| Co-Investigator(Kenkyū-buntansha) |
稲葉 有香 金沢大学, 新学術創成研究機構, 准教授 (20571970)
土屋 貴穂 筑波大学, 医学医療系, 助教 (70853167)
小林 大樹 新潟大学, 医歯学系, 助教 (20448517)
幡野 敦 新潟大学, 医歯学系, 助教 (30755533)
尾崎 遼 筑波大学, 医学医療系, 准教授 (10743346)
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| Budget Amount *help |
¥237,900,000 (Direct Cost: ¥183,000,000、Indirect Cost: ¥54,900,000)
Fiscal Year 2021: ¥50,050,000 (Direct Cost: ¥38,500,000、Indirect Cost: ¥11,550,000)
Fiscal Year 2020: ¥50,050,000 (Direct Cost: ¥38,500,000、Indirect Cost: ¥11,550,000)
Fiscal Year 2019: ¥50,050,000 (Direct Cost: ¥38,500,000、Indirect Cost: ¥11,550,000)
Fiscal Year 2018: ¥54,990,000 (Direct Cost: ¥42,300,000、Indirect Cost: ¥12,690,000)
Fiscal Year 2017: ¥32,760,000 (Direct Cost: ¥25,200,000、Indirect Cost: ¥7,560,000)
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| Outline of Final Research Achievements |
In this study, we identified a trans-omics network of metabolic adaptations and clarified the mechanisms of glucose metabolism in liver and muscle by omics measurement and data integration analysis of dynamic metabolic responses to glucose loading using ob/ob mice, a model of wild-type and type 2 diabetes mellitus. We have also developed OMELET, a mathematical model to analyze metabolic changes and their regulation based on multi-omics data without using isotope labeling experiments, and quantitatively clarified changes in liver glucose metabolism in ob/ob mice, a mouse model of obesity, and the regulation that causes these changes.
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