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Cell sensor and its model shift

Planned Research

Project AreaMolecular interaction and modal shift of cellular sensors
Project/Area Number 18077010
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

NABEKURA Junichi  National Institute for Physiological Sciences, 発達生理学研究系, 教授 (50237583)

Co-Investigator(Kenkyū-buntansha) TOMITA Koichi  生理学研究所, 行動代謝分子解析センター, 助教 (80314285)
TOMINAGA Makoto  岡崎統合バイオサイエンスセンター, 教授 (90260041)
OKADA Yasunobu  生理学研究所, 所長 (10025661)
MAKISHIMA Makoto  日本大学, 医学部, 教授 (70346146)
KOIZUMI Shuuichi  山梨大学, 医学部, 教授 (10280752)
Co-Investigator(Renkei-kenkyūsha) TOMINAGA Makoto  岡崎統合バイオサイエンスセンター, 教授 (90260041)
OKADA Yasunobu  生理学研究所, 所長 (10025661)
MAKISHIMA Makoto  日本大学, 医学部, 教授 (70346146)
KOIZUMI Shuuichi  山梨大学, 医学部, 教授 (10280752)
Project Period (FY) 2006 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥105,000,000 (Direct Cost: ¥105,000,000)
Fiscal Year 2010: ¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 2009: ¥7,500,000 (Direct Cost: ¥7,500,000)
Fiscal Year 2008: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2007: ¥36,000,000 (Direct Cost: ¥36,000,000)
Fiscal Year 2006: ¥52,400,000 (Direct Cost: ¥52,400,000)
Keywords支援活動 / セルセンサー / セルソーター / 2光子励起顕微鏡 / 遺伝子改変動物 / 細胞感覚 / 2光子顕微鏡 / モーダルシフト / 研究支援 / 機器管理 / 分子 / 遺伝子改変 / センサー / 細胞 / 生存 / 分子メカニズム / 支援 / 環境
Research Abstract

To promote each research and collaboration in the Cell-Sensor team efficiently, supporting team bought the expensive and advanced apparatus, and maintained the appropriate condition. In addition, visualization of sensor molecules and analysis of sensor function have been carried-out with a high resonant multiphoton microscopy. Also, we supported the production of gene-manipulated mice. To announce the supporting activity, the technical training course has been provided, to which more than 30 members attended. We also frequently sent the new information to all members with the news letters, which printed every 3-4 month.

Report

(7 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (35 results)

All 2011 2010 2009 2008 2007 Other

All Journal Article (20 results) (of which Peer Reviewed: 16 results) Presentation (12 results) Remarks (3 results)

  • [Journal Article] Rapid, phase-specific and size-dependent remodeling of synapses in the adult somatosensory cortex during development of neuropathic pain.2011

    • Author(s)
      Kim SK, Nabekura J.
    • Journal Title

      Journal of Neuroscience 31

      Pages: 5477-5482

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inter-regional contribution of enhanced activity of the primary somatosensory cortex to the anterior cingulate cortex accelerates chronic pain behavior.2011

    • Author(s)
      Eto K, Wake H, Watanabe M, Ishibashi H, Noda M, Yanagawa Y, Nabekura J.
    • Journal Title

      Journal of Neuroscience 31

      Pages: 7631-7636

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] V2 receptor-mediated autocrine role of somatodendritic release of AVP in rat vasopressin neurons under hypo-osmotic conditions.2011

    • Author(s)
      Sato K, Numata T, Saito T, Ueta Y, Okada Y.
    • Journal Title

      Science Signaling 4(157)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unilateral infarction of the visual cortex (VC) induced an increase in dendritic spine turnover in contralateral VC.2011

    • Author(s)
      Takatsuru Y, Koibuchi N, Nabekura J.
    • Journal Title

      Neuroscience Letter

      Volume: 488 Pages: 97-100

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid, phase-specific and size-dependent remodeling of synapses in the adult somatosensory cortex during development of neuropathic pain.2011

    • Author(s)
      Kim SK, Nabekura J.
    • Journal Title

      Journal of Neuroscience

      Volume: 31 Pages: 5477-5482

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The inhibitor of 20-HETE synthesis, TS-011, improves cerebral microcirculatory autoregulation impaired by middle cerebral artery occlusion in mice.2010

    • Author(s)
      Marumo T, Eto K, Wake H, Omura T, Nabekura J.
    • Journal Title

      British Journal of Pharmacology 161

      Pages: 1391-1402

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of a protein kinase Akt1 by apoptosis signal-regulating kinase-1 (ASK1) is involved in apoptotic inhibition of regulatory volume increase.2010

    • Author(s)
      Subramanyam M, Takahashi N, Hasegawa Y, Mohri T, Okada Y.
    • Journal Title

      Journal of Biological Chemistry 285

      Pages: 6109-6117

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bradykinin-induced astrocyte-neuron signaling : glutamate release is mediated by ROS-activated volume-sensitive outwardly rectifying anion channels.2009

    • Author(s)
      Liu H-T, Akita T, Shimizu T, Sabirov RZ, Okada Y.
    • Journal Title

      Journal of Physiology (London) 587

      Pages: 2197-2209

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals.2009

    • Author(s)
      Wake H, Moorhouse AJ, Jinno S, Kohsaka S, Nabekura J.
    • Journal Title

      Journal of Neuroscience 29

      Pages: 3974-3980

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clustering of neuronal K^+-Cl^- cotransporter in the lipid rafts by tyrosine phosphorylation2009

    • Author(s)
      Watanabe M, Wake H, Moorhouse A, Nabekura J.
    • Journal Title

      Journal of Biological Chemistry 284

      Pages: 27980-27988

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals.2009

    • Author(s)
      Wake H, Moorhouse AJ, Jinno S, Kohsaka S, Nabekura J.
    • Journal Title

      Journal of Neuroscience

      Volume: 29 Pages: 3974-3980

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal circuit remodeling in the contralateral cortical hemisphere during functional recovery from cerebral infarction.2009

    • Author(s)
      Takatsuru Y, Fukumoto D, Yoshitomo M, Nemoto T, Tsukada H, Nabekura J.
    • Journal Title

      Journal of Neuroscience

      Volume: 29 Pages: 10081-10086

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maternal separation decreases the stability of mushroom spines in adult mice somatosensory cortex.2009

    • Author(s)
      Takatsuru Y, Yoshitomo M, Nemoto T, Eto K, Nabekura J.
    • Journal Title

      Brain Research

      Volume: 1294 Pages: 45-51

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular determinants of sensitivity and conductivity of human TRPM7 to Mg^<2+> and Ca^<2+>.2008

    • Author(s)
      Numata T, Okada Y.
    • Journal Title

      Channels 2

      Pages: 283-286

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early changes in KCC2 phosphorylation in response to neuronal stress results in functional downregulation.2007

    • Author(s)
      Wake H, Watanabe M, Moorhouse AJ, Kanematsu T, Horibe S, Matsukawa N, Asai K, Ojika K, Hirata M, Nabekura J.
    • Journal Title

      Journal of Neuroscience 27

      Pages: 1642-1650

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosholipase C-Related Inactive Protein is involved in Trafficking of gamma2 Subunit Containing GABAA Receptor to Cell Surface.2007

    • Author(s)
      Mizokami A, Kanematsu Ti, Ishibashi H, Yamaguchi T, Tanida I, Takenaka K, Nakayama K, Fukami K, Takenawa T, Kominami E, Moss S, Yamamoto T, Nabekura J, Hirata M
    • Journal Title

      Journal of Neuroscience 27

      Pages: 1692-1701

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Early changes in KCC2 phosphorylation in response to neuronal stress results in functional downregulation.2007

    • Author(s)
      Wake H, Watanabe M, Moorhouse AJ, Kanematsu T, Horibe S, Matsukawa N, Asai K, Ojika K, Hirata M, Nabekura J
    • Journal Title

      Journal of Neuroscience 27

      Pages: 1642-1650

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of body temperature on neural activity in the hippocampus : regulation of resting membrane potentials by TRPV42007

    • Author(s)
      Shibasaki K, Suzuki M, Mizuno A, Tominaga
    • Journal Title

      Journal of Neuroscience 27

      Pages: 1566-1575

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Inter-regional contribution of enhanced activity of the primary somatosensory cortex to the anterior cingulate cortex accelerates chronic pain behavior.

    • Author(s)
      Eto K, Wake H, Watanabe M, Ishibashi H, Noda M, Yanagawa Y, Nabekura J.
    • Journal Title

      Journal of Neuroscience

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methyl p-hydroxybenzoate (methyl paraben) causes pain sensation through TRPA1 activation

    • Author(s)
      Fujita F, Moriyama T, Higashi T, Shima A, Tominaga
    • Journal Title

      Br. J. Pharmacol (In press)

    • NAID

      130005448854

    • Related Report
      2006 Annual Research Report
  • [Presentation] Microglia directly monitor the functional state of synapses and determine the fate of damaged axon terminals : in vivo observation.2010

    • Author(s)
      Nabekura J, Wake H, Eto K, Kim S, Inada H.
    • Organizer
      7th Forum of European Neuroscience
    • Place of Presentation
      Amsterdam (invited speaker)
    • Year and Date
      2010-07-06
    • Related Report
      2010 Final Research Report
  • [Presentation] シナプスのin vivoイメージング2009

    • Author(s)
      江藤圭, 和氣弘明, 鍋倉淳一
    • Organizer
      第62回自律神経学会
    • Place of Presentation
      ダイワロイネットホテル和歌山(和歌山県)
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Microglia Surveillance of Synapse : in vivo Observation.2009

    • Author(s)
      Nabekura J
    • Organizer
      8^<th> Japan-Korea Joint Symposium
    • Place of Presentation
      (Seoul, Korea)
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] In vivo two-photon calcium imaging of neuronal activities in layer 2/3 of primary somatosensory cortex in inflammatory chronic pain.2009

    • Author(s)
      Eto K, Wake H, Ishibashi H, Noda M, Nabekura J
    • Organizer
      The 39th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      McCormick Place convention center (Chicago, USA)
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Inhibitor of 20-HETE synthesis, TS-011, improves the penumbral microc irculation after middle cerebral artery occlusion in mice.2009

    • Author(s)
      Marumo T, Eto Kei, Wake H, Omura T, Nabekura J
    • Organizer
      The 39th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      McCormick Place convention center (Chicago, USA)
    • Year and Date
      2009-10-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 炎症性慢性疼痛時の一次体性感覚野における神経回路機能のin vivo2光子カルシウムイメージング.In vivo two-photon calcium imaging of neuronal activities in primary somatosensory cortex in inflammatory chronic pain.2009

    • Author(s)
      江藤圭, 和氣弘明, 石橋仁, 野田百美, 鍋倉淳一
    • Organizer
      The 32nd Amual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      名古屋白鳥国際会議場(愛知県)
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 嗅覚入力依存的な成体嗅球内ニューロン新生のin vivoイメージング.In vivo imaging of sensory input-dependent neurogenesis in the adult olfactory bulb.2009

    • Author(s)
      澤田雅人, 金子奈穂子, 和氣弘明, 稲田浩之, 加藤康子, 柳川右千夫, 根本知己, 鍋倉淳一, 澤本和延
    • Organizer
      The 32nd Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      名古屋白鳥国際会議場(愛知県)
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] The Functional Remodeling of Contralateral Hemisphere During the Recovery from the Focal Infarction in Somatosensory Cortex.2009

    • Author(s)
      Takatsuru Y, Fukumoto D, Yoshitomo M, Nemoto T, Tsukada H, Nabekura J
    • Organizer
      第36回国際生理学会世界大会36th International Congress of Physiological Sciences(IUPS2009)
    • Place of Presentation
      京都国際会議場(京都府)
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Roles of anion channels and disordered cell volume regulation in apoptotic and necrotic cell death : International Joint Symposium2009

    • Author(s)
      Okada Y, Shimizu T, Lee EL, Inoue H, Uramoto H, Sato K, Numata T.
    • Organizer
      Physiology of Anion Transport and Cell Volume Regulation (PAT- CVR 2009)
    • Place of Presentation
      Okazaki, Japan (invited speaker)
    • Related Report
      2010 Final Research Report
  • [Presentation] Roles of volume-sensitive anion channels in cell death induction and glia-to-neuron signaling2009

    • Author(s)
      Okada Y.
    • Organizer
      XXXVI International Congress of Physiological Sciences (IUPS2009)
    • Place of Presentation
      Kyoto, Japan (invited speaker)
    • Related Report
      2010 Final Research Report
  • [Presentation] 特定領域細胞感覚支援班活動について2008

    • Author(s)
      鍋倉淳一
    • Organizer
      特定領域「細胞感覚」冬の班会議
    • Place of Presentation
      岡崎コンファレンスセンター
    • Year and Date
      2008-12-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 特定領域細胞感覚支援班活動について2008

    • Author(s)
      鍋倉淳一
    • Organizer
      特定領域「細胞感覚」夏の班会議
    • Place of Presentation
      札幌市教育文化会館
    • Year and Date
      2008-07-01
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.nips.ac.jp/cellsensor/shien.html

    • Related Report
      2010 Final Research Report
  • [Remarks] 特定領域研究ニュースレター(No.1〜No.5)の各号にて支援班活動を紹介。

    • Related Report
      2008 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.nips.ac.jp/cellsensor/shien.html

    • Related Report
      2008 Annual Research Report

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Published: 2006-04-01   Modified: 2018-03-28  

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