| Project Area | Protein community: organization and maintenance of protein functions |
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| Project/Area Number |
19058003
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Morioka College (2010-2011)
The University of Tokyo (2007-2009) |
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Principal Investigator |
TOKUDA Hajime 盛岡大学, 栄養科学部, 教授 (40125943)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUYAMA Shin-ichi 立教大学, 理学部, 教授 (50183108)
NISIYAMA Kennichi 岩手大学, 農学部, 教授 (80291334)
NARITA Shin-ichiro 東京大学, 分子細胞生物学研究所, 助教 (30338751)
TAO Kazuyuki 東京大学, アイソトープ総合センター, 助教 (00211996)
TAKEDA Kazuki 京都大学, 理学研究科, 講師 (30332290)
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| Project Period (FY) |
2007 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥106,500,000 (Direct Cost: ¥106,500,000)
Fiscal Year 2011: ¥21,300,000 (Direct Cost: ¥21,300,000)
Fiscal Year 2010: ¥21,300,000 (Direct Cost: ¥21,300,000)
Fiscal Year 2009: ¥21,300,000 (Direct Cost: ¥21,300,000)
Fiscal Year 2008: ¥21,300,000 (Direct Cost: ¥21,300,000)
Fiscal Year 2007: ¥21,300,000 (Direct Cost: ¥21,300,000)
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| Keywords | 外膜 / 細胞質膜 / リポ蛋白質 / βバレル型蛋白質 / Lol 因子 / リポ多糖 / エンベロープストレス / 外膜形成 / Lolシステム / Secトランスロコン / 蛋白質輸送 / ABCトランスポーター / 分子シャペロン / 膜局在化 / 細胞表層 / βバレル型タンパク質 / リポタンパク質 / 生合成 |
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| Research Abstract |
Gram-negative bacteria generally possess outer membranes, which are essential for bacterial growth. In Escherichia coli, lipoproteins play critical roles in the biogenesis of outer membranes. Most E. coli lipoproteins are localized in the outer membrane. This is mediated by the Lol system comprising five Lol proteins in a manner dependent on lipoprotein sorting signals. The mechanisms underlying the biogenesis of E. coli outer membranes are examined by analyzing the outer membrane sorting of lipoproteins.
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