| Co-Investigator(Kenkyū-buntansha) |
井上 高良 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第六部, 室長 (20370984)
天野 睦紀 名古屋大学, 医学系研究科, 准教授 (90304170)
菅野 康太 鹿児島大学, 法文教育学域法文学系, 准教授 (80722470)
貝淵 弘三 名古屋大学, 医学系研究科, 教授 (00169377)
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| Budget Amount *help |
¥141,570,000 (Direct Cost: ¥108,900,000、Indirect Cost: ¥32,670,000)
Fiscal Year 2020: ¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000)
Fiscal Year 2019: ¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000)
Fiscal Year 2018: ¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2017: ¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2016: ¥48,750,000 (Direct Cost: ¥37,500,000、Indirect Cost: ¥11,250,000)
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| Outline of Final Research Achievements |
To understand the genetic factors that govern individuality, this study investigated the genetic factors behind male (masculine) and female (feminine) behavior, as well as those behind good social interaction. First, we found that the transcription factor Ptf1a is expressed in the hypothalamus during mouse embryonic development and functions in the normal differentiation of the brain into male and female brains by give the brain "sex-differentiation competence”. We also revealed that the AUTS2 gene, which is associated with autism spectrum disorders in humans, regulates the excitatory/inhibitory balance in the brain by limiting the number of excitatory synapses, and that the breakage of the gene causes diverse changes in social behavior in mice. This study provides clues to the genetic factors of individuality.
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