Development of a new sleep-wake control method for super stress environment, Space

• Project Area: "LIVING IN SPACE" - Integral Understanding of life-regulation mechanism from "SPACE"
• Project/Area Number: 15H05942
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: University of Tsukuba
• Principal Investigator: Nagase Hiroshi 筑波大学, 国際統合睡眠医科学研究機構, 教授 (70383651)
• Co-Investigator(Kenkyū-buntansha): 北川 博之 筑波大学, 計算科学研究センター, 教授 (00204876) ; 徳山 薫平 筑波大学, 国際統合睡眠医科学研究機構, 教授 (00207565) ; 小久保 利雄 筑波大学, 国際統合睡眠医科学研究機構, 教授 (30750004) ; 浅田 知栄 (松田知栄) 国立研究開発法人宇宙航空研究開発機構, 有人宇宙技術部門, 主任研究開発員 (50344099) ; 船戸 弘正 筑波大学, 国際統合睡眠医科学研究機構, 教授(WPI-IIIS) (90363118) ; 柳沢 正史 筑波大学, 国際統合睡眠医科学研究機構, 教授 (20202369)
• Project Period (FY): 2015-06-29 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥95,030,000 (Direct Cost: ¥73,100,000、Indirect Cost: ¥21,930,000); Fiscal Year 2019: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2018: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2017: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2016: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2015: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
• Keywords: 睡眠 / 睡眠診断法 / 不眠症治療薬 / 宇宙飛行士 / 睡眠覚醒制御遺伝子 / オレキシン受容体作動薬 / オレキシン / ストレス

Outline of Final Research Achievements

We worked on the development of AI EEG analysis software and a wearable EEG measurement device, and succeeded in the development of software that enables sleep stage determination with 96.6% accuracy in EEG analysis of mice by deep learning. By comparing the GABAA receptor agonist with the recently developed orexin receptor antagonist, it was proved that the latter has less effect on the physical and cognitive functions. In a study of sleep-regulating gene Sleepy, we found that phosphorylation of sleepy mutant mice increased phosphorylation of synaptic proteins with continued wakefulness. Research on orexin 1 receptor antagonists found that orexin 1 receptor is important for fear memory fixation and drug dependence.

Academic Significance and Societal Importance of the Research Achievements

現代はグローバル化による24時間型社会であり、多くの人々が厳しい環境とストレスにさらされて恒常性に異常をきたし、睡眠障害やリズム障害に苦しんでいる。国際宇宙ステーション（ISS）に居住する宇宙飛行士も、極端に短い日周期や閉鎖環境、過密スケジュール等の厳しい条件にさらされており、ISS環境は現代ストレス社会の究極と捉えることができる。本研究の成果睡眠診断法および新規睡眠覚醒制御手法を開発してISS環境における睡眠問題の解決が期待できる。さらに研究成果を地上で応用・展開することにより、現代ストレス社会・高齢化社会の睡眠問題の解決も期待する。

Research Products

• [Journal Article] MC-SleepNet: Large-scale Sleep Stage Scoring in Mice by Deep Neural Networks. (2019)
  • Author(s): Yamabe M, Horie K, Shiokawa H, Funato H, Yanagisawa M, Kitagawa H.
  • Journal Title: Sci Rep. Volume: 9 Issue: 1 Pages: 15793-15793
  • DOI: 10.1038/s41598-019-51269-8
  • NAID: 120007127675
  • Peer Reviewed / Open Access
• [Journal Article] Differential Roles of Each Orexin Receptor Signaling in Obesity (2019)
  • Author(s): Kakizaki Miyo、Tsuneoka Yousuke、Takase Kenkichi、Kim Staci J.、Choi Jinhwan、Ikkyu Aya、Abe Manabu、Sakimura Kenji、Yanagisawa Masashi、Funato Hiromasa
  • Journal Title: iScience Volume: 20 Pages: 1-13
  • DOI: 10.1016/j.isci.2019.09.003
  • NAID: 120007132695
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Distinct effects of orexin receptor antagonist and GABA(A) agonist on sleep and physical/cognitive functions after forced awakening. (2019)
  • Author(s): Seol J, Fujii Y, Park I, Suzuki Y, Kawana F, Yajima K, Fukusumi S, Okura T, Satoh M, Tokuyama K, Kokubo T, Yanagisawa M.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 116 Issue: 48 Pages: 24353-24358
  • DOI: 10.1073/pnas.1907354116
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quantitative phosphoproteomic analysis of the molecular substrates of sleep need (2018)
  • Author(s): Z. Wang, J. Ma, C. Miyoshi, Y. Li, M Sato, Y. Ogawa, T. Lou, C. Ma, X. Gao, C. Lee, T. Fujiyama, X. Yang, S. Zhou, N. Hotta-Hirashima, D. Klewe-Nebenus, A. Ikkyu, M. Kakizaki, S. Kanno, L. Cao, S. Takahashi, J. Peng, Y. Yu, H. Funato, M. Yanagisawa, Q. Liu
  • Journal Title: Nature Volume: 558 Issue: 7710 Pages: 435-439
  • DOI: 10.1038/s41586-018-0218-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors (2018)
  • Author(s): Wang, Y., Cao, L., Lee, C-Y., Matsuo, M., Wu, K., Asher, G., Saitoh, T., Klewe-Nebenius, D., Wang, L., Soya, S., Hasegawa, E., Cherasse, Y., Miyoshi,C., Irukayama, Y., Wang, Z., Sakurai, K., Funato, H., Sakurai, T., Yanagisawa, M., Nagase, H., Kobayakawa, R., Kobayakawa, K., Beutler, B., Liu, Q
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 2041-2041
  • DOI: 10.1038/s41467-018-04324-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Synthesis of novel 1,3-dioxa-5-thiazatriquinane and 1-oxa-3,5-dithiazatriquinane derivatives and their pharmacologies (2018)
  • Author(s): Ohshita R, Kutsumura N, Nagumo Y, Yamamoto N, Saitoh T, Hirayama S, Fujii H, and Nagase H*
  • Journal Title: Heterocycles Volume: 97 Issue: 2 Pages: 687-695
  • DOI: 10.3987/com-18-s(t)40
  • Peer Reviewed / Open Access
• [Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity (2018)
  • Author(s): Ohrui Sayaka、Yamamoto Naoshi、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
  • Journal Title: Bioorg Med Chem Lett. Volume: 28 Issue: 4 Pages: 774-777
  • DOI: 10.1016/j.bmcl.2017.12.069
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Acetic Anhydride Mediated Retro-Ene Reaction via a [4.4.3]Propellane Skeleton Intermediate Containing a Quaternary Ammonium Linkage (2018)
  • Author(s): Kutsumura N and Nagase H, et al.
  • Journal Title: Synthesis Volume: 20 Issue: 21 Pages: 1559-1562
  • DOI: 10.1055/s-0036-1589138
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sleep/Wake Behaviors in Mice During Pregnancy and Pregnancy-Associated Hypertensive Mice (2017)
  • Author(s): Komiya Haruna、Miyoshi Chika、Iwasaki Kanako、Hotta-Hirashima Noriko、Ikkyu Aya、Kanno Satomi、Honda Takato、Gosho Masahiko、Hamada Hiromi、Satoh Toyomi、Fukamizu Akiyoshi、Funato Hiromasa、Yanagisawa Masashi
  • Journal Title: Sleep Volume: 41 Issue: 3 Pages: 1-1
  • DOI: 10.1093/sleep/zsx209
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neurotransmitters and neuropeptides in gonadal steroid receptor-expressing cells in medial preoptic area subregions of the male mouse (2017)
  • Author(s): Yousuke Tsuneoka, Sachine Yoshida, Kenkichi Takase, Satoko Oda, Masaru Kuroda, Hiromasa Funato
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 1-16
  • DOI: 10.1038/s41598-017-10213-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor (2017)
  • Author(s): Yamamoto Naoshi、Ohrui Sayaka、Okada Takahiro、Yata Masahiro、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
  • Journal Title: Bioorg Med Chem Lett. Volume: 27 Issue: 17 Pages: 4176-4179
  • DOI: 10.1016/j.bmcl.2017.07.011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Moxd1 Is a Marker for Sexual Dimorphism in the Medial Preoptic Area, Bed Nucleus of the Stria Terminalis and Medial Amygdala (2017)
  • Author(s): Tsuneoka Y and Funato H et al.
  • Journal Title: Front Neuroanat Volume: 11 Pages: 26-26
  • DOI: 10.3389/fnana.2017.00026
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Forward-genetics analysis of sleep in randomly mutagenized mice. (2016)
  • Author(s): Funato H. and M. Yanagisawa et al.
  • Journal Title: Nature Volume: 539 Pages: 378-383
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification of mutations through dominant screening for obesity using C57BL/6 substrains. (2016)
  • Author(s): Hossain MS., H. Funato, and M. Yanagisawa et al.
  • Journal Title: Scientific Reports Volume: 6 Pages: 32453-32453
  • NAID: 120007129430
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 24.Nagase H., N. Yamamoto, and M. Yanagisawa et al. Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies (2016)
  • Author(s): Nagase H., N. Yamamoto, and M. Yanagisawa et al.
  • Journal Title: J. Med. Chem. Volume: 60 Pages: 1018-1040
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 脳波／筋電図を利用したマウスの睡眠ステージ判定 (2016)
  • Author(s): 鈴木 悠太, 佐藤 牧人, 塩川 浩昭, 柳沢 正史，北川 博之
  • Journal Title: 第8回データ工学と情報マネジメントに関するフォーラム(DEIM Forum 2016) Volume: G4-3
• [Journal Article] High-fat diet feeding alters olfactory-, social-, and reward-related behaviors of mice independent of obesity. (2016)
  • Author(s): Takase K, Tsuneoka Y, Oda S, Kuroda M, Funato H
  • Journal Title: Obesity Volume: 4 Issue: 4 Pages: 886-894
  • DOI: 10.1002/oby.21441
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Sleep as a biological problem: an overview of frontiers in sleep research (2016)
  • Author(s): Kanda T, Tsujino N, Kuramoto E, Koyama Y, Susaki EA, Chikahisa S, Funato H
  • Journal Title: J Physiol Sci Volume: 66 Issue: 1 Pages: 1-13
  • DOI: 10.1007/s12576-015-0414-3
  • Peer Reviewed / Open Access
• [Journal Article] Nighttime administration of nicotine improves hepatic glucose metabolism via the hypothalamic orexin system in mice. (2016)
  • Author(s): Tsuneki H, Nagata T, Fujita M, Kon K, Wu N, Takatsuki M, Yamaguchi K, Wada T, Nishijo H, Yanagisawa M, Sakurai T, Sasaoka T.
  • Journal Title: Endocrinology Volume: 157 Issue: 1 Pages: 195-206
  • DOI: 10.1210/en.2015-1488
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Functional ETA-ETB receptor cross-talk in basilar artery in situ from ETB receptor deficient rats. (2016)
  • Author(s): Yoon S, Gariepy CE, Yanagisawa M, Zuccarello M, Rapoport RM
  • Journal Title: J Cardiovasc Pharmacol Volume: 67 Issue: 3 Pages: 212-217
  • DOI: 10.1097/fjc.0000000000000335
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Intrathecal morphine-3-glucuronide-induced nociceptive behavior via δ-2 opioid receptors in the spinal cord (2016)
  • Author(s): Takaaki Komatsu, Soh Katsuyama, Hiroshi Nagase, Hirokazu Mizoguchi, Chikai Sakurada, Minoru Tsuzuki, Shinobu Sakurada, Tsukasa Sakurada
  • Journal Title: Pharmacology Biochemistry & Behavior Volume: 140 Pages: 68-74
  • DOI: 10.1016/j.pbb.2015.10.010
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Opioid systems in the lateral hypothalamus regulate feeding behavior through orexin and GABA neurons. (2016)
  • Author(s): Ardianto C, Yonemochi N, Yamamoto S, Yang L, Takenoya F, Shioda S, Nagase H, Ikeda H, Kamei J.
  • Journal Title: Neuroscience. Volume: 320 Pages: 183-193
  • DOI: 10.1016/j.neuroscience.2016.02.002
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 低分子オレキシン受容体アゴニストの創製 (2016)
  • Author(s): 斉藤毅, 長瀬博
  • Journal Title: MedChem News Volume: 26(2) Pages: 90-96
  • NAID: 130007383316
  • Peer Reviewed
• [Journal Article] 内因性オピオイドの痒みへの関与と痒み調節機構の解明 (2016)
  • Author(s): 長瀬 博, 沓村 憲樹
  • Journal Title: JOHNS Volume: 32 Pages: 564-567
  • Peer Reviewed
• [Journal Article] 難治性掻痒症治療薬 ナルフラフィンの研究開発 (2016)
  • Author(s): 長瀬 博, 沓村 憲樹
  • Journal Title: SAR News Volume: ３０ Pages: 2-7
  • Peer Reviewed
• [Journal Article] Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists (2015)
  • Author(s): Nagahara T, Saitoh T, Kutsumura N, Irukayama-Tomobe Y, Ogawa Y, Kuroda D, Gouda H, Kumagai H, Fujii H, Yanagisawa M, Nagase H
  • Journal Title: J. Med. Chem Volume: 58 Issue: 20 Pages: 7931-7937
  • DOI: 10.1021/acs.jmedchem.5b00988
  • Peer Reviewed
• [Journal Article] Endothelin-1 as a master regulator of whole-body Na+ homeostasis (2015)
  • Author(s): Speed JS, Heimlich JB, Hyndman KA, Fox BM, Patel V, Yanagisawa M, Pollock JS, Titze JM, Pollock DM
  • Journal Title: FASEB J Volume: 29 Issue: 12 Pages: 4937-44
  • DOI: 10.1096/fj.15-276584
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transformation of naltrexone into mesembrane and investigation of the binding properties of its intermediate derivatives to opioid receptors (2015)
  • Author(s): Konoura K, Fujii H, Imaide S, Gouda H, Hirayama S, Hirono S, Nagase H
  • Journal Title: Bioorg Med Chem Volume: 23 Issue: 3 Pages: 439-48
  • DOI: 10.1016/j.bmc.2014.12.032
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Peripheral opioid antagonist enhances the effect of anti-tumor drug by blocking a cell growth-suppressive pathway in vivo (2015)
  • Author(s): Masami Suzuki, Fumiko Chiwaki, Yumi Sawada, Maho Ashikawa, Kazuhiko Aoyagi, Takeshi Fujita, Kazuyoshi Yanagihara, Masayuki Komatsu, Minoru Narita, Tsutomu Suzuki, Hiroshi Nagase, Ryoji Kushima, Hiromi Sakamoto, Takeo Fukagawa, Hitoshi Katai, Hitoshi Nakagama, Teruhiko Yoshida, Yasuhito Uezono, Hiroki Sasaki
  • Journal Title: PLOS ONE Volume: 10(4) Issue: 4 Pages: 1-18
  • DOI: 10.1371/journal.pone.0123407
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Investigation of 7-benzylidenenaltrexone derivatives as a novel structural antitrichomonal lead compound (2015)
  • Author(s): Kutsumura, N.; Nakajima, R.; Koyama, Y.; Miyata, Y.; Saitoh, T.; Yamamoto, N.; Iwata, S.; Fujii, H.; Nagase, H.
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 25 Issue: 21 Pages: 4890-4892
  • DOI: 10.1016/j.bmcl.2015.06.002
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Inhibition of opioid systems in the hypothalamus as well as the mesolimbic area suppresses feeding behavior of mice (2015)
  • Author(s): Ikeda H, Ardianto C, Yonemochi N, Yang L, Ohashi T, Ikegami M, Nagase H, Kamei J
  • Journal Title: Neuroscience Volume: 311 Pages: 9-21
  • DOI: 10.1016/j.neuroscience.2015.10.002
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain (2015)
  • Author(s): Nakajima R, Yamamoto N, Hirayama S, Iwai T, Saitoh A, Nagumo Y, Fujii H, Nagase H.
  • Journal Title: Bioorg Med Chem. Volume: 23 Issue: 19 Pages: 6271-6279
  • DOI: 10.1016/j.bmc.2015.08.036
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Synthesis of Novel Triplets with a 1,3,5-Trioxazatriquinane Skeleton and their Pharmacologies for Opioid Receptors (2015)
  • Author(s): H. Nagase, N. Kutsumura
  • Journal Title: Arch. Pharm. Chem. Life Sci. Volume: 348 Issue: 6 Pages: 375-389
  • DOI: 10.1002/ardp.201500031
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 難治性そう痒症治療薬レミッチ®カプセルの創出 (2015)
  • Author(s): 長瀬 博
  • Journal Title: 医薬の門 Volume: 54 Pages: 20-24
  • Peer Reviewed
• [Journal Article] ナルフラフィン塩酸塩 (2015)
  • Author(s): 長瀬 博
  • Journal Title: メディカル朝日[特集]混合ワクチン最前線 サムライたちのクスリPart II「ニッポン発の創薬」を目指して（12） Volume: 7 Pages: 66-69
  • Peer Reviewed
• [Presentation] Design and synthesis of orexin receptor selective ligands and their pharmacology (2019)
  • Author(s): H. Nagase,
  • Organizer: Roman Pharmacists Association
  • Int'l Joint Research / Invited
• [Presentation] NR-GAN: Noise Reduction GAN for Mice Electroencephalogram Signals (2019)
  • Author(s): Sumiya, Y., Horie, K., Shiokawa, H., and Kitagawa, H.
  • Organizer: 4th International Conference on Biomedical Imaging
  • Int'l Joint Research
• [Presentation] Development of photocaged adenosine2A receptor activator, (2018)
  • Author(s): Tsuyoshi Saitoh, Shuji Ioka, Mustafa Korkutata, Yohei Chitose, Manabu Abe, Michael Lazarus, and Hiroshi Nagase
  • Organizer: The 13th International Symposium on Organic Reactions
  • Int'l Joint Research / Invited
• [Presentation] Forward genetic analysis of sleep in mice (2018)
  • Author(s): Hiromasa Funato, Masashi Yanagisawa
  • Organizer: Keystone symposia "State of the Brain
  • Int'l Joint Research
• [Presentation] 生体データ解析におけるGANを用いたデータ処理 (2018)
  • Author(s): 住谷 雄樹、堀江 和正、塩川 浩昭、北川 博之
  • Organizer: 情報処理学会
• [Presentation] ディープラーニングによる脳波/筋電データを用いたマウスの睡眠ステージ判定 (2018)
  • Author(s): 山部 剛士、堀江 和正、塩川 浩昭、柳沢 正史、北川 博之
  • Organizer: DEIM2018
• [Presentation] 深層学習を用いたマウスの睡眠ステージ分析 (2017)
  • Author(s): 鈴木 悠太，佐藤 牧人，塩川 浩昭，柳沢 正史，北川 博之
  • Organizer: 情報処理学会 第79回全国大会
  • Place of Presentation: 名古屋大学東山キャンパス愛知県名古屋市
  • Year and Date: 2017-03-16
• [Presentation] Hypothalamic Ptf1a is required for sexual differentiation of the brain and behavior (2017)
  • Author(s): Tomoyuki Fujiyama, Satoshi Miyashita, Yousuke Tsuneoka, Mai Nagaoka, Miyo Kakizaki, Satomi Kanno, Yukiko Ishikawa, Yoshiya Kawaguchi, Yuchio Yanagawa, Mark A. Magnuson, Yo-ichi Nabeshima, Masashi Yanagisawa, Hiromasa Funato, Mikio Hoshino.
  • Organizer: Neuroscience
  • Int'l Joint Research
• [Presentation] Design and synthesis of orexin receptor selective ligands (2017)
  • Author(s): Nagase H
  • Organizer: 26th French-Japanese Symposium on Medicinal and Fine Chemistry
  • Int'l Joint Research / Invited
• [Presentation] 生得的社会行動を制御する内側視索前野の機能解剖学的解析 (2016)
  • Author(s): 恒岡洋右, 吉田さちね, 小田哲子, 黒田優, 船戸弘正
  • Organizer: 第121回日本解剖学会学術集会
  • Place of Presentation: ビッグパレットふくしま（福島県郡山市)
  • Year and Date: 2016-03-28
  • Invited
• [Presentation] Design and synthesis of novel ligands of opioid receptors (2015)
  • Author(s): Hiroshi. Nagase
  • Organizer: Pacifichem 2015
  • Place of Presentation: ヒルトンハワイアンヴィレッジ（アメリカ、ハワイ、ホノルル）
  • Year and Date: 2015-12-17
  • Int'l Joint Research / Invited
• [Presentation] High-fat diet feeding alters social behaviors and sensorimotor system of mice independent of obesity (2015)
  • Author(s): Hiromasa Funato, Kenkichi Takase, Satoko Oda, Yousuke Tsuneoka, Masaru Kuroda
  • Organizer: Keystone Symposia Conference "Diabetes: New Insights into Molecular Mechanisms and Therapeutic Strategies"
  • Place of Presentation: ウェスティン都ホテル（京都府京都市）
  • Year and Date: 2015-10-26
  • Int'l Joint Research
• [Presentation] DESIGN AND SYNTHESIS OF NOVEL δ OPIOID AGONISTS AND THEIR PHARMACOLOGIES (2015)
  • Author(s): Hiroshi. Nagase
  • Organizer: Drug Discovery & Therapy World Congress 2015
  • Place of Presentation: カインズコンベンションセンター（アメリカ、マサチューセッツ、ボストン）
  • Year and Date: 2015-07-23
  • Int'l Joint Research / Invited
• [Book] アルカロイドの科学 (2016)
  • Author(s): 長瀬 博, 沓村 憲樹
  • Publisher: 化学同人