Molecular mechanisms underlying heterochromatin assembly

• Project Area: Chromatin potential for gene regulation
• Project/Area Number: 18H05532
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: National Institute for Basic Biology
• Principal Investigator: Nakayama Jun-ichi 基礎生物学研究所, クロマチン制御研究部門, 教授 (60373338)
• Co-Investigator(Kenkyū-buntansha): 小布施 力史 大阪大学, 大学院理学研究科, 教授 (00273855)
• Project Period (FY): 2018-06-29 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥142,090,000 (Direct Cost: ¥109,300,000、Indirect Cost: ¥32,790,000); Fiscal Year 2022: ¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000); Fiscal Year 2021: ¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000); Fiscal Year 2020: ¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000); Fiscal Year 2019: ¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000); Fiscal Year 2018: ¥30,810,000 (Direct Cost: ¥23,700,000、Indirect Cost: ¥7,110,000)
• Keywords: ヘテロクロマチン / HP1 / ヒストン修飾 / 転写制御

Outline of Final Research Achievements

In this study, we focused on heterochromatin in fission yeast and mouse ES cells and attempted to elucidate the molecular basis for determining chromatin potential. We found the division of labor between the HP1 isoforms, the relationship between mitotic phosphorylation of HP1 and chromosome segregation, novel crosstalk between histone methylation and ubiquitylation, and spore-specific chromatin structure. We also identified HBiX2 as a novel HP1 interactor and characterized its role in the formation of inactive X chromosomes.

Academic Significance and Societal Importance of the Research Achievements

真核生物の核内で観察されるヘテロクロマチンは、染色体の機能やゲノム恒常性の維持、エピジェネティックな遺伝子発現制御に重要な役割を果たしている。ヘテロクロマチンはヒストンH3のメチル化修飾とHP1タンパク質が重要な役割を果たしており、これらの制御に関わる新規の分子機構を明らかにした本研究は、ヘテロクロマチン形成の分子機構だけでなく、クロマチンポテンシャルの分子基盤を理解する上で重要な成果である。

Research Products

• [Int'l Joint Research] University of Aberdeen(英国)
• [Int'l Joint Research] Childrens Hospital of Philadelphia(米国)
• [Int'l Joint Research] Institut Curie(フランス)
• [Int'l Joint Research] University of Aberdeen(英国)
• [Int'l Joint Research] University of Toronto(カナダ)
• [Int'l Joint Research] University of Aberdeen(英国)
• [Int'l Joint Research] Leiden University Medical Center(オランダ)
• [Int'l Joint Research] Karolinska Institutet(スウェーデン)
• [Int'l Joint Research] University of Toronto(カナダ)
• [Int'l Joint Research] University of Aberdeen(英国)
• [Journal Article] Regulation of the SUV39H Family Methyltransferases: Insights from Fission Yeast (2023)
  • Author(s): Nakamura Rinko、Nakayama Jun-ichi
  • Journal Title: Biomolecules Volume: 13 Issue: 4 Pages: 593-593
  • DOI: 10.3390/biom13040593
  • Peer Reviewed / Open Access
• [Journal Article] Researchers support preprints and open access publishing, but with reservations: A questionnaire survey of MBSJ members (2023)
  • Author(s): Ide Kazuki、Nakayama Jun‐ichi
  • Journal Title: Genes to Cells Volume: - Issue: 5 Pages: 333-337
  • DOI: 10.1111/gtc.13015
  • Peer Reviewed
• [Journal Article] Inner nuclear membrane proteins Lem2 and Bqt4 interact with different lipid synthesis enzymes in fission yeast (2023)
  • Author(s): Hirano Yasuhiro、Kinugasa Yasuha、Kubota Yoshino、Obuse Chikashi、Haraguchi Tokuko、Hiraoka Yasushi
  • Journal Title: The Journal of Biochemistry Volume: online Issue: 1 Pages: 33-46
  • DOI: 10.1093/jb/mvad017
  • Peer Reviewed / Open Access
• [Journal Article] Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages (2023)
  • Author(s): Masui Osamu、Corbel Catherine、Nagao Koji、Endo Takaho A.、Kezuka Fuyuko、Diabangouaya Patricia、Nakayama Manabu、Kumon Mami、Koseki Yoko、Obuse Chikashi、Koseki Haruhiko、Heard Edith
  • Journal Title: Nature Cell Biology Volume: 25 Issue: 1 Pages: 134-144
  • DOI: 10.1038/s41556-022-01047-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells (2022)
  • Author(s): Sugawara S, Okada R, Loo TM, Tanaka H, Miyata K, Chiba M, Kawasaki H, Katoh K, Kaji S, Maezawa Y, Yokote K, Nakayama M, Oshima M, Nagao K, Obuse C, Nagayama S, Takubo K, Nakanishi A, Kanemaki MT, Hara E, Takahashi A.
  • Journal Title: Commun Biol Volume: 5 Issue: 1 Pages: 1420-1420
  • DOI: 10.1038/s42003-022-04369-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Multiple interfaces to recognize nucleosomal targets (2021)
  • Author(s): Rinko Nakamura, Jun-ichi Nakayama
  • Journal Title: The Journal of Biochemistry Volume: 171 Issue: 3 Pages: 257-259
  • DOI: 10.1093/jb/mvab139
  • Peer Reviewed
• [Journal Article] Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action (2021)
  • Author(s): Isobe Shin-Ya、Hiraga Shin-ichiro、Nagao Koji、Sasanuma Hiroyuki、Donaldson Anne D.、Obuse Chikashi
  • Journal Title: Cell Reports Volume: 36 Issue: 2 Pages: 109383-109383
  • DOI: 10.1016/j.celrep.2021.109383
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Chromatin loading of MCM hexamers is associated with di-/tri-methylation of histone H4K20 toward S phase entry. (2021)
  • Author(s): Hayashi-Takanaka Y, Hayashi Y, Hirano Y, Miyawaki-Kuwakado A, Ohkawa Y, Obuse C, Kimura H, Haraguchi T, Hiraoka Y.
  • Journal Title: Nucleic Acids Res. Volume: 49 Issue: 21 Pages: 12152-12166
  • DOI: 10.1093/nar/gkab1068
  • Peer Reviewed / Open Access
• [Journal Article] Proteomics-Based Systematic Identification of Nuclear Proteins Anchored to Chromatin via RNA (2020)
  • Author(s): Kyoko Hiragami-Hamada, Naoki Tani, Jun-Ichi Nakayama
  • Journal Title: Methods in Molecular Biology Volume: 2161 Pages: 89-99
  • DOI: 10.1007/978-1-0716-0680-3_8
  • ISBN: 9781071606797, 9781071606803
  • Peer Reviewed
• [Journal Article] Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19 (2020)
  • Author(s): Cheng Dong, Reiko Nakagawa, Kyohei Oyama, Yusuke Yamamoto, Weilian Zhang, Aiping Dong, Yanjun Li, Yuriko Yoshimura, Hiroyuki Kamiya, Jun-Ichi Nakayama, Jun Ueda, Jinrong Min
  • Journal Title: Elife Volume: 9
  • DOI: 10.7554/elife.58675
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Homozygous nonsense variant in LRIF1 associated with facioscapulohumeral muscular dystrophy (2020)
  • Author(s): Hamanaka Kohei、Sikrova Darina、Mitsuhashi Satomi、Masuda Hiroki、Sekiguchi Yukari、Sugiyama Atsuhiko、Shibuya Kazumoto、Lemmers Richard J.L.F.、Goossens Remko、Ogawa Megumu、Nagao Koji、Obuse Chikashi、Noguchi Satoru、Hayashi Yukiko K.、Kuwabara Satoshi、Balog Judit、Nishino Ichizo、van der Maarel Silvere M.
  • Journal Title: Neurology Volume: 94 Issue: 23
  • DOI: 10.1212/wnl.0000000000009617
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Rare variant of the epigenetic regulator SMCHD1 in a patient with pituitary hormone deficiency. (2020)
  • Author(s): Kinjo K, Nagasaki K, Muroya K, Suzuki E, Ishiwata K, Nakabayashi K, Hattori A, Nagao K, Nozawa R-S, Obuse C, Miyado K, Ogata T, Fukami M and Miyado M.
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 10985-10985
  • DOI: 10.1038/s41598-020-67715-x
  • Peer Reviewed / Open Access
• [Journal Article] Regulation of an adaptor protein STING by Hsp90β to enhance innate immune responses against microbial infections (2020)
  • Author(s): Seiichi Sato, Kai Li, Nozomi Sakurai, Mei Hashizume, Sunanda Baidya, Hirotaka Nonaka, Koki Noguchi, Kozo Ishikawa, Chikashi Obuse, Akinori Takaoka
  • Journal Title: Cellular Immunology Volume: 356 Pages: 104188-104188
  • DOI: 10.1016/j.cellimm.2020.104188
  • Peer Reviewed / Open Access
• [Journal Article] Mapping replication timing domains genome wide in single mammalian cells with single-cell DNA replication sequencing (2020)
  • Author(s): Miura Hisashi、Takahashi Saori、Shibata Takahiro、Nagao Koji、Obuse Chikashi、Okumura Katsuzumi、Ogata Masato、Hiratani Ichiro、Takebayashi Shin-ichiro
  • Journal Title: Nature Protocols Volume: 15 Issue: 12 Pages: 4058-4100
  • DOI: 10.1038/s41596-020-0378-5
  • Peer Reviewed / Open Access
• [Journal Article] Subacute cutaneous lupus erythematosus with melanocyte elimination induced by pembrolizumab. (2020)
  • Author(s): Ogawa-Momohara M, Muro Y, Goto K, Obuse C, Satoh M, Kono M, Akiyama M.
  • Journal Title: J. Dermatol. Volume: 47 Issue: 6
  • DOI: 10.1111/1346-8138.15316
  • NAID: 120006884960
  • Peer Reviewed
• [Journal Article] Chromosome-associated RNA ;protein complexes promote pairing of homologous chromosomes during meiosis in Schizosaccharomyces pombe. (2019)
  • Author(s): Ding DQ, Okamasa K, Katou Y, Oya E, Nakayama J, Chikashige Y, Shirahige K, Haraguchi T, Hiraoka Y.
  • Journal Title: Nature Communications Volume: 10 Issue: 1 Pages: 5598-5598
  • DOI: 10.1038/s41467-019-13609-0
  • Peer Reviewed / Open Access
• [Journal Article] H3K14 ubiquitylation promotes H3K9 methylation for heterochromatin assembly (2019)
  • Author(s): Oya Eriko、Nakagawa Reiko、Yoshimura Yuriko、Tanaka Mayo、Nishibuchi Gohei、Machida Shinichi、Shirai Atsuko、Ekwall Karl、Kurumizaka Hitoshi、Tagami Hideaki、Nakayama Jun‐ichi
  • Journal Title: EMBO reports Volume: 20 Issue: 10
  • DOI: 10.15252/embr.201948111
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] KDM2A-dependent reduction of rRNA transcription on glucose starvation requires HP1 in cells, including triple-negative breast cancer cells (2019)
  • Author(s): Okamoto Kengo、Tanaka Yuji、Ogasawara Sachiko、Obuse Chikashi、Nakayama Jun-ichi、Yano Hirohisa、Tsuneoka Makoto
  • Journal Title: Oncotarget Volume: 10 Issue: 46 Pages: 4743-4760
  • DOI: 10.18632/oncotarget.27092
  • Peer Reviewed / Open Access
• [Journal Article] Leo1 is essential for the dynamic regulation of heterochromatin and gene expression during cellular quiescence (2019)
  • Author(s): Eriko Oya, Mickael Durand-Dubief, Adiel Cohen, Vladimir Maksimov, Catherine Schurra, Jun-ichi Nakayama, Ronit Weisman, Benoit Arcangioli, Karl Ekwall
  • Journal Title: Epigenetics & Chromatin Volume: 12 Issue: 1 Pages: 45-45
  • DOI: 10.1186/s13072-019-0292-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Do the charges matter? - Balancing the charges of the chromodomain proteins on the nucleosome. (2019)
  • Author(s): Kyoko Hiragami-Hamada, Jun-ichi Nakayama
  • Journal Title: The Journal of Biochemistry Volume: － Issue: 6 Pages: 455-458
  • DOI: 10.1093/jb/mvz004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mitotic phosphorylation of HP1α regulates its cell cycle-dependent chromatin binding (2019)
  • Author(s): Gohei Nishibuchi, Shinichi Machida, Reiko Nakagawa, Yuriko Yoshimura, Kyoko Hiragami-Hamada, Yusuke Abe, Hitoshi Kurumizaka, Hideaki Tagami, Jun-ichi Nakayama
  • Journal Title: The Journal of Biochemistry Volume: 165 Issue: 5 Pages: 433-446
  • DOI: 10.1093/jb/mvy117
  • NAID: 40021880612
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Asymmetrical localization of Nup107-160 subcomplex components within the nuclear pore complex in fission yeast (2019)
  • Author(s): Asakawa Haruhiko、Kojidani Tomoko、Yang Hui-Ju、Ohtsuki Chizuru、Osakada Hiroko、Matsuda Atsushi、Iwamoto Masaaki、Chikashige Yuji、Nagao Koji、Obuse Chikashi、Hiraoka Yasushi、Haraguchi Tokuko
  • Journal Title: PLOS Genetics Volume: 15 Issue: 6 Pages: 008061-1008061
  • DOI: 10.1371/journal.pgen.1008061
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genome-wide stability of the DNA replication program in single mammalian cells (2019)
  • Author(s): Saori Takahashi, Hisashi Miura, Takahiro Shibata, Koji Nagao, Katsuzumi Okumura, Masato Ogata, Chikashi Obuse, Shin-ichiro Takebayashi and Ichiro Hiratani
  • Journal Title: Nature Genetics Volume: 51 Issue: 3 Pages: 529-540
  • DOI: 10.1038/s41588-019-0347-5
  • Peer Reviewed / Open Access
• [Journal Article] Role of SmcHD1 in establishment of epigenetic states required for the maintenance of the X-inactivated state in mice (2018)
  • Author(s): Sakakibara Yuki、Nagao Koji、Blewitt Marnie、Sasaki Hiroyuki、Obuse Chikashi、Sado Takashi
  • Journal Title: Development Volume: 145 Issue: 18 Pages: 806-821
  • DOI: 10.1242/dev.166462
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1. (2018)
  • Author(s): Terui R, Nagao K, Kawasoe Y, Taki K, Higashi TL, Tanaka S, Nakagawa T, Obuse C, Masukata H, Takahashi TS
  • Journal Title: Genes & development Volume: 32(11-12) Issue: 11-12 Pages: 806-821
  • DOI: 10.1101/gad.310995.117
  • Peer Reviewed / Open Access
• [Presentation] テトラヒメナのゲノム削減は複数のHP1様タンパク質の協調的作用により制御される (2022)
  • Author(s): 片岡 研介、Olivera Valentirovic 、吉村 ゆり子、Eliot Geraud、西本 裕希、中川 れい子、谷 直紀、望月 一史、中山 潤一
  • Organizer: 第15回日本エピジェネティクス研究会年会
• [Presentation] 分裂酵母における胞子クロマチン構造の網羅的解析 (2022)
  • Author(s): 林 亜紀、中川 れい子、大川 恭行、中山 潤一
  • Organizer: 第54回酵母遺伝学フォーラム
• [Presentation] Distinct biochemical properties of two HP1 proteins in fission yeast (2022)
  • Author(s): Anisa Fitri Rahayu, Yuriko Yoshimura, Reiko Nakagawa, Aki Hayashi, Jun-ichi Nakayama
  • Organizer: 第95回 日本生化学会大会
• [Presentation] 分裂酵母ヒストンメチル化酵素Clr4の活性制御機構の解析 (2022)
  • Author(s): 林 亜紀、中川 れい子、大川 恭行、中山 潤一
  • Organizer: 第45回 日本分子生物学会年会
• [Presentation] Distinct biochemical properties of two HP1 proteins in fission yeast (2022)
  • Author(s): Anisa Fitri Rahayu, Yuriko Yoshimura, Reiko Nakagawa, Aki Hayashi, Jun-ichi Nakayama
  • Organizer: 24th EMBL PhD Symposium
  • Int'l Joint Research
• [Presentation] 分裂酵母の胞子におけるヒストン修飾の網羅的解析 (2022)
  • Author(s): 林 亜紀、中川 れい子、大川 恭行、中山 潤一
  • Organizer: 第40回 染色体ワークショップ・第21回 核ダイナミクス研究会
• [Presentation] テトラヒメナのゲノム削減は複数のHP1様タンパク質の協調的作用により制御される (2022)
  • Author(s): 片岡 研介、Olivera Valentirovic、吉村 ゆり子、Eliot Geraud、西本 裕希、中川 れい子、谷 直紀、望月 一史、中山 潤一
  • Organizer: 第40回染色体ワークショップ・第21回核ダイナミクス研究会
• [Presentation] Mechanisms regulationg Clr4/SUV39H histone methyltransferase activity (2022)
  • Author(s): Rinko Nakamura, Yuriko Yoshimura, Reiko Nakagawa, Jun-ichi Nakayama
  • Organizer: Japan-UK Regulation through Chromatin Conference
  • Int'l Joint Research / Invited
• [Presentation] RNA polymerase II Ser7リン酸化は、転写と共役したヌクレオソーム弛緩・再構築を促進して転写一時停止を安定化する (2022)
  • Author(s): 梶谷 卓也、加藤 太陽、沖 昌也、木村 宏、大川 恭行、小布施 力史、Hermand Damien、Lis John、村上 洋太
  • Organizer: 第45回 日本分子生物学会年会
• [Presentation] ピゲノムとヘテロクロマチン構造構築に働きかけるHP1結合タンパク質 (2022)
  • Author(s): 小布施 力史、 磯部 真也、佐渡 敬、長尾 恒治
  • Organizer: 第45回 日本分子生物学会年会
• [Presentation] Replication dynamics identifies the folding principles of the inactive X chromosome (2022)
  • Author(s): Rawin Poonperm, Saya Ichihara, Hisashi Miura, Akie Tanigawa, Koji Nagao, Chikashi Obuse, Takashi Sado, Ichiro Hiratani
  • Organizer: 第45回 日本分子生物学会年会
• [Presentation] ポリコーム複合体PRC1とPRC2はマウス胚体外組織におけるＸ染色体不活性化の維持に必須である (2022)
  • Author(s): 増井 修、Corbel Catherine、長尾 恒治、遠藤 高帆、毛塚 芙由子、小布施 力史、Heard Edith、古関 明彦
  • Organizer: 第45回 日本分子生物学会年会
• [Presentation] PCGF6-PRC1 は着床後胚においてＸ染色体不活性化を安定に保つ役割を持つ (2022)
  • Author(s): 増井 修、長尾 恒治、信賀 順、遠藤 高帆、毛塚 芙由子、小布施 力史、古関 明彦
  • Organizer: 第45回 日本分子生物学会年会
• [Presentation] PHIP/ICEN4 regulates centromere via CENP-B (2022)
  • Author(s): arinela Perpelescu, Chikashi Obuse, Hiroshi Masumoto, Masato Kanemaki, Hiroshi Kimura
  • Organizer: 第45回 日本分子生物学会年会
• [Presentation] 分裂酵母の胞子クロマチン構造の制御機構の解析 (2021)
  • Author(s): 林亜紀、中川れい子、中山潤一
  • Organizer: 第５４回 酵母遺伝学フォーラム
• [Presentation] 分裂酵母における胞子ヒストン修飾の分子制御機構の解析 (2021)
  • Author(s): 林亜紀、中川れい子、中山潤一
  • Organizer: 第44回 日本分子生物学会年会
• [Presentation] 分裂酵母における胞子ヒストン修飾の分子制御機構の解析 (2021)
  • Author(s): 林亜紀、中川れい子、大川恭行、中山潤一
  • Organizer: 第39回 染色体ワークショップ・第19回 核ダイナミクス研究会
• [Presentation] Multi-HP1-like protein containing complex regulates DNA elimination in Tetrahymena (2021)
  • Author(s): Kensueke Kataoaka, Olivera Valentirovic, Yuriko Yoshimura, Eliot Geraud, Kazufumi Mochizuki, Jun-ichi Nakayama
  • Organizer: Ciliate Molecular Biology Meeting 2021
  • Int'l Joint Research / Invited
• [Presentation] The HP1-like protein Hpl8p is important for programmed DNA elimination in Tetrahymena (2021)
  • Author(s): Olivera Valentirovic, Jun-ichi Nakayama, Kensuke Kataoka
  • Organizer: Ciliate Molecular Biology Meeting 2021
  • Int'l Joint Research
• [Presentation] The HP1-like protein Hpl8p regulates vegetative growth and DNA elimination in Tetrahymena (2021)
  • Author(s): Olivera Valentirovic, Jun-ichi Nakayama and Kensuke Kataoka
  • Organizer: The 4th Asian Congress of Protistology
  • Int'l Joint Research
• [Presentation] テトラヒメナのゲノム削減は複数のHP1様タンパク質を含む複合体によって制御される (2021)
  • Author(s): 片岡研介、Olivera Valentirovic、吉村ゆり子、Eliot Geraud、西本裕希、中川れい子、望月一史、中山潤一
  • Organizer: 第44回 日本分子生物学会年会
• [Presentation] The HP1-like protein Hpl8p regulates vegetative growth and DNA elimination in Tetrahymena (2021)
  • Author(s): Olivera Valentirovic Jun-ichi Nakayama and Kensuke Kataoka
  • Organizer: 第44回 日本分子生物学会年会
• [Presentation] テトラヒメナのゲノム削減は複数のHP1様タンパク質の協調的作用により制御される (2021)
  • Author(s): 片岡研介、Olivera Valentirovic、吉村ゆり子、Eliot Geraud、西本裕希、中川れい子、望月一史、中山潤一
  • Organizer: 第39回 染色体ワークショップ・第19回 核ダイナミクス研究会
• [Presentation] PP1はRIF1のエフェクターとして、Shieldinに先立って相同組換え修復の制御を行う (2021)
  • Author(s): 磯部真也、平賀信一朗、長尾恒治、笹沼博之、Donaldson D. Anne、 小布施力史
  • Organizer: 第26回 DNA複製・組換え・修復ワークショップ
• [Presentation] RIF1-PP1 complexは、Shieldinに先立ってDNA end resectionを抑制する (2021)
  • Author(s): 磯部真也、平賀信一朗、長尾恒治、笹沼博之、Donaldson D. Anne、 小布施力史
  • Organizer: 第44回 日本分子生物学会年会
• [Presentation] PP1はRIF1のエフェクターとして、Shieldinに先立って相同組換え修復の制御を行う (2021)
  • Author(s): 磯部真也、平賀信一朗、長尾恒治、笹沼博之、Donaldson D. Anne、 小布施力史
  • Organizer: 第39回 染色体ワークショップ・第19回 核ダイナミクス研究会
• [Presentation] 分裂酵母における胞子クロマチン動態の分子制御機構の解析 (2021)
  • Author(s): 林 亜紀、中川 れい子、中山 潤一
  • Organizer: 第１４回エピジェネティクス研究会年会
• [Presentation] Protein Phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action (2021)
  • Author(s): 磯部 真也, 平賀 信一朗, 長尾 恒治, 笹沼 博之 , Donaldson D Anne, 小布施 力史
  • Organizer: 第38回 染色体ワークショッフ・第19回 核ダイナミクス研究会
• [Presentation] 分裂酵母における胞子クロマチン構造とその制御機構の解析 (2020)
  • Author(s): 林 亜紀、中川 れい子、中山 潤一
  • Organizer: 酵母遺伝学フォーラム 第５３回研究報告会
• [Presentation] 分裂酵母における胞子クロマチン動態の分子制御機構の解析 (2020)
  • Author(s): 林 亜紀、中川 れい子、中山 潤一
  • Organizer: 日本分子生物学会 第４３回年会
• [Presentation] PP1, another RIF1 effector to shieldin, suppresses resection of damaged DNA ends as a barrier against HDR (2020)
  • Author(s): 磯部 真也, 平賀 信一朗, 長尾 恒治, 野崎 直仁, Donaldson D Anne, 小布施 力史
  • Organizer: 日本分子生物学会 第４３回年会
• [Presentation] HP1のリン酸化はヌクレオソームの結合特異性を制御する (2019)
  • Author(s): 西淵剛平、川口隆之、田中万葉、沖昌也、田上英明、中山潤一
  • Organizer: 日本プロテオーム学会2019年大会・第70回日本電気泳動学会総会
  • Invited
• [Presentation] 分裂酵母のヘテロクロマチンを制御するヒストン修飾のクロストーク (2019)
  • Author(s): 大屋恵梨子、中川れい子、吉村ゆり子、田中万葉、西淵剛平、町田晋一、胡桃坂仁志、田上英明、中山潤一
  • Organizer: 日本遺伝学会第91回大会
  • Invited
• [Presentation] マウスES細胞分化および初期胚発生過程における1細胞全ゲノムDNA複製タイミング解析 (2019)
  • Author(s): 高橋沙央里、三浦尚、 柴田隆豊、長尾恒治、小布施力史、竹林慎一郎、平谷伊智朗
  • Organizer: 第42回日本分子生物学会年会
  • Invited
• [Presentation] Elucidation of the molecular basis of heterochromatin body formation (2019)
  • Author(s): Chikashi Obuse
  • Organizer: Chromosome Dynamics 2019
  • Int'l Joint Research / Invited
• [Presentation] ヘテロクロマチン構造形成に関わるヒストン修飾酵素複合体の機能解析 (2019)
  • Author(s): 蜂須賀亜紀、沖昌也、中山潤一
  • Organizer: 日本遺伝学会第91回大会
• [Presentation] 分裂酵母JmjCタンパク質Epe1によるゲノムワイドなヘテロクロマチン分布の制御 (2019)
  • Author(s): 反田真登、石崎裕章、海東亘、島田篤、中山潤一、村上洋太
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] PI3K複合体のエンドソーム局在化を介して依存性エンドサイトーシスを制御する (2019)
  • Author(s): 天野麻穂、藤岡容一朗、佐藤絢、堀内浩水、吉田藍子、笹島仁、小布施力史、大場雄介
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] マウス初期胚特異的なセントロメア構造およひ機能の分子機序の解明 (2019)
  • Author(s): 谷口稜弥、波多野裕、山崎大賀、舛本寛、小布施力史、山縣一夫
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] 高次クロマチン構造の形成と維持の分子機構 (2019)
  • Author(s): 中山潤一
  • Organizer: 染色体研究の最前線 2019
  • Invited
• [Presentation] Crosstalk between histone modifications during heterochromatin assembly (2018)
  • Author(s): Jun-ichi Nakayama
  • Organizer: The 4th Shanghai Int Workshop of Epigenetics in Development and Disease The 13th Annual Meeting of Asian Epigenome Alliance, Shanghai
  • Int'l Joint Research / Invited
• [Presentation] HP1によるヘテロクロマチン構造形成の分子機構 (2018)
  • Author(s): 中山潤一
  • Organizer: 第91回 日本生化学会大会
  • Invited
• [Presentation] X染色体不活性化過程におけるSmchd1-Hbix1の役割 (2018)
  • Author(s): 長尾恒治、榊原祐樹、元田裕佳里、坂口武久、木村宏、佐渡敬、小布施力史
  • Organizer: 第91回 日本生化学会大会
  • Invited
• [Presentation] RIF1-PP1複合体のDNA損傷における機能解析 (2018)
  • Author(s): 磯部 真也、長尾 恒治、野崎 直仁、木村 宏、小布施 力史
  • Organizer: 第41回 日本分子生物学会年会
• [Presentation] 染色体不活性化における非コードXIST RNAとSmchd1-Hbix1Xの役割 (2018)
  • Author(s): 長尾 恒治、榊原 祐樹、坂口 武久、木村 宏、佐渡 敬、小布施 力史
  • Organizer: 第41回 日本分子生物学会年会
  • Invited
• [Presentation] Smchd1-Hbix1依存的な不活性化X染色体の区画化 (2018)
  • Author(s): 長尾 恒治、榊原 祐樹、柴田 幸子、野澤 竜介、坂口 武久、木村 宏、佐渡 敬、小布施 力史
  • Organizer: 第41回 日本分子生物学会年会
• [Presentation] 分裂酵母に特異的な核膜孔複合体の構造と機能 (2018)
  • Author(s): 淺川 東彦、糀谷 知子、楊 恵如、大槻 千鶴、小坂田 裕子、松田 厚志、岩本 政明、近重 裕次、高木 尚充、長尾 恒治、小布施 力史、 平岡 泰、原口 徳子
  • Organizer: 第41回 日本分子生物学会年会
• [Presentation] Single-cell DNA replication timing profiling and 3D genome organization dynamics during development (2018)
  • Author(s): Hisashi Miura, Saori Takahashi, Takahiro Shibata, Koji Nagao, Chikashi Obuse, Shin-ichiro Takebayashi, Ichiro Hiratani
  • Organizer: Nuclear Organization & Function on Cold Spring Harbor Meeting
• [Presentation] 分化前後のES細胞における複製ドメインは細胞間で極めて均一なプロファイルを示す (2018)
  • Author(s): 高橋沙央里、三浦尚、柴田隆豊、長尾恒治、小布施力史、竹林慎一郎、平谷伊智朗
  • Organizer: 第12回 日本エピジェネティクス研究会年会
• [Book] 遺伝学の百科事典（ヘテロクロマチンとユークロマチン） (2022)
  • Author(s): 中山潤一（日本遺伝学会／編）
  • Total Pages: 690
  • Publisher: 丸善出版
  • ISBN: 9784621306604
• [Book] 相分離 メカニズムと疾患（ヘテロクロマチンの形成メカニズム） (2021)
  • Author(s): 野澤竜介、小布施力史（廣瀬哲郎、加藤昌人、中川真一／編）
  • Total Pages: 223
  • Publisher: 羊土社
  • ISBN: 9784758103954