| Budget Amount *help |
¥138,580,000 (Direct Cost: ¥106,600,000、Indirect Cost: ¥31,980,000)
Fiscal Year 2020: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2019: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2018: ¥29,250,000 (Direct Cost: ¥22,500,000、Indirect Cost: ¥6,750,000)
Fiscal Year 2017: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2016: ¥26,520,000 (Direct Cost: ¥20,400,000、Indirect Cost: ¥6,120,000)
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| Outline of Final Research Achievements |
A fundamental question in understanding tissue development is how resident stem cells or multipotent progenitors give rise to the various cell types in appropriate numbers and at the right locations to achieve tissue organization. Neural stem/progenitor cells (NPCs) in the mammalian neocortex initially divide symmetrically to increase their pool size (expansion phase). They then divide asymmetrically and give rise to neuronal and glial cell types in a region- and developmental stage-dependent manner and with high precision (neurogenic and gliogenic phases, respectively). In this study, we aimed to identify temporal regulators (“timers”) of these fate switches of neocortical NPCs and found a factor that may drive the transition from the expansion phase to the neurogenic phase. Moreover, we found distinct suppression modes of neurogenic genes by Polycomb group (PcG) complex, which may in part explain the transition from the neurogenic phase to the gliogenic phase.
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