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Role of sulfur-containing amino acid metabolism in protozoan infections

Planned Research

Project AreaMatrix of Infection Phenomena
Project/Area Number 18073001
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNational Institute of Infectious Diseases (2008-2010)
Gunma University (2006-2007)

Principal Investigator

NOZAKI Tomoyoshi  国立感染症研究所, 寄生動物部, 部長 (60198588)

Co-Investigator(Kenkyū-buntansha) ALI Vahab  群馬大学, 大学院・医学系研究科, 助教 (20400757)
TSUKUI Kumiko  国立感染症研究所, 寄生動物部, 主任研究官 (00420092)
SATO Dan  慶応義塾大学, 先端生命科学研究所, 特別研究助教 (50468477)
Project Period (FY) 2006 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥90,000,000 (Direct Cost: ¥90,000,000)
Fiscal Year 2010: ¥18,000,000 (Direct Cost: ¥18,000,000)
Fiscal Year 2009: ¥18,000,000 (Direct Cost: ¥18,000,000)
Fiscal Year 2008: ¥18,000,000 (Direct Cost: ¥18,000,000)
Fiscal Year 2007: ¥18,000,000 (Direct Cost: ¥18,000,000)
Fiscal Year 2006: ¥18,000,000 (Direct Cost: ¥18,000,000)
Keywords含硫アミノ酸 / 代謝 / 感染症 / メタボローム / トランスクリプトーム / 赤痢アメーバ / 含流アミノ酸 / 寄生虫 / 代謝学 / メタボロミクス / トランスクリプトミクス / 寄生 / 感染 / 病原機構
Research Abstract

To better understand the role played by metabolism in protozoan infections, we investigated metabolic responses of the enteric protozoan Entamoeba histolytica toward oxidative stress and stage conversion by "omics" approaches such as transcritpomics and metabolomics. We have discovered novel pathways and networks associated with cysteine-supplementation/deprivation stress and encystation. We have established comprehensive analytical methods to examine the metabolic networks using transcriptomics and metabolomics.

Report

(7 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (130 results)

All 2011 2010 2009 2008 2007 2006 Other

All Journal Article (51 results) (of which Peer Reviewed: 22 results) Presentation (74 results) Remarks (5 results)

  • [Journal Article] Mechanism of trifluoromethionine resistance in Entamoeba histolytica.2011

    • Author(s)
      Penuliar, G. M., Furukawa, A., Sato, D., and Nozaki, T.
    • Journal Title

      J. Antimicrob. Chemother.

      Volume: 66 Pages: 2045-2052

    • Related Report
      2010 Final Research Report
  • [Journal Article] Sulfate activation in mitosomes plays a crucial role in the proliferation of Entamoeba histolytica.2011

    • Author(s)
      Mi-ichi, F., Makiuchi, T., Furukawa, A., Sato, D., Nozaki, T.
    • Journal Title

      PLoS Neglect. Trop. Dis.

      Volume: 5

    • Related Report
      2010 Final Research Report
  • [Journal Article] Global Analysis of gene expression in response to L-cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica2011

    • Author(s)
      Husain, A., Jeelani, G., Sato, D., Nozaki, T.
    • Journal Title

      BMC Genomics

      Volume: 12 Pages: 275-275

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of trifluoromethionine resistance in Entamoeba histolytica2011

    • Author(s)
      Penuliar, G.M., Furukawa, A., Sato, D., Nozaki, T.
    • Journal Title

      J.Antimicrob.Chemother.

      Volume: 66 Pages: 2045-2052

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytotoxic effect of amide derivatives of trifluoromethionine to the enteric protozoan parasite Entamoeba histolytica.2010

    • Author(s)
      Sato., D., Kobayashi, S., Yasui, H., Shibata, N., Toru, T., Yamamoto, M., Tokoro, G., Ali, V., Soga, T., Takeuchi, T., Suematsu, M., and Nozaki, T.
    • Journal Title

      Int. J. Antimicrob. Agents.

      Volume: 35 Pages: 56-61

    • Related Report
      2010 Final Research Report
  • [Journal Article] Bacterial-type oxygen detoxification and iron-sulphur cluster assembly in amoebal relict mitochondria Cell.2010

    • Author(s)
      Maralikova, B., Ali, V., Nakada-Tsukui, K., Nozaki, T., van der Giezen, M., Henze, K., and Tovar, J.
    • Journal Title

      Microbiol.

      Volume: 12 Pages: 331-342

    • Related Report
      2010 Final Research Report
  • [Journal Article] Characterization of two isotypes of L-threonine dehydratase from Entamoeba histolytica2010

    • Author(s)
      Husain, A., Jeelani, G., Sato, D., Ali, V,, and Nozaki, T.
    • Journal Title

      Mol. Biochem. Parasitol.

      Volume: 170 Pages: 100-104

    • Related Report
      2010 Final Research Report
  • [Journal Article] Localization and targeting of unusual pyridine nucleotide transhydrogenase in Entamoeba histolytica.2010

    • Author(s)
      Yousuf, M. A., Mi-ichi, F., Nakada-Tsukui, K., and Nozaki, T.
    • Journal Title

      Eukaryot. Cell

      Volume: 9 Pages: 926-933

    • Related Report
      2010 Final Research Report
  • [Journal Article] Metabolome analysis revealed increase in S-methylcysteine and phosphatidylisopropanolamine synthesis upon L-cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica.2010

    • Author(s)
      Husain, A., Sato, D., Jeelani, G., Suematsu, M., Soga, T., and Nozaki, T.
    • Journal Title

      J. Biol. Chem.

      Volume: 285 Pages: 39160-39170

    • Related Report
      2010 Final Research Report
  • [Journal Article] Global Analysis of gene expression in response to L-cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica.2010

    • Author(s)
      Husain, A., Jeelani, G., Sato, D., and Nozaki, T.
    • Journal Title

      BMC Genomics

      Volume: 12 Pages: 275-275

    • Related Report
      2010 Final Research Report
  • [Journal Article] Cytotoxic effect of amide derivatives of trifluoromethionine to the enteric protozoan parasite Entamoeba histolytica2010

    • Author(s)
      Sato., D., Kobayashi, S., Yasui, H., Shibata, N., Toru, T., Yamamoto, M., Tokoro, G., Ali, V., Soga, T., Takeuchi, T., Suematsu, M., Nozaki, T.
    • Journal Title

      Int.J.Antimicrob.Agents.

      Volume: 35 Pages: 56-61

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] (2010) Bacterial-type oxygen detoxification and iron-sulphur cluster assembly in amoebal relict mitochondria2010

    • Author(s)
      Maralikova, B., Ali, V., Nakada-Tsukui, K., Nozaki, T., van der Giezen, M., Henze, K., Tovar, J.
    • Journal Title

      Cell.Microbiol.

      Volume: 12 Pages: 331-342

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of two isotypes of L-threonine dehydratase from Entamoeba histolytica2010

    • Author(s)
      Husain, A., Jeelani, G., Sato, D., Ali, V., Nozaki, T.
    • Journal Title

      Mol.Biochem.Parasitol.

      Volume: 170 Pages: 100-104

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization and targeting of unusual pyridine nucleotide transhydrogenase in Entamoeba histolytica2010

    • Author(s)
      Yousuf, M.A., Mi-ichi, F., Nakada-Tsukui, K., Nozaki, T.
    • Journal Title

      Eukaryot.Cell

      Volume: 9 Pages: 926-933

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conservation and function of Rab small GTPases in Entamoeba : annotation of E.invadens Rab and its use for the understanding of Entamoeba biology2010

    • Author(s)
      Nakada-Tsukui, K., Saito-Nakano, Y., Husain, A., Nozaki, T.
    • Journal Title

      Exp.Parasitol.

      Volume: 126(Review) Pages: 337-347

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two Atypical L-cysteine-regulated NADPH-dependent oxidoreductases involved in redox maintenance, L-cystine reduction, and metronidazole activation in the enteric protozoon Entamoeba histolytica2010

    • Author(s)
      Jeelani, G., Husain, A., Sato, D., Ali, V., Suematsue, M., Soga, T., Nozaki, T.
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 26889-26899

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolome analysis revealed increase in S-methylcysteine and phosphatidylisopropanolamine synthesis upon L-cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica2010

    • Author(s)
      Husain, A., Sato, D., Jeelani, G., Suematsu, M., Soga, T., Nozaki, T.
    • Journal Title

      J.Biol.Chetn.

      Volume: 285 Pages: 39160-39170

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sulfate activation in mitosomes plays a crucial role in the proliferation of Entamoeba histolytica2010

    • Author(s)
      Mi-ichi, F., Makiuchi, T., Furukawa, A., Sato, D., Nozaki, T.
    • Journal Title

      PLoS Negl.Trop.Dis.

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytotoxic effect of amide derivatives of trifluoromethionine to the enteric protozoan parasite Entamoeba histolytica.2010

    • Author(s)
      Sato, D., Kobayashi, S., Yasui, H., Shibata, N., Toru, T., Yamamoto, M., Tokoro, G., Ali, V., Soga, T., Takeuchi, T., Suematsu, M., Nozaki, T.
    • Journal Title

      Int.J.Antimicrob.Agents.

      Volume: 35 Pages: 56-61

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bacterial-type oxygen detoxification and iron-sulphur cluster assembly in amoebal relict mitochondria Cell.2010

    • Author(s)
      Maralikova, B., Ali, V., Nakada-Tsukui, K., Nozaki, T., van der Giezen, M., Henze, K., Tovar, J.
    • Journal Title

      Microbiol

      Volume: 12 Pages: 331-342

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isoform-dependent feedback regulation of serine O-acetyltransferase isoenzymes involved in L-cysteine biosynthesis of Entamoeba histolytica.2009

    • Author(s)
      Hussain, S., Ali, V., Jeelani, G., and Nozaki, T.
    • Journal Title

      Mol. Biochem. Parasitol.

      Volume: 163 Pages: 39-47

    • Related Report
      2010 Final Research Report
  • [Journal Article] Methionine gamma-lyase: the unique reaction mechanism, physiological roles, and therapeutic applications against infectious diseases and cancers.(Review)2009

    • Author(s)
      Sato, D. and Nozaki, T.
    • Journal Title

      IUBMB Life

      Volume: 61 Pages: 1019-1028

    • Related Report
      2010 Final Research Report
  • [Journal Article] Mitosomes in Entamoeba histolytica contain a sulfate activation pathway.2009

    • Author(s)
      Mi-ichi, F., Yousuf, M. A., Nakada-Tsukui, K., and Nozaki, T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA.

      Volume: 106 Pages: 21731-21736

    • Related Report
      2010 Final Research Report
  • [Journal Article] Isoform-dependent feedback regulation of serine O-acetyltransferase isoenzymes involved in L-cysteine biosynthesis of Entamoeba histolytica.2009

    • Author(s)
      Hussain, S., Ali, V., Jeelani, G., Nozaki, T.
    • Journal Title

      Mol.Biochem.Parasitol.

      Volume: 163 Pages: 39-47

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methionine gamma-lyase : the unique reaction mechanism, physiological roles, and therapeutic applications against infectious diseases and cancers.2009

    • Author(s)
      Sato, D., Nozaki, T.
    • Journal Title

      IUBMB Life

      Volume: 61 Pages: 1019-1028

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitosomes in Entamoeba histolytica contain a sulfate activation pathway.2009

    • Author(s)
      Mi-ichi, F., Yousuf, M.A., Nakada-Tsukui, K., Nozaki, T.
    • Journal Title

      Proc.Natl.Acad.Sci.USA.

      Volume: 106 Pages: 21731-21736

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isoform-dependent feedback regulation of serine O-acetyltransferase isoenzymes involved in L-cysteine biosynthesis of Entamoeba histolytica.2009

    • Author(s)
      Hussain, S., Ali, V., Jeelani, G., Nozaki, T.
    • Journal Title

      Mol. Biochem. Parasitol. 163

      Pages: 39-47

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Kinetic characterization of methionine gamma-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound against amoebiasis.2008

    • Author(s)
      Sato, D., Yamagata, W., Harada, S., and Nozaki, T.
    • Journal Title

      FEBS J.

      Volume: 275 Pages: 548-560

    • Related Report
      2010 Final Research Report
  • [Journal Article] Crystallization and preliminary X-ray analysis of L-methionine γ -lyase 1 from Entamoeba histolytica.2008

    • Author(s)
      Sato, D., Karaki, T., Shimizu, A., Kamei, K., Harada, S., and Nozaki, T.
    • Journal Title

      Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.

      Volume: 64 Pages: 697-699

    • Related Report
      2010 Final Research Report
  • [Journal Article] Kinetic characterization of methionine gamma-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound against amoebiasis.2008

    • Author(s)
      Sato, D., Yamagata, W., Harada, S., Nozaki, T.
    • Journal Title

      FEBS J. 275

      Pages: 548-560

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Crystallization and preliminary X-ray analysis of L-methionineγ-lyase 1 from Entamoeba histolytica.2008

    • Author(s)
      Sato, D., Karaki, T., Shimizu, A., Kamei, K., Harada, S., Nozaki, T.
    • Journal Title

      Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64

      Pages: 697-699

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] "Inject-mix-react-separate-and-quan titate" method for High-throughput screening of enzyme Inhibitors.2008

    • Author(s)
      Wong, E., Okhonin, V., Berezovski, M., Nozaki, T., Alexandrov, K., Krylov, S.
    • Journal Title

      J. Am. Chem. Soc. 130

      Pages: 11862-11863

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Kinetic characterization of methionine gamma-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound aaainst amoebiasis.2008

    • Author(s)
      Sato, D., Yamagata, W., Harada, S., and Nozaki, T.
    • Journal Title

      FEBS J. 275,

      Pages: 548-560

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystallization and preliminary X-ray analysis of L-methionine γ-lyase 1 from Entamoeba histolytica. Acta Crystallogr.2008

    • Author(s)
      Sato, D., Karaki, T., Shimizu, A., Kamei, K., Harada, S., and Nozaki, T.
    • Journal Title

      Sect. F Struct. Biol. Cryst. Commun. 64

      Pages: 697-699

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isoform-dependent feedback regulation of serine O-acetyltransferase isoenzymes involved in L-cysteine biosynthesis of Entamoeba histolytica.2008

    • Author(s)
      Hussain, S., Ali, V., Jeelani, G., and Nozaki, T.
    • Journal Title

      Mol. Biochem. Parasitol. 163

      Pages: 39-47

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] "Inject-mix-react-separate-and-quantitate" method for High-throughput screening of enzyme Inhibitors.2008

    • Author(s)
      Wong, E., Okhonin, V., Berezovski, M., Nozaki, T, Alexandrov, K., and Krylov, S.
    • Journal Title

      J. Am. Chem. Soc. 130

      Pages: 11862-11863

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kinetic characterization of methionine gamma-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound against amoebiasis.2008

    • Author(s)
      Sato, D., Yamagata, W., Harada, S., and Nozaki, T.
    • Journal Title

      FEBS J. 275

      Pages: 548-560

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current therapeutics, their problems, and sulfur-containing amino acid metabolism as a novel target against infections by "amitochondriate" protozoan parasites.2007

    • Author(s)
      Ali. V. and Nozaki, T.
    • Journal Title

      Clin. Microbiol. Rev.

      Volume: 20 Pages: 164-187

    • Related Report
      2010 Final Research Report
  • [Journal Article] Structure and content of the Entamoeba histolytica genome.2007

    • Author(s)
      Clark, C.G., Cecilia, U., Alsmark, M., Hofer, M., Saito-Nakano, Y., Ali, V., Marion, S., Weber, C., Mukherjee, C., Bruchhaus, I., Tannich, E., Leippe, M., Sicheritz-Ponten, T., Foster, P. G., Samuelson, J., Noel, C. J., Hirt, R. P., Embley, T. M., Gilchrist, C. A., Mann, B. J., Singh, U., Ackers, J. P., Bhattacharya, S., Bhattacharya, A., Lohia. A., Guillen, N., Duchene, M., Nozaki, T., and Hall, N.
    • Journal Title

      Adv. Parasitol.

      Volume: 65 Pages: 51-190

    • Related Report
      2010 Final Research Report
  • [Journal Article] Current therapeutics, their problems, and sulfur-containing amino acid metabolism as a novel target against infections by "amitochondriate" protozoan parasites.2007

    • Author(s)
      Ali. V., Nozaki, T.
    • Journal Title

      Clin. Microbiol. Rev. 20

      Pages: 164-187

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Structure and content of the Entamoeba histolyticagenome.2007

    • Author(s)
      Clark, C.G., Cecilia, U., Alsmark, M., Hofer, M., Saito-Nakano, Y., Ali, V., Marion, S., Weber, C., Mukherjee, C., Bruchhaus, I., Tannich, E., Leippe, M., Sicheritz-Ponten, T., Foster, P.G., Samuelson, J., Noel, C.J., Hirt, R.P., Embley, T.M., Gilchrist, C.A., Mann, B.J., Singh, U., Ackers, J.P., Bhattacharya, S., Bhattacharya, A., Lohia. A., Guillen, N., Duchene, M., Nozaki, T., Hall, N.
    • Journal Title

      Adv. Parasitol. 65

      Pages: 51-190

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Current therapeutics, their problems, and sulfur-containing amino acid metabolism as a novel target against infections by "amitochondriate" protozoan parasites.2007

    • Author(s)
      Ali. V. and Nozaki, T.
    • Journal Title

      Clin. Microbiol. Rev. 20

      Pages: 164-187

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structre and content of the Entamoeba histolytica genome.2007

    • Author(s)
      Clark, C. G., Cecilia, U., Alsmark, M., Hofer, M., Saito-Nakano, Y., Ali, V., Marion, S., Weber, C., Mukherjee, C., Bruchhaus, I., Tannich, E., Leippe, M., Sicheritz-Ponten, T., Foster, P. G., Samuelson, J., Noel, C. J., Hirt, R. P., Embley, T. M., Glchrist, C.A., Mann, B. J., Singh, U., Ackers, J. P., Bhattacharya, S., Bhattacharya, A., Lohia. A., Guillen, N., Duchene, M., Nozaki, T., and Hall, N.
    • Journal Title

      Adv. Parasitol. 65

      Pages: 51-190

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current therapeutics, their problems, and sulfur-containing amino acid metabolism as a novel target against infections by "amitochondriate" protozoan parasites.2007

    • Author(s)
      Ali.V., Nozaki, T.
    • Journal Title

      Clin.Microbiol.Rev. 20

      Pages: 164-187

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Biochemical and functional characterization of phosphoserine aminotransferase from Entameba histolytica, which possesses both phosphorylated and non-phosphorylated serine metabolic pathways.2006

    • Author(s)
      Ali, V. and Nozaki, T.
    • Journal Title

      Mol. Biochem. Parasitol.

      Volume: 145 Pages: 71-83

    • Related Report
      2010 Final Research Report
  • [Journal Article] Impact of intestinal colonization and invasion on the Entamoeba histolytica transcriptome.2006

    • Author(s)
      Gilchrist, C. A., Houpt, E., Trapaidze, N., Fei, Z., Crasta, O., Asgharpour, A., Evans, C., Martino-Catt, S., Baba, D. J., Stroup, S., Hamano, S., Ehrenkaufer, G., Okada, M., Singh, U., Nozaki, T., Mann, B. J., Petri, Jr., W.
    • Journal Title

      Mol. Biochem. Parasitol.

      Volume: 147 Pages: 163-176

    • Related Report
      2010 Final Research Report
  • [Journal Article] Expression, purification, and crystallization of L-methionine γ-lyase 2 from Entamoeba histolytica. Acta Crystallograph.2006

    • Author(s)
      Sato, D., Yamagata, W., Kamei, K., Nozaki, T. and Harada, S.
    • Journal Title

      Sect. F Struct. Biol. Cryst. Commun.

      Volume: 62 Pages: 1034-1036

    • Related Report
      2010 Final Research Report
  • [Journal Article] Impact of intestinal colonization and invasion on the Entamoeba histolytica transcriptome.2006

    • Author(s)
      Gilchrist, C.A., Houpt, E., Trapaidze, N., Fei, Z., Crasta, O., Asgharpour, A., Evans, C., Martino-Catt, S., Baba, D.J., Stroup, S., Hamano, S., Ehrenkaufer, G., Okada, M., Singh, U., Nozaki, T., Mann, B.J., Petri, Jr., W.
    • Journal Title

      Mol. Biochem. Parasitol. 147

      Pages: 163-176

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Expression, purification, and crystallization of L-methionine g-lyase 2 from Entamoeba histolytica.2006

    • Author(s)
      Sato, Ti, Yamagata, W., Kamei, K., Nozaki, T. Harada, S.
    • Journal Title

      Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. 62

      Pages: 1034-1036

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Impact of intestinal colonization and invasion on the Entamoebahistolytica transcriptome.2006

    • Author(s)
      Gilchrist, C.A., Houpt, E., Trapaidze, N., Fei, Z., Crasta, O., Asgharpour, A., Evans, C., Martino-Catt, S., Baba, D.J., Stroup, S., Hamano, S., Ehrenkaufer, G., Okada, M., Singh, U., Nozaki, T., Mann, B.J., Petri, Jr., W.
    • Journal Title

      Mol.Biochem.Parasitol. 147

      Pages: 163-176

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression, purification, and crystallization of L-methionine γ-lyase 2 from Entamoeba histolytica.2006

    • Author(s)
      Sato, D., Yamagata, W., Kamei, K., Nozaki, T., Harada, S.
    • Journal Title

      Acta Crystallograph.Sect.F Struct.Biol.Cryst.Commun. 62

      Pages: 1034-1036

    • Related Report
      2006 Annual Research Report
  • [Presentation] Mechanism of trifluoromethionine resistance in Entamoeba histolytica.2011

    • Author(s)
      Penuliar, G. M., Furukawa, A., Sato, D., and Nozaki, T.
    • Organizer
      The 45^<th> US-Japan Cooperative Medical Science Program
    • Place of Presentation
      Tokyo
    • Related Report
      2010 Final Research Report
  • [Presentation] Entamoeba invadens : transcriptome analysis during encystation.2011

    • Author(s)
      Escueta-de Cadiz, A., Nakada-Tsukui, K., Caler, E., and Nozaki, T.
    • Organizer
      The 45^<th> US-Japan Cooperative Medical Science Program
    • Place of Presentation
      Tokyo
    • Related Report
      2010 Final Research Report
  • [Presentation] Metabolomic analysis during differentiation of enteric protozoan parasite Entamoeba histolytica into the infectious cyst stage.2011

    • Author(s)
      Jeelani, G., Sato, D., Husein, A., Suematsu, M., Soga, T., and Nozaki, T.
    • Organizer
      The 45^<th> US-Japan Cooperative Medical Science Program
    • Place of Presentation
      Tokyo
    • Related Report
      2010 Final Research Report
  • [Presentation] Gene silencing of mitosomal proteins causes growth inhibition and suggests essentiality of mitosomes in Entamoeba histolytica.2011

    • Author(s)
      Mi-ichi, F, Yousuf, A., Makiuchi, T., Nakada-Tsukui, K., and Nozaki, T.
    • Organizer
      The 45^<th> US-Japan Cooperative Medical Science Program
    • Place of Presentation
      Tokyo
    • Related Report
      2010 Final Research Report
  • [Presentation] Metabolomic analysis of sulfur containing amino acid metabolism in E. histolytica.2011

    • Author(s)
      Husain, A., Sato, D., Jeelani, G., Mi-ichi, F., Ali, V., Suematsu, M., Soga, T., and Nozaki, T.
    • Organizer
      The 45^<th> US-Japan Cooperative Medical Science Program
    • Place of Presentation
      Tokyo
    • Related Report
      2010 Final Research Report
  • [Presentation] Analysis of the protein import machinery in the Entamoeba mitochondrial remnant.2011

    • Author(s)
      Makiuchi, T., Mi-ichi, F., Nakada-Tsukui, K., and Nozaki, T.
    • Organizer
      The 45^<th> US-Japan Cooperative Medical Science Program
    • Place of Presentation
      Tokyo
    • Related Report
      2010 Final Research Report
  • [Presentation] A novel class of hydrolase receptors involved in the lysosomal trafficking of virulence factors in Entamoeba histolytica.2011

    • Author(s)
      Nozaki, T.
    • Organizer
      The Second Cross-Straits and Asia Pacific International Conference on Parasites(Invited lecture)
    • Place of Presentation
      Tainan, Taiwan.
    • Related Report
      2010 Final Research Report
  • [Presentation] A novel import machinery of the highly divergent mitochondrion-related organelle from the anaerobic parasitic protist Entamoeba histolytica.2011

    • Author(s)
      Nozaki, T.
    • Organizer
      International Union of Microbiological Societies.(Symposist and Convenor)
    • Place of Presentation
      Sapporo, Japan.
    • Related Report
      2010 Final Research Report
  • [Presentation] Novel receptor family proteins mediate transport of lysosomal enzymes in the enteric protozoan parasite Entamoeba histolytica.2011

    • Author(s)
      Nakada-Tsukui, K., Tsuboi, K., Furukawa, A., Yamada, Y., and Nozaki, T.
    • Organizer
      International Union of Microbiological Societies.(Symposist)
    • Place of Presentation
      Sapporo, Japan.
    • Related Report
      2010 Final Research Report
  • [Presentation] Trafficking mechanisms of phagosomal proteins in Entamoeba histolytica.2011

    • Author(s)
      Furukawa, A., Nakada-Tsukui, K., and Nozaki, T.
    • Organizer
      International Union of Microbiological Societies.
    • Place of Presentation
      Sapporo, Japan.
    • Related Report
      2010 Final Research Report
  • [Presentation] Metabolomic analysis during differentiation of enteric protozoan Parasite Entamoeba histolytica into the infectious cyst stage2011

    • Author(s)
      Jeelani, G., Sato, D., Husein, A., Suematsu, M., Soga, T., Nozaki, T.
    • Organizer
      The 45^<th> US-Japan Cooperative Medical Science Program
    • Place of Presentation
      Tokyo
    • Related Report
      2010 Annual Research Report
  • [Presentation] Gene silencing of mitosomal proteins causes growth inhibition and suggests essentiality of mitosomes in Entamoeba histolytica2011

    • Author(s)
      Mi-ichi, F, Yousuf, A., Makiuchi, T., Nakada-Tsukui, K., Nozaki, T.
    • Organizer
      The 45^<th> US-Japan Cooperative Medical Science Program
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Metabolomic analysis of sulfur containing amino acid metabolism in E.histolytica2011

    • Author(s)
      Husain, A., Sato, D., Jeelani, G., Mi-ichi, F., Ali, V., Suematsu, M., Soga, T., Nozaki, T.
    • Organizer
      The 45^<th> US-Japan Cooperative Medical Science Program
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of the protein import machinery in the Entamoeba mitochondrial remnant2011

    • Author(s)
      Makiuchi, T., Mi-ichi, F., Nakada-Tsukui, K., Nozaki, T.
    • Organizer
      The 45^<th> US-Japan Cooperative Medical Science Program
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] A novel import machinery of the highly divergent mitochondrion-related organelle from the anaerobic parasitic protist Entamoeba histolytica2011

    • Author(s)
      Nozaki, T.
    • Organizer
      International Union of Microbiological Societies
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Novel receptor family proteins mediate transport of lysosomal enzymes in the enteric protozoan parasite Entamoeba histolytica2011

    • Author(s)
      Nakada-Tsukui, K., Tsuboi, K., Furukawa, A., Yamada, Y., Nozaki, T.
    • Organizer
      International Union of Microbiological Societies
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Function and transport of the highly divergent mitochondrion-related organelle from the anaerobic parasitic protist Entamoeba histolytica2011

    • Author(s)
      Nozaki, T.
    • Organizer
      The 1st As i an Conference of Prosistology
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2010 Annual Research Report
  • [Presentation] A novel class of hydrolase receptors involved in the lysosomal trafficking of virulence factors in Entamoeba histolytica2011

    • Author(s)
      Nozaki, T., Nakada-Tsukui, K., Furukawa, A.
    • Organizer
      The 1st Asian Conference of Prosistology
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mitosomes in the enteric protozoan parasite Entamoeba histolytica contain a sulfate activation pathway.2010

    • Author(s)
      Nozaki, T.
    • Organizer
      Adaptive and Innate Immune Response to Neglected Tropical Diseases. US-Japan Cooperative Medical Science Program.
    • Place of Presentation
      San Diego
    • Related Report
      2010 Final Research Report
  • [Presentation] Metabolic analysis of the human enteric parasite Entamoeba histolytica : Discovery of unique pathways and potential targets for chemotherapeutics.2010

    • Author(s)
      Sato, D., Husain, A., Jeelani, G., Suematsu, M., Soga, T., and Nozaki, T.
    • Organizer
      Metabolomics 2010
    • Place of Presentation
      Amsterdam, The Netherlands
    • Related Report
      2010 Final Research Report
  • [Presentation] Metabolomics of parasite differentiation : metabolomic profiling of the human enteric protozoan parasite Entamoeba histolyitca revealed activation of unpredicted pathways during differentiation of the proliferative into dormant stage.2010

    • Author(s)
      Jeelani, G., Sato, D., Jusain, A., Suematsu, M., Soga, T., and Nozaki, T.
    • Organizer
      Metabolomics 2010
    • Place of Presentation
      Amsterdam, The Netherlands
    • Related Report
      2010 Final Research Report
  • [Presentation] Unprecedented role of the mitosome in Entamoba histolytica.2010

    • Author(s)
      Nozaki, T.
    • Organizer
      The 18^<th> Meeting of the International Society for Evolutionary Protistology
    • Place of Presentation
      Kanazawa, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Mitosomes from the enteric protozoan parasite Entamoeba histolytica possess unique functions and minimal import machinery.2010

    • Author(s)
      Nozaki, T.
    • Organizer
      The XIIth International Congress of Parasitology.
    • Place of Presentation
      Melbourne, Australia.
    • Related Report
      2010 Final Research Report
  • [Presentation] Metabolomic analysis of Entamoeba : discovery of unique pathways and potential targets for chemotherapy.2010

    • Author(s)
      Nozaki, T, Husain, A., Jeelni, G, Sato, D., Suematsu, M., and Soga, T.
    • Organizer
      Amebiasis Workshop 2010, "Molecular Approaches and Clinical Aspects"
    • Place of Presentation
      Montreal.
    • Related Report
      2010 Final Research Report
  • [Presentation] Mechanism of trifluoromethionine resistance in Entamoeba histolytica.2010

    • Author(s)
      Penuliar, G. and Nozaki, T.
    • Organizer
      Amebiasis Workshop 2010, "Molecular Approaches and Clinical Aspects"
    • Place of Presentation
      Montreal
    • Related Report
      2010 Final Research Report
  • [Presentation] Entamoeba invadens : Transcriptome analysis during encystation.2010

    • Author(s)
      Escueta-de Cadiz, A., Nakada-Tsukui, K., Caler, E., and Nozaki, T.
    • Organizer
      21st Molecular Parasitology Meeting
    • Place of Presentation
      WoodsHole, Massachusetts, USA.
    • Related Report
      2010 Final Research Report
  • [Presentation] Analysis of the protein import machinery in the Entamoeba mitochondrial remnant.2010

    • Author(s)
      Makiuchi, T., Mi-ichi, F., Nakada-Tsukui, K., and Nozaki, T.
    • Organizer
      Biology of Symbiosis: Memorial Symposiumfor the 26^<th> International Prize for Biology-Celebrating Dr. Nancy A. Moran.
    • Place of Presentation
      Tsukuba, Japan.
    • Related Report
      2010 Final Research Report
  • [Presentation] Metabolic analysis of the human enteric parasite Entamoeba histolytica : Discovery of unique pathways and potential targets for chemotherapeutics2010

    • Author(s)
      Sato, D., Husain, A., Jeelani, G., Suematsu, M., Soga, T., Nozaki, T.
    • Organizer
      Metabolomics 2010
    • Place of Presentation
      Amsterdam, The Netherlands
    • Related Report
      2010 Annual Research Report
  • [Presentation] Metabolomics of parasite differentiation : metabolomic profiling of the human enteric protozoan parasite Entamoeba histolyitca revealed activation of unpredicted pathways during differentiation of the proliferative into dormant stage2010

    • Author(s)
      Jeelani, G., Sato, D., Jusain, A., Suematsu, M., Soga, T., Nozaki, T.
    • Organizer
      Metabolomics 2010
    • Place of Presentation
      Amsterdam, The Netherlands
    • Related Report
      2010 Annual Research Report
  • [Presentation] Unprecedented role of the mitosome in Entamoba histolytica2010

    • Author(s)
      Nozaki, T.
    • Organizer
      The 18^<th> Meeting of the International Society for Evolutionary Protistology
    • Place of Presentation
      Kanazawa, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mitosomes from the enteric protozoan parasite Entamoeba histolytica possess unique functions and minimal import machinery2010

    • Author(s)
      Nozaki, T.
    • Organizer
      The XIIth International Congeress of Parasitology
    • Place of Presentation
      Melbourne Australia
    • Related Report
      2010 Annual Research Report
  • [Presentation] Metabolomic analysis of Entamoeba : discovery of unique pathways and potential targets for chemotherapy2010

    • Author(s)
      Nozaki, T, Husain, A., Jeelni, G, Sato, D., Suematsu, M., Soga, T.
    • Organizer
      Amebiasis Workshop 2010, "Molecular Approaches and Clinical Aspects"
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mitosomes in the enteric protozoan parasite Entamoeba histolytica contain a sulfate activation pathway. Adaptive and Innate Immune Response to Neglected Tropical Diseases.2010

    • Author(s)
      Nozaki, T.
    • Organizer
      US-Japan Cooperative Medical Science Program
    • Place of Presentation
      San Diego
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role of sulfur-containing amino acid metabolism : characterization of two isotypes of methionine gamma-lyase in Entamoeba histolytica.2009

    • Author(s)
      Nozaki, T., Furukawa, A., Jeelani, G., Sato, D., Karaki, T., and Harada, S.
    • Organizer
      XVI Seminario Sobre Amibiasis and EMBO Workshop. Amoebiasis : Molecular Approaches in an Important but Neglected Disease.
    • Place of Presentation
      Guanajuato, Mexico.
    • Related Report
      2010 Final Research Report
  • [Presentation] Biochemical and physiological function of a novel reductase from the microaerophilic protozoan parasite Entamoeba histolytica.2009

    • Author(s)
      Jeelani, G., Husain, A., Sato, D., Suematsu, M., Ali, V., and Nozaki, T.
    • Organizer
      The 9th Awaji International Forum on Infection and Immunity.
    • Place of Presentation
      Awaji
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] MEtabolomic and transcriptomic analysis of sulfur-containing amino acid metabolism in enteric protozoan parasite Entamoeba histolytica.2009

    • Author(s)
      Husain, A., Jeelani, G., Sato, D., Mi-ichi, F., Soga, T., Suematsu, M., Ali, V., and Nozaki, T.
    • Organizer
      The 9th Awaji International Forum on Infection and Immunity.
    • Place of Presentation
      Awaji
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Rab small GTPases and phosphatidylinositides regulate phagocytosis and membrane trafficking of virulence factors : their roles in the pathogenesis of amebiasis.2009

    • Author(s)
      Nozaki, T.
    • Organizer
      XVIIIth Congress of Parasitology
    • Place of Presentation
      Aguascalientes, Mexico
    • Related Report
      2010 Final Research Report
  • [Presentation] 赤痢アメーバ症新規創薬2009

    • Author(s)
      野崎智義
    • Organizer
      第147回日本獣医学会学術集会
    • Place of Presentation
      宇都宮
    • Related Report
      2009 Annual Research Report
  • [Presentation] ミトコンドリア関連オルガネラの新規機能-赤痢アメーバ原虫"sulfosome"に存在する硫酸活性化経路2009

    • Author(s)
      見市文香、野崎智義
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] Entamoeba histolytica由来メチオニンガンマリアーゼ1と2のX線結晶構造解析2009

    • Author(s)
      唐木剛、村野祥子、亀井加恵子、佐藤暖、野崎智義、原田繁春
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腸管寄生性原虫赤痢アメーバにおける酸化ストレス応答のメタボローム解析2009

    • Author(s)
      野崎智義
    • Organizer
      第4回メタボロームシンポジウム
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 真核生物におけるミトコンドリアの多様性:腸管寄生原虫赤痢アメーバの新規オルガネラの解析2009

    • Author(s)
      野崎智義
    • Organizer
      第9回日本ミトコンドリア学会年会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role of sulfur-containing amino acid metabolism: characterization of two isotypes of methionine gamma-lyase in Entamooba histolytica.2009

    • Author(s)
      Nozaki, T., Furukawa, A., Jeelani, G., Sato, D., Karaki, T., Harada, S.
    • Organizer
      XVI Seminario Sobre Amibiasis and EMBO Workshop. Amoebiasis: Molecular Approaches in an Important but Neglected Disease.
    • Place of Presentation
      Guanajuato, Mexico.
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Role of sulfur-containing amino acid metabolism : characterization of two isotypes of methionine gamma-lyase in Entamoaha histnlytica.2009

    • Author(s)
      Nozaki, T., Furukawa, A., Jeelani, G., Sato, D., Karaki, T., and Harada, S.
    • Organizer
      XVI Seminario Sobre Amibiasis and EMBO Workshop. Amoebiasis : Molecular Approaches in an Important but Neglected Disease.
    • Place of Presentation
      Guanajuato, Mexico.
    • Related Report
      2008 Annual Research Report
  • [Presentation] The mitosome in Entamoeba histolytica.2008

    • Author(s)
      Miichi, F., Abu, Y. M., Nakada-Tsukui, K., and Nozaki, T.
    • Organizer
      US-Japan Cooperative Science Program.
    • Place of Presentation
      Davis, USA.
    • Related Report
      2010 Final Research Report
  • [Presentation] Kinetic characterizationof methionine gamma-lyase from Entamoeba histolytica against physiological substrates and trifluoromethionine.2008

    • Author(s)
      Sato, D., Yamagata, W., Karaki, T., Harada, S., and Nozaki, T.
    • Organizer
      The 4th International Conference on Anaerobic Protists: The Systems Biology of Anaerobic Protozoa.
    • Place of Presentation
      Taipei, Taiwan.
    • Related Report
      2010 Final Research Report
  • [Presentation] Metabolomic and transcriptomic analysis of sulfur-containing amino acid metabolism in the enteric protozoan parasite Entamoeba histolytica.2008

    • Author(s)
      Husein, A., Jeelani, G., Bilal, A. S., Sato, D., Mi-ichi, F., Hishiki, T., Gilchrist, C. A., Suematsu, M., Petri, Jr., W. A., and Nozaki, T.
    • Organizer
      The 8th Awaji International Forum on Infection and Immunity.
    • Place of Presentation
      Awaji
    • Related Report
      2010 Final Research Report 2008 Self-evaluation Report
  • [Presentation] Characterization of methionine gamma-lyases from enteric protozoan parasite, Entamoeba histolytica, as a potential drug target against amoebiasis".2008

    • Author(s)
      Sato, D., Yamagata, W., Karaki, T., Shimizu, A., Harada, S., and Nozaki, T.
    • Organizer
      The 8th Awaji International Forum on Infection and Immunity.
    • Place of Presentation
      Awaji
    • Related Report
      2010 Final Research Report
  • [Presentation] Regulation of cysteine protease secretion and phagocytosis in Entamoeba histolytica.2008

    • Author(s)
      Nozaki, T.
    • Organizer
      XVIIth International Congress for Tropical Medicine and Malaria (Invited talk in the symposium).
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2010 Final Research Report
  • [Presentation] The mitochondria-related organelle in the anaerobic parasitic protozoon Entamoeba histolytica.2008

    • Author(s)
      Mi-ichi, F., Abu, Y. M., Nakada-Tsukui, K., Kawai, S., and Nozaki, T.
    • Organizer
      International Symposium on Protistology: Evolution and Diversity.
    • Place of Presentation
      Tsukuba, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] The mitochondria-related organelle in the anaerobic protist Entamoeba histolytica.2008

    • Author(s)
      Mi-ichi, F., Abu, Y. M., Nakada-Tsukui, K., Kawai, S., and Nozaki, T.
    • Organizer
      International Symposium: Bacteria made ornangelles made eukaryotic cells.
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] 痢アメーバEntamoeba histolytica由来メチオニンγ-リアーゼのX線結晶構造解析2008

    • Author(s)
      清水顕、唐木剛、佐藤暖、亀井加恵子、野崎智義、原田繁春
    • Organizer
      第8回日本蛋白質科学会年会
    • Place of Presentation
      東京
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] 腸管寄生性アメーバ原虫のメチオニンγ-リアーゼと薬剤リード化合物の反応機構の解明2008

    • Author(s)
      佐藤暖、山形渉、唐木剛、原田繁春、野崎智義
    • Organizer
      日本ビタミン学会第60回大会
    • Place of Presentation
      仙台
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Characterization of methionine gamma-lyases from enteric protozoan parasite, Entamoeba histolytica, as a potential drug target against amoebiasis2008

    • Author(s)
      Sato, D., Yamagata, W., Karaki, T., Shimizu, A., Harada, S., Nozaki, T.
    • Organizer
      The 8th Awaji International Forum on Infection and Immunity.
    • Place of Presentation
      Awaji
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] 寄生性原虫の含硫アミノ酸代謝の重要性-メタボローム解析からのアプローチ2008

    • Author(s)
      佐藤暖、Afzal Husain, 曽我朋義、末松誠、野崎智義
    • Organizer
      第3回メタボロームシンポジウムーメタボロミクスが解き明かす生命のシステム
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] 含硫アミノ酸分解酵素・メチオニンγ-リアーゼを標的とした新規抗赤痢アメーバ薬の開発2008

    • Author(s)
      佐藤暖、唐木剛、原田繁春、柴田哲男、融健、野崎智義
    • Organizer
      BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] 硫黄含有アミノ酸生合成・分解経路を標的とする抗赤痢アメーバ薬の開発-メチオニンγリアーゼの立体構造と阻害剤の結合様式-2008

    • Author(s)
      唐木剛、清水顕、佐藤暖、亀井加恵子、原田繁春、野崎智義
    • Organizer
      第7回分子寄生虫・マラリア研究フォーラム
    • Place of Presentation
      松山
    • Related Report
      2008 Annual Research Report 2008 Self-evaluation Report
  • [Presentation] Kinetic characterization of methionine gamma-lyase from Entamoeba histolytica against physiological substrates and trifluoromethionine.2008

    • Author(s)
      Sato, D., Yamagata, W., Karaki, T., Harada, S., and Nozaki, T.
    • Organizer
      The 4th International Conference on Anaerobic Protists : The Systems Biology of Anaerobic Protozoa.
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2008 Annual Research Report
  • [Presentation] 赤痢アメーバEntamoeba histolytica由来メチオニンγ-リアーゼのX線結晶構造解析、2008

    • Author(s)
      清水顕, 唐木剛, 佐藤暖, 亀井加恵子, 野崎智義, 原田繁春
    • Organizer
      第8回日本蛋白質科学会年会、
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 腸管寄生性アメーバ原虫のメチオニンγ-リアーゼと薬剤リード化合物の反応機構の解明、2008

    • Author(s)
      佐藤暖, 山形渉, 唐木剛, 原田繁春, 野崎智義
    • Organizer
      日本ビタミン学会第60回大会
    • Place of Presentation
      仙台
    • Related Report
      2008 Annual Research Report
  • [Presentation] Metabolomic and transcriptomic analysis of sulfur-containing amino acid metabolism in the enteric protozoan parasite Entamoeba histolytica..2008

    • Author(s)
      Husein, A., Jeelani, G., Bilal, A. S., Sato, D., Mi-ichi, F., Hishiki, T., Gilchrist, C. A., Suematsu, M., Petri, Jr., W. A., and Nozaki, T
    • Organizer
      The 8th Awaji International Forum on Infection and Immunity. Awaji
    • Place of Presentation
      Awaji, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Characterization of methionine gamma-lyases from enteric protozoan parasite, Entamoeba histolytica, as a potential drug taraet against amoebiasis.2008

    • Author(s)
      Sato, D., Yamagata, W., Karaki, T., Shimizu, A., Harada, S., and Nozaki, T.
    • Organizer
      The 8th Awaji International Forum on Infection and Immunity.,
    • Place of Presentation
      Awaji, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] 寄生性原虫の含硫アミノ酸代謝の重要性-メタボローム解析からのアプローチ2008

    • Author(s)
      佐藤暖, Afzal Husain, 曽我朋義, 末松誠, 野崎智義
    • Organizer
      第3回メタボロームシンポジウム-メタボロミクスが解き明かす生命のシステム-
    • Place of Presentation
      鶴岡市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 含硫アミノ酵分解酵素・メチオニンγ-リアーゼを標的とした新規抗赤痢アメーバ薬の開発2008

    • Author(s)
      佐藤暖, 唐木剛, 原田繁春, 柴田哲男, 融健, 野崎智義
    • Organizer
      BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] Regulation and physiological importance of sulfur-containing amino acid metabolism in Entamoeba histolytica.2007

    • Author(s)
      Ali, V. and Nozaki, T.
    • Organizer
      41st Joint Conference on Parasitic Diseases of The Japa-United States Cooperative Medical Science Program
    • Place of Presentation
      Tokyo
    • Related Report
      2010 Final Research Report
  • [Presentation] Regulation of secretion of cysteine proteases by Rab11B small GTPase and proteinous inhibitors in Entamoeba histolytica.2007

    • Author(s)
      Nozaki, T.
    • Organizer
      5th European Congress on Tropical Medicine and International Health
    • Place of Presentation
      Amsterdam, the Netherlands
    • Related Report
      2010 Final Research Report
  • [Presentation] Characterization of cysteine biosynthetic pathway: a potential drug target in Entamoeba histolyitca.2007

    • Author(s)
      Ali, V., Husain, A., and Nozaki, T.
    • Organizer
      The 7th International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Characterization and evaluating the rol of serine O-acetyltransferase isoforms in cysteine biosynthetic pathway in Entamoeba histolyitca.2007

    • Author(s)
      Hussain, S., Ali, V., and Nozaki, T.
    • Organizer
      The 7th International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Metabolic and transcriptomic analysis of sulfur-containing amino acid metabolism in the enteric protozoan parasite Entamoeba histolyitca.2007

    • Author(s)
      Husain, A., Hishiki, T., Gilchrist, C. A., Ali, V., Suematsu, M., Petri, Jr., W. A., and Nozaki, T.
    • Organizer
      The 7th International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo
    • Related Report
      2010 Final Research Report
  • [Presentation] Autophagy in Entamoeba.2007

    • Author(s)
      Nozaki, T.
    • Organizer
      13^<th> Forum Cheju Korea-Japan Parasitology Seminar
    • Place of Presentation
      Chuncheon, Korea.
    • Related Report
      2010 Final Research Report
  • [Presentation] Proteomic analysis of the virulence of the enteric protozoan parasite Entamoeba histolyitca.2007

    • Author(s)
      Nozaki, T.
    • Organizer
      The 2^<nd> Mexican Symposium of Cellular and Molecular Proteomics of Mass Spectrometry
    • Place of Presentation
      Guanajuato, Mexico
    • Related Report
      2010 Final Research Report
  • [Presentation] Unique characteristics of pyridine nucleotide transhydrogenase in Entamoeba histolyitca.2007

    • Author(s)
      Yousuf, M.A., Nakada-Tsukui, K., and Nozaki, T.
    • Organizer
      International Symposium on Membrane Traffic
    • Place of Presentation
      Awaji, Hyogo, Japan.
    • Related Report
      2010 Final Research Report
  • [Presentation] Iron sulfur (Fe-S) cluster assembly in the enteric protozoan parasite Entamoeba histolytica: localization, oxygen sensitivity, and physiological significance.2006

    • Author(s)
      Ali, V. and Nozaki, T.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Final Research Report
  • [Presentation] Cysteine biosynthesis pathway in Entamoeba histolytica is a rational target to develop new chemotherapeutics against amebiasis.2006

    • Author(s)
      Ali, V. and Nozaki, T.
    • Organizer
      The 6th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo, Japan
    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.nih.go.jp/niid/para/parasite.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.nih.go.jp/niid/ja/2011-05-26-00-03-52.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.nih.go.jp/niid/para/parasite.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://parasite.dept.med.gunma-u.ac.jp/Enozaki_lab.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://parasite.dept.med.gunma-u.ac.jp/Enozaki_lab.html

    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2018-03-28  

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