| Co-Investigator(Kenkyū-buntansha) |
田村 康 山形大学, 理学部, 教授 (50631876)
細谷 孝充 東京医科歯科大学, 生体材料工学研究所, 教授 (60273124)
吉田 秀郎 兵庫県立大学, 理学研究科, 教授 (60378528)
矢木 宏和 名古屋市立大学, 医薬学総合研究院(薬学), 講師 (70565423)
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| Budget Amount *help |
¥253,890,000 (Direct Cost: ¥195,300,000、Indirect Cost: ¥58,590,000)
Fiscal Year 2021: ¥45,370,000 (Direct Cost: ¥34,900,000、Indirect Cost: ¥10,470,000)
Fiscal Year 2020: ¥44,070,000 (Direct Cost: ¥33,900,000、Indirect Cost: ¥10,170,000)
Fiscal Year 2019: ¥43,810,000 (Direct Cost: ¥33,700,000、Indirect Cost: ¥10,110,000)
Fiscal Year 2018: ¥49,010,000 (Direct Cost: ¥37,700,000、Indirect Cost: ¥11,310,000)
Fiscal Year 2017: ¥71,630,000 (Direct Cost: ¥55,100,000、Indirect Cost: ¥16,530,000)
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| Outline of Final Research Achievements |
We named the restricted functional regions of organelles as "zone", in which the regions of organelle response to various biological stimuli as "response zones" and the functional membrane contact regions between different organelles as "communication zones". We visualized each zone, identified the constituent molecules and formation mechanism, and clarified the physiological roles of the zones. For the "response zone," we analyzed the zone related to the stress response of the Golgi apparatus and the zone related to glycosylation. For the "communication zone," we performed functional analysis and molecular identification of the membrane contact region between mitochondria and endoplasmic reticulum. We also developed a technology to artificially turn on/off the organelle communication zone.
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