Co-Investigator(Kenkyū-buntansha) |
北川 博之 筑波大学, 計算科学研究センター, 教授 (00204876)
徳山 薫平 筑波大学, 国際統合睡眠医科学研究機構, 教授 (00207565)
小久保 利雄 筑波大学, 国際統合睡眠医科学研究機構, 教授 (30750004)
浅田 知栄 (松田知栄) 国立研究開発法人宇宙航空研究開発機構, 有人宇宙技術部門, 主任研究開発員 (50344099)
船戸 弘正 筑波大学, 国際統合睡眠医科学研究機構, 教授(WPI-IIIS) (90363118)
柳沢 正史 筑波大学, 国際統合睡眠医科学研究機構, 教授 (20202369)
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Budget Amount *help |
¥95,030,000 (Direct Cost: ¥73,100,000、Indirect Cost: ¥21,930,000)
Fiscal Year 2019: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2018: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2015: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
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Outline of Final Research Achievements |
We worked on the development of AI EEG analysis software and a wearable EEG measurement device, and succeeded in the development of software that enables sleep stage determination with 96.6% accuracy in EEG analysis of mice by deep learning. By comparing the GABAA receptor agonist with the recently developed orexin receptor antagonist, it was proved that the latter has less effect on the physical and cognitive functions. In a study of sleep-regulating gene Sleepy, we found that phosphorylation of sleepy mutant mice increased phosphorylation of synaptic proteins with continued wakefulness. Research on orexin 1 receptor antagonists found that orexin 1 receptor is important for fear memory fixation and drug dependence.
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