| Project Area | Cell Proliferation Control |
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| Project/Area Number |
19057003
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
KISHIMOTO Takeo 東京工業大学, 大学院・生命理工学研究科, 教授 (00124222)
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| Co-Investigator(Kenkyū-buntansha) |
CHIBA Kazuyoshi お茶の水女子大学, 理学部, 教授 (70222130)
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| Project Period (FY) |
2007 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥187,700,000 (Direct Cost: ¥187,700,000)
Fiscal Year 2011: ¥36,400,000 (Direct Cost: ¥36,400,000)
Fiscal Year 2010: ¥36,400,000 (Direct Cost: ¥36,400,000)
Fiscal Year 2009: ¥36,900,000 (Direct Cost: ¥36,900,000)
Fiscal Year 2008: ¥36,900,000 (Direct Cost: ¥36,900,000)
Fiscal Year 2007: ¥41,100,000 (Direct Cost: ¥41,100,000)
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| Keywords | 細胞周期 / 卵細胞 / 受精 / 細胞死 / Mos-MAPK-Rsk / サイクリン-CDK / カスパーゼ / Mos-MAPK-Psk / 前核の融合 / 卵割周期 / Mos-MAPK / 減数分裂 |
|---|
| Research Abstract |
Unfertilized mature eggs are arrested at a particular stage of the cell cycle, and fertilization releases the arrest to initiate embryonic cell cycle. Here we investigated molecular mechanisms underlying this cell cycle arrest and release. We found the dual lock for the arrest and the state of DNA replication machinery, and proposed the arrest mechanism common to metazoan eggs. We further found requirement of protein phosphatases for release of the cell cycle arrest after fertilization.
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Report
(7 results)
Research Products
(62 results)
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[Journal Article] Initiation of DNA replication after fertilization is regulated by p90Rsk at pre-RC/pre-IC transition in starfish eggs2010
Author(s)
Tachibana, K., Mori, M., Matsuhira, T., Karino, T., Inagaki, T., Nagayama, A., Nishiyama, A., Hara, M., and Kishimoto, T.
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 107
Pages: 5006-5011
Related Report
Peer Reviewed
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[Journal Article] Initiation of DNA replication after fertilization is regulated by p90Rsk at pre-RC/pre-IC transition in starfish eggs.2010
Author(s)
Tachibana, K., Mori, M., Matsuhira, T., Karino, T., Inagaki, T., Nagayama, A., Nishiyama, A., Hara, M., Kishimoto, T.
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Journal Title
Proc. Natl. Acad. Sci. USA 107
Pages: 5006-5011
Related Report
Peer Reviewed
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[Book] Cytostatic arrest : Post-ovulation arrest until fertilization in metazoan oocytes. In Oogenesis : The Universal Process (eds.Verlhac, M.H., Villeneuve, A.), Chapter 14.2010
Author(s)
Nishiyama, T., Tachibana, K., Kishimoto, T
Publisher
Wiley-Blackwell, UK
Related Report
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