科歯科大学難治疾患研究所病態生理化学分野、大学院医歯学総合研究科脂質生物学分野HP
  • URL: https://sites.google.com/view/byoutaiseirikagaku-university/home?authuser=1
• [Remarks] 東京医科歯科大学・難治疾患研究所・病態生理化学分野
  • URL: http://www.tmd.ac.jp/mri/section/pathophysiology/pip/index.html
• [Remarks] 秋田大学大学院医学系研究科 医学専攻 病態制御医学系 微生物学講座
  • URL: http://www.med.akita-u.ac.jp/~bisei/
• [Remarks] 研究室HP
  • URL: http://www.med.akita-u.ac.jp/~bisei/
• [Patent(Industrial Property Rights)] "新規リン脂質およびその利用ならびにリン脂質分離測 (2019)
  • Inventor(s): 佐々木雄彦ほか6名
  • Industrial Property Rights Holder: 佐々木雄彦ほか6名
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-528909
  • Filing Date: 2019
• [Patent(Industrial Property Rights)] 新規リン脂質およびその利用ならびにリン脂質分離測定法の開発 (2017)
  • Inventor(s): 佐々木雄彦、中西広樹ほか
  • Industrial Property Rights Holder: 秋田大学、Japan Lipid Technologies
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017
• [Patent(Industrial Property Rights)] 新規リン脂質およびその利用 (2017)
  • Inventor(s): 佐々木雄彦、中西広樹、石川将己、上野紀子、江口賢史、佐々木純子
  • Industrial Property Rights Holder: 秋田大学、Akita Lipid Technologies
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2017-051354
  • Filing Date: 2017-03-14
• [Patent(Industrial Property Rights)] ホスホイノシタイド分離測定法の開発 (2016)
  • Inventor(s): 中西広樹、佐々木雄彦、佐々木純子、江口賢史、中西貴代
  • Industrial Property Rights Holder: 秋田大学、Akita Lipid Technologies
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-144177
  • Filing Date: 2016-07-20