| Budget Amount *help |
¥129,220,000 (Direct Cost: ¥99,400,000、Indirect Cost: ¥29,820,000)
Fiscal Year 2021: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2020: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2019: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2018: ¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2017: ¥31,980,000 (Direct Cost: ¥24,600,000、Indirect Cost: ¥7,380,000)
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| Outline of Final Research Achievements |
Amyloid fibrils are ordered aggregates of denatured proteins associated with amyloidosis. By studying amyloid formation of various proteins, we showed that amyloid fibrils form above solubility by breaking supersaturation.
To clarify the mechanism of dialysis-related amyloidosis, we studied the effects of sera on beta2-microglobulin amyloid formation. Although sera inhibited amyloid formation, the inhibitory effects were weaker for sera collected from dialysis patients. When sera collected before and after maintenance dialysis treatments were compared, the latter inhibited amyloid formation more than the former. The results indicated that, although the inhibitory were deteriorated in dialysis patients, they were ameliorated by maintenance dialysis treatments. Among serum components, serum albumin prevented amyloid formation based on macromolecular crowding effects. The model constructed assuming accumulative effects of risk factors will be useful for predicting the onset of disease.
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