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• Project Area: Immunological Self Recognition and its Disorders
• Project/Area Number: 19059001
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: 地方独立行政法人宮城県立病院機構 宮城県立がんセンター(研究所) (2011); Miyagi Cancer Center Research Institute (2009-2010); Tohoku University (2007-2008)
• Principal Investigator: SUGAMURA Kazuo 地方独立行政法人宮城県立病院機構 宮城県立がんセンター(研究所), 発がん制御研究部, 特任部長 (20117360)
• Co-Investigator(Kenkyū-buntansha): ISHIKAWA Fumihiko 独立行政法人理化学研究所, ヒト疾患モデル研究ユニット, ユニットリーダー (30403918) ; ITOH Mamoru (財)実験動物中央研究所, 免疫研究室長 (00176364)
• Project Period (FY): 2007 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥131,000,000 (Direct Cost: ¥131,000,000); Fiscal Year 2011: ¥26,200,000 (Direct Cost: ¥26,200,000); Fiscal Year 2010: ¥26,200,000 (Direct Cost: ¥26,200,000); Fiscal Year 2009: ¥26,200,000 (Direct Cost: ¥26,200,000); Fiscal Year 2008: ¥26,200,000 (Direct Cost: ¥26,200,000); Fiscal Year 2007: ¥26,200,000 (Direct Cost: ¥26,200,000)
• Keywords: ヒト免疫系 / ヒト化マウス / 免疫不全症 / 免疫系ヒト化マウス / NOGマウス / HLA-DRトランスジェニックマウス / 免疫系ヒト化NOGマウス / MHC class II / IgGクラススイッチ / ヒト免疫 / ヒト型マウス / 免疫不全 / ヒト抗体

Research Abstract

In the present study,we established humanized immune mice by using immunodeficient NOG mice. We first established HLAtgMHCII(-/-) NOG mice by crossing of NOG mice which were transfected with HLA-DRB1*0405 gene onto NOG mice which were dencient of MHC class II gene. Susequently, the HLAtgMHCII(-/-) NOG mice were transfused with human cord blood stem cells expressing HLA-DRB1*0405 haplotype gene to establish humanized immune NOG mice. We compared T cell functions and immune responses between HLAtgMHCII(-/-)NOG mice carrying haplotype-matched human leukocytes and haplotype-mismatched human leukocytes. We detected signincant increases of the naive T cell population and cytokine production of T cells and antigen-specific IgG production in sera after TNP-OVA peptide antigen stimulation. These results indicate that the humanized HLAtgMHCII(-/-)NOG mice gain the function of human immune responses.

Research Products

• [Journal Article] Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/ γ cnull mouse. (2012)
  • Author(s): Suzuki M, Takahashi T, Katano T, Ito R, Ito M, Harigae H, Ishii N, Sugamura K.
  • Journal Title: Int. Immunol. Volume: 24 Pages: 243-252
• [Journal Article] Indispensable roles of OX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis of spontaneous pulmonary hypertension (2011)
  • Author(s): Rabieyousefi, M., Soroosh, P., Satoh, K., Date, F., Ishii, N., Yamashita, M., Oka, M., Shimokawa, M., Nose, M., Sugamura, K., Ono, M.
  • Journal Title: BMC Immunology Volume: 12 Pages: 67-67
  • Peer Reviewed
• [Journal Article] AMSH is required to degrade ubiquitinated proteins in the central nervous system (2011)
  • Author(s): Suzuki, S, Tamai, K, Watanabe, M, Kyuuma, M, Ono, M, Sugamura, K., Tanaka, N.
  • Journal Title: Biochem.Biophy.Res.Comm. Volume: 408 Pages: 582-588
  • Peer Reviewed
• [Journal Article] In vivo assay of human NK-dependent ADCC using NOD/SCID/γc^<null> (NOG) mice. (2010)
  • Author(s): Shiokawa, M., Takahashi, T., Murakami, A., Kita, S., lto, M., Sugamura, K. and Ishii, N.
  • Journal Title: Biochem.Biophy. Res. Comm. Volume: 399 Pages: 733-737
• [Journal Article] Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not ate pregnancy in allogeneic mice. (2010)
  • Author(s): Shima, T., Sasaki, Y., Itoh, M., Nakashima, A., Ishii, N., Sugamura, K. and Saito, S.
  • Journal Title: J. Rep. Immunol. Volume: 85 Pages: 121-129
• [Journal Article] Characterization of the EpCAM^+ cell population in hepatocellular carcinoma cell lines (2010)
  • Author(s): Kimura, 0., Takahashi, T., Ishii, N., Inoue, Y., Ueno, Y., Kogure, T., Fukushima, K., Shiina, M., Yamagiwa, Y., Kondo, Y., Inoue, J., Kakazu, E., Iwasaki, T., Kawagishi, N., Shimosegawa, T., and Sugamura, K
  • Journal Title: Cancer Sci. Volume: 101 Pages: 2145-2155
• [Journal Article] In vivo assay of human NK-dependent ADCC using NOD/SCID/γc^<null> (NOG) mice (2010)
  • Author(s): Shiokawa, M., Sugamura, K., et al.
  • Journal Title: Biochem.Biophy.Res.Comm. Volume: 399 Pages: 733-737
  • Peer Reviewed
• [Journal Article] Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein. (2010)
  • Author(s): Tamai, K., Sugamura, K., et al.
  • Journal Title: Biochem.Biophy.Res.Comm. Volume: 399 Pages: 384-390
  • Peer Reviewed
• [Journal Article] Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2rγ^<null> humanized mice (2010)
  • Author(s): Shultz, L.D., Ishikawa, F., et al.
  • Journal Title: Proc.Natl.Acad.Sci., USA Volume: 107 Pages: 13022-13027
  • Peer Reviewed
• [Journal Article] Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML. (2010)
  • Author(s): Saito Y, Ishikawa F, et al
  • Journal Title: Nature Biotechnology 28-3 Pages: 275-280
• [Journal Article] Highly sensitive model for xenogenic GVHD using severe immunodeficient NOG mice. (2009)
  • Author(s): Ito R, Katano I, Kawai K, Hirata H, 0gura T, Kamisako T, Eto T, and Ito M.
  • Journal Title: Transplantaion Volume: 87 Pages: 1654-1658
• [Journal Article] The analysis of the functions of human B and T cells in humanized NOD/shi-scid/{gamma}cnull(NOG) mice (hu-HSC NOG mice). (2009)
  • Author(s): Watanabe Y, Takahashi T, 0kajima A, Shiokawa M, Ishii N, Katano I,Ito R, Ito M, Minegishi M, Minegishi N, Tsuchiya S and Sugamura K.
  • Journal Title: Int. Immunol. Volume: 21 Pages: 843-858
• [Journal Article] Highly sensitive model for xenogenic GVHD using severe immunodeficient NOG mice. (2009)
  • Author(s): Ito R, Ito M, et al
  • Journal Title: Transplantation 87 Pages: 1654-1658
• [Journal Article] The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice). (2009)
  • Author(s): Watanabe Y, Takahashi T, Ito M, Sugamura K, et al
  • Journal Title: Int. Immunol. 21 Pages: 843-858
• [Journal Article] The analysis of the functions of human B and T cells in humanized NOD/shi-scid/{gamma}cnull (NOG) mice (hu-HSC NOG mice). (2009)
  • Author(s): Watanabe Y, Takahashi T, Okajima A, Shiokawa M, Ishii N, Katano I, Ito R, Ito M, Minegishi M, Minegishi N, Tsuchiya S, Sugamura K
  • Journal Title: Int Immunol Volume: 21 Pages: 843-858
  • Peer Reviewed
• [Journal Article] Highly sensitive model for xenogenic GVHD using severe immunodeficient NOG mice. (2009)
  • Author(s): Ito R, Katano I, Kawai K, Hirata H, Ogura T, Kamisako T, Eto T, Ito M.
  • Journal Title: Transplantation Volume: 87 Pages: 1654-1658
  • Peer Reviewed
• [Journal Article] NOD/Shi-scid IL2rgamma(null) (NOG) mice more appropriate for humanized mouse models. (2009)
  • Author(s): Ito M, Kobayashi K, Nakahata T.
  • Journal Title: Curr Top Microbiol Immunol Volume: 324 Pages: 53-76
  • Peer Reviewed
• [Journal Article] The differentiative and regenerative properties of human hematopoietic stem/progenitor cells in the NOD-SCTD/IL2rg^<null> mice. (2008)
  • Author(s): Ishikawa F, Saito Y, Yoshida S, Harada M, Shultz LD.
  • Journal Title: Curr TopMicrobiol Immunol Volume: 324 Pages: 87-94
• [Journal Article] NOD/Shi IL2rg<null>(NOG) mice appropriate for humanized mouse models. (2008)
  • Author(s): Ito M, Kobayashi K, Nakahata T
  • Journal Title: "Humanized mice" , Nomura T, et al.(eds.), Current Topics in Microbiol. and Immunol., Springer-Verlag Berlin Heidelberg Volume: 324 Pages: 53-76
• [Journal Article] Interleukin-4-transgenic hu-PBL-SCID mice: A model for the screening of antiviral drugs and immunotherapeutic agents against X4 HIV-1 viruses. (2008)
  • Author(s): Okuma K, Tanaka r, Ogura T, Ito M, Kumakura S, Yanaka M, Nishizawa M, Sugiura W, Yamamoto N, Tanaka Y
  • Journal Title: J. Infect. Dis. Volume: 197 Pages: 134-141
• [Journal Article] The origins of blood: induction of hematopoietic stem cells from different sources. (2008)
  • Author(s): Saito Y and Ishikawa F.
  • Journal Title: Cell Stem Cell Volume: 3 Pages: 8-10
• [Journal Article] Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival. (2008)
  • Author(s): Kikushige Y, Yoshimoto G, Miyamoto T, Iino T, Mori Y, Iwasaki H, Niiro H, Takenaka K, Nagafuji K, Harada M, Ishikawa F, Akashi K.
  • Journal Title: J Immunol. Volume: 180 Pages: 7358-67
• [Journal Article] Quiescent human hematopoietic stem cells in the bone marrow niches organize the hierarchical structure of hematopoiesis. (2008)
  • Author(s): Yahata, T, Muguruma Y, Yumino S, Sheng Y, Uno T, Matsuzawa H, Ito M, Kato S, Hotta T, and Ando K.
  • Journal Title: Stem Cells Volume: 26 Pages: 3228-3236
• [Journal Article] NOD/Shi-scid IL2rgamma(null)(NOG) mice more appropriate for humanized mouse models. (2008)
  • Author(s): Ito M, Kobayashi K and Nakahata T.
  • Journal Title: Curr. Top. Microbiol. Immunol. Volume: 324 Pages: 53-76
• [Journal Article] NOD/Shi-scid IL2rgamma(null) (NOG) mice more appropriate for humanized mouse models. (2008)
  • Author(s): Ito M, Kobayashi K, Nakahata T
  • Journal Title: Curr Top Microbiol Immunol 324 Pages: 53-76
• [Journal Article] Hematopoietic stem cell-engrafted NOD/SCID/IL2Rgamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses. (2007)
  • Author(s): Watanabe S, Terashima K, 0hta S, Horibata S, Yajima M, Shiozawa Y, Dewan MZ, Yu Z, Ito M, Morio T, Shimizu N, Honda M, Yamamoto N
  • Journal Title: Blood Volume: 109 Pages: 212-218
• [Journal Article] Humanized NOD/SCTD/IL2R{gamma}null mice transplanted with hematopoietic stem cells under non-myeloablative condition show prolonged lifespans and allow detailed analysis of HIV-1 pathogenesis. (2007)
  • Author(s): Watanabe S, 0hta S, Yajima M, Terashima K, Ito M, Mugishima H, Fujiwara S, Shimizu K, Honda M, Shimizu N, Yamamoto N
  • Journal Title: J. Virol.
• [Journal Article] Identification of a key molecular regulator of liver metastasis in human pancreatic carcinoma using a novel quantitative model of metastasis in NOD/SCID/gammacnull(NOG) mice. (2007)
  • Author(s): Suemizu H, Monnai M, 0hnishi Y, Ito M, Tamaoki N, Nakamura M
  • Journal Title: Int. J. Oncol. Volume: 31 Pages: 741-751
• [Journal Article] Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice. (2007)
  • Author(s): Ninomiya M, Abe A, Katsumi A, Xu J, Ito M, Arai F, Suda T, Ito M, Kiyoi H, Kinoshita T, Naoe T
  • Journal Title: Leukemia Volume: 21 Pages: 136-142
• [Journal Article] Noninvasive and real-time assessment of reconstructed functional human endortrium in NOD/SCID/{gamma}formula immunodeficient mice. (2007)
  • Author(s): Masuda H, Maruyama T, Hiratsu E, Yamane J, Iwanami A, Nagashima T, 0no M, Miyoshi H, 0kano HJ, Ito M, Tamaoki N, Nomura T, 0kano H, Matsuzaki Y, Yoshimura Y
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 104 Pages: 1925-1930
• [Journal Article] Human cord blood CD34+ cells develop into hepatocytes in the livers of NOD/SCTD/gamma(c)null mice through cell fusion. (2007)
  • Author(s): Fujino H, Hiramatsu H, Tsuchiya A, Niwa A, Noma H, Shiota M, Umeda K, Yoshimoto M, Ito M, Heike T, Nakahata T
  • Journal Title: Faseb J. Volume: 21 Pages: 3499-3510
• [Journal Article] Humanized mice in translational biomedical research. (2007)
  • Author(s): Shultz LD, Ishikawa F, Greiner DL.
  • Journal Title: Nature Reviews Immunol Volume: 7 Pages: 118-130
• [Journal Article] Chemotherapy-resistant human AML stem cells home to and engraft within the bone marrow endsteal region. (2007)
  • Author(s): Ishikawa F, Yoshida S, Saito Y, Hijikata A, Kitamura H, Tanaka S, Nakamura R, Tanaka T, Tomiyama H, Saito N, Fukata M, Miyamoto T, Lyons B, 0hshima K, Uchida N, Taniguchi S, 0hara 0, Akashi K, Harada M, Shultz LD.
  • Journal Title: Nature Biotechnol Volume: 25 Pages: 1315-1321
• [Journal Article] The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways. (2007)
  • Author(s): Ishikawa F, Niiro H, Iino T, Yoshida S, Saito N, 0nohara S, Miyamoto T, Minagawa H, Fujii SI, Shultz LD, Harada M, Akashi K.
  • Journal Title: Blood Volume: 119 Pages: 3591-3660
• [Journal Article] Chemotherapy-resistant human AML stem cells home to and engraft within the bone marrow endosteal region. (2007)
  • Author(s): Ishikawa F, et al
  • Journal Title: Nature Biotechnology 25 Pages: 1315-1321
• [Journal Article] Role of Hrs in maturation of autophagosomes in mammalian cells. (2007)
  • Author(s): Tamai, K., et. al.
  • Journal Title: Biochem. Biophy. Res. Comm. 360 Pages: 721-727
  • Peer Reviewed
• [Journal Article] Inhibition of tumor growth and metastasis by depletion of vesicular sorting protein Hrs: its regulatory role on E-Cadherin and β-Catenin. (2007)
  • Author(s): Toyoshima, M., et. al.
  • Journal Title: Cancer Res. 67 Pages: 5162-5171
  • Peer Reviewed
• [Journal Article] OX40 costimulation turns off FOXP3^+ T_<REGS-> (2007)
  • Author(s): Vu, MD., et. al.
  • Journal Title: Blood 110 Pages: 2511-2519
  • Peer Reviewed
• [Journal Article] Dendritic cell expression of OX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo. (2007)
  • Author(s): Jenkins, SJ., et. al.
  • Journal Title: J. Immunol. 179 Pages: 3515-3523
  • Peer Reviewed
• [Journal Article] Human CD4^+ central and effector memory T cells produce IL-21: effect on cytokine-driven proliferation of CD4^+ T cell subsets. (2007)
  • Author(s): Onoda, T., et. al.
  • Journal Title: Int. Immunol. 19 Pages: 1191-1199
  • Peer Reviewed
• [Journal Article] Differential requirements for OX40 signals on generation of effector and central memory CD4^+ T cells. (2007)
  • Author(s): Soroosh, P., et. al.
  • Journal Title: J. Immunol. 179 Pages: 5014-5023
  • Peer Reviewed
• [Journal Article] OX40 ligand in dendritic cells can costimulate NKT and CD4^+ helper T cell antitumor immunity. (2007)
  • Author(s): Zaini, J, et. al.
  • Journal Title: J. Clin. Invest. 117 Pages: 3330-3338
  • Peer Reviewed
• [Journal Article] Development of a multi-step leukemogenesis model of MLL-rearranged leukemia using humanized mice.
  • Author(s): Moriya, K., Suzuki, M., Watanabe, Y., Takahashi, T., Aoki, Y., Uchiyama, T., Kumaki, S., Sasahara, Y., Minegishi, M., Kure, S., Tsuchiya, S., Sugamura, K. and Ishii, N.
  • Journal Title: PLos ONE Volume: (in press)
• [Journal Article] Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/γcnull mouse
  • Author(s): Suzuki M, Takahashi T, Katano I, Ito R, Ito M, Harigae H, Ishii N, Sugamura K
  • Journal Title: Int.Immunol. Volume: (印刷中)
  • Peer Reviewed
• [Presentation] Regulation of memory T cell development by OX40 costimulatory Signals (2011)
  • Author(s): Sugamura K., Ishii N.
  • Organizer: 日欧先端科学セミナー
  • Place of Presentation: Hulshorst, Netherlands
  • Year and Date: 2011-03-03
• [Presentation] Understanding normal and diseased human immunity using humanized mouse (2010)
  • Author(s): 石川文彦
  • Organizer: 日本免疫学会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2010-12-03
• [Presentation] The analysis of the functions of human T cells in humanized NOD/shi-scid/γc^<null>(NOG)-HLA transgenic mice. (2010)
  • Author(s): 高橋武司, 他
  • Organizer: 国際免疫学会
  • Year and Date: 2010-08-23
• [Presentation] Understanding normal and diseased human immunity using humanized mouse. (2010)
  • Author(s): 石川文彦
  • Organizer: 国際免疫学会
  • Year and Date: 2010-08-23
• [Presentation] Positional identification of TNFRSF14, encoding the herpes virus entry mediator, as a susceptibility gene for inflammatory bowel disease in mice (2010)
  • Author(s): Kawabe T, Irie M, Ono M, Asao A, Zhang M, Yoshida A, Takahashi T, Uede T, Watanabe N, Sugamura K, Ishii N.
  • Organizer: 国際免疫学会
  • Place of Presentation: 神戸
• [Presentation] OX40-Mediated Susceptibility to Leishmania major Infection is Dependent on IL-13. (2010)
  • Author(s): Asao A, Ndhlovu LC, Hoshino T, Sugamura K, Ishii N.
  • Organizer: 国際免疫学会
  • Place of Presentation: 神戸
• [Presentation] The analysis of the functions of human T cells in humanized NOD/shi-scid/gamma c^<null> (NOG)-HLA transgenic mice. (2010)
  • Author(s): Takahashi T, Suzuki M, Katano I, Ito R, Ishii N, Ito M, Sugamura K.
  • Organizer: 国際免疫学会
  • Place of Presentation: 神戸
• [Presentation] Translational medicine using humanized mouse (2009)
  • Author(s): 石川文彦
  • Organizer: 第39回日本免疫学会総会・学術集会シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] The analysis of the functions of human B and T cells in humanized NOD/shi/ycnu11(NOG)mice (hu-HSC NOGmice). (2009)
  • Author(s): 高橋武司, 他
  • Organizer: 2nd lnt.Workshop on Humanized Mice (Sind 010fskape1/Amsterdam/The Netherlands)
  • Year and Date: 2009-04-04
• [Presentation] High sensitivity to xeno-GVHD in severely immunodeficient NOG mice attributable to dysfunction of dendritic cells. (2009)
  • Author(s): Ito R, Ito M, et al
  • Organizer: 第2回ヒト化マウス国際ワークショップ
  • Place of Presentation: オランダ
• [Presentation] The analysis of the functions of human B and T cells in humanized NOD/shi/γcnull (NOG) mice (hu-HSC NOG mice). (2009)
  • Author(s): Takahashi T, Ito M, Sugamura K, et al
  • Organizer: 第2回ヒト化マウス国際ワークショップ
  • Place of Presentation: オランダ
• [Presentation] The analysis of the functions of human B and T cells in humanized NOD/shi/γcnull (NOG) mice (hu-HSC NOG mice) (2009)
  • Author(s): Takahashi T, Watanabe Y, Okajima A, Katano I, Ito R, Ito M, Ishii N, Tsuchiya S, Sugamura K
  • Organizer: 2nd international workshop on humanized mice
  • Place of Presentation: オランダ・アムステルダム
• [Presentation] Analysis of the functional human T cells in reconstituted NOG mice Facilitating the human B cell development in humanized NOG mice (2008)
  • Author(s): 高橋武司
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2008-12-02
• [Presentation] Analysis of the functional human T cells in reconstitutional humanized NOGmice (2008)
  • Author(s): 岡嶋亮良, 他
  • Organizer: 日本免疫学会
• [Presentation] STAM1/2 double knockout mice enhance inflammatory reaction. (2007)
  • Author(s): 井草龍太郎
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] OX40-OX40L Interactions Determine the Size of Memory CD8+ T cell pools against Listeria Infection (2007)
  • Author(s): Mousavi, SF., et. al.
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] BTLA, HVEMに対するモノクローナル抗体の作製 (2007)
  • Author(s): 青木淳
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] Characterization of human lymphocytes in humanized NOG mice (2007)
  • Author(s): 渡辺庸平, 他
  • Organizer: 日本免疫学会
  • Year and Date: 2007-11-21
• [Presentation] Characterization of human lymphocytes in humanized NOG mice (2007)
  • Author(s): 渡邊庸平
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] Regulation of MHC class II function by ESCRT proteins, STAM1/2Regulation of MHC class II function by ESCRT proteins, STAM1/2. (2007)
  • Author(s): 村田和子
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] c-Cb1 regurates IL-6 Signaling through go130 ubiquitination and Hrs-dependent degradation (2007)
  • Author(s): 田中義乃
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] Co-inhibitory roles for Glucocorticoid-induced TNF receptor (GITR) in CD1d-dependent natural killer T cells. (2007)
  • Author(s): 陳書明
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] Clathrin-dependent entry of severe acute repiratory syndorome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted. (2007)
  • Author(s): 井上 雄喜
  • Organizer: 日本ウイルス学会
  • Place of Presentation: 札幌
  • Year and Date: 2007-10-21
• [Presentation] Clathrin-dependent entry of severe acute repiratory syndorome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted. (2007)
  • Author(s): 井上 雄喜
  • Organizer: Office of Life Science/National University of Singapore-Tohoku University/Centre of Excellence Joint Symposium
  • Place of Presentation: シンガポール
  • Year and Date: 2007-09-05
• [Presentation] Role of Hrs in maturation of autophagosomes in mammalian cells. (2007)
  • Author(s): 玉井 恵一
  • Organizer: Office of Life Science/National University of Singapore-Tohoku University/Centre of Excellence Joint Symposium
  • Place of Presentation: シンガポール
  • Year and Date: 2007-09-05
• [Presentation] Characterization of human lymphocytes in humanized NOG mice (2007)
  • Author(s): 渡邊庸平
  • Organizer: 第61回日本細菌学会東北支部総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-08-23
• [Presentation] OX40-OX40L Interactions Determine the Size of Memory CD8+ T cell pools against Listeria Infection (2007)
  • Author(s): Mousavi, SF., et. al.
  • Organizer: 第61回日本細菌学会東北支部総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-08-23
• [Presentation] オートファジーを介した連鎖球菌の排除におけるHrsの役割の検討 (2007)
  • Author(s): 玉井 恵一
  • Organizer: 第61回日本細菌学会東北支部総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-08-23
• [Presentation] Clathrin-dependent entry of severe acute repiratory syndorome coronavirusinto target cells expressing ACE2 with the cytoplasmic tail deleted. (2007)
  • Author(s): 井上 雄喜
  • Organizer: 第61回日本細菌学会東北支部総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-08-23
• [Book] The differentiative and regenerative properties of human hematopoietic stem/progenitor cells in the NOD-SCID/IL2rgnull mice (2008)
  • Author(s): Ishikawa F, et al
  • Publisher: Springer
• [Patent(Industrial Property Rights)] 白血病幹細胞マーカー (2009)
  • Inventor(s): 石川文彦、小原収、齊藤頼子、北村浩、土方敦司、小澤秀俊
  • Industrial Property Rights Holder: 独立行政法人理化学研究所
  • Industrial Property Number: 2009-072400
  • Filing Date: 2009-03-24
• [Patent(Industrial Property Rights)] 白血病の再発予防薬 (2009)
  • Inventor(s): 石川文彦、齊藤頼子、Shultz LD
  • Industrial Property Rights Holder: 独立行政法人理化学研究所、Shultz LD
  • Industrial Property Number: 2009-052723
  • Filing Date: 2009-03-05
• [Patent(Industrial Property Rights)] 「ヒト白血病幹細胞および白血病非幹細胞が増幅されたマウスおよびその製造方法」 (2007)
  • Inventor(s): 石川文彦、齊藤頼子(PCT:石川文彦、齊藤頼子、小原収、Shultz LD)
  • Industrial Property Rights Holder: 独立行政法人理化学研究所、Shultz LD
  • Industrial Property Number: 2007-271870
  • Filing Date: 2007-10-01