| Budget Amount *help |
¥187,700,000 (Direct Cost: ¥187,700,000)
Fiscal Year 2011: ¥36,400,000 (Direct Cost: ¥36,400,000)
Fiscal Year 2010: ¥36,400,000 (Direct Cost: ¥36,400,000)
Fiscal Year 2009: ¥36,900,000 (Direct Cost: ¥36,900,000)
Fiscal Year 2008: ¥36,900,000 (Direct Cost: ¥36,900,000)
Fiscal Year 2007: ¥41,100,000 (Direct Cost: ¥41,100,000)
|
|---|
| Research Abstract |
Unfertilized mature eggs are arrested at a particular stage of the cell cycle, and fertilization releases the arrest to initiate embryonic cell cycle. Here we investigated molecular mechanisms underlying this cell cycle arrest and release. We found the dual lock for the arrest and the state of DNA replication machinery, and proposed the arrest mechanism common to metazoan eggs. We further found requirement of protein phosphatases for release of the cell cycle arrest after fertilization.
|
