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Dissection and Regulation of Plant Function with Synthetic Molecules

Planned Research

Project AreaChemical Approaches for Miscellaneous / Crowding Live Systems
Project/Area Number 17H06350
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionInstitute of Physical and Chemical Research (2018-2021)
Nagoya University (2017)

Principal Investigator

Hagihara Shinya  国立研究開発法人理化学研究所, 環境資源科学研究センター, チームリーダー (80373348)

Project Period (FY) 2017-06-30 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Fiscal Year 2021: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2020: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2019: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2018: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2017: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywords植物ホルモン / ケミカルバイオロジー / 植物ケミカルバイオロジー / 植物科学 / 植物
Outline of Final Research Achievements

Molecular recognition in miscellaneous and crowding multimolecular biosystems plays an important role in biological functions. Especially, the specific interaction between plant hormone and its receptor protein is crucial for long-distance signal transduction that enables plants to rapidly adapt to environmental changes. Although recent biological studies have made substantial progress in our understanding of plant hormone signaling, delineating plant hormone response at molecular level remains a major challenge. So far, we have developed chemistry-based approaches to understand and regulate auxin signaling. In this project, we applied the identical approach to regulate cytokinin and gibberellin signaling. The technology developed in this project should provide a key methodology that anables sustainable agriculture.

Academic Significance and Societal Importance of the Research Achievements

植物の多様な生理機能の多くは、植物ホルモンによって制御されている。植物ホルモンの作用を細胞や器官レベルで制御する手法は、植物の生理機能解明だけでなく、農作業の手間を劇的に軽減する可能性をもっている。我々が今回開発した技術は、内在性の植物ホルモンとは独立してシグナルをオンにすることが可能で、これを活用すれば、望みの器官や細胞で植物ホルモンの効果を発現することができる。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (25 results)

All 2022 2021 2020 2019 2018 2017

All Journal Article (11 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 11 results,  Open Access: 7 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Int'l Joint Research: 5 results,  Invited: 9 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Development of 1,8-naphthalimide dyes for rapid imaging of subcellular compartments in plants2022

    • Author(s)
      Kusano Shuhei、Nakamura Sakuya、Izumi Masanori、Hagihara Shinya
    • Journal Title

      Chemical Communications

      Volume: 58 Issue: 11 Pages: 1685-1688

    • DOI

      10.1039/d1cc05798g

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A super-sensitive auxin-inducible degron system with an engineered auxin-TIR1 pair.2020

    • Author(s)
      Kohei Nishimura , Ryotaro Yamada , Shinya Hagihara , Rie Iwasaki , Naoyuki Uchida , Takumi Kamura , Koji Takahashi , Keiko U Torii , Tatsuo Fukagawa
    • Journal Title

      Nucleic acids research

      Volume: 48 Issue: 18 Pages: e108-e108

    • DOI

      10.1093/nar/gkaa748

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of potent inhibitors for strigolactone receptor DWARF 142020

    • Author(s)
      Yoshimura Masahiko、Kim Sojung F.、Takise Ryosuke、Kusano Shuhei、Nakamura Sakuya、Izumi Masanori、Yagi Akiko、Itami Kenichiro、Hagihara Shinya
    • Journal Title

      Chemical Communications

      Volume: 56 Issue: 94 Pages: 14917-14919

    • DOI

      10.1039/d0cc01989e

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.2019

    • Author(s)
      Oshima T, Niwa Y, Kuwata K, Srivastava A, Hyoda T, Tsuchiya Y, Kumagai M, Tsuyuguchi M, Tamaru T, Sugiyama A, Ono N, Zolboot N, Aikawa Y, Oishi S, Nonami A, Arai F, Hagihara S, Yamaguchi J, Tama F, Kunisaki Y, Yagita K, Ikeda M, Kinoshita T, Kay SA, Itami K, Hirota T.
    • Journal Title

      Science Advance

      Volume: 23 Issue: 1 Pages: 9060-9060

    • DOI

      10.1126/sciadv.aau9060

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Harnessing synthetic chemistry to probe and hijack auxin signaling.2018

    • Author(s)
      Torii KU, Hagihara S, Uchida N and Takahashi K
    • Journal Title

      New Phytol.

      Volume: 202 Issue: 2 Pages: 417-424

    • DOI

      10.1111/nph.15337

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A super strong engineered auxin-TIR1 pair.2018

    • Author(s)
      Yamada R, Murai K, Uchida N, Takahashi K, Iwasaki R, Tada Y, Kinoshita T, Itami K, Torii KU and Hagihara S
    • Journal Title

      Plant Cell Physiol.

      Volume: 59 Issue: 8 Pages: 1538-1544

    • DOI

      10.1093/pcp/pcy127

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rapid and reversible root growth inhibition by TIR1 auxin signalling2018

    • Author(s)
      Fendrych Maty??、Akhmanova Maria、Merrin Jack、Glanc Matou?、Hagihara Shinya、Takahashi Koji、Uchida Naoyuki、Torii Keiko U.、Friml Ji??
    • Journal Title

      Nature Plants

      Volume: 4 Issue: 7 Pages: 453-459

    • DOI

      10.1038/s41477-018-0190-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The dynamics of strigolactone perception in Striga hermonthica: a working hypothesis2018

    • Author(s)
      Tsuchiya Yuichiro、Yoshimura Masahiko、Hagihara Shinya
    • Journal Title

      Journal of Experimental Botany

      Volume: 69 Issue: 9 Pages: 2281-2290

    • DOI

      10.1093/jxb/ery061

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical hijacking of auxin signaling with an engineered auxin-TIR1 pair2018

    • Author(s)
      Uchida N, Takahashi K, Iwasaki R, Yamada R, Yoshimura M, Endo TA, Kimura S, Zhang H, Nomoto M, Tada Y, Kinoshita T, Itami K, Hagihara S and Torii KU
    • Journal Title

      Nature Chem. Biol.

      Volume: 14 Issue: 3 Pages: 299-305

    • DOI

      10.1038/nchembio.2555

    • NAID

      120006473593

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Discovery of shoot branching regulator targeting strigolactone receptor DWARF14.2018

    • Author(s)
      Yoshimura M, Sato A, Kuwata K, Inukai Y, Kinoshita T, Itami K, Tsuchiya Y, Hagihara S
    • Journal Title

      ACS Central Science

      Volume: 4 Issue: 2 Pages: 230-234

    • DOI

      10.1021/acscentsci.7b00554

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthetic small molecules that enhance the number of stomatal: C-H Functionalization chemistry for plant biology2017

    • Author(s)
      Ziadi, A, Uchida, N., Kato, H., Hisamatsu, R., Sato, Y., Hagihara, S., *Itami, K., and *Torii, K.U.
    • Journal Title

      Chem Commun

      Volume: 53 Issue: 69 Pages: 9632-9632

    • DOI

      10.1039/c7cc04526c

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Development of Chemical Tools for Plant Science2022

    • Author(s)
      萩原伸也
    • Organizer
      CMCB2022
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Precise regulation of plant hormone signaling by combining synthetic chemistry and biology2021

    • Author(s)
      萩原伸也
    • Organizer
      Pacifichem 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 分子で実現する迅速育種技術2021

    • Author(s)
      萩原伸也
    • Organizer
      日本植物バイオテクノロジー学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 植物ホルモン受容体の機能制御2021

    • Author(s)
      萩原伸也
    • Organizer
      酵素工学研究会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 人工分子を用いた植物の機能制御2018

    • Author(s)
      萩原伸也
    • Organizer
      第一回分子夾雑関東地区シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 人工分子を用いた植物ホルモンシグナルの制御2018

    • Author(s)
      萩原伸也
    • Organizer
      第2回植物成長調節物質若手研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 植物ホルモン受容体を介したシグナル伝達の精密制御2018

    • Author(s)
      萩原伸也
    • Organizer
      第18回日本蛋白質科学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Regulation of plant hormone signaling with synthetic molecules2018

    • Author(s)
      萩原伸也
    • Organizer
      ACS on Campus University of Tokyo & RIKEN
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 植物ホルモンシグナルの人工的制御2018

    • Author(s)
      萩原伸也
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Invited
  • [Presentation] Synthetic approach toward site-specific control of plant hormone signaling2018

    • Author(s)
      山田 遼太郎・Letitia Sarah・岩崎 理恵・高橋 宏二・打田 直行・木下 俊則・鳥居 啓子・伊丹 健一郎・萩原 伸也
    • Organizer
      日本化学会 第98春季年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Probing auxin signaling with synthetic auxin-engineered receptor pair2017

    • Author(s)
      Ryotaro Yamada, Naoyuki Uchida, Koji Takahashi, Rie Iwasaki, Masahiko Yoshimura, Hua Zhang, Toshinori Kinoshita, Kenichiro Itami, Keiko U. Torii, Shinya Hagihara
    • Organizer
      The Second International Symposium on Biofunctional Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Discovery of germination inhibitor for parasitic plant Striga2017

    • Author(s)
      Masahiko Yoshimura, Yuichiro Tsuchiya, Ayato Sato, Yoshikatsu Sato, Keiko Kuwata, Toshinori Kinoshita, Kenichiro Itami, Shinya Hagihara
    • Organizer
      The Second International Symposium on Biofunctional Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Small molecules that regulate plant hormone signaling2017

    • Author(s)
      Shinya Hagihara
    • Organizer
      The Second International Symposium on Biofunctional Chemistry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Patent(Industrial Property Rights)] デンプンまたはグリコーゲン検出用試薬およびキット、デンプンまたはグリコーゲンの検出方法、ならびに新規の化合物2022

    • Inventor(s)
      草野修平、中村咲耶、泉正範、萩原伸也
    • Industrial Property Rights Holder
      草野修平、中村咲耶、泉正範、萩原伸也
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Related Report
      2021 Annual Research Report

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Published: 2017-07-04   Modified: 2023-01-30  

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