| Budget Amount *help |
¥96,980,000 (Direct Cost: ¥74,600,000、Indirect Cost: ¥22,380,000)
Fiscal Year 2020: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2019: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2018: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2017: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2016: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
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| Outline of Final Research Achievements |
In neurons of the brain, various stimuli induce a phenomenon called “dematuration,” in which neurons return to a pseudo-immature state, and a similar phenomenon has been observed in the brains of various animal models of neuropsychiatric and neurodegenerative disorders. In such immature neurons, the morphology of synapses is altered, as revealed by analysis using super-resolution microscopy and electron microscopy. We also found that induction of dematuration leads to large-scale and long-term changes in gene expression patterns and three-dimensional genome structure. Furthermore, in vivo neuronal activity measurements revealed that the information processing is disrupted in the neuronal population of the brain with dematured neurons, suggesting that neuronal network abnormalities associated with dematuration are involved in abnormalities in higher brain functions and brain-related diseases.
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